Article
Psychology, Clinical
Congcong Liu, Lei Xu, Jialin Li, Feng Zhou, Xi Yang, Xiaoxiao Zheng, Meina Fu, Keshuang Li, Cornelia Sindermann, Christian Montag, Yina Ma, Dirk Scheele, Richard P. Ebstein, Shuxia Yao, Keith M. Kendrick, Benjamin Becker
Summary: Early life stress is associated with emotional dysregulations and altered brain structure, with serotonin playing a key role in neuroplasticity. The TPH2 gene modulates the impact of early life stress on brain function, with findings suggesting a phenotype characterized by facilitated threat avoidance in interaction with neural organization of limbic-prefrontal circuits.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Ruhan Deniz Topuz, Mehmet Zahid Cetinkaya, Dilsat Erumit, Kubra Duvan Aydemir, Ozgur Gunduz, Cetin Hakan Karadag, Ahmet Ulugol
Summary: Dipyrone exhibited antidepressant and anxiolytic effects in mice exposed to chronic unpredictable mild stress, with its anxiolytic effect possibly mediated through CB1 receptors and its antidepressant action possibly mediated through TRPV1 receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Clinical Neurology
Lei Li, Tianyu Wang, Suzhen Chen, Yingying Yue, Zhi Xu, Yonggui Yuan
Summary: The study found significantly higher levels of DNA methylation at two CpG sites in BDNF exon VI in patients with major depressive disorder, which were associated with the onset of depression and response to antidepressant treatment, especially in females. These findings suggest that gender-specific alterations in methylation of certain CpG sites in BDNF exon VI may serve as a potential biomarker for MDD and antidepressant-induced remission.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Jamie L. Hanson, Brendon M. Nacewicz
Summary: This review examines the impact of early life adversity on the amygdala and proposes models and mechanisms to address existing inconsistencies in research. Researchers aim to explore the effects of ELA on neurobiology and psychosocial adaptation by integrating past and new findings.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Xia Qin, Xiao-Xuan Liu, Yu Wang, Dan Wang, Ying Song, Jia-Xin Zou, Han-Qing Pan, Xiao-Zhou Zhai, Yong-Mei Zhang, Yang-Bo Zhang, Ping Hu, Wen-Hua Zhang
Summary: Early life stress (ELS) increases the risk of anxiety disorders and depression in later life, potentially through hyperactivation of basolateral amygdala (BLA) neurons. In a mouse model mimicking ELS through maternal separation (MS), it was found that MS significantly increased anxiety-like behavior in adulthood and altered neuronal activity and synaptic transmission in BLA projection neurons. This study provides new insights into the mechanisms underlying ELS-induced anxiety disorders.
Article
Clinical Neurology
Tianyu Wang, Lei Li, Yingying Yue, Xiaoyun Liu, Suzhen Chen, Tian Shen, Zhi Xu, Yonggui Yuan
Summary: This study investigates the influence of P11 gene DNA methylation and life stress on the response to antidepressants in patients with major depressive disorder. The results show that the methylation of the P11 gene is significantly higher in patients with major depressive disorder, and the interaction between P11 DNA methylation and early-life stress may affect the response to short-term antidepressant treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Kaila N. Parker, Michael H. Donovan, Kylee Smith, Linda J. Noble-Haeusslein
Summary: The article explores the impact of early life stress on recovery after early brain injury, highlighting the interaction between early life stress and subsequent brain injuries, and summarizing how early life stress affects the immune cell response to injury.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Amelia Cuarenta, Stacey L. Kigar, Ashley P. Keese, Sarah E. Guagliardo, Liza Chang, Vaishali P. Bakshi, Anthony P. Auger
Summary: DNA topoisomerases are important for maintaining genomic integrity by inducing DNA breakage. Our study investigated the effects of early life stress on three topoisomerases in the developing rat brain. We found that exposure to predator odor resulted in a decrease in Top3 beta expression levels, suggesting that early life stress may have consequences for genomic structural integrity and mental health risk.
Review
Nutrition & Dietetics
Ana Agusti, Femke Lamers, Maria Tamayo, Carlos Benito-Amat, Gara V. Molina-Mendoza, Brenda W. J. H. Penninx, Yolanda Sanz
Summary: Exposure to early life stress can significantly impact mental and physical health. The role of the intestinal microbiome in human health, particularly mental health, is becoming increasingly evident. This systematic review found a link between early life stress and the gut microbiome, but no consensus microbiome signatures were identified, highlighting the need for further studies with consistent stressors and validated measures to draw definitive conclusions.
Article
Multidisciplinary Sciences
Feng Zhou, Weihua Zhao, Ziyu Qi, Yayuan Geng, Shuxia Yao, Keith M. Kendrick, Tor D. Wager, Benjamin Becker
Summary: The study developed a neural signature for predicting subjective fear using fMRI and machine learning, showing the crucial role of distributed brain systems in accurate fear prediction. The findings suggest that the neural representation of subjective fear differs from conditioned threat and general negative affect.
NATURE COMMUNICATIONS
(2021)
Article
Environmental Sciences
A. Faria, P. J. Fonseca, M. Vieira, L. M. F. Alves, M. F. L. Lemos, S. C. Novais, A. B. Matos, D. Vieira, M. C. P. Amorim
Summary: This study provides the first evidence of the detrimental effects of boat noise exposure on fish development and stress biomarker responses in the field. If critical early stages are unable to compensate and adapt to noise stress later in ontogeny, anthropogenic noise has the potential to severely impact marine fish populations' resilience and dynamics.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Psychology, Multidisciplinary
Sonja Sudimac, Simone Kuehn
Summary: Urban dwellers are more susceptible to mental disorders, while short-term exposure to nature can improve mood and reduce stress. This study found that amygdala activity decreased after a walk in nature for women, but not for men. Additionally, women performed better on arithmetic tasks after the walk in nature, while men performed better after the walk in an urban environment.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychiatry
Lauren Den Ouden, Chao Suo, Lucy Albertella, Lisa-Marie Greenwood, Rico S. C. Lee, Leonardo F. Fontenelle, Linden Parkes, Jeggan Tiego, Samuel R. Chamberlain, Karyn Richardson, Rebecca Segrave, Murat Yucel
Summary: Compulsivity, which underlies multiple disorders, is still poorly understood. This study identified three stable and distinct subtypes of compulsivity using a heterogeneous sample and data-driven statistical modeling. These subtypes showed meaningful differences in mood, intolerance of uncertainty, urgency, and neurobiological measures.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Behavioral Sciences
Hugo Bottemanne, Lucie Berkovitch, Christophe Gauld, Alexander Balcerac, Liane Schmidt, Stephane Mouchabac, Philippe Fossati
Summary: Ketamine has been considered a promising treatment for MDD, with its rapid antidepressant effects potentially attributed to disrupting predictive processing neural mechanisms. Ketamine impairs top-down predictions by blocking NMDA receptors and enhances the generation of prediction errors, leading to transient dissociative symptoms and fast-acting antidepressant effects.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Alla B. Salmina, Yana V. Gorina, Yulia K. Komleva, Yulia A. Panina, Natalia A. Malinovskaya, Olga L. Lopatina
Summary: Early life stress causes long-lasting changes in brain plasticity, primarily through hyperactivation of hypothalamic-pituitary-adrenal axis, development of neuroinflammation, aberrant neurogenesis and angiogenesis, and significant alterations in brain metabolism. These changes are associated with mitochondrial dysfunction and deregulation of metabolic reprogramming.
Article
Psychology, Clinical
Haeme R. P. Park, Miranda R. Chilver, Arthur Montalto, Javad Jamshidi, Peter R. Schofield, Leanne M. Williams, Justine M. Gatt
Summary: Higher levels of mental wellbeing are associated with increased neural activity in the brain region involved in processing positive emotions. This association is influenced by unique environmental factors, not genetics.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Arthur Montalto, Haeme R. P. Park, Leanne M. Williams, Mayuresh S. Korgaonkar, Miranda R. Chilver, Javad Jamshidi, Peter R. Schofield, Justine M. Gatt
Summary: The study found that greater resilience to trauma is associated with less activation of the anterior insula during a condition requiring sustained attention. This possibly suggests a pattern of 'neural efficiency' in people who may be more resilient to trauma.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Aleksandra Klimova, Isabella A. Breukelaar, Richard A. Bryant, Mayuresh S. Korgaonkar
Summary: This study compared the neural connectivity between mTBI and PTSD and found no significant differences between the two conditions. However, mTBI patients showed reduced connectivity compared to healthy controls in multiple regions, while PTSD patients also exhibited abnormal connectivity within these networks.
HUMAN BRAIN MAPPING
(2023)
Review
Psychiatry
Mara Parellada, Alvaro Andreu-Bernabeu, Monica Burdeus, Antonia San Jose Caceres, Elena Urbiola, Linda L. Carpenter, Nina V. Kraguljac, William M. McDonald, Charles B. Nemeroff, Carolyn I. Rodriguez, Alik S. Widge, Matthew W. State, Stephan J. Sanders
Summary: The aim of this study was to evaluate response biomarkers correlated with autism spectrum disorder (ASD) symptoms. A systematic review was conducted and 280 articles were included, reporting on 940 biomarkers. However, the studies showed high heterogeneity and there is currently no sufficient evidence for response biomarkers in ASD clinical trials.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Boadie W. Dunlop, Jungho Cha, Ki Sueng Choi, Justin K. Rajendra, Charles B. Nemeroff, W. Edward Craighead, Helen S. Mayberg
Summary: This study aimed to determine the shared and unique changes in brain resting-state functional connectivity (rsFC) between patients with major depressive disorder who achieved remission with cognitive-behavioral therapy (CBT) or with antidepressant medication. The results showed that remission from major depression via treatment with CBT or medication is associated with changes in rsFC that are mostly specific to the treatment modality, providing biological support for the clinical practice of switching between or combining these treatment approaches.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Statistics & Probability
J. Kenneth Tay, Nima Aghaeepour, Trevor Hastie, Robert Tibshirani
Summary: In some supervised learning settings, practitioners may have additional information on prediction features. Our proposed method, called the feature-weighted elastic net (fwelnet), uses this information to improve prediction by adjusting penalties on feature coefficients in the elastic net penalty. In simulations, fwelnet outperforms the lasso in terms of test mean squared error and often improves true positive or false positive rates for feature selection. Comparison with other methods reveals fwelnet's superiority, and its application to early prediction of preeclampsia shows improved performance compared to the lasso.
Article
Multidisciplinary Sciences
Aaron T. Mayer, Derek R. Holman, Anav Sood, Utkarsh Tandon, Salil S. Bhate, Sunil Bodapati, Graham L. Barlow, Jeff Chang, Sarah Black, Erica C. Crenshaw, Alexander N. Koron, Sarah E. Streett, Sanjiv S. Gambhir, William J. Sandborn, Brigid S. Boland, Trevor Hastie, Robert Tibshirani, John T. Chang, Garry P. Nolan, Christian M. Schuerch, Stephan Rogalla
Summary: This study uses CODEX technology to create a tissue atlas of inflammation in UC patients and healthy individuals. The analysis reveals the association between cellular functional states and cellular neighborhoods, as well as the presence of resistant niches in UC patients with TNFi treatment. Additionally, the study explores the use of CNNs in predicting patient clinical variables and provides guidelines for reporting predictions in similar datasets.
Article
Environmental Sciences
Shinnosuke Nakayama, WenXin Dong, Richard G. G. Correro, Elizabeth R. R. Selig, Colette C. C. Wabnitz, Trevor J. J. Hastie, Jim Leape, Serena Yeung, Fiorenza Micheli
Summary: Monitoring marine vessel activities is crucial but challenging, especially with limited capacity and resources. Satellite imagery offers a promising solution to observe vessel activities not captured by publicly available tracking data. However, the lack of understanding on its complementarity with existing data hampers its broader use.
FRONTIERS IN MARINE SCIENCE
(2023)
Review
Psychiatry
Alik S. Widge, Ayana Jordan, Nina V. Kraguljac, Christi R. P. Sullivan, Saydra Wilson, Tami D. Benton, Jonathan E. Alpert, Linda L. Carpenter, John H. Krystal, Charles B. Nemeroff, Kafui Dzirasa
Summary: Investigators from minoritized backgrounds are underrepresented in psychiatric research, leading to disparities in mental health care. This underrepresentation is a result of the interlocking effects of structural biases, such as limited access to advanced training and opportunities, stereotype threats and microaggressions, isolation, limited funding, and unique financial pressures. Structural racism, which perpetuates race-based disparities, exists despite efforts to increase diversity. Potential approaches to address these biases include undergraduate research experiences, financial support for training programs, targeted mentoring, better use of diversity funding, scientific reentry support, diversity efforts in leadership, and examination of hiring and promotion practices. Implementing these approaches alongside outcome measurement has the potential to reverse decades of structural bias in psychiatry and psychiatric research.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sheryl L. Foster, Isabella A. Breukelaar, Kanchana Ekanayake, Sarah Lewis, Mayuresh S. Korgaonkar
Summary: This study aims to provide an overview of 3T fMRI protocols used for imaging and functional connectivity (FC) of the amygdala, with a focus on spatial resolution. The secondary objective is to provide context for a discussion leading to recommendations for a standardized protocol for imaging amygdala activation and its subregions.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Mathematics, Interdisciplinary Applications
Booil Jo, Trevor J. J. Hastie, Zetan Li, Eric A. A. Youngstrom, Robert L. L. Findling, Sarah McCue Horwitz
Summary: This study proposes a method for integrating latent variable (LV) modeling into supervised learning. By combining the traditions of LV modeling, psychometrics, and supervised learning, practical prediction targets can be generated and systematically validated based on clinical validators. The feasibility of this integrated approach is demonstrated using data from the LAMS Study.
MULTIVARIATE BEHAVIORAL RESEARCH
(2023)
Article
Psychiatry
Shaunna L. Clark, Cody G. Dodd, Leslie Taylor, Sunita Stewart, Nancy Yang, Jeffrey D. Shahidullah, Andrew G. Guzick, Robyn Richmond, Nazan Aksan, Paul J. Rathouz, Justin F. Rousseau, D. Jeffrey Newport, Karen Dineen Wagner, Charles B. Nemeroff
Summary: This study investigated the substance use patterns and co-occurring psychiatric disorders in trauma-exposed youth. Four primary patterns of substance use were identified, with different characteristics. The findings highlight the importance of universal assessments of trauma, substance misuse, and mental health symptoms in youth.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Boadie W. Dunlop, Jungho Cha, Ki Sueng Choi, Charles B. Nemeroff, W. Edward Craighead, Helen S. Mayberg
Summary: Using neuroimaging data, researchers identified increased connectivity between the subcallosal cingulate cortex and the anterior insula, as well as decreased connectivity between the subcallosal cingulate cortex and the bilateral primary visual cortex and the insula and the bilateral caudate, as predictive factors for recurrence in major depressive disorder (MDD).
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Catherine Ley, Frederik Heath, Trevor Hastie, Zijun Gao, Myroslava Protsiv, Julie Parsonnet
Summary: This cross-sectional study determines the normal oral temperature ranges based on age, sex, height, weight, and time of day by analyzing a large number of clinical visit records. The findings have important implications for temperature assessment and disease diagnosis in clinical medicine.
JAMA INTERNAL MEDICINE
(2023)