Article
Psychology, Clinical
Sinead McLoughlin, Rose Anne Kenny, Cathal McCrory
Summary: This study found that childhood poverty, childhood physical abuse, and having a spouse/partner/child experience a life-threatening illness/accident were associated with increased allostatic load (AL) burden. However, the cumulative adversity was not significantly associated with AL burden, with only three out of 11 adversities showing a relationship with AL.
Article
Behavioral Sciences
Anna Vannucci, Andrea Fields, Eleanor Hansen, Ariel Katz, John Kerwin, Ayumi Tachida, Nathan Martin, Nim Tottenham
Summary: It has been established that early-life adversity has varying effects on brain volumes, depending on age, experience, and region. Interpersonal early adversity, such as family-based maltreatment, initially leads to larger volumes in frontolimbic regions until around 10 years old, after which these exposures are associated with smaller volumes. On the other hand, socioeconomic disadvantage, like poverty, is linked to smaller volumes in temporal-limbic regions in childhood, but this association diminishes with age. These findings contribute to ongoing debates about the impact of early-life adversity on later neural outcomes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Neurosciences
Wen-Hua Zhang, Jun-Yu Zhang, Andrew Holmes, Bing-Xing Pan
Summary: This review highlights the critical role of the amygdala in promoting homeostasis in response to stress by regulating physiological and behavioral responses. It also discusses how stress can cause structural and functional remodeling of amygdala circuits, as well as environmental and genetic factors that influence the amygdala's response to stress. Translating these findings to clinics may lead to valuable tools for prevention, diagnosis, and treatment of stress-related neuropsychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Jing Li, Yue Yu, Jingyi Yuan, Deyun Liu, Jiao Fang, Peipei Wu, Yi Zhou, Ya Wang, Ying Sun
Summary: The study investigates early life adversity in girls with precocious puberty and its association with allostatic load. It found that over two-thirds of girls with central precocious puberty reported early life adversity exposure, and such exposure was associated with significantly higher allostatic load scores. The metabolic system was particularly sensitive to cumulative early life adversity exposure.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Immunology
Erik L. Knight, Yanping Jiang, Jacqueline Rodriguez-Stanley, David M. Almeida, Christopher G. Engeland, Samuele Zilioli
Summary: Exposure to and perceptions of stress are associated with altered systemic inflammation, with diurnal cortisol slopes playing a role in linking self-reported psychological stress to inflammation. The results support an allostatic load model of psychosomatic health, highlighting the importance of cortisol in understanding the relationship between stress exposure, perceived stress, and immune functioning.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Oncology
Jie Shen, Bernard F. Fuemmeler, Yufan Guan, Hua Zhao
Summary: This study examined the association between chronic stress and cancer risk, finding that women with higher levels of chronic stress had a 64% increased risk of overall cancer. This suggests that chronic stress may play a role in the development of cancer.
Article
Endocrinology & Metabolism
Danielle D'Amico, Maya E. Amestoy, Alexandra J. Fiocco
Summary: Early life adversity has a significant impact on cognitive health in mid to late-life, potentially mediated by allostatic load. In middle-aged and older adults without cognitive impairment, allostatic load significantly mediated the relationship between early life adversity and global cognition as well as executive function, but not episodic memory.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Sport Sciences
Sean Latimer Corrigan, Sean Bulmer, Spencer S. H. Roberts, Stuart Warmington, Jace Drain, Luana C. Main
Summary: This study analyzed data from 48 recruits during 12 weeks of basic military training and found that heart rate variability was predicted by subjective responses to the training workload, rather than objective measures of physical activity.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Physiology
Yingxin Zhang, Zhengling Yang, Huan Yang, Xiuyong Li, Zhi Liu, Youwei Bai, Guangrong Qian, Han Wu, Ji Li, Yuwen Guo, Shanfei Yang, Lei Chen, Jian Yang, Jiuhuai Han, Shengyin Ma, Jing Yang, Linfei Yu, Runzhi Shui, Xiping Jin, Hongyu Wang, Fan Zhang, Tianhao Chen, Xinke Li, Xiaoying Zong, Li Liu, Jihui Fan, Wei Wang, Yong Zhang, Guangcai Shi, Deguang Wang, Shuman Tao
Summary: This study investigated the association between serum magnesium (Mg2+) levels and allostatic load (AL) in hemodialysis patients. The results showed that patients with lower levels of serum Mg2+ were more likely to have high AL. Higher serum Mg2+ concentrations may contribute to lower health risk in hemodialysis populations.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Natalia Orendain, Adriana Galvan, Emma Smith, Elizabeth S. Barnert, Paul J. Chung
Summary: Every year, a large number of youth arrests in the United States put significant neurodevelopmental strain on these young individuals, particularly those who have experienced early life adversity. Disproportionate contact with the juvenile justice system is observed among males, Black and Latinx youth, and those from low socioeconomic status households. The conditions of confinement in the system, which include threat, abuse, and isolation from family and social supports, restrict youths' educational and exploratory behaviors. These conditions, along with their ineffectiveness in preventing future delinquent behaviors and high recidivism rates, likely worsen the adversity burden and harm neurodevelopment during adolescence. Developmentally appropriate interventions that minimize confinement and leverage adolescents' rehabilitative potential should be advocated for by pediatric and behavioral health care communities.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Charles C. Lanfear, Rebecca Bucci, David S. Kirk, Robert J. Sampson
Summary: This study examines the differences in exposure to firearm violence by race, sex, and cohort in a longitudinal survey of children in the United States. The findings show significant disparities in exposure to violence based on race and sex, suggesting that societal conditions play a key role. The study highlights the importance of understanding the factors influencing exposure to firearm violence. Evaluation: 8 out of 10.
Article
Business
Jarvis Smallfield, Donald H. Kluemper
Summary: This study suggests that organizational personality change is malleable but lacks a comprehensive theoretical model. By integrating recent advances in biology, epigenetics, and psychology, a comprehensive model of organizational personality change is introduced, explaining how workplace stress appraisal alters employee personality through neurochemical systems and impacts organizational outcomes.
JOURNAL OF MANAGEMENT
(2022)
Article
Cell Biology
Wenjing Ma, Pengfei Liu, Jie Zheng, Jinhui Lu, Qian Zhao, Danni Li, Yuefan Guo, Lu Qian, Qiong Wang, Xinman Miao, Zuoren Yu
Summary: This study revealed that mental stress can lead to elevated stress hormone levels, decreased T and NK cell percentages, accelerated tumor growth, and promoted cell proliferation. miRNA screening identified downregulated miRNAs in tumors of stressed mice, with miR-346 and miR-493 targeting CCND1 as the top two most significantly downregulated miRNAs. The stress-miRNA-CCND1 signaling regulation of tumor cell proliferation was confirmed in vitro, suggesting a potential therapeutic strategy for cancer patients suffering mental stress.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Psychology, Multidisciplinary
Benjamin Otto, Lisa Kokkelink, Martin Brune
Summary: The study found that BPD patients had higher scores on the fast Pace-of-Life Syndrome (PoLS), were more aggressive, experienced more chronic stress, and had more severe childhood adversity. Childhood trauma predicted PoLS, which in turn predicted allostatic load (AL).
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychiatry
Stefanie L. Sequeira, Jennifer S. Silk, Cecile D. Ladouceur, Jamie L. Hanson, Neal D. Ryan, Judith K. Morgan, Dana L. McMakin, Philip C. Kendall, Ronald E. Dahl, Erika E. Forbes
Summary: The study identified a relationship between neural activation to rewards and response to psychotherapy in youths with anxiety disorders, showing differences compared to healthy youths. Activation in the striatum to rewards did not differentiate between anxiety and healthy youths, but greater striatal responsivity to rewards may help youths with anxiety improve during treatment. This suggests that function in reward circuitry may guide the development of treatments for youths with anxiety.
AMERICAN JOURNAL OF PSYCHIATRY
(2021)
Article
Psychology, Developmental
Esther E. Palacios-Barrios, Jamie L. Hanson, Kelly R. Barry, W. Dustin Albert, Stuart F. White, Ann T. Skinner, Kenneth A. Dodge, Jennifer E. Lansford
Summary: Research shows that lower family income during childhood is associated with increased rates of adolescent depression. Individuals with depression exhibit hypoactivation in brain regions involved in reward learning and decision-making processes. This suggests a link between lower family income and disruptions in reward and decision-making brain circuitry contributing to adolescent depression.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Elizabeth A. Shirtcliff, Jamie L. Hanson, Jenny M. Phan, Paula L. Ruttle, Seth D. Pollak
Summary: Research shows that post-institutionalized youth have lower morning cortisol levels and flatter diurnal rhythms in the lab, but higher morning cortisol levels at home. Those who have endured the most severe early adversity exhibit lower cortisol levels at home. This highlights the impact of early adversity on HPA axis activity and the importance of considering context when studying post-institutionalized youth.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Neurosciences
Stefanie L. Sequeira, Jennifer S. Silk, Elizabeth A. Edershile, Neil P. Jones, Jamie L. Hanson, Erika E. Forbes, Cecile D. Ladouceur
Summary: This study utilized fMRI computer tasks and ecological momentary assessment protocols to investigate the neural responses to social threat and their associations with brain regions related to threat processing in daily life. The findings suggested that daily life reactivity to perceived social threat was linked to neural activity in threat-related brain regions, as well as functional connectivity between these regions during rejection feedback. Unexpectedly, heightened amygdala and insula activation to peer acceptance in daily life was also observed in individuals with greater social threat reactivity, providing insights into brain-behavior associations supporting sensitivity to social evaluation in adolescence.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2021)
Article
Neurosciences
Bryan Kennedy, Jamie L. Hanson, Nicholas J. Buser, Wouter van den Bos, Karen D. Rudolph, Richard J. Davidson, Seth D. Pollak
Summary: This study investigates the neural and behavioral alterations in reward-learning in children who have experienced early life adversity, finding a correlation between higher ELA and lower quantitative anisotropy in accumbofrontal white matter, leading to differences in reward learning.
NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Behavioral Sciences
Shannon D. Donofry, Chelsea M. Stillman, Jamie L. Hanson, Margaret Sheridan, Shufang Sun, Eric B. Loucks, Kirk Erickson
Summary: Adverse childhood experiences have long-term negative impacts on brain health in adulthood, potentially leading to premature and severe declines. Physical activity may serve as a low-cost intervention for mitigating these effects, yet research on its impact among individuals with a history of early life adversity is limited.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Nicole L. Hair, Jamie L. Hanson, Barbara L. Wolfe, Seth D. Pollak
Summary: Despite advancements in the study of brain maturation at different developmental epochs, this study aimed to link the significant neural changes occurring just after birth to the subtler refinements in the brain occurring in childhood and adolescence. The data revealed significant structural differences in gray matter development for children living in or near poverty, which evolve throughout adolescence.
Review
Psychiatry
Jamie L. Hanson, Alexia Williams, Debra A. Bangasser, Catherine J. Pena
Summary: Early life stress increases the risk of mood, anxiety, and substance use disorders throughout one's lifetime, mainly through changes in motivation and reward processing in the reward circuit. Research indicates that early life stress impacts the structure and function of the reward circuit.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Tochukwu Nweze, Michael Ezenwa, Cyriacus Ajaelu, Jamie L. Hanson, Chukwuemeka Okoye
Summary: Different methodological approaches, including latent class analysis and structured lifecourse modelling, were applied to study the complex effects of childhood adversity on cognitive outcomes. The findings suggest that dimensional approaches can be used to identify co-occurring adversity patterns and target interventions, while lifecourse modelling highlights the critical timeframes for intervention. These findings are important for understanding the impact of childhood adversity on cognitive outcomes.
Article
Public, Environmental & Occupational Health
Jamie L. Hanson, Kristen O'Connor, Dorthea J. Adkins, Isabella Kahhale
Summary: This study investigates the association between childhood adversity and COVID-19-related hospitalization and mortality. The results suggest a significant association between childhood adversity and higher likelihood of COVID-19-related hospitalization and death, even after adjusting for potential confounders.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Multidisciplinary Sciences
Isabella Kahhale, Kelly R. Barry, Jamie L. Hanson
Summary: Childhood stress has negative effects on youth behavior and brain development. Positive parenting can act as a buffer against these effects. This study found that self-reported positive parenting mitigated the association between childhood stress and youth behavior problems as well as decreased hippocampal volumes.
Article
Psychology, Developmental
Idil Yazgan, Jamie L. Hanson, John E. Bates, Jennifer E. Lansford, Gregory S. Pettit, Kenneth A. Dodge
Summary: One in four children experience a traumatic event by the age of four, which may lead to later antisocial behavior. Research suggests that deficits in neurocognitive functioning, specifically passive avoidance problems, may play a critical mediating role between early childhood adversity and later antisocial behavior.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2021)
Article
Psychology, Developmental
Jamie L. Hanson, W. Dustin Albert, Ann T. Skinner, Shutian H. Shen, Kenneth A. Dodge, Jennifer E. Lansford
DEVELOPMENT AND PSYCHOPATHOLOGY
(2019)
Article
Psychology, Developmental
W. Dustin Albert, Jamie L. Hanson, Ann T. Skinner, Kenneth A. Dodge, Laurence Steinberg, Kirby Deater-Deckard, Marc H. Bornstein, Jennifer E. Lansford
DEVELOPMENTAL SCIENCE
(2020)
