Article
Behavioral Sciences
Vincent DeLuca, Toms Voits
Summary: Bilingualism has been found to delay age-related neurocognitive decline and influence white matter integrity. However, previous research has mainly focused on older adults and young adults, neglecting the middle-aged population. This study used DTI to examine the effects of bilingualism and degree of bilingual engagement on white matter integrity. The results showed that bilingualism, particularly higher engagement, can slow down the decline in white matter integrity associated with aging.
Article
Clinical Neurology
Megan McMahon, Yoshita Malneedi, Darrell A. Worthy, David M. Schnyer
Summary: This study found a significant association between rest-activity rhythm stability and white matter microstructure in healthy adults across different age groups, suggesting that rest-activity rhythm may serve as a biomarker of brain health throughout the adult lifespan.
Article
Neurosciences
Matthew Kiely, Curtis Triebswetter, Luis E. Cortina, Zhaoyuan Gong, Maryam H. Alsameen, Richard G. Spencer, Mustapha Bouhrara
Summary: This study evaluated sex and age-related differences in white matter microstructure using diffusion tensor imaging (DTI) and magnetic resonance imaging (MRI). The results showed that myelin content and axonal density in white matter exhibited nonlinear changes with age, and the posterior white matter regions were more preserved from neurodegeneration compared to anterior regions. Additionally, DTI indices were moderately correlated with myelin content, indicating their sensitivity to other constituents of white matter tissue.
Article
Neurosciences
Derek Sayre Andrews, Joshua K. Lee, Danielle Jenine Harvey, Einat Waizbard-Bartov, Marjorie Solomon, Sally J. Rogers, Christine Wu Nordahl, David G. Amaral
Summary: The study found that autistic children showed slower development of fractional anisotropy in certain white matter regions, and changes in white matter diffusion parameters were associated with longitudinal changes in autism severity. These findings suggest that differences in white matter development are linked to functional differences in the autistic brain and may be indicative of atypical neurodevelopment.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Dani Beck, Ann-Marie G. de Lange, Ivan I. Maximov, Genevieve Richard, Ole A. Andreassen, Jan E. Nordvik, Lars T. Westlye
Summary: The study reveals that advanced diffusion models provide sensitive measures of age-related microstructural changes in white matter, complementing and extending the conventional DTI contribution. Through linear mixed effects models and machine learning, the research assessed age trajectories in healthy individuals and compared the age prediction accuracy of different diffusion models, showing that advanced models performed similarly to conventional DTI.
Article
Psychiatry
Nakul Aggarwal, Lisa E. Williams, Do P. M. Tromp, Daniel S. Pine, Ned H. Kalin
Summary: This longitudinal study found a dynamic relationship between whole-brain white matter microstructural integrity and anxiety symptoms in girls with pathological anxiety. The findings suggest that targeting white matter development could be a viable approach in the treatment of anxiety-related psychopathology.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Samantha K. K. Holden, Brianne M. M. Bettcher, Christopher M. M. Filley, Dan Lopez-Paniagua, Victoria S. S. Pelak
Summary: This study explored the relationship between scores on the Colorado Posterior Cortical Questionnaire (CPC-Q) and white matter integrity. The results showed that CPC-Q scores were correlated with DTI FA of the averaged posterior white matter regions, with the DTI FA of the posterior thalamic radiations showing the strongest association. These findings suggest that the integrity of posterior white matter tracts is related to scores on the CPC-Q, providing further validation for this questionnaire.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Jingyi Tang, Yue Xie, Weihua Liao, Youming Zhang, Fangxue Yang, Linmei Zhao, Gaofeng Zhou, Yuanchao Zhang, Hong Jiang, Wu Xing
Summary: Gray matter volume and thickness reductions have been found in SCA3 patients. This study explored cortical gyrification alterations using LGI and FA and found widespread reductions in LGI and white matter FA in SCA3 patients. The abnormalities in gyrification may contribute to the clinical heterogeneity of SCA3 and may be mediated by white matter microstructural abnormalities.
Article
Clinical Neurology
Clarissa Lin Yasuda, Luciana Ramalho Pimentel-Silva, Guilherme Coco Beltramini, Min Liu, Brunno Machado de Campos, Ana Carolina Coan, Christian Beaulieu, Fernando Cendes, Donald William Gross
Summary: Typical aging is associated with cognitive decline and changes in brain structure. In mesial temporal lobe epilepsy patients, cognitive decline starts early in life and runs parallel to controls, suggesting initial insult rather than accelerated decline due to seizures. Whether TLE patients show similar age-related gray and white matter changes as healthy controls is uncertain.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Martin Domin, Brenton Hordacre, Pavel Hok, Lara A. Boyd, Adriana B. Conforto, Justin W. Andrushko, Michael R. Borich, Richard C. Craddock, Miranda R. Donnelly, Adrienne N. Dula, Steven J. Warach, Steven A. Kautz, Bethany P. Lo, Christian Schranz, Na Jin Seo, Shraddha Srivastava, Kristin A. Wong, Artemis Zavaliangos-Petropulu, Paul M. Thompson, Sook-Lei Liew, Martin Lotze
Summary: The study found that stroke patients with severe CST damage rely on residual pathways for better upper limb function recovery.
Article
Neurosciences
Dongha Lee, Hae-Jeong Park
Summary: This study investigates the three-dimensional organization of neural fiber connections in the white matter of the brain. By analyzing connection distribution maps and related parameters, the study reveals the patterns of major fiber bundle connections in the white matter.
Article
Geriatrics & Gerontology
Jenna L. Merenstein, Maria M. Corrada, Claudia H. Kawas, Ilana J. Bennett
Summary: The study found nonlinear declines in white matter microstructure, especially in medial temporal fibers, across different fiber classes. These patterns persisted even after excluding the oldest-old participants with cognitive impairment no dementia, suggesting that white matter microstructure aging cannot solely be explained by pathology associated with early cognitive impairment. Furthermore, the mediation of age effects on episodic memory by medial temporal fiber microstructure indicates its essential role in facilitating memory-related neural signals across the older adult lifespan.
NEUROBIOLOGY OF AGING
(2021)
Review
Neurosciences
Francis A. M. Manno, Raul Rodriguez-Cruces, Rachit Kumar, J. Tilak Ratnanather, Condon Lau
Summary: Hearing loss, a heterogeneous disorder, is found to impact grey and white matter in nearly every brain region according to MRI studies. Congenital loss decreases grey matter in frontal lobe most, while acquired loss shows significant decreases in both frontal and insula grey matter. Different impacts on hemispheres are observed between congenital and acquired hearing loss.
Article
Psychiatry
Feng Chen, Marina Mihaljevic, Zhipeng Hou, Yang Li, Hanzhang Lu, Susumu Mori, Akira Sawa, Andreia V. Faria
Summary: This study investigated the relationship between cerebral blood flow (CBF) and white matter structure in early-stage schizophrenia patients. The findings revealed an inverse correlation between CBF and fractional anisotropy (FA) in the corpus callosum, as well as a positive correlation between FA and processing speed. Mediation analysis showed that the effect of FA on processing speed was mediated by CBF.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Jingxuan Ruan, Ningkai Wang, Junle Li, Jing Wang, Qihong Zou, Yating Lv, Han Zhang, Jinhui Wang
Summary: In this study, a comprehensive analysis was conducted to examine the topological changes in single-subject morphological brain networks across the adult lifespan. Age-related changes were observed in the global attributes and efficiency, local nodal centralities, and interregional similarities of these networks. The changes mainly occurred in the cortical thickness networks, particularly in frontal regions and highly connected hubs, and were characterized by linear, quadratic, and cubic patterns. Additionally, the morphological similarity in cortical thickness between two frontal regions was found to mediate the relationship between age and cognition.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Robert Jones, Giorgia Grisot, Jean Augustinack, Caroline Magnain, David A. Boas, Bruce Fischl, Hui Wang, Anastasia Yendiki
Review
Neurosciences
Suzanne N. Haber, Anastasia Yendiki, Saad Jbabdi
Summary: This study examined the similarities and differences across four deep brain stimulation targets, finding that these targets generally involve similar connections but also have some unique connections. Delineating the similarities and differences across targets is critical for evaluating and comparing their effectiveness and how circuits contribute to therapeutic outcomes.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Yoon Ji Lee, Xavier Guell, Nicholas A. Hubbard, Viviana Siless, Isabelle R. Frosch, Mathias Goncalves, Nicole Lo, Atira Nair, Satrajit S. Ghosh, Stefan G. Hofmann, Randy P. Auerbach, Diego A. Pizzagalli, Anastasia Yendiki, John D. E. Gabrieli, Susan Whitfield-Gabrieli, Sheeba Arnold Anteraper
Summary: This study found differences in functional connectivity in the cerebellar output circuit among adolescents with anxiety disorders, indicating that the dentate nuclei may be a clinical and subclinical marker of anxiety.
Article
Neurosciences
Alina Scholz, Robin Etzel, Markus W. May, Mirsad Mahmutovic, Qiyuan Tian, Gabriel Ramos-Llorden, Chiara Maffei, Berkin Bilgic, Thomas Witzel, Jason P. Stockmann, Choukri Mekkaoui, Lawrence L. Wald, Susie Yi Huang, Anastasia Yendiki, Boris Keil
Summary: In this study, a 48-channel ex vivo whole brain array coil was designed and constructed for high-resolution and high b-value diffusion-weighted imaging on a 3T Connectome scanner. The coil showed significantly increased SNR in the peripheral cortex and center regions compared to a 64-channel head coil designed for in vivo use. Additionally, the coil reduced noise amplification in highly parallel imaging, allowing for higher acceleration factors.
Article
Neurosciences
Aina Frau-Pascual, Jean Augustinack, Divya Varadarajan, Anastasia Yendiki, David H. Salat, Bruce Fischl, Iman Aganj
Summary: This study used a structural connectivity quantification measure derived from diffusion magnetic resonance imaging to analyze brain connectivity in dementia, showing expected trends of conductance with age and cognitive scores, and potential for prediction. The measure could be useful for studying effects such as anticorrelation in structural connections.
BRAIN CONNECTIVITY
(2021)
Article
Neurosciences
Susie Y. Huang, Thomas Witzel, Boris Keil, Alina Scholz, Mathias Davids, Peter Dietz, Elmar Rummert, Rebecca Ramb, John E. Kirsch, Anastasia Yendiki, Qiuyun Fan, Qiyuan Tian, Gabriel Ramos-Llorden, Hong-Hsi Lee, Aapo Nummenmaa, Berkin Bilgic, Kawin Setsompop, Fuyixue Wang, Alexandru Avram, Michal Komlosh, Dan Benjamini, Kulam Najmudeen Magdoom, Sudhir Pathak, Walter Schneider, Dmitry S. Novikov, Els Fieremans, Slimane Tounekti, Choukri Mekkaoui, Jean Augustinack, Daniel Berger, Alexander Shapson-Coe, Jeff Lichtman, Peter J. Basser, Lawrence L. Wald, Bruce R. Rosen
Summary: The Human Connectome Project marked advancements in MRI technology for mapping the structural connections of the human brain, showcasing the potential of high-gradient performance scanners for studying neural tissue microstructure. The development of the next-generation Connectome scanner aims to optimize the study of neural tissue microstructure and connectional anatomy, pushing diffusion resolution to unprecedented levels and creating an ultimate diffusion MRI instrument capable of capturing the multi-scale organization of the living human brain.
Article
Neurosciences
Robert Jones, Chiara Maffei, Jean Augustinack, Bruce Fischl, Hui Wang, Berkin Bilgic, Anastasia Yendiki
Summary: The study evaluates the application of compressed sensing techniques in diffusion spectrum imaging, finding that CS-DSI can be used to accurately reconstruct the EAP with high fidelity and approximate fully sampled DSI data in a shorter acquisition time. However, the study notes that the signal-to-noise ratio affects the accuracy of CS-DSI, and increasing the CS acceleration factor beyond a certain point may impact the accuracy of the reconstruction methods.
Article
Neurosciences
Giorgia Grisot, Suzanne N. Haber, Anastasia Yendiki
Summary: Anatomic tracing is used to assess the accuracy of diffusion MRI (dMRI) tractography in the same macaque brain, revealing common failure modes involving geometries such as branching or turning. Default thresholds in tractography are conservative, with deterministic tractography exhibiting higher sensitivity than probabilistic tractography in a very conservative threshold regime. Inter-individual variability in macaque brains highlights caution when using dMRI and tracer data from different animals for validation purposes.
Article
Biochemical Research Methods
Chao J. Liu, William Ammon, Robert J. Jones, Jackson Nolan, Ruopeng Wang, Shuaibin Chang, Matthew P. Frosch, Anastasia Yendiki, David A. Boas, Caroline Magnain, Bruce Fischl, Hui Wang
Summary: The importance of polarization-sensitive optical coherence tomography (PS-OCT) in human brain imaging is increasingly recognized. This study investigated the effect of refractive index matching on the improvement of PS-OCT measurements in ex vivo human brain tissue. The results showed that refractive index matching reduced noise in axis orientation measurements and enabled more precise measurements of apparent birefringence, leading to improved results in fiber tract quantification.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Arman Avesta, Anastasia Yendiki, Vincent Perlbarg, Lionel Velly, Omid Khalilzadeh, Louis Puybasset, Damien Galanaud, Rajiv Gupta
Summary: This study aimed to assess if quantitative diffusion magnetic resonance imaging analysis would improve prognostication of individual patients with severe traumatic brain injury. The results showed that quantifying severity of injury to white-matter tracts complements qualitative imaging findings and improves outcome prediction in severe traumatic brain injury.
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
(2022)
Article
Neurosciences
Anastasia Yendiki, Manisha Aggarwal, Markus Axer, Amy F. D. Howard, Anne-Marie van Cappellen van Walsum, Suzanne N. Haber
Summary: This review discusses methods for validating the features of connectional anatomy extracted from dMRI, including macro-scale trajectories of axon bundles and micro-scale axonal orientations. A range of validation tools, including anatomic tracer studies, Klingler's dissection, myelin stains, and label-free optical imaging techniques, are presented. The basic principles, limitations, and insights into the accuracy of different dMRI acquisition and analysis approaches are overviewed.
Article
Neurosciences
Qiuyun Fan, Cornelius Eichner, Maryam Afzali, Lars Mueller, Chantal M. W. Tax, Mathias Davids, Mirsad Mahmutovic, Boris Keil, Berkin Bilgic, Kawin Setsompop, Hong-Hsi Lee, Qiyuan Tian, Chiara Maffei, Gabriel Ramos-Llorden, Aapo Nummenmaa, Thomas Witzel, Anastasia Yendiki, Yi-Qiao Song, Chu-Chung Huang, Ching-Po Lin, Nikolaus Weiskopf, Alfred Anwander, Derek K. Jones, Bruce R. Rosen, Lawrence L. Wald, Susie Y. Huang
Summary: In the past decade, tremendous efforts have been made to advance cutting-edge MRI technology in order to map the structural connectivity in the living human brain. This review article summarizes the technical developments in using the Connectom scanner for large-scale and scientific studies of the human brain, and discusses the scientific impact of the Connectom MRI scanner.
Article
Neurosciences
Chiara Maffei, Gabriel Girard, Kurt G. Schilling, Dogu Baran Aydogan, Nagesh Adluru, Andrey Zhylka, Ye Wu, Matteo Mancini, Andac Hamamci, Alessia Sarica, Achille Teillac, Steven H. Baete, Davood Karimi, Fang-Cheng Yeh, Mert E. Yildiz, Ali Gholipour, Yann Bihan-Poudec, Bassem Hiba, Andrea Quattrone, Aldo Quattrone, Tommy Boshkovski, Nikola Stikov, Pew-Thian Yap, Alberto de Luca, Josien Pluim, Alexander Leemans, Vivek Prabhakaran, Barbara B. Bendlin, Andrew L. Alexander, Bennett A. Landman, Erick J. Canales-Rodriguez, Muhamed Barakovic, Jonathan Rafael-Patino, Thomas Yu, Gaetan Rensonnet, Simona Schiavi, Alessandro Daducci, Marco Pizzolato, Elda Fischi-Gomez, Jean-Philippe Thiran, George Dai, Giorgia Grisot, Nikola Lazovski, Santi Puch, Marc Ramos, Paulo Rodrigues, Vesna Prckovska, Robert Jones, Julia Lehman, Suzanne N. Haber, Anastasia Yendiki
Summary: Efforts to improve the accuracy of brain pathway reconstruction through dMRI tractography have been made. The IronTract Challenge aims to optimize dMRI analysis methods and assess their accuracy using high-resolution dMRI data. The challenge highlights the difficulty in reconstructing complex fiber configurations and provides a valuable validation tool for users and developers in the dMRI community.
Article
Medicine, General & Internal
Joao Paulo Lima Santos, Michele Bertocci, Genna Bebko, Tina Goldstein, Tae Kim, Satish Iyengar, Lisa Bonar, MaryKay Gill, John Merranko, Anastasia Yendiki, Boris Birmaher, Mary L. Phillips, Amelia Versace
Summary: Diffusion Magnetic Resonance Imaging (dMRI) studies have found abnormalities in emotion regulation circuits in patients with early-onset bipolar disorder (BD), and this study aims to examine the contribution of previous illness and its neural correlates. The results show that a higher number of depressive episodes during childhood/adolescence and higher percentage of time with syndromic depression were associated with lower fractional anisotropy (FA) in certain brain regions. Lower FA in these regions was also correlated with higher depressive and anxiety symptoms. Interestingly, higher FA in certain brain regions was protective against the recurrence of depressive episodes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biophysics
Gabriel Ramos-Llorden, Rodrigo A. Lobos, Tae Hyung Kim, Qiyuan Tian, Thomas Witzel, Hong-Hsi Lee, Alina Scholz, Boris Keil, Anastasia Yendiki, Berkin Bilgic, Justin P. Haldar, Susie Y. Huang
Summary: Ex vivo diffusion magnetic resonance imaging allows for mapping of structural connectivity in the human brain with high spatial resolution. However, strong diffusion-sensitizing gradients and multishot/segmented echo-planar imaging sequences can lead to ghosting artifacts that limit the accuracy of the imaging. A recently developed k-space reconstruction method based on structured low-rank matrix modeling can effectively correct for these artifacts.
NMR IN BIOMEDICINE
(2023)
