Retigabine, a Kv7.2/Kv7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 Mutations

Potent KCNQ2/3-Specific Channel Activator Suppresses In Vivo Epileptic Activity and Prevents the Development of Tinnitus

(2015) B. I. Kalappa et al.   JOURNAL OF NEUROSCIENCE

A recurrent KCNQ2 pore mutation causing early onset epileptic encephalopathy has a moderate effect on M current but alters subcellular localization of Kv7 channels

(2015) Affef Abidi et al.   NEUROBIOLOGY OF DISEASE

Antiseizure drugs differentially modulate theta-burst induced long-term potentiation in C57BL/6 mice

(2014) Peter J. West et al.   EPILEPSIA

Kv7.2 regulates the function of peripheral sensory neurons

(2014) Chih H. King et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Conditional Deletions of Epilepsy-Associated KCNQ2 and KCNQ3 Channels from Cerebral Cortex Cause Differential Effects on Neuronal Excitability

(2014) H. Soh et al.   JOURNAL OF NEUROSCIENCE

The GABA excitatory/inhibitory developmental sequence: A personal journey

(2014) Y. Ben-Ari   NEUROSCIENCE

The Kick-In System: A Novel Rapid Knock-In Strategy

(2014) Yuko Tomonoh et al.   PLoS One

Blue-Gray Mucocutaneous Discoloration

(2014) Tali Garin Shkolnik et al.   JAMA Dermatology

Dominant-negative effects ofKCNQ2mutations are associated with epileptic encephalopathy

(2013) Gökce Orhan et al.   ANNALS OF NEUROLOGY

Clinical spectrum of early onset epileptic encephalopathies caused byKCNQ2mutation

(2013) Mitsuhiro Kato et al.   EPILEPSIA

Similar early characteristics but variable neurological outcome of patients with a de novo mutation of KCNQ2

(2013) Mathieu Milh et al.   Orphanet Journal of Rare Diseases

Effects of KCNQ2 Gene Truncation on M-Type Kv7 Potassium Currents

(2013) Jon Robbins et al.   PLoS One

The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy

(2012) Martin J. Gunthorpe et al.   EPILEPSIA

The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: Implications for clinical use

(2012) Charles H. Large et al.   EPILEPSIA

How theories evolved concerning the mechanism of action of barbiturates

(2012) Wolfgang Löscher et al.   EPILEPSIA

KCNQ2 abnormality in BECTS: Benign childhood epilepsy with centrotemporal spikes following benign neonatal seizures resulting from a mutation of KCNQ2

(2012) Atsushi Ishii et al.   EPILEPSY RESEARCH

KCNQ2 encephalopathy: Emerging phenotype of a neonatal epileptic encephalopathy

(2011) Sarah Weckhuysen et al.   ANNALS OF NEUROLOGY

Temperature and pharmacological rescue of a folding-defective, dominantl-negative KV7.2 mutation associated with neonatal seizures

(2011) Snezana Maljevic et al.   HUMAN MUTATION

Phenobarbital but Not Diazepam Reduces AMPA/kainate Receptor Mediated Currents and Exerts Opposite Actions on Initial Seizures in the Neonatal Rat Hippocampus

(2011) Romain Nardou et al.   Frontiers in Cellular Neuroscience

Retigabine (ezogabine) as add-on therapy for partial-onset seizures: an update for clinicians

(2011) Jacklyn A. Harris et al.   Therapeutic Advances in Chronic Disease

Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier

(2010) A. Peretz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A KCNQ channel opener for experimental neonatal seizures and status epilepticus

(2009) YogendraSinh H. Raol et al.   ANNALS OF NEUROLOGY

Electroconvulsive seizure thresholds and kindling acquisition rates are altered in mouse models of humanKCNQ2andKCNQ3mutations for benign familial neonatal convulsions

(2009) James F. Otto et al.   EPILEPSIA

Development of Spontaneous Recurrent Seizures after Kainate-Induced Status Epilepticus

(2009) P. A. Williams et al.   JOURNAL OF NEUROSCIENCE

Deletions involving both KCNQ2 and CHRNA4 present with benign familial neonatal seizures

(2009) H. Kurahashi et al.   NEUROLOGY

A revised Racine's scale for PTZ-induced seizures in rats

(2009) Annika Lüttjohann et al.   PHYSIOLOGY & BEHAVIOR

Ablation of NMDA Receptors Enhances the Excitability of Hippocampal CA3 Neurons

(2009) Fumiaki Fukushima et al.   PLoS One

Developmental changes in KCNQ2 and KCNQ3 expression in human brain: Possible contribution to the age-dependent etiology of benign familial neonatal convulsions

(2008) Takeshi Kanaumi et al.   BRAIN & DEVELOPMENT

A de novo KCNQ2 mutation detected in non-familial benign neonatal convulsions

(2008) Atsushi Ishii et al.   BRAIN & DEVELOPMENT

Mouse models of humanKCNQ2andKCNQ3mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization

(2008) Nanda A. Singh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Nervous system KV7 disorders: breakdown of a subthreshold brake

(2008) Snezana Maljevic et al.   JOURNAL OF PHYSIOLOGY-LONDON

Refinement of the Binding Site and Mode of Action of the Anticonvulsant Retigabine on KCNQ K+ Channels

(2008) W. Lange et al.   MOLECULAR PHARMACOLOGY

Contribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currents

(2008) A. V. Tzingounis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA