Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes

Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation

(2015) Alexander Scholz et al.   Annals of the New York Academy of Sciences

Manganese-Mediated MRI Signals Correlate With Functional β-Cell Mass During Diabetes Progression

(2015) Anke Meyer et al.   DIABETES

Human Islets Have Fewer Blood Vessels than Mouse Islets and the Density of Islet Vascular Structures Is Increased in Type 2 Diabetes

(2015) Marcela Brissova et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Human Islet Morphology Revisited

(2015) Susan Bonner-Weir et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Efficacy of Tie2 Receptor Antagonism in Angiosarcoma

(2015) Jason R. Hasenstein et al.   NEOPLASIA

Vascular Niche Controls Organ Regeneration

(2014) Yosif Manavski et al.   CIRCULATION RESEARCH

MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes

(2014) Amin Ardestani et al.   NATURE MEDICINE

Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat

(2014) J. Hu et al.   SCIENCE

Pancreatic Islet Vasculature Adapts to Insulin Resistance Through Dilation and Not Angiogenesis

(2013) C. Dai et al.   DIABETES

In Vitro Formation of β Cell Pseudoislets Using Islet-Derived Endothelial Cells

(2013) Michael G. Spelios et al.   PLoS One

Angiopoietin-2 Is Critical for Cytokine-Induced Vascular Leakage

(2013) Andrew V. Benest et al.   PLoS One

Tie1 regulates the Tie2 agonistic role of angiopoietin-2 in human lymphatic endothelial cells

(2012) Sun-Hwa Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Angiopoietin-2 Functions as a Tie2 Agonist in Tumor Models, Where It Limits the Effects of VEGF Inhibition

(2012) C. Daly et al.   CANCER RESEARCH

Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation

(2012) Qing Cai et al.   DEVELOPMENTAL BIOLOGY

Vascular Endothelial Growth Factor-Mediated Islet Hypervascularization and Inflammation Contribute to Progressive Reduction of  -Cell Mass

(2012) J. Agudo et al.   DIABETES

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

(2012) Moritz Felcht et al.   JOURNAL OF CLINICAL INVESTIGATION

Proliferation and plasticity of human beta cells on physiologically occurring laminin isoforms

(2012) Meenal Banerjee et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Angiopoietin 2 Alters Pancreatic Vascularization in Diabetic Conditions

(2012) Sophie Calderari et al.   PLoS One

Circulating angiopoietin-2 and soluble Tie-2 in type 2 diabetes mellitus: a cross-sectional study

(2011) Sazan Rasul et al.   Cardiovascular Diabetology

Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for  -Cell Function

(2011) J. Olerud et al.   DIABETES

Neutralizing Interleukin-1β (IL-1β) Induces β-Cell Survival by Maintaining PDX1 Protein Nuclear Localization

(2011) Amin Ardestani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

XOMA 052, an Anti-IL-1β Monoclonal Antibody, Improves Glucose Control and β-Cell Function in the Diet-Induced Obesity Mouse Model

(2010) Alexander M. Owyang et al.   ENDOCRINOLOGY

High glucose and elevated fatty acids suppress signaling by the endothelium protective ligand angiopoietin-1

(2010) Harprit Singh et al.   MICROVASCULAR RESEARCH

Tie1-Tie2 Interactions Mediate Functional Differences between Angiopoietin Ligands

(2010) Tom C.M. Seegar et al.   MOLECULAR CELL

‘Giving and taking’: endothelial and β-cells in the islets of Langerhans

(2010) Daniel Eberhard et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Normal islet vascularization is dispensable for expansion of beta-cell mass in response to high-fat diet induced insulin resistance

(2009) Yukiko Toyofuku et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CXCL10 Impairs β Cell Function and Viability in Diabetes through TLR4 Signaling

(2009) Fabienne T. Schulthess et al.   Cell Metabolism

Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1

(2009) Shigetomo Fukuhara et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Reduced Insulin Secretion and Content in VEGF-A Deficient Mouse Pancreatic Islets

(2008) N. Jabs et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

(2008) Shigetomo Fukuhara et al.   NATURE CELL BIOLOGY