Vorinostat Eliminates Multicellular Resistance of Mesothelioma 3D Spheroids via Restoration of Noxa Expression

Histone/protein deacetylases and T-cell immune responses

(2012) T. Akimova et al.   BLOOD

Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed

(2012) Berkley E Gryder et al.   Future Medicinal Chemistry

Phase II Clinical Trial of First or Second-Line Treatment with Bortezomib in Patients with Malignant Pleural Mesothelioma

(2012) Dean A. Fennell et al.   Journal of Thoracic Oncology

Sensitization of tumor cells by targeting histone deacetylases

(2011) Paola Perego et al.   BIOCHEMICAL PHARMACOLOGY

Vorinostat-Induced Apoptosis in Mantle Cell Lymphoma Is Mediated by Acetylation of Proapoptotic BH3-Only Gene Promoters

(2011) S. Xargay-Torrent et al.   CLINICAL CANCER RESEARCH

Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737

(2011) K. M. Lucas et al.   CLINICAL CANCER RESEARCH

Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent

(2011) Jane L. Hurwitz et al.   EUROPEAN JOURNAL OF CANCER

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

(2011) Omar Khan et al.   IMMUNOLOGY AND CELL BIOLOGY

Noxa/Bcl-2 Protein Interactions Contribute to Bortezomib Resistance in Human Lymphoid Cells

(2011) Alyson J. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Development and Characterization of a Human Mesothelioma In Vitro 3D Model to Investigate Immunotoxin Therapy

(2011) Xinran Xiang et al.   PLoS One

The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance

(2011) D Barbone et al.   Cell Death & Disease

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

(2010) Yi-Chung Tung et al.   ANALYST

Valproate-doxorubicin: promising therapy for progressing mesothelioma. A phase II study

(2010) A. Scherpereel et al.   EUROPEAN RESPIRATORY JOURNAL

Perturbation of the Bcl-2 Network and an Induced Noxa/Bcl-xL Interaction Trigger Mitochondrial Dysfunction after DNA Damage

(2010) Hernando Lopez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase Inhibitors in Malignant Pleural Mesothelioma: Preclinical Rationale and Clinical Trials

(2010) Paul K. Paik et al.   Journal of Thoracic Oncology

Malignant pleural mesothelioma cells resist anoikis as quiescent pluricellular aggregates

(2009) J Daubriac et al.   CELL DEATH AND DIFFERENTIATION

Vorinostat in solid and hematologic malignancies

(2009) David Siegel et al.   Journal of Hematology & Oncology

Noxa: at the tip of the balance between life and death

(2009) C Ploner et al.   ONCOGENE

CaSm (LSm-1) Overexpression in Lung Cancer and Mesothelioma Is Required for Transformed Phenotypes

(2008) Patricia M. Watson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

mTOR Mediates Survival Signals in Malignant Mesothelioma Grown as Tumor Fragment Spheroids

(2008) Shannon M. Wilson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Bcl-2 Family Proteins Contribute to Apoptotic Resistance in Lung Cancer Multicellular Spheroids

(2008) Tsung-Ming Yang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mammalian Target of Rapamycin Contributes to the Acquired Apoptotic Resistance of Human Mesothelioma Multicellular Spheroids

(2008) Dario Barbone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY