Article
Entomology
Yifang Ren, Huanhuan Lu, Longyan Chen, Simone Sabatelli, Chaojie Wang, Guanglin Xie, Ping Wang, Meike Liu, Wenkai Wang, Paolo Audisio
Summary: This study sequenced the mitogenomes of two species representing two tribes of Lamiinae, revealing their highly conservative nature, and reconstructed phylogenetic trees of Lamiinae based on mitogenomic data. The relationships between some tribes were explored, providing new insights into the evolution of Lamiinae.
Article
Microbiology
Christopher Ruis, Josephine M. Bryant, Scott C. Bell, Rachel Thomson, Rebecca M. Davidson, Nabeeh A. Hasan, Jakko van Ingen, Michael Strong, R. Andres Floto, Julian Parkhill
Summary: This article discusses the evolutionary analyses of M. abscessus clinical isolates, revealing the emergence of dominant circulating clones (DCCs) in non-CF individuals that later spread in the CF community. The study shows the synchronous expansion of six unrelated DCCs in the 1960s due to rare intercontinental transmission events, shedding light on the global spread of these clones.
NATURE MICROBIOLOGY
(2021)
Article
Plant Sciences
Achyut Kumar Banerjee, Fengxiao Tan, Hui Feng, Xinru Liang, Jiakai Wang, Minghui Yin, Hao Peng, Yuting Lin, Nannan Zhang, Yelin Huang
Summary: This study aimed to understand the phylogenetic relationship between alien plant species at different stages of invasion and the influence of environmental filtering process on this relationship. The results showed that phylogenetically related species tend to cluster together at smaller spatial scales, indicating the importance of environmental filtering process. The presence of close relatives in the community may facilitate the successful naturalization and invasion of introduced alien species. Temperature has a stronger effect on phylogenetic patterns than precipitation, especially at smaller spatial scales. Different plant families showed different phylogenetic patterns, but all tend to form more clustered assemblages.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Jin Li, Christopher Cullis
Summary: The chloroplast genomes of 84 marama samples from southern Africa were compared, revealing that certain regions of the marama plastome were more diverse. 15 haplotypes were identified, divided into two groups with differences at specific loci and an inversion. Furthermore, it was found that most individuals had both types of chloroplast genomes, albeit at a low frequency. The inheritance and coexistence of these complex chloroplast genomes raised questions for further research.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Microbiology
Noemi Navarro-Lleo, Cristina Santiso-Bellon, Susana Vila-Vicent, Noelia Carmona-Vicente, Roberto Gozalbo-Rovira, Roberto Carcamo-Calvo, Jesus Rodriguez-Diaz, Javier Buesa
Summary: This study analyzed stool samples from gastroenteritis patients in Spain from January 2016 to April 2020, and found that norovirus was the most commonly detected enteric virus, with various genotypes and a high prevalence of recombinant strains. Two new tentative genotypes were also identified.
MICROBIOLOGY SPECTRUM
(2022)
Article
Veterinary Sciences
Zuhua Yu, Yuhao Zhang, Zedian Li, Qingzhong Yu, Yanyan Jia, Chuan Yu, Jian Chen, Songbiao Chen, Lei He
Summary: The reverse genetics system of the Newcastle disease virus (NDV) has been improved with a two-step ligation-independent cloning (LIC) strategy, allowing for the rapid construction of full-length NDV genomes and rescue of different genotypes in a matter of weeks. This method significantly reduces cloning steps and saves researchers time, making it applicable for the development of NDV-vectored vaccines and recombinant NDVs for cancer therapy.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Genetics & Heredity
Alexander Byrne, Severine Ollier, Kapil Tahlan, Franck Biet, Nathalie Bissonnette
Summary: This study characterized MAP isolates from cows in Canadian dairy herds and found that the transmission of MAP primarily occurs through the fecal-oral route, and the introduction of infected animals is an important transmission route. The isolates showed high genetic diversity, but were broadly separated into two main clades regardless of the province of origin. The study highlights the impact of MAP genetic variation on host-pathogen interactions and emphasizes the importance of whole genome sequencing in epidemiological studies and detecting mixed genotypes infections.
FRONTIERS IN GENETICS
(2023)
Article
Virology
Qin Zhou, Dengfeng Li, Wei Lin, Linting Pan, Minhua Qian, Fei Wang, Ruqian Cai, Chenxin Qu, Yigang Tong
Summary: Freshwater cyanophages play a crucial role in limiting the population development of cyanobacteria and exchanging genes with bacteria. In this study, a novel freshwater cyanophage was isolated and its genome was analyzed. This research enhances our understanding of freshwater cyanophages.
Article
Microbiology
Juan Monroy-Nieto, Jolene R. Bowers, Parker Montfort, Guillermo Adame, Constanza Giselle Taverna, Hayley Yaglom, Jane E. Sykes, Shane Brady, A. Brian Mochon, Wieland Meyer, Kenneth Komatsu, David M. Engelthaler
Summary: Whole-genome sequencing was used to analyze the population structure of the pathogenic species Cryptococcus gattii, leading to the discovery of a genetically distant VGVI isolate in Mexico. This study expands the understanding of Cryptococcus ecological range and highlights the clinical importance of VGVI as a separate molecular type.
Article
Virology
Benoit Visseaux, Melanie Bertine, Quentin Le Hingrat, Valentine Ferre, Charlotte Charpentier, Fideline Collin, Florence Damond, Sophie Matheron, Stephane Hue, Diane Descamps
Summary: Genetic diversity of HIV-2 groups A and B was analyzed, revealing two distinct lineages within group A (A1 and A2) with different geographic distributions. The estimated early diversification times for groups A and B in human populations were 1940 and 1961, respectively. A1 experienced an early diversification in Guinea-Bissau or Senegal, while A2 and B lineages showed growth during the 80s economic crisis.
Article
Virology
Benoit Visseaux, Melanie Bertine, Quentin Le Hingrat, Valentine Ferre, Charlotte Charpentier, Fideline Collin, Florence Damond, Sophie Matheron, Stephane Hue, Diane Descamps
Summary: Genetic diversity of HIV-2 groups A and B has not been fully described, especially in Western African countries like Ivory-Coast and Mali. This study identified two distinct lineages within HIV-2 group A, A1 and A2, with A1 related to coastal countries and A2 to inland countries. The early diversification times for groups A and B in human populations were estimated to be around 1940 and 1961, respectively. A1 experienced early diversification in 1942, while A2 and B lineages showed later growth during the 80s economic crisis.
Article
Microbiology
Ranjitha Shankaregowda, Yuan Hu Allegretti, Mahadevaiah Neelambike Sumana, Morubagal Raghavendra Rao, Eva Raphael, Padukudru Anand Mahesh, Lee W. Riley
Summary: The association between tuberculosis and type 2 diabetes mellitus is a challenge in managing the convergence of these epidemics. Our study aimed to determine the diversity of Mycobacterium tuberculosis genotypes in patients with and without type 2 diabetes.
Article
Plant Sciences
Ahmed EL-Banhawy, Iman H. Nour, Carmen Acedo, Ahmed ElKordy, Ahmed Faried, Widad AL-Juhani, Ahmed M. H. Gawhari, Asmaa O. Olwey, Faten Y. Ellmouni
Summary: The genus Silene L. is one of the largest genera in Caryophyllaceae, distributed in the Northern Hemisphere and South America. The endemic species Silene leucophylla and near-endemic S. schimperiana are native to the Sinai Peninsula, Egypt, with reduced populations and endangered status. This research integrates SEM, species micromorphology, DNA markers analysis to study these neglected species, revealing their micro-morphological characteristics and phylogenetic relationships. The study proposes two Silene complexes based on morphological and phylogenetic data, suggesting more investigation and sampling are needed for a better understanding of their complex phylogenetic relationships.
Article
Plant Sciences
Yuying Huang, Jing Li, Zerui Yang, Wenli An, Chunzhu Xie, Shanshan Liu, Xiasheng Zheng
Summary: The study analyzed the plastomes of ten Ficus species, revealing their similar genome structure but with variation in inverted repeat regions. The comparative analysis showed low sequence variability and suggested eight variable regions as potential molecular markers. Phylogenetic analysis grouped the species into three clades based on subgenera, supporting the Berg classification system. The study contributes to understanding genetic diversity and species evolution of Ficus, providing valuable information for taxonomic and phylogenetic studies.
Article
Cell Biology
Platon Selemenakis, Neelam Sharma, Mollie E. Uhrig, Jeffrey Katz, Youngho Kwon, Patrick Sung, Claudia Wiese
Summary: This study reveals a synthetic interaction between RAD51AP1 and RAD54L and investigates their functions and mechanisms. The results demonstrate the critical compensatory roles of RAD51AP1 and RAD54L in the HR pathway, suggesting their potential as targets for anti-cancer therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yu-Min Choi, So-Young Lee, Bum-Joon Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Byoung-Jun Kim, Ga-Na Kim, Bo-Ram Kim, Tae-Sun Shim, Yoon-Hoh Kook, Bum-Joon Kim
Article
Oncology
So-Young Lee, Soo-Bin Yang, Yu-Min Choi, Song-Ji Oh, Byung-Jun Kim, Yoon-Hoh Kook, Bum-Joon Kim
Article
Immunology
Yu-Min Choi, Hong Kim, Seoung-Ae Lee, So-Young Lee, Bum-Joon Kim
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Microbiology
Ji Yeon Lee, Byoung-Jun Kim, Hyeon-Kyoung Koo, Junghyun Kim, Jee-min Kim, Yoon-Hoh Kook, Bum-Joon Kim
Article
Oncology
Soo-Bin Yang, Mi-Hyun Lee, Bo-Ram Kim, Yu-Min Choi, Bum-Joon Kim
Summary: Recent studies have shown that a tumor necrosis factor (TNF)/inducible nitric oxide synthase (iNOS)-producing dendritic cell (Tip-DC) may activate CD8+ T cells in tumor microenvironments. The development of a new immunotherapeutic agent, such as Poly6, has gained attention in enhancing Tip-DC activity for anticancer immune response. Poly6 treatment has demonstrated potential in activating an antitumor immune response in mice, suggesting its use as an adjuvant for cancer immunotherapy.
Article
Medicine, General & Internal
Ji Yeon Lee, Byoung-Jun Kim, Jee-min Kim, Junghyun Kim, Joon-Sung Joh, Ina Jeong, Yoon-Hoh Kook, Bum-Joon Kim
Article
Immunology
Hyein Jeong, Yu-Min Choi, Hyejun Seo, Bum-Joon Kim
Summary: In this study, a novel DNA vaccine candidate against SARS-CoV-2 called W4P-RBD was developed and shown to induce robust humoral and cell-mediated immune responses in vaccinated mice, suggesting its potential as a protective measure against SARS-CoV-2 infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Hyein Jeong, Dong Hyun Kim, Yu-Min Choi, HyeLim Choi, Donghyun Kim, Bum-Joon Kim
Summary: The study showed that HBV rt269I type is more prone to overall genome mutations compared to rt269L type in genotype C2 infections, especially in the Pol region and MHR, leading to lower HBV DNA replication, HBsAg and HBeAg secretion, potential NAr variants and HCC. Furthermore, rt269L type may contribute to liver disease progression through immune escape or enhanced persistent infection in chronic patients of genotype C2.
Article
Virology
Yu-Min Choi, Hyein Jeong, Uni Park, Nam-Hyuk Cho, Bum-Joon Kim
Summary: Poly6, a hepatitis B virus hexamer peptide, shows an anti-SARS-CoV-2 effect with an estimated inhibitory concentration of 2.617 mu M in human bronchial epithelial cells, mediated through an IFN-I dependent manner. It also inhibits IL-6 production enhanced by SARS-CoV-2 in an IFN-I dependent manner, indicating its potential as a COVID-19 drug with potent antiviral and anti-inflammatory activities.
Article
Immunology
Byoung-Jun Kim, Hyein Jeong, Hyejun Seo, Mi-Hyun Lee, Hyun Mu Shin, Bum-Joon Kim
Summary: This study developed a novel vaccine candidate that induced strong immune responses in mice, showing potential efficacy against SARS-CoV-2 infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Hyein Jeong, So-Young Lee, Hyejun Seo, Bum-Joon Kim
Summary: The rSmeg-hMIF-hIL-7 vaccine demonstrated strong anti-tumor immune response in mice by inhibiting MIF-dependent tumorigenesis promotion and enhancing cytotoxic T cell recruitment into tumor microenvironments. It also showed enhanced anticancer effect with immune checkpoint inhibitors, suggesting its potential as an adjuvant for cancer immunotherapy. This study is the first to demonstrate the anticancer potential of an immunotherapeutic vaccine targeting immune response against MIF.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Microbiology
Mi-Hyun Lee, Bum-Joon Kim
Summary: This review presents the current status of COVID-19 vaccine development based on recombinant viral and bacterial delivery systems, and discusses the use of licensed live vaccines to prevent COVID-19 infections.
JOURNAL OF MICROBIOLOGY
(2022)
Article
Oncology
Hyein Jeong, So-Young Lee, Hyejun Seo, Dong Hyun Kinnar, Duhyung Lee, Bum-Joon Kim
Summary: The study demonstrates the potential of TBCM as an immunoadjuvant for DC-based cancer immunotherapy. TBCM can activate DCs and induce a strong anticancer immune response, inhibiting tumor growth and metastasis through functional cytotoxic T lymphocyte-mediated oncolytic activity and inhibition of cancer proliferation- and metastasis-related genes.
Article
Immunology
Bo-Ram Kim, Byoung-Jun Kim, Yoon-Hoh Kook, Bum-Joon Kim
FRONTIERS IN IMMUNOLOGY
(2019)