Blockade of Inhibitors of Apoptosis Proteins in Combination with Conventional Chemotherapy Leads to Synergistic Antitumor Activity in Medulloblastoma and Cancer Stem-Like Cells

XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NFκB activation

(2015) Fang Lin et al.   HUMAN MOLECULAR GENETICS

Inhibition of PI3K Signalling Selectively Affects Medulloblastoma Cancer Stem Cells

(2015) Chiara Frasson et al.   Biomed Research International

Synergistic effects of IAP inhibitor LCL161 and paclitaxel on hepatocellular carcinoma cells

(2014) Aiping Tian et al.   CANCER LETTERS

Treatment outcomes and late toxicities in patients with embryonal central nervous system tumors

(2014) Kazumasa Odagiri et al.   Radiation Oncology

XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling

(2013) Xing Huang et al.   EMBO JOURNAL

High-Risk Medulloblastoma: A Pediatric Oncology Group Randomized Trial of Chemotherapy Before or After Radiation Therapy (POG 9031)

(2013) Nancy J. Tarbell et al.   JOURNAL OF CLINICAL ONCOLOGY

Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms

(2013) Dhruv Kumar et al.   Molecular Cancer

A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy

(2013) W He et al.   ONCOGENE

Medullospheres from DAOY, UW228 and ONS-76 Cells: Increased Stem Cell Population and Proteomic Modifications

(2013) Cristina Zanini et al.   PLoS One

Hyperfractionated Versus Conventional Radiotherapy Followed by Chemotherapy in Standard-Risk Medulloblastoma: Results From the Randomized Multicenter HIT-SIOP PNET 4 Trial

(2012) Birgitta Lannering et al.   JOURNAL OF CLINICAL ONCOLOGY

Long-term results of combined preradiation chemotherapy and age-tailored radiotherapy doses for childhood medulloblastoma

(2012) Maura Massimino et al.   JOURNAL OF NEURO-ONCOLOGY

Targeting the Inhibitor of Apoptosis Proteins as a Novel Therapeutic Strategy in Medulloblastoma

(2012) J. Keating et al.   MOLECULAR CANCER THERAPEUTICS

Survival and secondary tumors in children with medulloblastoma receiving radiotherapy and adjuvant chemotherapy: results of Children's Oncology Group trial A9961

(2012) Roger J. Packer et al.   NEURO-ONCOLOGY

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Challenging issues in pediatric oncology

(2011) Ching-Hon Pui et al.   Nature Reviews Clinical Oncology

A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo

(2011) D. S. Ziegler et al.   NEURO-ONCOLOGY

Medulloblastoma-derived tumor stem-like cells acquired resistance to TRAIL-induced apoptosis and radiosensitivity

(2010) Cheng-Chia Yu et al.   CHILDS NERVOUS SYSTEM

Targeting XIAP Bypasses Bcl-2-Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

(2008) M. Vogler et al.   CANCER RESEARCH

Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins

(2008) David S. Ziegler et al.   JOURNAL OF CLINICAL INVESTIGATION

Oct-4 Expression Maintained Cancer Stem-Like Properties in Lung Cancer-Derived CD133-Positive Cells

(2008) Yu-Chih Chen et al.   PLoS One

Direct Orthotopic Transplantation of Fresh Surgical Specimen Preserves CD133+Tumor Cells in Clinically Relevant Mouse Models of Medulloblastoma and Glioma

(2008) Qin Shu et al.   STEM CELLS

Successful isolation and long-term establishment of a cell line with stem cell-like features from an anaplastic medulloblastoma

(2007) A. Raso et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY