LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer

ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer

(2015) Min Ho Choe et al.   Oncotarget

DFS70/LEDGFp75: An Enigmatic Autoantigen at the Interface between Autoimmunity, AIDS, and Cancer

(2015) Anamika Basu et al.   Frontiers in Immunology

Transcriptional Regulation of Vascular Endothelial Growth Factor C by Oxidative and Thermal Stress Is Mediated by Lens Epithelium-Derived Growth Factor/p75

(2015) Batya Cohen et al.   NEOPLASIA

Heat shock and other apoptosis-related proteins as therapeutic targets in prostate cancer

(2014) NoahM Hahn et al.   ASIAN JOURNAL OF ANDROLOGY

AGR2, ERp57/GRP58, and some other human protein disulfide isomerases

(2014) S. S. Shishkin et al.   BIOCHEMISTRY-MOSCOW

Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features

(2014) Fabio J. Pacheco et al.   INFLAMMATION RESEARCH

Oncogenic Human Papillomaviruses Activate the Tumor-Associated Lens Epithelial-Derived Growth Factor (LEDGF) Gene

(2014) Jenny Leitz et al.   PLoS Pathogens

Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75)

(2013) H Méreau et al.   LEUKEMIA

A Transcriptome-proteome Integrated Network Identifies Endoplasmic Reticulum thiol oxidoreductase (ERp57) as a Hub that Mediates Bone Metastasis

(2013) Naiara Santana-Codina et al.   MOLECULAR & CELLULAR PROTEOMICS

Lysosomal pathways to cell death and their therapeutic applications

(2012) Maruša Hafner Česen et al.   EXPERIMENTAL CELL RESEARCH

Small heat shock proteins in cancer therapy and prognosis

(2012) Amina Zoubeidi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Stress Oncoprotein LEDGF/p75 Interacts with the Methyl CpG Binding Protein MeCP2 and Influences Its Transcriptional Activity

(2012) L. S. Leoh et al.   MOLECULAR CANCER RESEARCH

Differential proteomics identifies PDIA3 as a novel chemoprevention target in human colon cancer cells

(2012) Antoine Ménoret et al.   MOLECULAR CARCINOGENESIS

HumanMCS5A1candidate breast cancer susceptibility geneFBXO10is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF)

(2012) Xin Xu et al.   MOLECULAR CARCINOGENESIS

LEDGF (p75) promotes DNA-end resection and homologous recombination

(2012) Mads Daugaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expression of the Stress Response Oncoprotein LEDGF/p75 in Human Cancer: A Study of 21 Tumor Types

(2012) Anamika Basu et al.   PLoS One

Staurosporine Induces Necroptotic Cell Death under Caspase-Compromised Conditions in U937 Cells

(2012) Zsuzsanna A. Dunai et al.   PLoS One

The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy

(2012) Frauke Christ et al.   VIROLOGY

LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway

(2012) B Bhargavan et al.   Cell Death & Disease

Glucose-regulated protein 58 modulates cell invasiveness and serves as a prognostic marker for cervical cancer

(2011) Chia-Jung Liao et al.   CANCER SCIENCE

Oxidative stress and androgen receptor signaling in the development and progression of castration-resistant prostate cancer

(2011) Masaki Shiota et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of the PWWP Domain of Lens Epithelium-derived Growth Factor (LEDGF)/p75 Cofactor in Lentiviral Integration Targeting

(2011) Rik Gijsbers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Clinically Relevant Protein Targets in Prostate Cancer with 2D-DIGE Coupled Mass Spectrometry and Systems Biology Network Platform

(2011) Ramesh Ummanni et al.   PLoS One

Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells

(2011) Anamika Basu et al.   PROSTATE

ERp57, a multifunctional endoplasmic reticulum resident oxidoreductase

(2010) Helen Coe et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

BAMLET Activates a Lysosomal Cell Death Program in Cancer Cells

(2010) P. Rammer et al.   MOLECULAR CANCER THERAPEUTICS

LEDGF Hybrids Efficiently Retarget Lentiviral Integration Into Heterochromatin

(2010) Rik Gijsbers et al.   MOLECULAR THERAPY

High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region

(2010) Jan De Rijck et al.   NUCLEIC ACIDS RESEARCH

Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer

(2009) Barbara Seliger et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Oxidative stress in prostate cancer

(2009) Lakshmipathi Khandrika et al.   CANCER LETTERS

Gonadotropin-Regulated Lymphangiogenesis in Ovarian Cancer Is Mediated by LEDGF-Induced Expression of VEGF-C

(2009) S. Sapoznik et al.   CANCER RESEARCH

Comparative Proteomic Analysis of Paclitaxel Sensitive A2780 Epithelial Ovarian Cancer Cell Line and Its Resistant Counterpart A2780TC1 by 2D-DIGE: The Role of ERp57

(2009) Lucia Cicchillitti et al.   JOURNAL OF PROTEOME RESEARCH

Differential expression of apoptotic genes PDIA3 and MAP3K5 distinguishes between low- and high-risk prostate cancer

(2009) Nicole Pressinotti et al.   Molecular Cancer

Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75

(2009) Melanie Mediavilla-Varela et al.   Molecular Cancer

Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes

(2008) Akihiko Yokoyama et al.   CANCER CELL

Pdcd4 protein and mRNA level alterations do not correlate in human lung tumors

(2008) Svetlana V. Kalinichenko et al.   LUNG CANCER

Alternative Splicing and Caspase-Mediated Cleavage Generate Antagonistic Variants of the Stress Oncoprotein LEDGF/p75

(2008) T. A. Brown-Bryan et al.   MOLECULAR CANCER RESEARCH

LEDGF binding to stress response element increases αB-crystallin expression in astrocytes with oxidative stress

(2008) Joo-Hyun Shin et al.   NEUROSCIENCE LETTERS