IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation

In vitro studies in VCP-associated multisystem proteinopathy suggest altered mitochondrial bioenergetics

(2015) Angèle Nalbandian et al.   MITOCHONDRION

Mitochondrial function in neuronal cells depends on p97/VCP/Cdc48-mediated quality control

(2015) Lei Fang et al.   Frontiers in Cellular Neuroscience

Create and preserve: Proteostasis in development and aging is governed by Cdc48/p97/VCP

(2013) André Franz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structural and mechanistic insights into the arginine/lysine-rich peptide motifs that interact with P97/VCP

(2013) Shuai Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation

(2013) Yingli Wang et al.   BIOTECHNOLOGY LETTERS

Different dynamic movements of wild-type and pathogenic VCPs and their cofactors to damaged mitochondria in a Parkin-mediated mitochondrial quality control system

(2013) Yoko Kimura et al.   GENES TO CELLS

A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization

(2013) Yalcin Erzurumlu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interaction between Salt-inducible Kinase 2 (SIK2) and p97/Valosin-containing Protein (VCP) Regulates Endoplasmic Reticulum (ER)-associated Protein Degradation in Mammalian Cells

(2013) Fu-Chia Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations

(2013) Nam Chul Kim et al.   NEURON

Combined Inhibition of p97 and the Proteasome Causes Lethal Disruption of the Secretory Apparatus in Multiple Myeloma Cells

(2013) Holger W. Auner et al.   PLoS One

Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death

(2012) Ozlem Oral et al.   APOPTOSIS

mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy

(2012) J. K. Ching et al.   HUMAN MOLECULAR GENETICS

Heteromeric p97/p97R155C Complexes Induce Dominant Negative Changes in Wild-Type and Autophagy 9-Deficient Dictyostelium strains

(2012) Khalid Arhzaouy et al.   PLoS One

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

(2011) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

Distinct distal myopathy phenotype caused by VCP gene mutation in a Finnish family

(2011) Johanna Palmio et al.   NEUROMUSCULAR DISORDERS

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

(2010) Emilie Tresse et al.   Autophagy

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

(2009) Jeong-Sun Ju et al.   JOURNAL OF CELL BIOLOGY

A novel mutation in the VCP gene (G157R) in a german family with inclusion-body myopathy with paget disease of bone and frontotemporal dementia

(2009) Atbin Djamshidian et al.   MUSCLE & NERVE

Clinical outcome in 19 French and Spanish patients with valosin-containing protein myopathy associated with Paget’s disease of bone and frontotemporal dementia

(2009) Tanya Stojkovic et al.   NEUROMUSCULAR DISORDERS

VCP disease associated with myopathy, Paget disease of bone and frontotemporal dementia: Review of a unique disorder

(2008) Virginia E. Kimonis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia

(2008) C C Weihl et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

An Italian family with inclusion-body myopathy and frontotemporal dementia due to mutation in theVCP gene

(2007) Teresa Gidaro et al.   MUSCLE & NERVE