Suppression of USP18 Potentiates the Anti-HBV Activity of Interferon Alpha in HepG2.2.15 Cells via JAK/STAT Signaling

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance

(2015) Lars Ketscher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection

(2015)   JOURNAL OF HEPATOLOGY

Pegylated IFN-α regulates hepatic gene expression through transient Jak/STAT activation

(2014) Michael T. Dill et al.   JOURNAL OF CLINICAL INVESTIGATION

The Level of Hepatitis B Virus Replication Is Not Affected by Protein ISG15 Modification but Is Reduced by Inhibition of UBP43 (USP18) Expression

(2014) J.-H. Kim et al.   JOURNAL OF IMMUNOLOGY

USP18 is crucial for IFN-γ-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity

(2014) Bangxing Hong et al.   Molecular Cancer

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

(2014) Xianqin Zhang et al.   NATURE

Activation of endogenous type I IFN signaling contributes to persistent HCV infection

(2014) Yujia Li et al.   REVIEWS IN MEDICAL VIROLOGY

Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10

(2013) Christoph Burkart et al.   EMBO Molecular Medicine

Roles of the ubiquitin peptidaseUSP18in multiple sclerosis and the response to interferon-βtreatment

(2013) S. Malhotra et al.   EUROPEAN JOURNAL OF NEUROLOGY

Ubiquitin specific protease 18 (Usp18) is a WT1 transcriptional target

(2013) Mohammad Shahidul Makki et al.   EXPERIMENTAL CELL RESEARCH

USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1–TAB1 complex

(2013) Xikui Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Therapeutic potential of furin inhibitors for the chronic infection of hepatitis B virus

(2013) Yan J. Pang et al.   LIVER INTERNATIONAL

Usp18 Driven Enforced Viral Replication in Dendritic Cells Contributes to Break of Immunological Tolerance in Autoimmune Diabetes

(2013) Nadine Honke et al.   PLoS Pathogens

Evidence for the Ubiquitin Protease UBP43 as an Antineoplastic Target

(2012) Y. Guo et al.   MOLECULAR CANCER THERAPEUTICS

Knockdown of USP18 Increases Alpha 2a Interferon Signaling and Induction of Interferon-Stimulating Genes but Does Not Increase Antiviral Activity in Huh7 Cells

(2011) E. J. Murray et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rickettsia conorii infection stimulates the expression of ISG15 and ISG15 protease UBP43 in human microvascular endothelial cells

(2011) Punsiri M. Colonne et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Two Independent Mechanisms Promote Expression of an N-terminal Truncated USP18 Isoform with Higher DeISGylation Activity in the Nucleus

(2011) Christoph Burkart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Usp18 Regulates Epidermal Growth Factor (EGF) Receptor Expression and Cancer Cell Survival via MicroRNA-7

(2011) Jason E. Duex et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preactivation of the interferon signalling in liver is correlated with nonresponse to interferon alpha therapy in patients chronically infected with hepatitis B virus

(2011) C. Xiao et al.   JOURNAL OF VIRAL HEPATITIS

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

(2011) Véronique François-Newton et al.   PLoS One

Identification of USP18 as an Important Regulator of the Susceptibility to IFN-  and Drug-Induced Apoptosis

(2010) H. Potu et al.   CANCER RESEARCH

Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy

(2009) Mohammad Salajegheh et al.   ANNALS OF NEUROLOGY

ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro: implications for chronic infection and response to treatment

(2009) L. Chen et al.   JOURNAL OF GENERAL VIROLOGY

Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43

(2009) M. Sarasin-Filipowicz et al.   MOLECULAR AND CELLULAR BIOLOGY