IL-2 / α-IL-2 Complex Treatment Cannot Be Substituted for the Adoptive Transfer of Regulatory T cells to Promote Bone Marrow Engraftment

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms

(2015) Jamie B. Spangler et al.   IMMUNITY

Suppression of Murine Allergic Airway Disease by IL-2:Anti-IL-2 Monoclonal Antibody-Induced Regulatory T Cells

(2014) M. S. Wilson et al.   JOURNAL OF IMMUNOLOGY

Dosimetric challenges of small animal irradiation with a commercial X-ray unit

(2014) Peter Kuess et al.   Zeitschrift fur Medizinische Physik

T-regulatory cell treatment prevents chronic rejection of heart allografts in a murine mixed chimerism model

(2013) Nina Pilat et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Induced Regulatory T Cells Promote Tolerance When Stabilized by Rapamycin and IL-2 In Vivo

(2013) P. Zhang et al.   JOURNAL OF IMMUNOLOGY

Regulatory T-Cell Therapy in Transplantation: Moving to the Clinic

(2013) Q. Tang et al.   Cold Spring Harbor Perspectives in Medicine

Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial

(2013) Agnès Hartemann et al.   Lancet Diabetes & Endocrinology

CTLA4-Ig Restores Rejection of MHC Class-II Mismatched Allografts by Disabling IL-2-Expanded Regulatory T Cells

(2012) L.-M. Charbonnier et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Deleterious Effect of CTLA4-Ig on a Treg-Dependent Transplant Model

(2012) L. V. Riella et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Identification and expansion of highly suppressive CD8+FoxP3+ regulatory T cells after experimental allogeneic bone marrow transplantation

(2012) R. J. Robb et al.   BLOOD

Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2/STAT5 signalling pathways

(2012) Seon-Yeong Lee et al.   IMMUNOLOGY

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+T reg cells

(2012) Jonathan M. Weiss et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-2 Signals Determine the Degree of TCR Signaling Necessary To Support Regulatory T Cell Proliferation In Vivo

(2012) T. Zou et al.   JOURNAL OF IMMUNOLOGY

Application of IL-2 therapy to target T regulatory cell function

(2012) Ethan M. Shevach   TRENDS IN IMMUNOLOGY

In Vivo Expansion of Regulatory T cells With IL-2/IL-2 mAb Complexes Prevents Anti-factor VIII Immune Responses in Hemophilia A Mice Treated With Factor VIII Plasmid-mediated Gene Therapy

(2011) Chao-Lien Liu et al.   MOLECULAR THERAPY

Therapeutic Efficacy of Polyclonal Tregs Does Not Require Rapamycin in a Low-Dose Irradiation Bone Marrow Transplantation Model

(2011) Nina Pilat et al.   TRANSPLANTATION

Treg-Therapy Allows Mixed Chimerism and Transplantation Tolerance Without Cytoreductive Conditioning

(2010) N. Pilat et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Transplantation tolerance through mixed chimerism

(2010) Nina Pilat et al.   Nature Reviews Nephrology

IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor   subunit CD25

(2010) S. Letourneau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells

(2010) C. Krieg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Situ Activation and Expansion of Host Tregs: A New Approach to Enhance Donor Chimerism and Stable Engraftment in Major Histocompatibility Complex-Matched Allogeneic Hematopoietic Cell Transplantation

(2009) Alwi Shatry et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease

(2009) X. Chen et al.   BLOOD

Human T Regulatory Cell Therapy: Take a Billion or So and Call Me in the Morning

(2009) James L. Riley et al.   IMMUNITY

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

The Biology of Interleukin-2

(2007) Thomas R. Malek   Annual Review of Immunology