Clinical significance of receptor shedding-platelet GPVI as an emerging diagnostic and therapeutic tool

High-frequency ultrasound-guided disruption of glycoprotein VI-targeted microbubbles targets atheroprogressison in mice

(2015) Katja Metzger et al.   BIOMATERIALS

Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation

(2015) E. Mammadova-Bach et al.   BLOOD

Platelet Receptor Expression and Shedding: Glycoprotein Ib-IX-V and Glycoprotein VI

(2014) Elizabeth E. Gardiner et al.   TRANSFUSION MEDICINE REVIEWS

Molecular Imaging Reveals Rapid Reduction of Endothelial Activation in Early Atherosclerosis With Apocynin Independent of Antioxidative Properties

(2013) Elham Khanicheh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Positron Emission Tomography/Computed Tomographic and Magnetic Resonance Imaging in a Murine Model of Progressive Atherosclerosis Using 64 Cu-Labeled Glycoprotein VI-Fc

(2013) Boris Bigalke et al.   Circulation-Cardiovascular Imaging

An adenine insertion in exon 6 of humanGP6generates a truncated protein associated with a bleeding disorder in four Chilean families

(2013) V. Matus et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Noninvasive Ultrasound Molecular Imaging of the Effect of Statins on Endothelial Inflammatory Phenotype in Early Atherosclerosis

(2013) Elham Khanicheh et al.   PLoS One

The GPVI-Fc Fusion Protein Revacept Improves Cerebral Infarct Volume and Functional Outcome in Stroke

(2013) Silvia Goebel et al.   PLoS One

The GPVI – Fc Fusion Protein Revacept Reduces Thrombus Formation and Improves Vascular Dysfunction in Atherosclerosis without Any Impact on Bleeding Times

(2013) Martin Ungerer et al.   PLoS One

The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice

(2012) Tanja Schönberger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

(2012) J. M. Burkhart et al.   BLOOD

Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels

(2012) M. Al-Tamimi et al.   BLOOD

Novel Single-Chain Antibody-Targeted Microbubbles for Molecular Ultrasound Imaging of Thrombosis

(2012) Xiaowei Wang et al.   CIRCULATION

Molecular Imaging of Inflammation and Platelet Adhesion in Advanced Atherosclerosis Effects of Antioxidant Therapy With NADPH Oxidase Inhibition

(2012) Yani Liu et al.   Circulation-Cardiovascular Imaging

Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood

(2012) Stephanie M. Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The future of glycoprotein VI as an antithrombotic target

(2012) M. ZAHID et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Plasma levels of soluble glycoprotein VI (sGPVI) are associated with ischemic stroke

(2012) Thomas Wurster et al.   PLATELETS

Platelet GPVI: a target for antithrombotic therapy?!

(2012) Sebastian Dütting et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Platelet Glycoprotein VI Dimerization, an Active Process Inducing Receptor Competence, Is an Indicator of Platelet Reactivity

(2011) Stéphane Loyau et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa

(2011) M. Al-Tamimi et al.   BLOOD

Sandwich Immunoassay for Soluble Glycoprotein VI in Patients with Symptomatic Coronary Artery Disease

(2011) B. Bigalke et al.   CLINICAL CHEMISTRY

Imaging of injured and atherosclerotic arteries in mice using fluorescence-labeled glycoprotein VI-Fc

(2011) Boris Bigalke et al.   EUROPEAN JOURNAL OF RADIOLOGY

Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke

(2011) B. NIESWANDT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Ex vivoimaging of injured arteries in rabbits using fluorescence-labelled glycoprotein VI-Fc

(2011) Boris Bigalke et al.   PLATELETS

Proteolysis of platelet receptors in humans and other species

(2010) Jian L. Qiao et al.   BIOLOGICAL CHEMISTRY

Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases

(2010) M. Bender et al.   BLOOD

Restored platelet function after romiplostim treatment in a patient with immune thrombocytopenic purpura

(2010) Elizabeth E. Gardiner et al.   BRITISH JOURNAL OF HAEMATOLOGY

Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease

(2010) Thaddeus J. Wadas et al.   CHEMICAL REVIEWS

Glycoprotein VI as a prognostic biomarker for cardiovascular death in patients with symptomatic coronary artery disease

(2010) Boris Bigalke et al.   Clinical Research in Cardiology

Glycoprotein VI for diagnosis of acute coronary syndrome when ECG is ambiguous

(2010) Boris Bigalke et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Impact of glycoprotein VI and platelet adhesion on atherosclerosis—A possible role of fibronectin

(2010) Andreas Bültmann et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A 2-Step Mechanism of Arterial Thrombus Formation Induced by Human Atherosclerotic Plaques

(2010) Armin J. Reininger et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Diagnostic and Therapeutic Potentials of Platelet Glycoprotein VI

(2010) Boris Bigalke et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Soluble Glycoprotein VI Is Raised in the Plasma of Patients With Acute Ischemic Stroke

(2010) Mohammad Al-Tamimi et al.   STROKE

Platelet glycoprotein VI (GPVI) for early identification of acute coronary syndrome in patients with chest pain

(2010) Boris Bigalke et al.   THROMBOSIS RESEARCH

Regulation of platelet glycoprotein VI (GPVI) surface expression and of soluble GPVI in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS)

(2009) Boris Bigalke et al.   BASIC RESEARCH IN CARDIOLOGY

Expression of platelet glycoprotein VI is associated with transient ischemic attack and stroke

(2009) B. Bigalke et al.   EUROPEAN JOURNAL OF NEUROLOGY

Design and humanization of a murine scFv that blocks human platelet glycoprotein VIin vitro

(2009) Julien Muzard et al.   FEBS Journal

An acquired inhibitor to the GPVI platelet collagen receptor in a patient with lupus nephritis

(2009) P. NURDEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcγRIIa and induce GPVI ectodomain shedding

(2009) Mohammad Al-Tamimi et al.   PLATELETS

Measuring soluble platelet glycoprotein VI in human plasma by ELISA

(2009) Mohammad Al-Tamimi et al.   PLATELETS

Platelet collagen receptor glycoprotein VI as a possible novel indicator for the acute coronary syndrome

(2008) Boris Bigalke et al.   AMERICAN HEART JOURNAL

Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo

(2008) Christian Schulz et al.   BASIC RESEARCH IN CARDIOLOGY

The immunoadhesin glycoprotein VI-Fc regulates arterial remodelling after mechanical injury in ApoE−/− mice

(2008) Tanja Schönberger et al.   CARDIOVASCULAR RESEARCH

A novel antiplatelet antibody therapy that induces cAMP-dependent endocytosis of the GPVI/Fc receptor γ-chain complex

(2008) Hiroshi Takayama et al.   JOURNAL OF CLINICAL INVESTIGATION

Radionuclide Imaging

(2008) Harald F. Langer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura

(2008) E. E. GARDINER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression

(2008) P. OHLMANN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Regulation of the proteolytic disintegrin metalloproteinases, the ‘Sheddases’

(2008) Gillian Murphy   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Association of platelet-derived soluble glycoprotein VI in plasma with Alzheimer’s disease

(2007) Christoph Laske et al.   JOURNAL OF PSYCHIATRIC RESEARCH