Plant-based oral vaccines against zoonotic and non-zoonotic diseases

Vaccination via Chloroplast Genetics: Affordable Protein Drugs for the Prevention and Treatment of Inherited or Infectious Human Diseases

(2016) Henry Daniell et al.   Annual Review of Genetics

Low cost delivery of proteins bioencapsulated in plant cells to human non-immune or immune modulatory cells

(2016) Yuhong Xiao et al.   BIOMATERIALS

The case for plant-made veterinary immunotherapeutics

(2016) Edward Topp et al.   BIOTECHNOLOGY ADVANCES

Cold chain and virus-free chloroplast-made booster vaccine to confer immunity against different poliovirus serotypes

(2016) Hui-Ting Chan et al.   PLANT BIOTECHNOLOGY JOURNAL

Low cost industrial production of coagulation factor IX bioencapsulated in lettuce cells for oral tolerance induction in hemophilia B

(2015) Jin Su et al.   BIOMATERIALS

The fusion ofToxoplasma gondiiSAG1 vaccine candidate toLeishmania infantumheat shock protein 83-kDa improves expression levels in tobacco chloroplasts

(2015) Romina M. Albarracín et al.   Biotechnology Journal

The increasing value of plant-made proteins

(2015) Markus Sack et al.   CURRENT OPINION IN BIOTECHNOLOGY

Nationwide outbreak of multidrug-resistant Salmonella Heidelberg infections associated with ground turkey: United States, 2011

(2015) J. A. ROUTH et al.   EPIDEMIOLOGY AND INFECTION

Plant-made oral vaccines against human infectious diseases-Are we there yet?

(2015) Hui-Ting Chan et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant-produced viral bovine vaccines: what happened during the last 10 years?

(2015) Vanesa Ruiz et al.   PLANT BIOTECHNOLOGY JOURNAL

Low-cost oral delivery of protein drugs bioencapsulated in plant cells

(2015) Kwang-Chul Kwon et al.   PLANT BIOTECHNOLOGY JOURNAL

Commercial-scale biotherapeutics manufacturing facility for plant-made pharmaceuticals

(2015) Barry R. Holtz et al.   PLANT BIOTECHNOLOGY JOURNAL

Expression of H3N2 nucleoprotein in maize seeds and immunogenicity in mice

(2015) Hartinio N. Nahampun et al.   PLANT CELL REPORTS

The Engineered Chloroplast Genome Just Got Smarter

(2015) Shuangxia Jin et al.   TRENDS IN PLANT SCIENCE

A transgenic ginseng vaccine for bovine viral diarrhea

(2015) Yugang Gao et al.   Virology Journal

ERAIZDA: a model for holistic annotation of animal infectious and zoonotic diseases

(2015) Teresia M. Buza et al.   Database-The Journal of Biological Databases and Curation

Transgenic Carrot Expressing Fusion Protein ComprisingM. tuberculosisAntigens Induces Immune Response in Mice

(2015) Natalia V. Permyakova et al.   Biomed Research International

The fusion ofToxoplasma gondiiSAG1 vaccine candidate toLeishmania infantumheat shock protein 83-kDa improves expression levels in tobacco chloroplasts

(2015) Romina M. Albarracín et al.   Biotechnology Journal

Transient Expression of Foot and Mouth Disease Virus (FMDV)Coat Protein in Tobacco (Nicotiana tabacom) via Agroinfiltration

(2015) Maziar Habibi-Pirkoohi et al.   Iranian Journal of Biotechnology

Newcastle Disease: Present status and future challenges for developing countries

(2014) A Ashraf et al.   African Journal of Microbiology Research

Induction of immune responses in mice and pigs by oral administration of classical swine fever virus E2 protein expressed in rice calli

(2014) Myunghwan Jung et al.   ARCHIVES OF VIROLOGY

Recent developments in therapeutic protein expression technologies in plants

(2014) Shah Fahad et al.   BIOTECHNOLOGY LETTERS

Generation of the Bovine Viral Diarrhea Virus E0 Protein in TransgenicAstragalusand Its Immunogenicity in Sika Deer

(2014) Yugang Gao et al.   Evidence-based Complementary and Alternative Medicine

Livestock and food security: vulnerability to population growth and climate change

(2014) Olivia F. Godber et al.   GLOBAL CHANGE BIOLOGY

Generation of protective immune response against anthrax by oral immunization with protective antigen plant-based vaccine

(2014) Jyotsna Gorantala et al.   JOURNAL OF BIOTECHNOLOGY

Vaccine-Derived Polioviruses

(2014) C. C. Burns et al.   JOURNAL OF INFECTIOUS DISEASES

Expression of Rabies Glycoprotein and Ricin Toxin B Chain (RGP–RTB) Fusion Protein in Tomato Hairy Roots: A Step Towards Oral Vaccination for Rabies

(2014) Ankit Singh et al.   MOLECULAR BIOTECHNOLOGY

Oral immunization of haemaggulutinin H5 expressed in plant endoplasmic reticulum with adjuvant saponin protects mice against highly pathogenic avian influenza A virus infection

(2014) Goeun Lee et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant-based vaccines against viruses

(2014) Edward P Rybicki   Virology Journal

A novel plant-produced Pfs25 fusion subunit vaccine induces long-lasting transmission blocking antibody responses

(2014) R Mark Jones et al.   Human Vaccines & Immunotherapeutics

Recent advances and safety issues of transgenic plant-derived vaccines

(2013) Zheng-jun Guan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Grow Your Own: Protalix BioTherapeutics Produces Drugs in Carrot Cells

(2013) Wendy Wolfson   CHEMISTRY & BIOLOGY

Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection

(2013) Daisuke Tokuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of verocytotoxicEscherichia coliantigens in tobacco seeds and evaluation of gut immunity after oral administration in mouse model

(2013) Luciana Rossi et al.   Journal of Veterinary Science

How can plant genetic engineering contribute to cost-effective fish vaccine development for promoting sustainable aquaculture?

(2013) Jihong Liu Clarke et al.   PLANT MOLECULAR BIOLOGY

Low Cost Tuberculosis Vaccine Antigens in Capsules: Expression in Chloroplasts, Bio-Encapsulation, Stability and Functional Evaluation In Vitro

(2013) Priya Saikumar Lakshmi et al.   PLoS One

A Plant-Produced Pfs25 VLP Malaria Vaccine Candidate Induces Persistent Transmission Blocking Antibodies against Plasmodium falciparum in Immunized Mice

(2013) R. Mark Jones et al.   PLoS One

Transient expression of VP2 in Nicotiana benthamiana and its use as a plant-based vaccine against Infectious Bursal Disease Virus

(2013) Evangelina Gómez et al.   VACCINE

Protective effect of oral administration of transgenic tobacco seeds against verocytotoxic Escherichia coli strain in piglets

(2013) Luciana Rossi et al.   VETERINARY RESEARCH COMMUNICATIONS

Identification and Manipulation of the Molecular Determinants Influencing Poliovirus Recombination

(2013) Charles Runckel et al.   PLoS Pathogens

Oral Immunogenicity of Plant-MadeMycobacterium tuberculosisESAT6 and CFP10

(2013) Elena A. Uvarova et al.   Biomed Research International

Agrobacterium infection and plant defense—transformation success hangs by a thread

(2013) Andrea Pitzschke   Frontiers in Plant Science

Oral immunogenicity of potato-derived antigens to Mycobacterium tuberculosis in mice

(2012) Y. Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells

(2012) Kwang-Chul Kwon et al.   ADVANCED DRUG DELIVERY REVIEWS

RNA viral vectors for improved Agrobacterium-mediated transient expression of heterologous proteins in Nicotiana benthamiana cell suspensions and hairy roots

(2012) Jeffrey S Larsen et al.   BMC BIOTECHNOLOGY

A One Health Framework for Estimating the Economic Costs of Zoonotic Diseases on Society

(2012) Clare Narrod et al.   EcoHealth

Immunogenicity of foot-and-mouth disease virus structural polyprotein P1 expressed in transgenic rice

(2012) Yuanyuan Wang et al.   JOURNAL OF VIROLOGICAL METHODS

Oral immunogenicity of porcine reproductive and respiratory syndrome virus antigen expressed in transgenic banana

(2012) Hui-Ting Chan et al.   PLANT BIOTECHNOLOGY JOURNAL

A chloroplast-derivedToxoplasma gondiiGRA4 antigen used as an oral vaccine protects against toxoplasmosis in mice

(2012) María del L. Yácono et al.   PLANT BIOTECHNOLOGY JOURNAL

Immunogenicity of a neutralizing epitope from porcine epidemic diarrhea virus: M cell targeting ligand fusion protein expressed in transgenic rice calli

(2012) Nguyen-Xuan Huy et al.   PLANT CELL REPORTS

Functional ectodomain of the hemagglutinin-neuraminidase protein is expressed in transgenic tobacco cells as a candidate vaccine against Newcastle disease virus

(2012) Kok Song Lai et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Transgenic lettuce (Lactuca sativa L.) expressing H1N1 influenza surface antigen (neuraminidase)

(2012) Cheng-Wei Liu et al.   SCIENTIA HORTICULTURAE

Induction of a protective immune response to rabies virus in sheep after oral immunization with transgenic maize, expressing the rabies virus glycoprotein

(2012) Elizabeth Loza-Rubio et al.   VACCINE

Immunocompetent truncated E2 glycoprotein of bovine viral diarrhea virus (BVDV) expressed in Nicotiana tabacum plants: A candidate antigen for new generation of veterinary vaccines

(2012) Guillermo Nelson et al.   VACCINE

Plant expressed Coccidial antigens as potential vaccine candidates in protecting chicken against Coccidiosis

(2012) Kota Sathish et al.   VACCINE

Protective efficacy against Chlamydophila psittaci by oral immunization based on transgenic rice expressing MOMP in mice

(2012) Xiu-Xiang Zhang et al.   VACCINE

Efficacy of a BVDV subunit vaccine produced in alfalfa transgenic plants

(2012) María Sol Pérez Aguirreburualde et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Induction of protective immunity in chickens immunized with plant-made chimeric Bamboo mosaic virus particles expressing very virulent Infectious bursal disease virus antigen

(2012) Tsung-Hsien Chen et al.   VIRUS RESEARCH

Transformation of Two VP1 Genes of O- and Asia 1-Type Foot-and-Mouth Disease Virus into Maize

(2011) Su-zhi ZHANG et al.   Agricultural Sciences in China

Production, characterisation and immunogenicity of a plant-made Plasmodium antigen—the 19 kDa C-terminal fragment of Plasmodium yoelii merozoite surface protein 1

(2011) Charles Ma et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Mice Orally Immunized with a Transgenic Plant Expressing the Glycoprotein of Crimean-Congo Hemorrhagic Fever Virus

(2011) S. M. Ghiasi et al.   Clinical and Vaccine Immunology

Clinical development of plant-produced recombinant pharmaceuticals: Vaccines, antibodies and beyond

(2011) Vidadi Yusibov et al.   Human vaccines & immunotherapeutics

VP8* antigen produced in tobacco transplastomic plants confers protection against bovine rotavirus infection in a suckling mouse model

(2011) E.M. Lentz et al.   JOURNAL OF BIOTECHNOLOGY

Epidemic and Economic Impacts of Delayed Detection of Foot-And-Mouth Disease: A Case Study of a Simulated Outbreak in California

(2011) Tim E. Carpenter et al.   JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION

Robust production of virus-like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce

(2011) Huafang Lai et al.   PLANT BIOTECHNOLOGY JOURNAL

Immunogenicity of a plant-derived edible chimeric EspA, Intimin and Tir of Escherichia coli O157:H7 in mice

(2011) Jafar Amani et al.   PLANT SCIENCE

An Oral Vaccine Based on U-Omp19 Induces Protection against B. abortus Mucosal Challenge by Inducing an Adaptive IL-17 Immune Response in Mice

(2011) Karina A. Pasquevich et al.   PLoS One

A plant based protective antigen [PA(dIV)] vaccine expressed in chloroplasts demonstrates protective immunity in mice against anthrax

(2011) Jyotsna Gorantala et al.   VACCINE

Plant expressed EtMIC2 is an effective immunogen in conferring protection against chicken coccidiosis

(2011) K. Sathish et al.   VACCINE

Immunogenicity of recombinant F4 (K88) fimbrial adhesin FaeG expressed in tobacco chloroplast

(2010) H. Shen et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Vaccine production in plant systems — An aid to the control of viral diseases in domestic animals: A review

(2010) Elizabeth Loza-Rubio et al.   ACTA VETERINARIA HUNGARICA

Current trends in edible vaccine development using transgenic plants

(2010) Tae-Geum Kim et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Effect of codon optimization and subcellular targeting on Toxoplasma gondii antigen SAG1 expression in tobacco leaves to use in subcutaneous and oral immunization in mice

(2010) Melina Laguía-Becher et al.   BMC BIOTECHNOLOGY

Current status of plant-made vaccines for veterinary purposes

(2010) Huai-Yian Ling et al.   Expert Review of Vaccines

Transgenic carrot tap roots expressing an immunogenic F1–V fusion protein from Yersinia pestis are immunogenic in mice

(2010) Sergio Rosales-Mendoza et al.   JOURNAL OF PLANT PHYSIOLOGY

Expression of a Cholera Toxin B Subunit-Neutralizing Epitope of the Porcine Epidemic Diarrhea Virus Fusion Gene in Transgenic Lettuce (Lactuca sativa L.)

(2010) Nguyen-Xuan Huy et al.   MOLECULAR BIOTECHNOLOGY

The Role of Heterologous Chloroplast Sequence Elements in Transgene Integration and Expression

(2010) T. Ruhlman et al.   PLANT PHYSIOLOGY

Expression of an immunogenic F1-V fusion protein in lettuce as a plant-based vaccine against plague

(2010) Sergio Rosales-Mendoza et al.   PLANTA

The economic and poverty impacts of animal diseases in developing countries: New roles, new demands for economics and epidemiology

(2010) Karl M. Rich et al.   PREVENTIVE VETERINARY MEDICINE

Production of double repeated B subunit of Shiga toxin 2e at high levels in transgenic lettuce plants as vaccine material for porcine edema disease

(2010) Takeshi Matsui et al.   TRANSGENIC RESEARCH

Oral administration of plant-based rotavirus VP6 induces antigen-specific IgAs, IgGs and passive protection in mice

(2010) Bo Zhou et al.   VACCINE

Immune responses to hemagglutinin-neuraminidase protein of peste des petits ruminants virus expressed in transgenic peanut plants in sheep

(2010) Abha Khandelwal et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Enhancing Oral Vaccine Potency by Targeting Intestinal M Cells

(2010) Ali Azizi et al.   PLoS Pathogens

Generation and immunogenicity of Japanese encephalitis virus envelope protein expressed in transgenic rice

(2009) Yuanyuan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tobacco, a highly efficient green bioreactor for production of therapeutic proteins

(2009) Reynald Tremblay et al.   BIOTECHNOLOGY ADVANCES

Prevention of bubonic and pneumonic plague using plant-derived vaccines

(2009) M. Lucrecia Alvarez et al.   BIOTECHNOLOGY ADVANCES

Pea-derived vaccines demonstrate high immunogenicity and protection in rabbits against rabbit haemorrhagic disease virus

(2009) Heike Mikschofsky et al.   PLANT BIOTECHNOLOGY JOURNAL

Chloroplast-derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery

(2009) Abdoreza Davoodi-Semiromi et al.   PLANT BIOTECHNOLOGY JOURNAL

High expression level of a foot and mouth disease virus epitope in tobacco transplastomic plants

(2009) Ezequiel Matías Lentz et al.   PLANTA

Facing pandemic influenza threats: The importance of including poultry and swine workers in preparedness plans

(2009) G. C. Gray et al.   POULTRY SCIENCE

Rabies glycoprotein fused with B subunit of cholera toxin expressed in tobacco plants folds into biologically active pentameric protein

(2009) Sribash Roy et al.   PROTEIN EXPRESSION AND PURIFICATION

Stable production of peptide antigens in transgenic tobacco chloroplasts by fusion to the p53 tetramerisation domain

(2009) Susana M. Ortigosa et al.   TRANSGENIC RESEARCH

Expression of rabies virus G protein in carrots (Daucus carota)

(2009) Edith Rojas-Anaya et al.   TRANSGENIC RESEARCH

Plant-made vaccine antigens and biopharmaceuticals

(2009) Henry Daniell et al.   TRENDS IN PLANT SCIENCE

Immunogenicity of recombinant GP5 protein of porcine reproductive and respiratory syndrome virus expressed in tobacco plant

(2009) Min-Yuan Chia et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Expression of Chlamydophila psittaci MOMP heat-labile toxin B subunit fusion gene in transgenic rice

(2008) Xiuxiang Zhang et al.   BIOLOGICALS

The expression of classical swine fever virus structural protein E2 gene in tobacco chloroplasts for applying chloroplasts as bioreactors

(2008) Hong-Bo Shao et al.   COMPTES RENDUS BIOLOGIES

Recent progress in the development of plant derived vaccines

(2008) Vidadi Yusibov et al.   Expert Review of Vaccines

Mucosal immunity induced by orally administered transgenic plants

(2008) E GOMEZ et al.   IMMUNOBIOLOGY

Effective Plague Vaccination via Oral Delivery of Plant Cells Expressing F1-V Antigens in Chloroplasts

(2008) P. A. Arlen et al.   INFECTION AND IMMUNITY

Expression of a modified Mannheimia haemolytica GS60 outer membrane lipoprotein in transgenic alfalfa for the development of an edible vaccine against bovine pneumonic pasteurellosis

(2008) R LEE et al.   JOURNAL OF BIOTECHNOLOGY

Transgenic plants for animal health: plant-made vaccine antigens for animal infectious disease control

(2008) J. J. Joensuu et al.   PHYTOCHEMISTRY REVIEWS

Expression of the rabies virus nucleoprotein in plants at high-levels and evaluation of immune responses in mice

(2008) Irene Perea Arango et al.   PLANT CELL REPORTS

Plant-expressed HA as a seasonal influenza vaccine candidate

(2008) Yoko Shoji et al.   VACCINE

Isolation and identification of canine parvovirus serotype 2a and its VP2 protein expression in transgenic tobacco

(2008) Ning Xiong et al.   VIROLOGICA SINICA