Diterpenes: Advances in Neurobiological Drug Research

Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson’s disease: Involvement of antioxidative enzymes induction

(2015) Chi-Rei Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response element signaling pathway

(2015) X.S. Zhang et al.   NEUROSCIENCE

Carnosic acid attenuates apoptosis induced by amyloid-β 1–42 or 1–43 in SH-SY5Y human neuroblastoma cells

(2015) Pengfei Meng et al.   NEUROSCIENCE RESEARCH

Carnosic acid

(2015) Simona Birtić et al.   PHYTOCHEMISTRY

Identification of dehydroabietc acid from Boswellia thurifera resin as a positive GABAA receptor modulator

(2014) Diana C. Rueda et al.   FITOTERAPIA

Two novel clerodane diterpenenes with NGF-potentiating activities from the twigs of Croton yanhuii

(2014) Yihang Sun et al.   FITOTERAPIA

Impact of caffeine and coffee on our health

(2014) Elvira Gonzalez de Mejia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Andrographolide, a major component of Andrographis paniculata leaves, has the neuroprotective effects on glutamate-induced HT22 cell death

(2014) Eun-Ju Yang et al.   Journal of Functional Foods

Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use

(2014) Elfahmi et al.   Journal of Herbal Medicine

Reynosin protects against neuronal toxicity in dopamine-induced SH-SY5Y cells and 6-hydroxydopamine-lesioned rats as models of Parkinson's disease: Reciprocal up-regulation of E6-AP and down-regulation of α-synuclein

(2013) Ahrom Ham et al.   BRAIN RESEARCH

Anxiolytic-like effects of phytol: Possible involvement of GABAergic transmission

(2013) Jéssica Pereira Costa et al.   BRAIN RESEARCH

Structural modeling and simulation studies of human cyclooxygenase (COX) isozymes with selected terpenes: Implications in drug designing and development

(2013) Swati Singh et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Chemistry and functional properties in prevention of neurodegenerative disorders of five Cistus species essential oils

(2013) Monica Rosa Loizzo et al.   FOOD AND CHEMICAL TOXICOLOGY

Reprint of: Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs

(2013) Takumi Satoh et al.   FREE RADICAL BIOLOGY AND MEDICINE

The impact of coffee on health

(2013) A. Cano-Marquina et al.   MATURITAS

Effects of the neoclerodane Hardwickiic acid on the presynaptic opioid receptors which modulate noradrenaline and dopamine release in mouse central nervous system

(2013) Anna Pittaluga et al.   NEUROCHEMISTRY INTERNATIONAL

Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells

(2013) Hidemi Yoshida et al.   NEUROSCIENCE RESEARCH

Phytochemical profiling of Curcuma kwangsiensis rhizome extract, and identification of labdane diterpenoids as positive GABAA receptor modulators

(2013) Anja Schramm et al.   PHYTOCHEMISTRY

Role of Oxidative Stress in Parkinson's Disease

(2013) Onyou Hwang   Experimental Neurobiology

Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls

(2012) Azadeh Ebrahimi et al.   AGEING RESEARCH REVIEWS

Scabronine M, a novel inhibitor of NGF-induced neurite outgrowth from PC12 cells from the fungus Sarcodon scabrosus

(2012) Li Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemical constituents from the submerged plant Potamogeton crispus and their effects on NAD(P)H:quinone oxidoreductase 1

(2012) Miao Ye et al.   CHINESE CHEMICAL LETTERS

Do benzodiazepines still deserve a major role in the treatment of psychiatric disorders? A critical reappraisal

(2012) B. Dell’osso et al.   EUROPEAN PSYCHIATRY

Structure of the human κ-opioid receptor in complex with JDTic

(2012) Huixian Wu et al.   NATURE

Ginkgolide B preconditioning on astrocytes promotes neuronal survival in ischemic injury via up-regulating erythropoietin secretion

(2012) Xiaomei Wu et al.   NEUROCHEMISTRY INTERNATIONAL

Involvement of Nrf2 signaling pathway in the neuroprotective activity of natural kaurane diterpenes

(2012) E. González-Burgos et al.   NEUROSCIENCE

Anticonvulsant effect of phytol in a pilocarpine model in mice

(2012) J.P. Costa et al.   NEUROSCIENCE LETTERS

Effect of a phytopharmaceutical medicine, Ginko biloba extract 761, in an animal model of Parkinson's disease: Therapeutic perspectives

(2012) Patricia Rojas et al.   NUTRITION

Leonurenones A–C: Labdane diterpenes from Leonotis leonurus

(2012) Fang He et al.   PHYTOCHEMISTRY

Impact of coffee components on inflammatory markers: A review

(2012) Nancy J. Frost-Meyer et al.   Journal of Functional Foods

Coffee Consumption and Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies

(2011) S. C. Larsson et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues

(2011) Cécile Béguin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Intrathecal administration of triptolide, a T lymphocyte inhibitor, attenuates chronic constriction injury-induced neuropathic pain in rats

(2011) Jin-Yu Hu et al.   BRAIN RESEARCH

Geranylgeraniol and 6α,7β-dihydroxyvouacapan-17β-oate methyl ester isolated from Pterodon pubescens Benth.: Further investigation on the antinociceptive mechanisms of action

(2011) Humberto M. Spindola et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Motor complications, levodopa metabolism and progression of Parkinson's disease

(2011) Thomas Müller   Expert Opinion on Drug Metabolism & Toxicology

Neuroprotective labdane diterpenes from Fritillaria ebeiensis

(2011) Jing Xu et al.   FITOTERAPIA

Rutin Protects Dopaminergic Neurons from Oxidative Stress in an Animal Model of Parkinson’s Disease

(2011) Mohd. Moshahid Khan et al.   NEUROTOXICITY RESEARCH

l-DOPA: A scapegoat for accelerated neurodegeneration in Parkinson's disease?

(2011) Janusz Lipski et al.   PROGRESS IN NEUROBIOLOGY

Prevalence and Correlates of Generalized Anxiety Disorder in a National Sample of Older Adults

(2010) Corey S. Mackenzie et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

The role of caspases in Alzheimer’s disease; potential novel therapeutic opportunities

(2010) Troy T. Rohn   APOPTOSIS

Design, synthesis, and characterization of BK channel openers based on oximation of abietane diterpene derivatives

(2010) Yong-Mei Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: Behavioral, neurochemical and immunohistochemical studies

(2010) Gulrana Khuwaja et al.   BRAIN RESEARCH

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

(2010) S Tobaben et al.   CELL DEATH AND DIFFERENTIATION

Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis

(2010) Kelvin Kin-Kwan Wong et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The new diterpene isodojaponin D inhibited LPS-induced microglial activation through NF-kappaB and MAPK signaling pathways

(2010) Ji-Youn Lim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Labdane diterpenes in Curcuma mangga rhizomes inhibit lipid peroxidation, cyclooxygenase enzymes and human tumour cell proliferation

(2010) Yunbao Liu et al.   FOOD CHEMISTRY

Patterns in the use of benzodiazepines in British Columbia: Examining the impact of increasing research and guideline cautions against long-term use

(2010) Colleen M. Cunningham et al.   HEALTH POLICY

In vitro biological activities of niloticane, a new bioactive cassane diterpene from the bark of Acacia nilotica subsp. kraussiana

(2010) I.M.S. Eldeen et al.   JOURNAL OF ETHNOPHARMACOLOGY

A Mouse Model of Amyloid   Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo

(2010) T. Tomiyama et al.   JOURNAL OF NEUROSCIENCE

Delayed Dominant-Negative TNF Gene Therapy Halts Progressive Loss of Nigral Dopaminergic Neurons in a Rat Model of Parkinson's Disease

(2010) Ashley S Harms et al.   MOLECULAR THERAPY

The evidence for pharmacological treatment of neuropathic pain

(2010) Nanna Brix Finnerup et al.   PAIN

Central nervous system activities of two diterpenes isolated from Aloysia virgata

(2010) Cristina Wasowski et al.   PHYTOMEDICINE

Synthesis and biological evaluation of C-12 triazole and oxadiazole analogs of salvinorin A

(2009) Lu Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols

(2009) María Rosario Campos-Esparza et al.   CELL CALCIUM

Neuroprotective effects of the new diterpene, CBNU06 against beta-amyloid-induced toxicity through the inhibition of NF-kappaB signaling pathway in PC12 cells

(2009) Hyo-Shin Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibitory Effects and Molecular Mechanism of Dieckol Isolated from Marine Brown Alga on COX-2 and iNOS in Microglial Cells

(2009) Won-Kyo Jung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use

(2009) Ulrich Dirnagl et al.   LANCET NEUROLOGY

Salvinorin A exerts opposite presynaptic controls on neurotransmitter exocytosis from mouse brain nerve terminals

(2009) Massimo Grilli et al.   NEUROPHARMACOLOGY

Kappa-opioid ligands in the study and treatment of mood disorders

(2009) William A. Carlezon et al.   PHARMACOLOGY & THERAPEUTICS

Plants with neurobiological activity as potential targets for drug discovery

(2009) Nelson G.M. Gomes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress

(2008) Yong Pil Hwang et al.   FEBS LETTERS

Neurotrophin-3 reduces apoptosis induced by 6-OHDA in PC12 cells through Akt signaling pathway

(2008) Zhiquan Li et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

The Effects of Herkinorin, the First  -Selective Ligand from a Salvinorin A-Derived Scaffold, in a Neuroendocrine Biomarker Assay in Nonhuman Primates

(2008) E. R. Butelman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Synthetic studies of neoclerodane diterpenoids from Salvia splendens and evaluation of opioid receptor affinity

(2008) Gianfranco Fontana et al.   TETRAHEDRON