Article
Biotechnology & Applied Microbiology
Lu Yang, Jianxin Yang, Xiao Liang, Wenjun Huang, Xiaoxi Zhang, Rong Li
Summary: This study utilized bioinformatics approaches to uncover the mechanisms by which metformin treats obesity-related hypertension, revealing its involvement in metabolic regulation, inflammatory suppression, and modulation of immune signaling pathways. Key target proteins and interaction genes were identified through network pharmacology and molecular docking analyses, highlighting the potential clinical applications of metformin in future.
Article
Neurosciences
Manuel Pedro Pereira, Martin Schmelz, Sonja Staender
Summary: Neuropathic pruritus conditions result from damage to the nervous system, and novel findings strengthen the specificity theory of pruritus transmission. Activation of nociceptors and specific discharge patterns of primary afferents also contribute to itch development. Interactions between excitatory and inhibitory interneurons, non-neuronal cells, and descending modulation from upper centers contribute to neuronal sensitization, leading to chronic itch and accompanying phenomena.
CURRENT OPINION IN NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, Chih-Yao Hou, Wei-Hsuan Hsu, You-Lin Tain
Summary: Metabolic syndrome (MetS) has developmental origins, which can be programmed by adverse early-life conditions. Early interventions have potential to prevent MetS, and mechanism-targeted strategies including antioxidants and probiotics are being explored. Further research is needed to determine insults, mechanisms, and reprogramming strategies for clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Catherine A. Fitton, Michael Fleming, Lorna Aucott, Jill P. Pell, Daniel F. Mackay, James S. McLay
Summary: A retrospective cohort study in Scotland found that in-utero exposure to antihypertensive medication may be associated with an increased risk of circulatory defects, but no increased risk of developmental outcomes was observed at 2.5 years of age.
JOURNAL OF HYPERTENSION
(2021)
Review
Pharmacology & Pharmacy
F. T. Bekedam, M. J. Goumans, H. J. Bogaard, F. S. de Man, A. Llucia-Valldeperas
Summary: Right ventricular fibrosis is a stress response caused by activation of cardiac fibroblasts, leading to increased synthesis and remodeling of the extracellular matrix. While it provides structural protection in response to damage, it also contributes to increased myocardial stiffness and dysfunction. This review summarizes current knowledge and studies on the development of right ventricular fibrosis in response to pressure overload and its potential for improving cardiac function. (c) 2023 Published by Elsevier Inc.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Nutrition & Dietetics
Anns Mahboob, Samson Mathews Samuel, Arif Mohamed, Mohmmad Younus Wani, Sofiane Ghorbel, Nabil Miled, Dietrich Buesselberg, Ali Chaari
Summary: Obesity is a major health challenge linked to various non-communicable diseases. Despite being modifiable and preventable, current prevention and treatment strategies have limited success. This manuscript explores the pathophysiology of obesity as an inflammatory disease, evaluates existing anti-obesity treatments, and discusses the potential of flavonoid-based interventions. The use of naturally occurring flavonoids for long-term obesity prevention and treatment is also highlighted.
FRONTIERS IN NUTRITION
(2023)
Article
Immunology
Wenji Liu, Jie Peng, Yixin Wu, Zuxiang Ye, Zhen Zong, Rui Wu, Hui Li
Summary: Gout is an autoimmune disease characterized by inflammation and damage to bone joints caused by the deposition of monosodium urate crystals. Research has uncovered the involvement of immune cells, inflammatory cytokines, and inflammasomes in gouty inflammation, providing insights into targeted therapy and further understanding the pathogenesis of gout.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Da-Hong Chen, Ji-Gang Zhang, Chuan-Xing Wu, Qin Li
Summary: This review discusses the relationship between non-coding RNA m6A modification and cancer progression from the perspective of various cancers, focusing on important mechanisms such as proliferation, apoptosis, invasion and metastasis, tumor angiogenesis. Clinical applications are introduced to illustrate the broad research prospects of non-coding RNA m6A modification in cancer research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chrishan J. A. Ramachandra, Shuo Cong, Xavier Chan, En Ping Yap, Fan Yu, Derek J. Hausenloy
Summary: Cardiac hypertrophy is an adaptive change of the heart to maintain normal function, with oxidative stress identified as a critical inducer. In addition to traditional mediators of oxidative stress, metabolic disturbances, mitochondrial dysfunction, inflammation, dysregulated autophagy, and protein homeostasis also contribute to cardiac pathophysiology through oxidative stress mechanisms. Novel therapeutic targets and repurposed drugs aimed at counteracting oxidative stress have shown promise in attenuating cardiac hypertrophy.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Marlyn J. Mayo
Summary: The treatment for primary biliary cholangitis (PBC) with ursodeoxycholic acid (UDCA) may not be sufficient for all patients, and new approaches are needed. This review discusses potential therapeutic targets in PBC and provides examples of specific agents under development for the treatment of PBC, including targets related to bile, inflammation, cell survival, and fibrosis.
Review
Neurosciences
Lijun Dai, Li Zou, Lanxia Meng, Guifen Qiang, Mingmin Yan, Zhentao Zhang
Summary: Cholesterol is essential for cell membrane integrity and plays critical roles in physiological processes, particularly in the brain where its metabolism is closely linked to neurodegenerative diseases. Statins, a class of lipid-lowering drugs, have been reported to have a positive impact on neurodegenerative diseases, but the specific mechanisms are still under investigation.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Cheng Ju, Yang-Guang Ma, Xiao-Shuang Zuo, Xuan-Kang Wang, Zhi-Wen Song, Zhi-Hao Zhang, Zhi-Jie Zhu, Xin Li, Zhuo-Wen Liang, Tan Ding, Zhe Wang, Xue-Yu Hu
Summary: Photobiomodulation, also known as low-level laser therapy, is a classic noninvasive physiotherapy widely used for the treatment of various diseases. It has been found to promote spinal cord injury repair by inhibiting STAT3 expression and activating the miR-330-5p/STAT3 pathway.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Linh Ho, Nazir Hossen, Trieu Nguyen, Au Vo, Fakhrul Ahsan
Summary: Pulmonary arterial hypertension (PAH) is a disease that leads to right-ventricular failure and death. Epigenetic modifications play an important role in the pathology of PAH. Dysregulation of epigenetic mechanisms is strongly associated with the pathological vascular remodeling during PAH development. Targeting these epigenetic regulators offers potential candidates for drug discovery and treatment of PAH.
Article
Multidisciplinary Sciences
Rachel S. Riley, Meghana Kashyap, Margaret M. Billingsley, Brandon White, Mohamad-Gabriel Alameh, Sourav K. Bose, Philip W. Zoltick, Hiaying Li, Rui Zhang, Andrew Y. Cheng, Drew Weissman, William H. Peranteau, Michael J. Mitchell
Summary: Using ionizable lipid nanoparticles, mRNA can be effectively and safely delivered to mouse fetuses to produce therapeutic secreted proteins, providing a platform for prenatal gene editing and protein replacement.
Article
Biochemistry & Molecular Biology
Yun-Fang Hao, Ting Luo, Zhong-Yu Lu, Chun-Yan Shen, Jian-Guo Jiang
Summary: Rhodiola rosea extracts have sedative and hypnotic effects by regulating neurotransmitters, hormones, and inflammation cytokines, with potential involvement of the serotonergic, GABAergic, and immune systems.
Article
Sport Sciences
Laura M. Reyes, Sauleha M. Farooq, Rachel J. Skow, Stephen A. Busch, Kyra E. Pyke, Rshmi Khurana, Radha S. Chari, Michael K. Stickland, Maureen Devolin, Sandra T. Davidge, Frances Sobierajski, Anna Lugg, Craig D. Steinback, Margie H. Davenport
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2020)
Correction
Multidisciplinary Sciences
Tina Napso, Yin-Po Hung, Sandra T. Davidge, Alison S. Care, Amanda N. Sferruzzi-Perri
SCIENTIFIC REPORTS
(2020)
Review
Public, Environmental & Occupational Health
Ayah Abdul-Hussein, Ayesha Kareem, Shrankhala Tewari, Julie Bergeron, Laurent Briollais, John R. G. Challis, Sandra T. Davidge, Claudio Delrieux, Isabel Fortier, Daniel Goldowitz, Pablo Nepomnaschy, Ashley Wazana, Kristin L. Connor
Summary: This study conducted a Rapid Evidence Review within the DOHaD framework, finding that the majority of DOHaD research data come from high-income countries, with studies examining social determinants of health and paternal influences being underrepresented. Only 23% of the articles explored resiliency factors.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)
Article
Medicine, Research & Experimental
Tamara Saez, Floor Spaans, Raven Kirschenman, Tatsuya Sawamura, Sandra T. Davidge
Article
Biochemistry & Molecular Biology
Esha Ganguly, Raven Kirschenman, Floor Spaans, Claudia D. Holody, Thomas E. J. Phillips, C. Patrick Case, Christy-Lynn M. Cooke, Michael P. Murphy, Helene Lemieux, Sandra T. Davidge
Summary: Complications associated with prenatal hypoxia can lead to increased placental oxidative stress, impacting fetal development. A placenta-targeted treatment strategy using nMitoQ was found to improve placental mitochondrial function in both male and female placentae exposed to prenatal hypoxia. This strategy could potentially enhance placental function in complicated pregnancies by reducing oxidative stress.
Article
Physiology
Laura Marcela Reyes, Charlotte W. Usselman, Rshmi Khurana, Radha S. Chari, Michael K. Stickland, Sandra T. Davidge, Colleen G. Julian, Craig D. Steinback, Margie H. Davenport
Summary: This study found that women with preeclampsia had higher baseline mean arterial pressure, noradrenaline concentrations, and MSNA occurrence probability compared to controls, but no significant difference in baseline MSNA levels between the two groups. The chemoreflex does not contribute to increased MSNA in women with preeclampsia.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nataliia Hula, Floor Spaans, Jennie Vu, Anita Quon, Raven Kirschenman, Christy-Lynn M. Cooke, Tom J. Phillips, C. Patrick Case, Sandra T. Davidge
Summary: Offspring born from pregnancies complicated by prenatal hypoxia are at higher risk of cardiovascular disease in adulthood. Cardiac tolerance to ischemia/reperfusion (I/R) insult is decreased in both male and female offspring exposed to hypoxia during fetal life, but can be improved by maternal treatment with nMitoQ. The molecular mechanisms underlying the improved cardiac tolerance to I/R may involve changes in the levels/phosphorylation of proteins important for intracellular Ca2+ cycling.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Kalyanaraman Kumaran, Ghattu Krishnaveni, Kumar Gavali Suryanarayana, Manohar Prabhu Prasad, Antonisamy Belavendra, Stephanie Atkinson, Ramaswamy Balasubramaniam, Robert H. J. Bandsma, Zulfiqar A. Bhutta, Giriraj Ratan Chandak, Elena M. Comelli, Sandra T. Davidge, Cindy-Lee Dennis, Geoffrey L. Hammond, Prabhat Jha, K. S. Joseph, Sadhana R. Joshi, Murali Krishna, Kang Lee, Stephen Lye, Patrick McGowan, Pablo Nepomnaschy, Vivek Padvetnaya, Saumyadipta Pyne, Harshpal Singh Sachdev, Sirazul Ameen Sahariah, Nalini Singhal, Jacquetta Trasler, Chittaranjan S. Yajnik, Janis Baird, Mary Barker, Marie-Claude Martin, Nusrat Husain, Daniel Sellen, Caroline H. D. Fall, Prakesh S. Shah, Stephen G. Matthews
Summary: The study protocol describes a comprehensive intervention to reduce non-communicable disease risks in children through a village-based cluster randomised design in rural India. The multifaceted intervention includes measures to optimize nutrition, parenting programme, lifestyle behavior change intervention, and environmental pollution reduction. The study will collect various biospecimens to assess intervention effects and conduct intention-to-treat analysis and process and economic evaluations.
Review
Biochemistry & Molecular Biology
Jamie Strain, Floor Spaans, Mohamed Serhan, Sandra T. Davidge, Kristin L. Connor
Summary: Exposome research aims to understand the various environmental exposures that impact human health, particularly the mechanism behind obesity. Maternal metabolic exposome and early environmental exposures increase the risk of offspring obesity through mechanisms such as epigenetic modifications, altered placental function, changes in gut microbiome and breast milk composition, and metabolic inflammation affecting development of the central appetite system, adipose tissues, and liver.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Physiology
Mazhar Pasha, Amy L. Wooldridge, Raven Kirschenman, Floor Spaans, Sandra T. Davidge, Christy-Lynn M. Cooke
Summary: The study found that advanced maternal age is associated with heightened blood pressure in non-pregnant rats, and different responses in endothelium-dependent relaxation to vasodilators and big endothelin-1, indicating compensatory mechanisms in vascular function in aged rats.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nataliia Hula, Ricky Liu, Floor Spaans, Mazhar Pasha, Anita Quon, Raven Kirschenman, Christy-Lynn M. Cooke, Sandra T. T. Davidge
Summary: Prenatal hypoxia predisposes offspring to cardiovascular dysfunction in adulthood, impairing endothelium-dependent vasodilation and increasing PGHS-dependent vasoconstriction. Additionally, prenatal hypoxia enhances the contribution of endothelium-dependent hyperpolarization to coronary artery vasodilation.
Article
Biochemistry & Molecular Biology
Paulami Chatterjee, Claudia D. Holody, Raven Kirschenman, Murilo E. Graton, Floor Spaans, Tom J. Phillips, C. Patrick Case, Stephane L. Bourque, Helene Lemieux, Sandra T. Davidge
Summary: Prenatal hypoxia impairs cardiac mitochondrial function in adult female offspring, but this can be improved with prenatal treatment using a nanoparticle-encapsulated mitochondrial antioxidant. The study found that prenatal hypoxia did not affect cardiac mitochondrial function in male offspring, while it decreased the capacity of certain mitochondrial pathways in females. However, treatment with nMitoQ increased respiratory coupling efficiency in female offspring exposed to prenatal hypoxia. This suggests that targeting placental oxidative stress in prenatal hypoxia may reduce the risk of cardiovascular disease in adult offspring by improving cardiac mitochondrial function, specifically in females.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Victor Do, Luke Eckersley, Lily Lin, Sandra T. Davidge, Michael K. Stickland, Tiina Ojala, Jesus Serrano-Lomelin, Lisa K. Hornberger
Summary: The study revealed that children of diabetic mothers continue to exhibit interventricular septal thickening and increased aortic stiffness in early childhood, which is correlated with maternal blood sugar control. Compared to children from healthy pregnancies, the offspring of diabetic mothers show significant cardiovascular abnormalities.
Review
Medicine, Research & Experimental
Stephane L. Bourque, Sandra T. Davidge
Article
Physiology
Praveen Kumar, Jude S. Morton, Amin Shah, Victor Do, Consolato Sergi, Jesus Serrano-Lomelin, Sandra T. Davidge, Donna Beker, Jody Levasseur, Lisa K. Hornberger
PHYSIOLOGICAL REPORTS
(2020)