Journal
CHEMSUSCHEM
Volume 8, Issue 12, Pages 2066-2072Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.201500318
Keywords
carbon dioxide; formamide; metathesis; reaction mechanisms; synthetic methods
Funding
- National Natural Science Foundation of China [21303189, 21273231, 21422308]
- Hundred Person Project of the Chinese Academy of Sciences
Ask authors/readers for more resources
Herein, we report CO2-mediated metathesis reactions between amines and DMF to synthesize formamides. More than 20amines, including primary, secondary, aromatic, and heterocyclic amines, diamines, and amino acids, are converted to the corresponding formamides with good-to-excellent conversions and selectivities under mild conditions. This strategy employs CO2 as a mediator to activate the amine under metal-free conditions. The experimental data and insitu NMR and attenuated total reflectance IR spectroscopy measurements support the formation of the N-carbamic acid as an intermediate through the weak acid-base interaction between CO2 and the amine. The metathesis reaction is driven by the formation of a stable carbamate, and a reaction mechanism is proposed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available