Article
Polymer Science
Amaraporn Wongrakpanich, Nichakan Khunkitchai, Yanisa Achayawat, Jiraphong Suksiriworapong
Summary: This study developed ketorolac microparticles using hyaluronic acid stabilized poly(lactide-co-glycolide) (PLGA), poly(lactide) (PLA), and their blend for osteoarthritis treatment. Different emulsification techniques and polymer compositions influenced the microparticle characteristics, with probe sonication resulting in smaller size and broader size distribution than high-speed stirring. The microparticles showed biphasic drug release over 35 days and demonstrated potential for treating osteoarthritis.
Article
Pharmacology & Pharmacy
F. Tamani, C. Bassand, M. C. Hamoudi, F. Siepmann, J. Siepmann
Summary: This study aimed to investigate the drug release mechanisms in PLGA microparticles, focusing on factors such as polymer swelling & degradation, drug dissolution and diffusion. The results show that the burst release and steady release phases are strongly temperature-dependent, with a rapid release phase observed only at 37 degrees C. These findings confirm the hypothesized root causes for drug release from PLGA microparticles at lower temperatures.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Shuaikai Ren, Chunxin Wang, Liang Guo, Congcong Xu, Yan Wang, Changjiao Sun, Haixin Cui, Xiang Zhao
Summary: Microcapsules with uniform size and tailored dimensions were prepared using emulsification and solvent evaporation methods in this study for the construction of controlled-release drug carriers. Morphology and structure of the microcapsules could be tailored by regulating the preparation conditions, and the release rate of protein could be controlled by adjusting the pore size. This controlled-release novel microcapsule carrier system shows great potential for biomedical applications.
Article
Engineering, Biomedical
Ji Min Seok, Min Ji Kim, Jin Ho Park, Dahong Kim, Dongjin Lee, Seon Ju Yeo, Jun Hee Lee, Kangwon Lee, June-Ho Byun, Se Heang Oh, Su A. Park
Summary: This study presents a 3D printed bioactive microparticle-loaded scaffold for bone regeneration applications, which provides sustained release of growth factors without the use of toxic substances. The addition of bioactive microparticles enhances osteogenic differentiation and mineralization mediated by human periosteum-derived cells. This alternative bioprinting strategy improves biofunctional properties and is suitable for clinical bone regeneration applications.
MATERIALS TODAY BIO
(2023)
Article
Polymer Science
Zhicheng Deng, Jinjun Li, Yun Chen, Chao Huang, Nanjing Zhong, Yong Hu
Summary: A novel Cur/TPP-β-CD/CS/Vc microparticles filled CMCS/OSA composite hydrogel was successfully prepared and characterized. The polymeric MPs were homogenously embedded in the composite hydrogel, resulting in enhanced mechanical strength and stability. The controlled release of Cur and Vc was achieved by different encapsulation pathways in the hydrogel.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Pharmacology & Pharmacy
Wenting Lin, Tao Xu, Zhongzhi Wang, Jianghan Chen
Summary: The study synthesized AMB-loaded thermogel for the treatment of cryptococcal meningitis, demonstrating its sustained release, reduced neurotoxicity, and improved therapeutic effect compared to traditional AMB solution, indicating the potential of the PLGA-PEG-PLGA thermogel as a biocompatible carrier for intrathecal drug delivery.
Article
Materials Science, Multidisciplinary
Marcin K. Heljak, Wojciech Swieszkowski
Summary: This paper presents a computational model of bevacizumab release from PLGA microspheres administered intravitreally, validated against experimental data, to evaluate anti-VEGF therapies in ocular transport.
Review
Biochemistry & Molecular Biology
Abdelwahab Khalil, Basem H. Elesawy, Tarek M. Ali, Osama M. Ahmed
Summary: Insects of the order Hymenoptera, such as honeybees, have venom containing various bioactive compounds that have potential therapeutic applications. Research suggests that bee venom and its components exhibit multiple biological activities, including anti-microbial, anti-inflammatory, and anti-cancer properties. There is ongoing exploration of utilizing bee venom as a drug delivery vehicle and discussing its molecular mechanisms for potential medical benefits.
Article
Chemistry, Medicinal
Stijn H. S. Koshari, Xutao Shi, Linda Jiang, Debby Chang, Karthikan Rajagopal, Abraham M. Lenhoff, Norman J. Wagner
Summary: An extensive data set was used to advance the development of a model-informed design of controlled drug release. An improved drug-release model incorporating mechanistic modeling of hydrolytic polymer degradation was used and validated against in vitro experiments. The study demonstrates the potential for achieving a priori design of controlled drug release by combining parameter estimates from the literature with model fits to the data set. The results highlight the importance of careful selection of the polymer grade and the need for better understanding of phenomena like pore formation in designing drug release systems.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Marcin K. Heljak, Wojciech Swieszkowski
Summary: A computational model for the sustained release of bevacizumab from intravitreal poly(lactic-co-glycolic acid) (PLGA) microspheres and its concentration in ocular tissues has been developed. The model showed high accuracy in predicting the release of bevacizumab from different sizes of PLGA microspheres and its concentration in the retina when given in solution.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Materials Science, Multidisciplinary
Gregory Callahan, Austin Veith, Alberto Madariaga, Manuel K. Rausch, Daniel Stromberg, Aaron B. Baker
Summary: In this study, a drug eluting chest tube was developed to reduce the use of systemic opioids in patients after chest tube implantation. The tube was made from a porous polymer loaded with bupivacaine, which was protected during tube insertion and following implantation. The optimized solid casting strategy released high amounts of the drug for at least 14 days.
APPLIED MATERIALS TODAY
(2023)
Review
Food Science & Technology
Aida A. Abd El-Wahed, Shaden A. M. Khalifa, Mohamed H. Elashal, Syed G. Musharraf, Aamer Saeed, Alfi Khatib, Haroon Elrasheid Tahir, Xiaobo Zou, Yahya Al Naggar, Arshad Mehmood, Kai Wang, Hesham R. El-Seedi
Summary: Bee venom is widely used in skin care products to treat various skin diseases, but safety concerns exist due to potential allergic reactions. Studies have shown that adverse reactions to bee venom can lead to excessive immune responses, including anaphylaxis, which typically resolve over time.
Article
Chemistry, Multidisciplinary
Fangfei Hu, Jianping Qi, Yi Lu, Haisheng He, Wei Wu
Summary: To overcome the short half-life and low stability of peptide and protein drugs, long-acting drug delivery systems using PLGA implants have been developed. Various technologies have been developed for lab-scale fabrication or industrial manufacture to meet the demand for delivering peptides and proteins. This review introduces recent advances in PLGA implants, including their fundamental properties, fabrication technologies, drug release processes, and future perspectives.
CHINESE CHEMICAL LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Anna Kurek-Gorecka, Katarzyna Komosinska-Vassev, Anna Rzepecka-Stojko, Pawel Olczyk
Summary: Bee venom, also known as apitoxin, is widely used in the treatment of inflammatory diseases and has been found to accelerate wound healing by regulating growth factors, cell activities and promoting cell proliferation and migration in the skin.
Article
Multidisciplinary Sciences
Samia E. El-Didamony, Reham Amer, Ghada H. El-Osaily
Summary: In this study, enteric-coated cross-linked microspheres loaded with bee venom were prepared and evaluated for their properties and release characteristics. The results showed that the optimized microsphere formula had anti-growth effects on human prostate adenocarcinoma cells, while being non-toxic to normal oral epithelial cells. Furthermore, the microspheres inhibited tumor cell growth by inducing apoptosis. Therefore, the microspheres have the potential to be a good candidate for future cancer therapy.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Alam Zeb, Isra Rana, Ho-Ik Choi, Cheol-Ho Lee, Seong-Woong Baek, Chang-Wan Lim, Namrah Khan, Sadia Tabassam Arif, Najam us Sahar, Arooj Mohsin Alvi, Fawad Ali Shah, Fakhar ud Din, Ok-Nam Bae, Jeong-Sook Park, Jin-Ki Kim
Article
Biochemistry & Molecular Biology
Suji Ryu, Seungyeop Park, Ha Yeon Lee, Hyungjun Lee, Cheong-Weon Cho, Jong-Suep Baek
Summary: This study developed microcapsules loaded with alginate-coated chitosan to increase the encapsulation efficiency of hydrophilic drugs while reducing initial burst release, providing controlled and sustained release. The encapsulation of nanoparticles in PLGA microcapsules demonstrated enhanced encapsulation efficiency of hydrophilic drugs, showing promising potential for sustained release with reduced initial burst release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Phuong Tran, Jeong-Sook Park
Summary: Dexibuprofen-loaded solid dispersion (SD) was formulated to improve solubility and bioavailability, with results demonstrating excellent potential for the SD formulation as a solution for poorly soluble drug Dexibuprofen.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Min-Ki Kim, Do-Hyung Ki, Young-Guk Na, Hae-Soo Lee, Jong-Suep Baek, Jae-Young Lee, Hong-Ki Lee, Cheong-Weon Cho
Summary: By utilizing statistical experimental methods, nano-sized mesoporous silica nanoparticles (MSNs) with excellent physicochemical properties were successfully synthesized. The optimized MSNs exhibited potential as a drug delivery system and showed negligible toxicity in cytotoxicity tests.
Article
Pharmacology & Pharmacy
Hyeonmin Lee, Jun-Bae Bang, Young-Guk Na, Jae-Young Lee, Cheong-Weon Cho, Jong-Suep Baek, Hong-Ki Lee
Summary: The study prepared a nanosuspension loaded with CUR and modified it with tannic acid to increase its mucoadhesion in the gastrointestinal tract. The results showed that this approach can enhance the retention time of CUR in the GI tract, thereby increasing its absorption and overcoming the low bioavailability of CUR.
Article
Pharmacology & Pharmacy
Phuong Tran, Jeong-Sook Park
Summary: The purpose of this study was to design and evaluate chitosan nanoparticles coated with alginate for the protection of protein drugs from acid degradation. The results showed that the nanoparticles effectively protected the stability of the protein and exhibited no cytotoxicity. Therefore, these chitosan nanoparticles have the potential for oral delivery of protein drugs.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2022)
Review
Pharmacology & Pharmacy
Thu Nhan Nguyen, Jeong-Sook Park
Summary: This review summarizes and discusses various drug delivery systems applied to intratympanic administration, including conventional formulations and combinations of hydrogels and nanoparticles. The combination of hydrogels and nanoparticles is a promising area for future investigation.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2023)
Article
Pharmacology & Pharmacy
Phuong Tran, Thu Nhan Nguyen, Jeong-Sook Park
Summary: This study aimed to improve the dissolution and oral bioavailability of celecoxib (CXB) by preparing a co-carrier-based solid dispersion (SD). The CXB-loaded SD formulation consisted of CXB, pol407, Aerosil 200, and Eudragit L100 at a specific weight ratio. The results showed that the optimized CXB-SD had significantly higher dissolution efficiency compared to raw CXB, and its bioavailability was also improved. In conclusion, SDs can enhance the dissolution and oral bioavailability of poorly water-soluble CXB.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Thu Nhan Nguyen, Phuong Tran, Yeong-Eun Choi, Jeong-Sook Park
Summary: The purpose of this study was to prepare a solid dispersion (SD) formulation of MBZ to improve dissolution and oral bioavailability. SDS was used as a carrier to prepare the SD formulation of MBZ via lyophilization method. The structural properties and morphology of the MBZ-SD formulation were confirmed using PXRD, DSC, FTIR, and SEM. The MBZ-SD formulation significantly improved the aqueous solubility and dissolution of MBZ, and showed increased bioavailability and anticancer effects.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2023)
Article
Pharmacology & Pharmacy
Dong-Hyun Kim, Thu Nhan Nguyen, Yujin Jin, Naehwan Baek, So Young Back, Sohyun Sim, Kyung-Sun Heo, Jeong-Sook Park
Summary: The study aimed to evaluate the synergistic effect of ginsenoside Rh1, Rg2, and Hydrangea extract on skin-lightening and assess the skin-lightening effect of a cream formulation containing these substances. The combination of ginsenosides Rh1, Rg2, and Hydrangea extract reduced the activity of tyrosinase and inhibited melanin synthesis more effectively than each component alone. The permeability of Rh1 was improved when loaded into a cream base, and addition of flower extract to the cream formulation further increased its permeability.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2023)
Article
Pharmacology & Pharmacy
Yong-Chul Pyo, Thu Nhan Nguyen, Ye-Seul Lee, Yeong-Eun Choi, Jeong-Sook Park
Summary: This study aimed to improve the solubility and bioavailability of esomeprazole magnesium by preparing solid dispersions using a supercritical anti-solvent process. The results showed that the solid dispersion prepared using this process exhibited higher dissolution rate and better pharmacokinetic profile compared to other formulations.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Dong-Hyun Kim, Thu Nhan Nguyen, Young-Min Han, Phuong Tran, Jinhyung Rho, Jae-Young Lee, Hwa-Young Son, Jeong-Sook Park
Summary: In this study, an intratympanic delivery system using PLGA nanoparticles and thermosensitive gels was developed for sustained release of dexamethasone. The system showed potential as a drug delivery system for the inner ear, with efficient drug release and minimal inflammatory response after administration.
Review
Pharmacology & Pharmacy
Phuong Tran, Jeong-Sook Park
Summary: SEDDS is a potential formulation for drug delivery that can improve the rate and extent of oral absorption by maximizing drug solubility in the intestinal absorption site. Due to the lipid-based formulation of SEDDS, it can stimulate and enhance lymphatic transport of drugs to avoid hepatic first-pass metabolism, thus improving their bioavailability.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2021)
Review
Pharmacology & Pharmacy
Dong-Hyun Kim, Sang-Eun Lee, Yong-Chul Pyo, Phuong Tran, Jeong-Sook Park
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2020)
Article
Biochemistry & Molecular Biology
Jin-Seok Choi, Jeong-Sook Park
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
