Potential and Applications of Nanocarriers for Efficient Delivery of Biopharmaceuticals

Nanostructured lipid carriers-mediated brain delivery of carbamazepine for improved in vivo anticonvulsant and anxiolytic activity

(2020) Namrah Khan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Melatonin-Loaded Nanoparticles for Enhanced Antidepressant Effects and HPA Hormone Modulation

(2020) Min Si et al.   ADVANCES IN POLYMER TECHNOLOGY

Enhanced Oral Vaccine Efficacy of Polysaccharide-Coated Calcium Phosphate Nanoparticles

(2020) Pei Cao et al.   ACS Omega

Solid lipid nanoparticles-mediated enhanced antidepressant activity of duloxetine in lipopolysaccharide-induced depressive model

(2020) Isra Rana et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Scope and limitations on aerosol drug delivery for the treatment of infectious respiratory diseases

(2020) Hana Douafer et al.   JOURNAL OF CONTROLLED RELEASE

Simvastatin-loaded solid lipid nanoparticles for enhanced anti-hyperlipidemic activity in hyperlipidemia animal model

(2019) Syed Zaki Husain Rizvi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Polymeric Nanogels as Versatile Nanoplatforms for Biomedical Applications

(2019) Fakhara Sabir et al.   Journal of Nanomaterials

Novel polyurethane-based nanoparticles of infliximab to reduce inflammation in an in-vitro intestinal epithelial barrier model

(2019) Ritesh M. Pabari et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Regulatory T Cells Tailored with pH-Responsive Liposomes Shape an Immuno-Antitumor Milieu against Tumors

(2019) Wenquan Ou et al.   ACS Applied Materials & Interfaces

Interferon‐gamma carrying nanoemulsion with immunomodulatory and anti‐tumor activities

(2019) Elton B. Ribeiro et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

A Novel Formulation Strategy to Deliver Combined DNA and VLP Based HPV Vaccine

(2019) Mohammad Nasir Uddin et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Nanoparticle Delivery Systems in the Treatment of Diabetes Complications

(2019) Eliana B. Souto et al.   MOLECULES

Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure

(2018) Hongxia Liang et al.   ACS Nano

Glycosaminoglycan-based hybrid hydrogel encapsulated with polyelectrolyte complex nanoparticles for endogenous stem cell regulation in central nervous system regeneration

(2018) Wei-Hong Jian et al.   BIOMATERIALS

Trastuzumab- and Fab′ fragment-modified curcumin PEG-PLGA nanoparticles: preparation and evaluation in vitro and in vivo

(2018) Dongyu Duan et al.   International Journal of Nanomedicine

Anti-angiogenic effects of CD73-specific siRNA-loaded nanoparticles in breast cancer-bearing mice

(2018) Ghasem Ghalamfarsa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

(2018) Li Tang et al.   NATURE BIOTECHNOLOGY

Estrogen therapy for osteoporosis in the modern era

(2018) V. A. Levin et al.   OSTEOPOROSIS INTERNATIONAL

Biocompatible single-chain polymer nanoparticles loaded with an antigen mimetic as potential anticancer vaccine

(2018) Raquel Gracia et al.   ACS Macro Letters

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization

(2018) Susan Hua et al.   Frontiers in Pharmacology

Virus-Like Particle, Liposome, and Polymeric Particle-Based Vaccines against HIV-1

(2018) Yong Gao et al.   Frontiers in Immunology

Extra-Large Pore Mesoporous Silica Nanoparticles Enabling Co-Delivery of High Amounts of Protein Antigen and Toll-like Receptor 9 Agonist for Enhanced Cancer Vaccine Efficacy

(2018) Bong Geun Cha et al.   ACS Central Science

Endothelial siRNA delivery in nonhuman primates using ionizable low–molecular weight polymeric nanoparticles

(2018) Omar F. Khan et al.   Science Advances

Liposome: composition, characterization, preparation, and recent innovation in clinical applications

(2018) Kamel S. Ahmed et al.   JOURNAL OF DRUG TARGETING

Cationic lipid-assisted nanoparticles for delivery of mRNA cancer vaccine

(2018) Ya-Nan Fan et al.   Biomaterials Science

Physiologically Based Pharmacokinetic Modeling of Nanoparticles

(2018) Dongfen Yuan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Vaccine nanoparticles displaying recombinant Ebola virus glycoprotein for induction of potent antibody and polyfunctional T cell responses

(2018) Joseph D. Bazzill et al.   Nanomedicine-Nanotechnology Biology and Medicine

The Activity of Peptides of the Calcitonin Family in Bone

(2018) Dorit Naot et al.   PHYSIOLOGICAL REVIEWS

A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague

(2018) Pan Tao et al.   mBio

Specific cancer stem cell-therapy by albumin nanoparticles functionalized with CD44-mediated targeting

(2018) Yuanyuan Li et al.   JOURNAL OF NANOBIOTECHNOLOGY

Poly(lactic acid) nanoparticles and cell-penetrating peptide potentiate mRNA-based vaccine expression in dendritic cells triggering their activation

(2018) Anne-Line Coolen et al.   BIOMATERIALS

Oral Helicobacter pylori vaccine-encapsulated acid-resistant HP55/PLGA nanoparticles promote immune protection

(2017) Zhoulin Tan et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

(2017) Fakhar ud Din et al.   International Journal of Nanomedicine

Extra-Large Pore Mesoporous Silica Nanoparticles for Directing in Vivo M2 Macrophage Polarization by Delivering IL-4

(2017) Dohyeong Kwon et al.   NANO LETTERS

Sound understanding of environmental, health and safety, clinical, and market aspects is imperative to clinical translation of nanomedicines

(2017) Matthias Rösslein et al.   Nanotoxicology

siRNA Delivery Strategies: A Comprehensive Review of Recent Developments

(2017) Katyayani Tatiparti et al.   Nanomaterials

Physiologically Based Pharmacokinetic (PBPK) Modeling of Pharmaceutical Nanoparticles

(2016) Min Li et al.   AAPS Journal

Interleukin-2 Functionalized Nanocapsules for T Cell-Based Immunotherapy

(2016) Stefanie U. Frick et al.   ACS Nano

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

A chemical engineering perspective of nanoparticle-based targeted drug delivery: A unit process approach

(2016) Aaron C. Anselmo et al.   AICHE JOURNAL

α-Galactosidase delivery using 30Kc19-human serum albumin nanoparticles for effective treatment of Fabry disease

(2016) Hong Jai Lee et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Transdermal delivery of estradiol-loaded PLGA nanoparticles using iontophoresis for treatment of osteoporosis

(2016) Issei Takeuchi et al.   BIO-MEDICAL MATERIALS AND ENGINEERING

Nanoparticle-enhanced generation of gene-transfected mesenchymal stem cells for in vivo cardiac repair

(2016) Kai Zhu et al.   BIOMATERIALS

Cellular uptake of PLGA nanoparticles targeted with anti-amyloid and anti-transferrin receptor antibodies for Alzheimer’s disease treatment

(2016) Joana A. Loureiro et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel

(2016) Eameema Muntimadugu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Recent advances in polymeric micelles for anti-cancer drug delivery

(2016) Swati Biswas et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Improved skin permeation of methotrexate via nanosized ultradeformable liposomes

(2016) Jin Ki Kim et al.   International Journal of Nanomedicine

Nanotechnology for protein delivery: Overview and perspectives

(2016) Mikyung Yu et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

(2016) Cláudia Saraiva et al.   JOURNAL OF CONTROLLED RELEASE

Colonic gene silencing using siRNA-loaded calcium phosphate/PLGA nanoparticles ameliorates intestinal inflammation in vivo

(2016) Annika Frede et al.   JOURNAL OF CONTROLLED RELEASE

New progress and prospects: The application of nanogel in drug delivery

(2016) Hui Zhang et al.   Materials Science & Engineering C-Materials for Biological Applications

Lipid Nanoparticles Loaded with an Antisense Oligonucleotide Gapmer Against Bcl-2 for Treatment of Lung Cancer

(2016) Xinwei Cheng et al.   PHARMACEUTICAL RESEARCH

Paracrine co-delivery of TGF-β and IL-2 using CD4-targeted nanoparticles for induction and maintenance of regulatory T cells

(2015) Michael D. McHugh et al.   BIOMATERIALS

Noninvasive Imaging of Nanomedicines and Nanotheranostics: Principles, Progress, and Prospects

(2015) Sijumon Kunjachan et al.   CHEMICAL REVIEWS

Delivery Systems for Biopharmaceuticals. Part I: Nanoparticles and Microparticles

(2015) Ana Silva et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Delivery systems for biopharmaceuticals. Part II: Liposomes, Micelles, Microemulsions and Dendrimers

(2015) Ana Silva et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Nanocarriers and their Actions to Improve Skin Permeability and Transdermal Drug Delivery

(2015) Nauman Khan et al.   CURRENT PHARMACEUTICAL DESIGN

Delivery of bortezomib with nanoparticles for basal-like triple-negative breast cancer therapy

(2015) Song Shen et al.   JOURNAL OF CONTROLLED RELEASE

Co-delivery of VEGF and Bcl-2 dual-targeted siRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo

(2015) So Jin Lee et al.   JOURNAL OF CONTROLLED RELEASE

Optimization of Self-Assembled Chitosan/Streptokinase Nanoparticles and Evaluation of Their Cytotoxicity and Thrombolytic Activity

(2015) Hadi Baharifar et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Nanomedicines: addressing the scientific and regulatory gap

(2014) Sally Tinkle et al.   Annals of the New York Academy of Sciences

Poly(lactic acid) nanoparticles coated with combined WGA and water-soluble chitosan for mucosal delivery of β-galactosidase

(2014) Yan Sheng et al.   DRUG DELIVERY

Treatment of glioma by cisplatin-loaded nanogels conjugated with monoclonal antibodies against Cx43 and BSAT1

(2014) Vladimir P. Baklaushev et al.   DRUG DELIVERY

The therapeutic monoclonal antibody market

(2014) Dawn M Ecker et al.   mAbs

Active Targeting Docetaxel-PLA Nanoparticles Eradicate Circulating Lung Cancer Stem-like Cells and Inhibit Liver Metastasis

(2014) Nan Yang et al.   MOLECULAR PHARMACEUTICS

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

(2014) Luis A Brito et al.   MOLECULAR THERAPY

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

(2014) Sutapa Barua et al.   Nano Today

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

(2014) Samir Mitragotri et al.   NATURE REVIEWS DRUG DISCOVERY

Dendrimers: synthesis, applications, and properties

(2014) Elham Abbasi et al.   Nanoscale Research Letters

Layer-by-Layer Nanoparticles for Systemic Codelivery of an Anticancer Drug and siRNA for Potential Triple-Negative Breast Cancer Treatment

(2013) Zhou J. Deng et al.   ACS Nano

Pharmacokinetic studies of protein drugs: Past, present and future

(2013) Eric Ezan   ADVANCED DRUG DELIVERY REVIEWS

Anti-neoplastic biosimilars--the same rules as for cytotoxic generics cannot be applied

(2013) H. Mellstedt   ANNALS OF ONCOLOGY

Drug-Induced Nanocarrier Assembly as a Strategy for the Cellular Delivery of Nucleotides and Nucleotide Analogues

(2013) Giovanna Giacalone et al.   BIOMACROMOLECULES

Suppression of pancreatic tumor growth by targeted arsenic delivery with anti-CD44v6 single chain antibody conjugated nanoparticles

(2013) Chenchen Qian et al.   BIOMATERIALS

Targeted therapy of brain ischaemia using Fas ligand antibody conjugated PEG-lipid nanoparticles

(2013) Ying-mei Lu et al.   BIOMATERIALS

Nanoparticles Engineered with Rituximab and Loaded with Nutlin-3 Show Promising Therapeutic Activity in B-Leukemic Xenografts

(2013) R. Voltan et al.   CLINICAL CANCER RESEARCH

Optimization of an anti-HER2 monoclonal antibody targeted delivery system using PEGylated human serum albumin nanoparticles

(2013) Hasan Kouchakzadeh et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

In vivo targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes

(2013) Yiran Zheng et al.   JOURNAL OF CONTROLLED RELEASE

CD133-targeted paclitaxel delivery inhibits local tumor recurrence in a mouse model of breast cancer

(2013) Suresh Kumar Swaminathan et al.   JOURNAL OF CONTROLLED RELEASE

The effect of dual ligand-targeted micelles on the delivery and efficacy of poorly soluble drug for cancer therapy

(2013) Rupa R. Sawant et al.   JOURNAL OF DRUG TARGETING

Antibody Conjugated PLGA Nanoparticles for Targeted Delivery of Paclitaxel Palmitate: Efficacy and Biofate in a Lung Cancer Mouse Model

(2013) Nour Karra et al.   Small

Nanoparticle vaccines

(2013) Liang Zhao et al.   VACCINE

Vaccine delivery using nanoparticles

(2013) Anthony E. Gregory et al.   Frontiers in Cellular and Infection Microbiology

Development of dextran nanoparticles for stabilizing delicate proteins

(2013) Fei Wu et al.   Nanoscale Research Letters

Antibody-Drug Conjugates in Cancer Therapy

(2012) Eric L. Sievers et al.   Annual Review of Medicine

Antiandrogen Gold Nanoparticles Dual-Target and Overcome Treatment Resistance in Hormone-Insensitive Prostate Cancer Cells

(2012) Erik C. Dreaden et al.   BIOCONJUGATE CHEMISTRY

Dual ionic interaction system based on polyelectrolyte complex and ionic, injectable, and thermosensitive hydrogel for sustained release of human growth hormone

(2012) Mi-Ran Park et al.   BIOMATERIALS

Enhanced transdermal permeability of estradiol using combination of PLGA nanoparticles system and iontophoresis

(2012) Keishiro Tomoda et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Trastuzumab decorated methotrexate–human serum albumin conjugated nanoparticles for targeted delivery to HER2 positive tumor cells

(2012) Azade Taheri et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Particle-mediated delivery of cytokines for immunotherapy

(2012) David A Christian et al.   Immunotherapy

HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin

(2012) Zhi Min Wu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Macromolecular therapeutics in cancer treatment: The EPR effect and beyond

(2012) Hiroshi Maeda   JOURNAL OF CONTROLLED RELEASE

Strategies for non-invasive delivery of biologics

(2012) Seung Woo Chung et al.   JOURNAL OF DRUG TARGETING

Antibody-functionalized polymer-coated gold nanoparticles targeting cancer cells: an in vitro and in vivo study

(2012) Riccardo Marega et al.   JOURNAL OF MATERIALS CHEMISTRY

Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin

(2012) Sanyog Jain et al.   Nanomedicine

Preparation and characterization of recombinant human growth hormone–Zn2+-dextran nanoparticles using aqueous phase–aqueous phase emulsion

(2012) Weien Yuan et al.   Nanomedicine-Nanotechnology Biology and Medicine

Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars

(2012) Steven A. Berkowitz et al.   NATURE REVIEWS DRUG DISCOVERY

Enhanced Angiogenesis by Transplantation of Mesenchymal Stem Cell Sheet Created by a Novel Magnetic Tissue Engineering Method

(2011) Masakazu Ishii et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

N,N,N-Trimethyl chitosan nanoparticles for the delivery of monoclonal antibodies against hepatocellular carcinoma cells

(2011) Preeyanat Vongchan et al.   CARBOHYDRATE POLYMERS

Investigation of siRNA-Loaded Polyethylenimine-Coated Human Serum Albumin Nanoparticle Complexes for the Treatment of Breast Cancer

(2011) Sana Abbasi et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Effect of Subconjunctivally Injected Liposome-Encapsulated Tissue Plasminogen Activator on the Absorption Rate of Subconjunctival Hemorrhages in Rabbits

(2011) Sang Beom Han et al.   CORNEA

Platelets directed liposomes for the delivery of streptokinase: Development and characterization

(2011) Bhuvaneshwar Vaidya et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Cellular uptake mechanism and knockdown activity of siRNA-loaded biodegradable DEAPA-PVA-g-PLGA nanoparticles

(2011) Markus Benfer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Cyclodextrin-based siRNA delivery nanocarriers: a state-of-the-art review

(2011) Kiran Chaturvedi et al.   Expert Opinion on Drug Delivery

Therapeutic effect of chitosan modification on salmon-calcitonin-loaded PLGA nanoparticles

(2011) Min-Jeong Lee et al.   KOREAN JOURNAL OF CHEMICAL ENGINEERING

Cysteine proteinase type I, encapsulated in solid lipid nanoparticles induces substantial protection against Leishmania major infection in C57BL/6 mice

(2011) D. DOROUD et al.   PARASITE IMMUNOLOGY

Polymer nanoparticles: Preparation techniques and size-control parameters

(2011) J. Prasad Rao et al.   PROGRESS IN POLYMER SCIENCE

Thrombolytic efficacy of tissue plasminogen activator-loaded echogenic liposomes in a rabbit thrombus model

(2011) Susan T. Laing et al.   THROMBOSIS RESEARCH

Generation of HIV-1 Virus-Like Particles expressing different HIV-1 glycoproteins

(2011) M.L. Visciano et al.   VACCINE

Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies

(2010) Ron J. Keizer et al.   CLINICAL PHARMACOKINETICS

Nanotechnology and Nanomedicine: Going Small Means Aiming Big

(2010) Mahesh Kumar Teli et al.   CURRENT PHARMACEUTICAL DESIGN

Targeting EGFR-overexpressing tumor cells using Cetuximab-immunomicelles loaded with doxorubicin and superparamagnetic iron oxide

(2010) Chengde Liao et al.   EUROPEAN JOURNAL OF RADIOLOGY

Chitosan as a carrier for targeted delivery of small interfering RNA

(2010) Walter E. Rudzinski et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin

(2010) Abdallah Makhlof et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug

(2010) Gayong Shim et al.   JOURNAL OF CONTROLLED RELEASE

Biopharmaceutical benchmarks 2010

(2010) Gary Walsh   NATURE BIOTECHNOLOGY

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The characteristics and performance of a multifunctional nanoassembly system for the co-delivery of docetaxel and iSur-pDNA in a mouse hepatocellular carcinoma model

(2009) Zhenghong Xu et al.   BIOMATERIALS

Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

(2009) Akin Akinc et al.   MOLECULAR THERAPY

Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery

(2009) B. Mishra et al.   Nanomedicine-Nanotechnology Biology and Medicine

Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier

(2009) B. C. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gold nanoparticles in delivery applications☆

(2008) P GHOSH et al.   ADVANCED DRUG DELIVERY REVIEWS

Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers☆

(2008) I SLOWING et al.   ADVANCED DRUG DELIVERY REVIEWS

Barrier properties of mucus

(2008) Richard A. Cone   ADVANCED DRUG DELIVERY REVIEWS

Nanoparticles for Gene Transfer to Human Embryonic Stem Cell Colonies

(2008) Jordan J. Green et al.   NANO LETTERS

(Re)defining biopharmaceutical

(2008) Ronald A Rader   NATURE BIOTECHNOLOGY

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY