Neutrophil elastase inhibitors: recent advances in the development of mechanism-based and nonelectrophilic inhibitors

Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase

(2011) Letizia Crocetti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Unexpected Active-Site Flexibility in the Structure of Human Neutrophil Elastase in Complex with a New Dihydropyrimidone Inhibitor

(2011) Guido Hansen et al.   JOURNAL OF MOLECULAR BIOLOGY

Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase

(2010) Dengfeng Dou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phosphonic pseudopeptides as human neutrophil elastase inhibitors—a combinatorial approach

(2010) Marcin Sieńczyk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dual function inhibitors of relevance to chronic obstructive pulmonary disease

(2010) Dengfeng Dou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold

(2010) Guijia He et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structures of human proteinase 3 and neutrophil elastase - so similar yet so different

(2010) Eric Hajjar et al.   FEBS Journal

Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase

(2010) Jalmira Mulchande et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S′ subsite binding

(2009) Yi Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase

(2009) Kevin R. Shreder et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

X-ray Snapshot of the Mechanism of Inactivation of Human Neutrophil Elastase by 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives†

(2008) Weijun Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Complex of human neutrophil elastase with 1/2SLPI

(2008) Masahiro Koizumi et al.   JOURNAL OF SYNCHROTRON RADIATION

Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions

(2007) Brice Korkmaz et al.   BIOCHIMIE