Continuous Flow Reduction of Artemisinic Acid Utilizing Multi-Injection Strategies-Closing the Gap Towards a Fully Continuous Synthesis of Antimalarial Drugs

Continuous synthesis of artemisinin-derived medicines

(2014) Kerry Gilmore et al.   CHEMICAL COMMUNICATIONS

Antimalarials in Development in 2014

(2014) David S. Barnett et al.   CHEMICAL REVIEWS

Immobilized Iron Oxide Nanoparticles as Stable and Reusable Catalysts for Hydrazine-Mediated Nitro Reductions in Continuous Flow

(2014) Mojtaba Mirhosseini Moghaddam et al.   ChemSusChem

A comprehensive review on synthetic approach for antimalarial agents

(2014) Ajay Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Photodriven Transfer Hydrogenation of Olefins

(2014) Dasheng Leow et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Nonclassical CH−π Supramolecular Interactions in Artemisinic Acid Favor a Single Conformation, Yielding High Diastereoselectivity in the Reduction with Diazene

(2014) Bertrand Castro et al.   JOURNAL OF ORGANIC CHEMISTRY

Tools for chemical synthesis in microsystems

(2014) Klavs F. Jensen et al.   LAB ON A CHIP

Semisynthetic Artemisinin, the Chemical Path to Industrial Production

(2014) Joël Turconi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

In Situ Generation of Diimide from Hydrazine and Oxygen: Continuous-Flow Transfer Hydrogenation of Olefins

(2013) Bartholomäus Pieber et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Continuous-Flow Process for the Synthesis of Artemisinin

(2013) Daniel Kopetzki et al.   CHEMISTRY-A EUROPEAN JOURNAL

Novel Process Windows for Enabling, Accelerating, and Uplifting Flow Chemistry

(2013) Volker Hessel et al.   ChemSusChem

The role of flow in green chemistry and engineering

(2013) Stephen G. Newman et al.   GREEN CHEMISTRY

Continuous process technology: a tool for sustainable production

(2013) Charlotte Wiles et al.   GREEN CHEMISTRY

Hydrazine-mediated Reduction of Nitro and Azide Functionalities Catalyzed by Highly Active and Reusable Magnetic Iron Oxide Nanocrystals

(2013) David Cantillo et al.   JOURNAL OF ORGANIC CHEMISTRY

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Pharmaceutical Roundtable Study Demonstrates the Value of Continuous Manufacturing in the Design of Greener Processes

(2013) Peter Poechlauer et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Pilot Plant PAT Approach for the Diastereoselective Diimide Reduction of Artemisinic Acid

(2013) Martin P. Feth et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Iron(III) Chloride-Catalysed Aerobic Reduction of Olefins using Aqueous Hydrazine at Ambient Temperature

(2012) Manjunath Lamani et al.   ADVANCED SYNTHESIS & CATALYSIS

In Situ Generated Iron Oxide Nanocrystals as Efficient and Selective Catalysts for the Reduction of Nitroarenes using a Continuous Flow Method

(2012) David Cantillo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

(2012) François Lévesque et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A simple and straightforward approach toward selective C=C bond reduction by hydrazine

(2012) Hao Chen et al.   CANADIAN JOURNAL OF CHEMISTRY

Continuous flow metal-free oxidation of picolines using air

(2012) Masaya Hamano et al.   CHEMICAL COMMUNICATIONS

Guanidine catalyzed aerobic reduction: a selective aerobic hydrogenation of olefins using aqueous hydrazine

(2012) Manjunath Lamani et al.   CHEMICAL COMMUNICATIONS

The integration of flow reactors into synthetic organic chemistry

(2012) Ian R. Baxendale   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Continuous Flow Synthesis. A Pharma Perspective

(2012) Laia Malet-Sanz et al.   JOURNAL OF MEDICINAL CHEMISTRY

A light touch to a deadly problem

(2012) Kevin Booker-Milburn   Nature Chemistry

Using Continuous Processes to Increase Production

(2012) Neal G. Anderson   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

(2012) P. J. Westfall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can New Chemistry Make a Malaria Drug Plentiful and Cheap?

(2012) K. Kupferschmidt   SCIENCE

Efficient and Chemoselective Reduction of Olefins Catalyzed by Fe3O4Nanoparticles using Hydrazine Hydrate

(2011) Eun-Suk Kim et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Simple one-pot synthesis of Rh–Fe3O4 heterodimer nanocrystals and their applications to a magnetically recyclable catalyst for efficient and selective reduction of nitroarenes and alkenes

(2011) Youngjin Jang et al.   CHEMICAL COMMUNICATIONS

Aerobic Reduction of Olefins by In Situ Generation of Diimide with Synthetic Flavin Catalysts

(2011) Yasushi Imada et al.   CHEMISTRY-A EUROPEAN JOURNAL

Continuous flow reactors: a perspective

(2011) Charlotte Wiles et al.   GREEN CHEMISTRY

Heat Management in Single and Multi-injection Microstructured Reactors: Scaling Effects, Stability Analysis, and Role of Mixing

(2011) J. Haber et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Organocatalytic Reduction of Carbon−Carbon Double Bonds in Racemization-Sensitive Compounds

(2011) Johannes F. Teichert et al.   ACS Catalysis

Organocatalytic diimide reduction of enamides in water

(2010) Barrie J. Marsh et al.   CHEMICAL COMMUNICATIONS

Demand for malaria drug soars

(2010) Richard Van Noorden   NATURE

Continuous Multi-Injection Reactor for Multipurpose Production - Part I

(2008) P. Barthe et al.   CHEMICAL ENGINEERING & TECHNOLOGY

Development of an Industrial Multi-Injection Microreactor for Fast and Exothermic Reactions - Part II

(2008) D. M. Roberge et al.   CHEMICAL ENGINEERING & TECHNOLOGY

Reduction of Carbon−Carbon Double Bonds Using Organocatalytically Generated Diimide

(2008) Christian Smit et al.   JOURNAL OF ORGANIC CHEMISTRY