CaII Binding Regulates and Dominates the Reactivity of a Transition-Metal-Ion-Dependent Diesterase from Mycobacterium tuberculosis

Use of magnetic circular dichroism to study dinuclear metallohydrolases and the corresponding biomimetics

(2015) James A. Larrabee et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

The Non-catalytic “Cap Domain” of a Mycobacterial Metallophosphoesterase Regulates Its Expression and Localization in the Cell

(2014) Nishad Matange et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of theBacillus subtilisPhosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site

(2014) Fernanda Rodriguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry

(2014) Marcelo M. Pedroso et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

A complex iron-calcium cofactor catalyzing phosphotransfer chemistry

(2014) S. C. Yong et al.   SCIENCE

Binuclear Metallohydrolases: Complex Mechanistic Strategies for a Simple Chemical Reaction

(2012) Gerhard Schenk et al.   ACCOUNTS OF CHEMICAL RESEARCH

Promiscuity comes at a price: Catalytic versatility vs efficiency in different metal ion derivatives of the potential bioremediator GpdQ

(2012) Lena J. Daumann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Purple acid phosphatase: A journey into the function and mechanism of a colorful enzyme

(2012) Gerhard Schenk et al.   COORDINATION CHEMISTRY REVIEWS

Electronic and geometric structures of the organophosphate-degrading enzyme from Agrobacterium radiobacter (OpdA)

(2011) Fernanda Ely et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Directed evolution combined with rational design increases activity of GpdQ toward a non-physiological substrate and alters the oligomeric structure of the enzyme

(2011) Sylvia H-C. Yip et al.   PROTEIN ENGINEERING DESIGN & SELECTION

The organophosphate-degrading enzyme fromAgrobacterium radiobacterdisplays mechanistic flexibility for catalysis

(2010) Fernanda Ely et al.   BIOCHEMICAL JOURNAL

Electronic Structure Analysis of the Dinuclear Metal Center in the Bioremediator Glycerophosphodiesterase (GpdQ) fromEnterobacter aerogenes

(2010) Kieran S. Hadler et al.   INORGANIC CHEMISTRY

A Mycobacterial Cyclic AMP Phosphodiesterase That Moonlights as a Modifier of Cell Wall Permeability

(2009) Marjetka Podobnik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Flexibility Enhances the Reactivity of the Bioremediator Glycerophosphodiesterase by Fine-Tuning Its Mechanism of Hydrolysis

(2009) Kieran S. Hadler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Phosphate-binding Histidine of Binuclear Metallophosphodiesterase Enzymes Is a Determinant of 2′,3′-Cyclic Nucleotide Phosphodiesterase Activity

(2008) Niroshika Keppetipola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase fromEnterobacter aerogenes

(2008) Kieran S. Hadler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle

(2008) Gerhard Schenk et al.   BMC STRUCTURAL BIOLOGY