Directed evolution combined with rational design increases activity of GpdQ toward a non-physiological substrate and alters the oligomeric structure of the enzyme

Electronic Structure Analysis of the Dinuclear Metal Center in the Bioremediator Glycerophosphodiesterase (GpdQ) fromEnterobacter aerogenes

(2010) Kieran S. Hadler et al.   INORGANIC CHEMISTRY

Conserved sequence pattern in a wide variety of phosphoesterases

(2010) Eugene V. Koonin   PROTEIN SCIENCE

A Mycobacterial Cyclic AMP Phosphodiesterase That Moonlights as a Modifier of Cell Wall Permeability

(2009) Marjetka Podobnik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Flexibility Enhances the Reactivity of the Bioremediator Glycerophosphodiesterase by Fine-Tuning Its Mechanism of Hydrolysis

(2009) Kieran S. Hadler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Directed Evolution of Yeast Pyruvate Decarboxylase 1 for Attenuated Regulation and Increased Stability

(2008) Bradley J. Stevenson et al.   BIOCHEMISTRY

Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase fromEnterobacter aerogenes

(2008) Kieran S. Hadler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of glycerophosphodiester phosphodiesterase (GDPD) fromThermoanaerobacter tengcongensis, a metal ion-dependent enzyme: Insight into the catalytic mechanism

(2008) Liang Shi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS