NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer

Oxidative Stress in Disease and Aging: Mechanisms and Therapies

(2016) Claudio Cabello-Verrugio et al.   Oxidative Medicine and Cellular Longevity

ROS Generation in Peroxisomes and its Role in Cell Signaling

(2016) Luis A. del Río et al.   PLANT AND CELL PHYSIOLOGY

The role of oxidative stress on breast cancer development and therapy

(2016) Fabio Hecht et al.   TUMOR BIOLOGY

Dimethyl fumarate in relapsing–remitting multiple sclerosis: rationale, mechanisms of action, pharmacokinetics, efficacy and safety

(2015) Duvyanshu Dubey et al.   Expert Review of Neurotherapeutics

Peroxiredoxin 2, glutathione peroxidase, and catalase in the cytosol and membrane of erythrocytes under H2O2-induced oxidative stress

(2015) S. Rocha et al.   FREE RADICAL RESEARCH

Mitochondria: Much ado about nothing? How dangerous is reactive oxygen species production?

(2015) Eliška Holzerová et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dimethyl fumarate in relapsing–remitting multiple sclerosis: rationale, mechanisms of action, pharmacokinetics, efficacy and safety

(2015) Duvyanshu Dubey et al.   Expert Review of Neurotherapeutics

Nox family NADPH oxidases: Molecular mechanisms of activation

(2014) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development

(2014) Kaïs H. Al-Gubory   REPRODUCTIVE BIOMEDICINE ONLINE

Cytoprotection “gone astray’’: Nrf2 and its role in cancer

(2014) Heiner Schafer et al.   OncoTargets and Therapy

Xanthine Oxidase Inhibition by Febuxostat Attenuates Experimental Atherosclerosis in Mice

(2014) Johji Nomura et al.   Scientific Reports

Detection of superoxide anion and hydrogen peroxide production by cellular NADPH oxidases

(2013) William M. Nauseef   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

PHASE II DRUG METABOLIZING ENZYMES

(2012) Petra Jancova et al.   BIOMEDICAL PAPERS-OLOMOUC

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance

(2012) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

MRP3 gene expression correlates with NRF2 mutations in lung squamous cell carcinomas

(2012) HIDEFUMI SASAKI et al.   Molecular Medicine Reports

Ethyl pyruvate-mediated Nrf2 activation and hemeoxygenase 1 induction in astrocytes confer protective effects via autocrine and paracrine mechanisms

(2012) Joo-Hyun Shin et al.   NEUROCHEMISTRY INTERNATIONAL

Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications

(2011) Young-Sam Keum   Annals of the New York Academy of Sciences

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

(2011) P. A. Konstantinopoulos et al.   CANCER RESEARCH

Peroxiredoxin 1 and its role in cell signaling

(2011) Carola A. Neumann et al.   CELL CYCLE

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Oxidation of Zinc–Thiolate Complexes of Biological Interest by Hydrogen Peroxide: A Theoretical Study

(2011) Rima Kassim et al.   INORGANIC CHEMISTRY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Generation of reactive oxygen species induced by gold nanoparticles under x-ray and UV Irradiations

(2011) Masaki Misawa et al.   Nanomedicine-Nanotechnology Biology and Medicine

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features

(2010) L. M. Solis et al.   CLINICAL CANCER RESEARCH

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

(2009) Yoo Ri Kim et al.   JOURNAL OF PATHOLOGY

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Potent Induction of Total Cellular and Mitochondrial Antioxidants and Phase 2 Enzymes by Cruciferous Sulforaphane in Rat Aortic Smooth Muscle Cells: Cytoprotection Against Oxidative and Electrophilic Stress

(2008) Hong Zhu et al.   Cardiovascular Toxicology

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

(2008) Shih-Ching Lo et al.   EXPERIMENTAL CELL RESEARCH

Targeting Receptor Tyrosine Kinases for Chemoprevention by Green Tea Catechin, EGCG

(2008) Masahito Shimizu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

(2008) M. Kobayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA