Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Marcela Munoz-Penuela, Fabiana Laura Lo Nostro, Aline Dal'Olio Gomes, Carlos Eduardo Tolussi, Giovana Souza Branco, Joao Paulo Silva Pinheiro, Filipe Guilherme Andrade de Godoi, Renata Guimaraes Moreira
Summary: This study evaluated the toxic effects of diclofenac and caffeine on Astyanax altiparanae males under acute exposure. The results showed that effects caused by the drugs separately were more pronounced, with caffeine triggering more harmful effects.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nicola Rizzardi, Laura Pezzolesi, Chiara Samori, Federica Senese, Chiara Zalambani, Walter Pitacco, Natalia Calonghi, Christian Bergamini, Cecilia Prata, Romana Fato
Summary: Astaxanthin is a red orange xanthophyll carotenoid with potent antioxidant properties. Natural astaxanthin is considered safe for human consumption and is environmentally friendly to produce. It is water-soluble and has been shown to protect against oxidative stress in neuroblastoma cell models. Additionally, its lipophilic nature makes it protective against lipid peroxidation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Etelvina Figueira, Diana Matos, Paulo Cardoso, Adilia Pires, Celia Fernandes, Roma Tauler, Carmen Bedia
Summary: The effects of mercury (Hg) on the saltmarsh halophyte Halimione portulacoides were investigated using a biochemical and lipidomic approach. Plants were collected from two Hg contaminated saltmarsh sites, and the accumulation and distribution of Hg, as well as biochemical parameters (antioxidant and metabolic) and lipid profiles, were analyzed and compared between different plant organs and sites. The study found that Hg did not induce changes in antioxidant enzyme activity, but it did cause alterations in lipid profiles, particularly in leaves, resulting in decreased unsaturation level, membrane fluidity and stability. This research provides valuable insights for selecting effective methodologies to restore Hg polluted areas in saltmarshes, addressing a significant environmental concern.
MARINE POLLUTION BULLETIN
(2023)
Article
Chemistry, Multidisciplinary
Habiba Kausar, Ghazala Ambrin, Mohammad K. Okla, Saud A. Alamri, Walid H. Soufan, Eid I. Ibrahim, Mostafa A. Abdel-Maksoud, Altaf Ahmad
Summary: Vitamin E, with alpha-tocopherol as its most superior form, plays a significant role in living organisms. The deficiency of alpha-tocopherol can lead to severe consequences, prompting researchers to develop a nanosensor called FLIP-alpha to monitor its flux in living cells, showing high specificity and biocompatibility.
Review
Biochemistry & Molecular Biology
Carolina Di Fabrizio, Veronica Giorgione, Asma Khalil, Colin E. Murdoch
Summary: Human pregnancy can be affected by various pathologies, including gestational diabetes mellitus and hypertensive disorders, which can have severe consequences. Health issues during pregnancy and postpartum contribute significantly to maternal mortality and morbidity. This review focuses on the latest evidence on oxidative stress in pregnancy complications, early diagnosis, and potential therapies.
Article
Biochemistry & Molecular Biology
Gianni Paulis, Giovanni De Giorgio
Summary: This study describes three cases of Peyronie's disease patients who achieved complete resorption of plaque through antioxidant treatment, providing useful experience for urological clinical practice.
Review
Biochemistry & Molecular Biology
Fernando Bartolome, Eva Carro, Carolina Alquezar
Summary: Oxidative stress is the imbalance between reactive oxygen species (ROS) production and the antioxidant capacity of cells. The human brain is highly susceptible to oxidative stress, making it an essential component in the pathophysiology of neurodegenerative diseases such as tauopathies. However, there currently exist no effective therapies for these diseases. Although antioxidant therapies have shown promise in preclinical studies, clinical trials have been disappointing. To develop effective antioxidant therapies, a complete understanding of the molecular mechanisms underlying oxidative stress in tauopathies is crucial.
Review
Biochemistry & Molecular Biology
Izabela Korczowska-Lacka, Bartosz Slowikowski, Thomas Piekut, Mikolaj Hurla, Natalia Banaszek, Oliwia Szymanowicz, Pawel P. Jagodzinski, Wojciech Kozubski, Agnieszka Permoda-Pachuta, Jolanta Dorszewska
Summary: In diseases of the central nervous system, oxidative stress load commonly exceeds the body's antioxidant capacity. Endogenous antioxidants such as enzymes and exogenous antioxidants like vitamins and polyphenols play a significant role in preventing oxidative damage. However, the clinical efficacy and effectiveness of these antioxidants in neurological diseases need further research and definition.
Review
Biochemistry & Molecular Biology
Munsoo Han, Dabin Lee, Sang Hag Lee, Tae Hoon Kim
Summary: Oxidative stress plays a crucial role in redox metabolism in various physiological and pathological conditions, and antioxidants are important in treating associated diseases. Allergic rhinitis significantly impacts daily function and quality of life, with a high socioeconomic burden and prevalence, with recent studies focusing on the role of oxidative stress and antioxidants in this condition.
Article
Toxicology
Amal Mameri, Lamine Bournine, Lotfi Mouni, Sihem Bensalem, Mokrane Iguer-Ouada
Summary: This study investigated the direct effects of anticancer drugs on red blood cells (RBCs) by measuring RBCs oxidative stress (OS) status. The findings suggest that anticancer drugs can induce membrane damages through exacerbation of OS via membrane lipid peroxidation and Hb oxidation even inside RBCs.
TOXICOLOGY IN VITRO
(2021)
Review
Biochemistry & Molecular Biology
Gianni Paulis, Giovanni De Giorgio, Luca Paulis
Summary: The article provides a narrative review of the current literature on antioxidant therapy for Peyronie's disease. The results demonstrate the positive effects of antioxidant treatment on the disease, although further randomized controlled studies are needed for confirmation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
F. Timoteo-Ferreira, D. Abreu, S. Mendes, L. Matos, A. R. Rodrigues, H. Almeida, E. Silva
Summary: The age of women having their first child is increasing, posing a major health challenge to society. Advanced maternal age is associated with decreased fertility, pregnancy complications, and offspring health issues. Ovarian aging, due to a decline in follicle number and oocyte quality, is a key contributor to female reproductive decline.
AGEING RESEARCH REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Karolina Pierzynowska, Lidia Gaffke, Zuzanna Cyske, Grzegorz Wegrzyn, Brigitta Buttari, Elisabetta Profumo, Luciano Saso
Summary: Mucopolysaccharidoses (MPS) are metabolic diseases caused by gene mutations, with oxidative stress being a major factor influencing disease progression. Available treatments such as enzyme replacement therapy and stem cell transplantation are limited in effectiveness, leading to discussions on the potential use of molecules with antioxidative activities as accompanying drugs for MPS management.
Review
Chemistry, Multidisciplinary
Young Geon Kim, Yunjung Lee, Nohyun Lee, Min Soh, Dokyoon Kim, Taeghwan Hyeon
Summary: The field of nanocatalytic therapy, which employs catalytic reactions mediated by nanomaterials to intervene in disease-critical biomolecular processes, has gained increasing interest in the last 20 years. Ceria nanoparticles have shown unique scavenging properties against biologically noxious free radicals, making them potential candidates for self-regenerating antioxidative and anti-inflammatory agents in disease therapy. This review provides an overview of the characteristics of ceria nanoparticles, their scavenging mechanisms, and recent therapeutic applications, as well as the challenges and future research directions.
ADVANCED MATERIALS
(2023)
Article
Urology & Nephrology
Susana Coimbra, Susana Rocha, Henrique Nascimento, Maria Joao Valente, Cristina Catarino, Petronila Rocha-Pereira, Maria Sameiro-Faria, Jose Gerardo Oliveira, Jose Madureira, Joao Carlos Fernandes, Vasco Miranda, Luis Belo, Elsa Bronze-da-Rocha, Alice Santos-Silva
Summary: In ESRD patients on dialysis, high levels of cfDNA were associated with inflammation, anaemia, oxidative stress, and haemostatic disturbances. Deceased patients had significantly higher levels of cfDNA, which was identified as the best predictor of prognosis in ESRD patients.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Susana Coimbra, Flavio Reis, Maria Joao Valente, Susana Rocha, Cristina Catarino, Petronila Rocha-Pereira, Maria Sameiro-Faria, Elsa Bronze-da-Rocha, Luis Belo, Alice Santos-Silva
Summary: Dyslipidemia is a major risk factor for cardiovascular disease in chronic kidney disease patients, but the role of HDL in this population is complex and poorly understood. The unique proteome and lipid composition of large HDL in CKD patients may impair their cholesterol efflux capacity, contributing to a paradoxical coexistence of increased large HDL and enhanced risk for CVD events. Additional research is needed to better understand how these changes in HDL functionality impact cardiovascular risk in CKD patients.
Article
Toxicology
Nicia Reis Sousa, Susana Rocha, Alice Santos-Silva, Susana Coimbra, Maria Joao Valente
Summary: Mounting evidence suggests that gadolinium [Gd (III)]-based contrast agents used in magnetic resonance imaging can have short- and long-term adverse effects on the kidneys. This study investigated the cellular and molecular mechanisms of Gd (III) nephrotoxicity using a human proximal tubular cell model. The results showed that Gd (III) exposure could lead to oxidative stress, mitochondrial dysfunction, cell death by apoptosis and necrosis, autophagic activation, lipid metabolism disturbance, and increased expression of signaling pathway regulators related to renal disease development. The findings highlight the need for further clarification of the risks and benefits of current Gd (III)-based contrast agents.
TOXICOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Irina Lousa, Luis Belo, Maria Joao Valente, Susana Rocha, Ines Preguica, Petronila Rocha-Pereira, Idalina Beirao, Filipe Mira, Rui Alves, Flavio Reis, Alice Santos-Silva
Summary: Inflammation plays an important role in chronic kidney disease (CKD). This study found that inflammatory biomarkers in the blood were associated with kidney function and injury parameters, and could potentially be used as early markers for diagnosis and staging of CKD.
INFLAMMATION RESEARCH
(2022)
Letter
Hematology
Catarina Lau, Marta Goncalves, Monica Pereira, Catarina Monteiro, Sara Morais, Margarida Lima
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Irina Lousa, Flavio Reis, Alice Santos-Silva, Luis Belo
Summary: Chronic kidney disease is a global public health problem with high morbidity and mortality. Inflammation and inflammatory mediators, such as tumor necrosis factor-related biomarkers, play a role in the development and progression of CKD. Tumor necrosis factor receptors 1 and 2 have been associated with changes in kidney function and injury, and could potentially serve as biomarkers for CKD prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Ermelinda Santos Silva, Susana Rocha, Rita Candeias Ramos, Helena Coutinho, Cristina Catarino, Fernanda Teixeira, Graca Henriques, Ana Isabel Lopes, Alice Santos-Silva, Dora Brites
Summary: This study found a potential association between bile acids profile and redox status in healthy infants, with the type of diet potentially influencing this relationship.
PEDIATRIC RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Susana Coimbra, Susana Rocha, Maria Joao Valente, Cristina Catarino, Elsa Bronze-da-Rocha, Luis Belo, Alice Santos-Silva
Summary: Chronic kidney disease is often accompanied by multiple comorbidities and poor clinical outcomes. Malnutrition-inflammation-atherosclerosis syndrome is common in severe stages of CKD, and adiponectin and leptin may be associated with the risk of cardiovascular disease events.
Article
Biochemistry & Molecular Biology
Susana Rocha, Rita Felix, Maria Joao Valente, Andreia Bento-Silva, Rute Rebelo, Celia Gomes Amorim, Alberto da Nova Araujo, Rui Moreira, Alice Santos-Silva, Maria Conceicao B. S. M. Montenegro
Summary: This study aimed to evaluate the bioactivity and biocompatibility of polysulfone (PSU) hemodialysis (HD) membranes doped with human neutrophil elastase inhibitors (HNEIs). The results showed that all biomaterials were bioactive and hemocompatible. Compared to Sivelestat, both D4L-1 and D4L-2 exhibited stronger inhibitory abilities.
Article
Biochemistry & Molecular Biology
Susana Coimbra, Cristina Catarino, Maria Sameiro Faria, Jose Pedro L. Nunes, Susana Rocha, Maria Joao Valente, Petronila Rocha-Pereira, Elsa Bronze-da-Rocha, Nuno Bettencourt, Ana Beco, Sofia Homem de Melo Marques, Jose Gerardo Oliveira, Jose Madureira, Joao Carlos Fernandes, Vasco Miranda, Luis Belo, Alice Santos-Silva
Summary: Left ventricular hypertrophy (LVH) is common in end-stage kidney disease (ESKD) patients, and is associated with lower leptin levels, higher biomarkers of myocardial stress/injury, and specific nutritional status. Leptin and NT-proBNP are independent determinants of LVH, while dialysis vintage, hemoglobin, calcium, NT-proBNP, and leptin are predictive markers for LVH development. Further studies are needed to elucidate the role of leptin in LVH in ESKD patients.
Meeting Abstract
Transplantation
Susana Rocha, Rute Rebelo, Celia Amorim, Rui Moreira, Alice Santos-Silva, Maria Conceicao Branco Da Silva Montenegro
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Meeting Abstract
Transplantation
Susana Coimbra, Cristina Catarino, Maria do Sameiro Faria, Jose Pedro Lopes Nunes, Susana Rocha, Maria Joao Valente, Petronila Rocha-Pereira, Elsa Bronze-da-Rocha, Nuno Bettencourt, Ana Beco, Sofia Homem Melo Marques, Jose Gerardo Oliveira, Jose Madureira, Vasco M. P. Miranda, Luis Belo, Alice Santos-Silva
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)