Article
Veterinary Sciences
Duncan J. Pearce, Peta L. Hitchens, Fatemeh Malekipour, Babatunde Ayodele, Peter Vee Sin Lee, R. Chris Whitton
Summary: This study investigated the mechanical and structural properties of equine subchondral bone. The findings suggest that the superficial layer of the bone is less stiff than the deeper layer, despite differences in bone density and damage levels. The superficial layer plays an important role in energy dissipation, but it is unclear whether this is a specific adaptation or a result of microdamage accumulation.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Cell Biology
Xiaobo Zhu, Yau Tsz Chan, Patrick S. H. Yung, Rocky S. Tuan, Yangzi Jiang
Summary: This review discusses the cellular and molecular mechanisms of subchondral bone remodeling in relation to osteoarthritis, as well as potential therapeutic targets and interventions for this process. It also outlines candidate treatments for subchondral bone remodeling in OA, including the use of bone-acting reagents and regenerative therapies, based on current clinical therapies and responses in subchondral bone remodeling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Susan E. Lad, Hannah Kowalkowski, Daniel F. Liggio, Hui Ding, Matthew J. Ravosa
Summary: Bone adaptation to mechanical loading occurs through modeling and remodeling. This study provides evidence that the number of load cycles is associated with remodeling, independent of strain magnitude. The findings challenge traditional understanding of Haversian remodeling and highlight the importance of considering mechanical factors beyond strain magnitude in skeletal adaptation research.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Cell Biology
Chuangxin Lin, Zhong Chen, Dong Guo, Laixi Zhou, Sipeng Lin, Changchuan Li, Shixun Li, Xinjia Wang, Bendan Lin, Yue Ding
Summary: This study investigated the role of osteopontin (OPN) in the subchondral bone changes of osteoarthritis (OA) and found that increased expression of OPN accelerates the turnover and remodeling of subchondral bone and mediates articular cartilage degeneration induced by subchondral bone metabolism. Additionally, inhibition of the PI3K/AKT signaling pathway was found to inhibit OPN-mediated subchondral bone remodeling and cartilage degeneration.
Article
Pharmacology & Pharmacy
Chenyang Zhuang, Zixiang Wang, Weisin Chen, Hanquan Wang, Bo Tian, Hong Lin
Summary: The study demonstrates that Jtg inhibits osteoclast differentiation in subchondral bone and chondrocyte apoptosis in cartilage through the NF-κB signaling pathway, indicating its potential therapeutic value for treating OA. In vivo evaluation shows that Jtg significantly attenuates subchondral bone remodeling and cartilage destruction in ACLT mouse models.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Orthopedics
Xuequan Han, Junqi Cui, Linyang Chu, Weituo Zhang, Kai Xie, Xu Jiang, Zihao He, Jingke Du, Songtao Ai, Qi Sun, Liao Wang, Haishan Wu, Mengning Yan, Zhifeng Yu
Summary: The study found that abnormal knee alignment may lead to abnormal subchondral trabecular bone remodeling and microstructural changes, accelerating cartilage degradation and potentially affecting load stress transmission from cartilage to subchondral trabecular bone.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Review
Cell Biology
Gundula Roesch, Frank Zaucke, Zsuzsa Jenei-Lanzl
Summary: Osteoarthritis is a common degenerative joint disease characterized by changes in subchondral bone. Early on, there is increased bone resorption, but as the disease progresses, bone formation increases, leading to higher bone density and sclerosis. Recent evidence suggests that the autonomic nervous system plays a role in regulating subchondral bone remodeling in osteoarthritis.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Immunology
Gundula Roesch, Dominique Muschter, Shahed Taheri, Karima El Bagdadi, Christoph Dorn, Andrea Meurer, Frank Zaucke, Arndt F. Schilling, Susanne Graessel, Rainer H. Straub, Zsuzsa Jenei-Lanzl
Summary: Recent studies have shown that beta 2-adrenoceptors (ARs) contribute to the development of osteoarthritis (OA). In this study, the role of beta 2-AR in knee OA was investigated using beta 2-AR-deficient mice. The results showed that beta 2-AR deficiency led to changes in cartilage degeneration, synovial inflammation, and subchondral bone remodeling in OA. These findings suggest that beta 2-AR plays a significant role in OA-related subchondral bone remodeling and could be a potential target for new therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Orthopedics
Jianqun Wu, Yonghao Pan, Yangyi Yu, Qihao Yang, Qisong Liu, Yang Liu, Jinhao Zhong, Linhao Fu, Haotian Cai, Chao Liu, Guangheng Li
Summary: The timing of mechanical loading and ALN treatment influences the pathobiological changes of OA. Early loading and ALN can protect against OA by suppressing subchondral bone remodeling. Late loading, on the other hand, promotes cartilage degeneration in advanced OA.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Biology
Qi Sun, Gehua Zhen, Tuo Peter Li, Qiaoyue Guo, Yusheng Li, Weiping Su, Peng Xue, Xiao Wang, Mei Wan, Yun Guan, Xinzhong Dong, Shaohua Li, Ming Cai, Xu Cao
Summary: The study demonstrates that intermittent parathyroid hormone can alleviate osteoarthritis pain through multiple mechanisms and may serve as a potential disease-modifying therapy for osteoarthritis.
Review
Orthopedics
Tamas Olah, Magali Cucchiarini, Henning Madry
Summary: Elucidating subchondral bone remodeling in preclinical models of traumatic meniscus injury may address clinically relevant questions about determinants of knee osteoarthritis. Large animal models are capable of providing high topographical detail, suggesting that they may represent suitable study systems reflecting the clinical complexities.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
McKenzie S. White, Ross J. Brancati, Lindsey K. Lepley
Summary: This study used a rodent model of ACL injury to investigate the direct effect of ACL injury on joint kinematics and the development of PTOA. The results showed that knee flexion angle and subchondral bone microarchitecture were severely impacted after ACL injury and were associated with PTOA development.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Orthopedics
Guoqing Li, Su Liu, Yixiao Chen, Huihui Xu, Tiantian Qi, Ao Xiong, Deli Wang, Fei Yu, Jian Weng, Hui Zeng
Summary: This study investigates the potential therapeutic effect and mechanisms of Teriparatide (PTH (1-34)) on knee osteoarthritis (KOA). The results show that PTH (1-34) can ameliorate cartilage degradation, inhibit abnormal remodeling of subchondral bone (SCB), promote chondrocyte proliferation, enhance extracellular matrix synthesis, and have the potential to be a novel therapy for KOA.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Medicine, Research & Experimental
Long Ma, Xin Zhao, Yibin Liu, Jiang Wu, Xiaochun Yang, Qunhua Jin
Summary: The study investigated the potential of DHA in alleviating osteoarthritis by reducing MMP-13 and VEGF expression in articular cartilage, decreasing OARSI scores, and inhibiting abnormal subchondral bone remodeling. DHA also attenuated bone remodeling by reducing sclerostin inhibition and LIF secretion, thereby inhibiting angiogenesis in subchondral bone and reducing OA progression.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
T. L. Haut Donahue, G. E. Narez, M. Powers, L. M. Dejardin, F. Wei, R. C. Haut
Summary: This study aimed to investigate post-traumatic osteoarthritis (PTOA) and found degeneration in the menisci, cartilage, and subchondral bone. The results revealed a significant correlation between medial meniscal damage and damage to the underlying cartilage and subchondral bone. These findings suggest the need for alternative treatments for meniscal injuries instead of complete or partial meniscectomy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Orthopedics
Natalie R. Danna, Bryan G. Beutel, Austin J. Ramme, Thorsten Kirsch, Oran D. Kennedy, Eric Strauss
Article
Radiology, Nuclear Medicine & Medical Imaging
Uran Ferizi, Amparo Ruiz, Ignacio Rossi, Jenny Bencardino, Jose G. Raya
MAGNETIC RESONANCE IN MEDICINE
(2018)
Article
Orthopedics
Austin J. Ramme, Matin S. Lendhey, Eric J. Strauss, Oran D. Kennedy
JOURNAL OF KNEE SURGERY
(2018)
Review
Orthopedics
Tamara Alliston, Christopher J. Hernandez, David M. Findlay, David T. Felson, Oran D. Kennedy
JOURNAL OF ORTHOPAEDIC RESEARCH
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alejandra Duarte, Amparo Ruiz, Uran Ferizi, Jenny Bencardino, Steven B. Abramson, Jonathan Samuels, Svetlana Krasnokutsky-Samuels, Jose G. Raya
EUROPEAN RADIOLOGY
(2019)
Article
Acoustics
Amparo Ruiz, Dalibel Bravo, Alejandra Duarte, Ronald S. Adler, Jose U. Raya
ULTRASOUND IN MEDICINE AND BIOLOGY
(2019)
Review
Radiology, Nuclear Medicine & Medical Imaging
Teodoro Martin Noguerol, Jose G. Raya, Daniel E. Wessell, Joan C. Vilanova, Ignacio Rossi, Antonio Luna
BRITISH JOURNAL OF RADIOLOGY
(2019)
Article
Orthopedics
Noam Ben-Eliezer, Jose G. Raya, James S. Babb, Thomas Youm, Daniel K. Sodickson, Riccardo Lattanzi
Summary: A new study proposed a normalized T2-index method to evaluate cartilage in FAI patients, showing high accuracy in detecting cartilage lesions. Normalizing T2 values was found to be important to address interpatient variability, and the T2-index may be a promising biomarker for cartilage lesion detection in FAI. Further research is needed to explore the combination of T2-index with morphologic MRI and other quantitative biomarkers to improve cartilage assessment in FAI.
Article
Radiology, Nuclear Medicine & Medical Imaging
Phuong Duong, Sogol Mostoufi-Moab, Jose G. Raya, Camilo Jaimes, Jorge Delgado, Diego Jaramillo
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2020)
Article
Orthopedics
A. Ruiz, A. Duarte, D. Bravo, E. Ramos Gavila, C. Zhang, M. K. Cowman, T. Kirsch, M. Milne, L. G. Luyt, J. G. Raya
Summary: This study developed and validated imaging probes based on a hyaluronan-binding peptide for imaging inflammatory signaling in PTOA. The results demonstrated the potential of these probes to effectively visualize inflammatory response in vivo and correlate with histologic severity in cartilage and meniscus.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Diego Jaramillo, Phuong Duong, Jie C. Nguyen, Sogol Mostoufi-Moab, Michael K. Nguyen, Andrew Moreau, Christian A. Barrera, Shijie Hong, Jose G. Raya
Summary: This study validated the use of physeal DTI metrics as predictors of height velocity and total height gain in children. It also compared the prediction accuracy of DTI-based models with bone age-based models. The results showed that models using tract volume derived from diffusion tensor imaging may perform better in predicting height velocity and total height gain compared to bone age-based models.
Letter
Acoustics
Amparo Ruiz, Ronald S. Adler, Jose G. Raya
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Paige V. Hinton, Katelyn J. Genoud, James O. Early, Fergal J. O'Brien, Oran D. Kennedy
Summary: Bone cells, including osteoblasts and chondrocytes, communicate with each other through interstitial fluid movement and fluid flow shear stresses. This study developed an in vitro bone-cartilage crosstalk system to examine the effect of fluid flow shear stresses on these cell types. The findings show that primary cells exhibit a more reliable and reproducible response to shear stresses, and different levels of shear stresses have varying effects on bone formation and degradation. Additionally, osteoblast-derived factors can induce catabolic changes in chondrocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jose G. Raya, Alejandra Duarte, Nian Wang, Valentina Mazzoli, Diego Jaramillo, Andrew M. M. Blamire, Olaf Dietrich
Summary: Diffusion-weighted imaging (DWI) is a well-established MRI technique for investigating tissue microstructure. Musculoskeletal tissues, with their highly ordered structure, are an ideal application for DWI. However, there are specific challenges in acquiring DWI data for musculoskeletal applications. This review provides an overview of the technical aspects of DWI acquisition and discusses its applications in various musculoskeletal tissues.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Orthopedics
James X. Liu, Dalibel Bravo, John Buza, Thorsten Kirsch, Oran Kennedy, Andrew Rokito, Joseph D. Zuckerman, Mandeep S. Virk
JOURNAL OF ORTHOPAEDICS
(2018)