☆ 4.8 Article

Ruthenium-Catalyzed Enantioselective Hydrogenation of 1,8-Naphthyridine Derivatives

ORGANIC LETTERS (2016)

Journal

ORGANIC LETTERS

Volume 18, Issue 11, Pages 2730-2733

Publisher

AMER CHEMICAL SOC

DOI: 10.1021/acs.orglett.6b01186

Keywords

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Categories

Chemistry, Organic

Funding

National Natural Science Foundation of China [21232008, 21402041, 21521002]
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Abstract

The first asymmetric hydrogenation of 2,7-disubstituted 1,3-naphthyridines catalyzed by chiral cationic ruthenium diamine complexes has been developed. A wide range of U-naphthyridine derivatives were effectively hydro-genated to give 1,2,3,4-tetrahydro-1,8-naphthyridines with up to 99% ee and full conversions. The method provides a practical and facile approach to the preparation of valuable chiral heterocyclic building blocks and useful motifs for a new kind of P,N-ligand.

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