Review
Pharmacology & Pharmacy
Judy S. Y. Choi, Judy B. de Haan, Arpeeta Sharma
Summary: Diabetes is a chronic metabolic disorder with accelerated development of vascular complications, causing related morbidity and mortality. Current research on diabetes-driven vascular complications relies on animal models to study cellular and molecular pathways. Selecting appropriate animal models is crucial in identifying innovative and mechanism-based targeted therapies for diabetic complications.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Michael G. Fadel, Sidra Rauf, Hesham S. Mohamed, Siraj Yusuf, Andrew J. Hayes, Kieran Power, Myles J. Smith
Summary: This study compared the performance of indocyanine green (ICG) and blue dye in detecting sentinel lymph nodes (SLNs) in cutaneous melanoma. The results showed that ICG had a higher detection rate and was equally effective in detecting pathological SLNs compared to blue dye. Therefore, ICG can be a useful adjunct to radioisotope in SLN biopsy for cutaneous melanoma.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Pinar Helin Ergen, Susan Shorter, Vasilis Ntziachristos, Saak Victor Ovsepian
Summary: The highly specific and potent biological toxins that target various ion channels and receptors have attracted significant interest for delivering therapeutics to specific cell types and subcellular compartments. By fusing with reporter proteins or labeling with fluorophores and nanocomposites, animal toxins and their detoxified variants offer opportunities for visualizing molecular processes and functions in preclinical models and clinical studies. This article presents state-of-the-art optical probes derived from neurotoxins that target ion channels and discusses their applications in basic and translational biomedical research. It describes the design and production of these probes, reviews their advantages and limitations, and outlines prospects for future improvements.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Roman Vuerich, Elena Groppa, Simone Vodret, Nadja Annelies Ruth Ring, Chiara Stocco, Fleur Bossi, Chiara Agostinis, Matteo Cauteruccio, Andrea Colliva, Mohammad Ramadan, Francesca Simoncello, Federica Benvenuti, Anna Agnelli, Franca Dore, Flavia Mazzarol, Massimo Moretti, Alice Paulitti, Silvia Palmisano, Nicolo De Manzini, Mattia Chiesa, Manuel Casaburo, Angela Raucci, Daniela Lorizio, Giulio Pompilio, Roberta Bulla, Giovanni Papa, Serena Zacchigna
Summary: Nonhealing wounds have a negative impact on the quality of life for patients and health systems. Skin substitutes have been used, but have limited efficacy due to inadequate vascularization. The use of the stromal vascular fraction (SVF) from adipose tissue shows promise in overcoming this limitation, but additional research is needed to determine its precise mechanism of action.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Surgery
Can Zheng, Qiang Fu, Gui-wen Zhou, Lin-ying Lai, Li-xia Zhang, De-quan Zhang, Guo-jie Chen, Li-ming Liang, Min-liang Chen
Summary: Percutaneous facial or supratrochlear arterial hyaluronidase injection is an effective treatment for skin necrosis and ptosis caused by HA filler embolism.
AESTHETIC SURGERY JOURNAL
(2022)
Article
Clinical Neurology
Bart A. A. Franx, Annette Van der Toorn, Caroline Van Heijningen, Denis Vivien, Thomas Bonnard, Rick M. Dijkhuizen
Summary: Molecular MRI can detect vascular inflammation after acute ischemic stroke, providing complementary information for treatment decision-making. In the study, it was found that VCAM-1 expression significantly increased at 6 hours post-recanalization and declined after 24 hours, but remained elevated in lesion borderzones.
Article
Orthopedics
Young Jin Choi, In Sook Lee, You Seon Song, Kyung Un Choi, Hyo Yeong Ahn
Summary: Recently, injectable materials have been widely used in cosmetic procedures. In this case, a 56-year-old woman presented with multiple painless palpable lumps, which were found to be a result of migration of filler material from a breast augmentation procedure done years ago.
SKELETAL RADIOLOGY
(2022)
Article
Neurosciences
Min-Chien Tu, Sheng-Min Huang, Yen-Hsuan Hsu, Jir-Jei Yang, Chien-Yuan Lin, Li-Wei Kuo
Summary: The study found that DKI metrics may be more sensitive than DTI metrics in reflecting microstructural changes within the gray matter, providing complementary information for the pathogenesis of SIVD and AD.
HUMAN BRAIN MAPPING
(2021)
Article
Biochemistry & Molecular Biology
Hamideh Basiri, Seyed Sepehr Mohseni, Ali Abouei Mehrizi, Alireza Rajabnejadkeleshteri, Azadeh Ghaee, Mehdi Farokhi, Eugenia Kumacheva
Summary: In this study, microfluidically generated microgels containing VEGF-conjugated fluorescent carbon dots were used for imaging-monitored tracking of VEGF delivery to ischemic muscles. The microgels exhibited sustained release of bioactive VEGF and high angiogenesis potential, resulting in enhanced therapeutic angiogenesis of ischemic muscles. The successful localization and controlled release of VEGF from composite polymer microgels via intramuscular administration highlight their potential for ischemic disease treatment.
Article
Endocrinology & Metabolism
Anna Kufner, Ahmed A. Khalil, Ivana Galinovic, Elias Kellner, Ralf Mekle, Torsten Rackoll, Philipp Boehm-Sturm, Jochen B. Fiebach, Agnes Floel, Martin Ebinger, Matthias Endres, Alexander H. Nave
Summary: This study found that MRI-based VSI can assess cerebral microvasculature and tissue perfusion in the subacute phases of ischemic stroke, and may have relevant prognostic value in terms of lesion volume and stroke severity.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Dermatology
L. Schelke, O. Liplavk, S. Cotofana, S. Shah-Desai, P. Velthuis
Summary: This study evaluated patients with malar edema after hyaluronic acid filler treatment and found that filler material was mainly located inside the SMAS. With duplex-ultrasound guided filler removal, clinical improvement of malar edema was observed minutes after treatment.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vincent Q. Sier, Alwin de Jong, Paul H. A. Quax, Margreet R. de Vries
Summary: This study quantified vascular remodeling and blood flow changes in murine VG and AVF models using ultra-high-frequency ultrasound imaging. Results showed significantly increased wall volume and outward remodeling in Apoe3*Leiden mice, whereas wall volume remained constant in C57BL/ 6J mice. For VGs, there was a decrease in proximal pulsatility index, resistive index, and peak systolic velocity, and an increase in maximum acceleration in the distal region. Distinct flow patterns were observed in AVFs compared to control carotid arteries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Lin Tan, Jian Xing, Zhenqi Wang, Xiao Du, Ruidi Luo, Jianhang Wang, Jinyi Zhao, Weina Zhao, Changhao Yin
Summary: This study investigates the structural imaging changes in patients with subcortical ischemic vascular disease (SIVD)-vascular cognitive impairment no dementia (VCIND) and their correlation with cognitive impairment, aiming to provide new targets for early diagnosis and treatment.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Surgery
Ming-Feng Tsai, Chia-Meng Yu, Yu-Fan Chen, Tzu-Yi Chung, Guan-Heng Lin, An-Li Lee, Chin-Yi Yang, Chieh-Ming Yu, Hsuan-Yu Huang, Ying-Chun Liu, Wen-Chen Huang, Kwang-Yi Tung, Wen-Teng Yao
Summary: This study investigated the use of LSCI in the evaluation and treatment of vascular complications after facial dermal filler injections. LSCI accurately delineated the occluded blood vessels in real time and guided the treatment more accurately.
AESTHETIC PLASTIC SURGERY
(2023)
Review
Medicine, General & Internal
An-Li Lee, Yu-Fan Chen, Wen-Teng Yao, Ying-Chun Liu, Chia-Meng Yu, Chieh-Ming Yu, Chih-Peng Tu, Wen-Chen Huang, Kwang-Yi Tung, Ming-Feng Tsai
Summary: This study evaluated the use of laser Doppler imaging (LDI) in the treatment of vascular complications caused by dermal filler injections. The results showed that LDI accurately identified areas of vascular occlusion and improved treatment precision, providing fast and noninvasive delineation of affected areas. Further large-scale studies are needed to confirm these findings.