Article
Surgery
Yun Jeong Lee, Se Joon Woo
Summary: This study analyzed the long-term visual outcomes and complications of facial filler-related ophthalmic and retinal artery occlusion, finding that most patients experienced irreversible visual impairment despite various treatments. Various long-term ocular and extraocular complications were observed, emphasizing the importance of prevention over treatment.
AESTHETIC SURGERY JOURNAL
(2022)
Review
Surgery
Qiang Fu, Can Zheng, Gui-wen Zhou, Xiao Xu, Lin-ying Lai, Xu-er Sun, Li-xia Zhang, Qian Wu, Hong-fan Ding, Yi Yang, Hui-juan Fu, Min-liang Chen
Summary: Percutaneous intra-arterial hyaluronidase injection is an effective treatment for vascular embolism caused by HA fillers, but there is currently a lack of a unified treatment protocol.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Surgery
Jennifer J. Danks, James D. Dalgliesh, Tom Ayton
Summary: The authors report a case of visual recovery after treatment with hyaluronidase for visually loss induced by aesthetic injection. This case provides valuable information for the development of treatment protocols.
AESTHETIC SURGERY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Shancheng Si, Linying Lai, Xue Ding, Wei Su, Guiwen Zhou, Qihua Wang, Lei Wang, Yicong Ji, Anming Chen, Youtao Yu, Minliang Chen, Yuntao Hu
Summary: A new injury severity scale has been proposed to evaluate the prognosis of different ocular complications following cosmetic filler injection. This scale can help inform injured patients about the possibility of certain complications and the extent of improvement.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Dermatology
Raffaele Rauso, Nicola Zerbinati, Romolo Fragola, Giovanni Francesco Nicoletti, Gianpaolo Tartaro
Summary: HYAL has the capability to degrade crosslinked HA injected into human vessels, relieving vascular obstruction. In case of embolism, multiple high doses of HYAL may be required to restore blood flow.
DERMATOLOGIC SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Danny J. Soares
Summary: Biocompatible hyaluronic acid gel implants have revolutionized surgery and medicine, particularly in cosmetic applications. However, the increased use of injectable dermal fillers has led to a rise in complications, including vascular occlusion. This article reviews the mechanisms and treatment strategies for filler-induced vascular occlusion, as well as recent advances in prevention and management.
Article
Clinical Neurology
Jong Suk Lee, Jun Yup Kim, Se Joon Woo
Summary: This report describes a case of bilateral brain infarction associated with iatrogenic ophthalmic artery occlusion following cosmetic facial filler injection. Unilateral blindness and bilateral brain infarction were observed, likely through the anterior communicating artery as a possible route of filler material dispersal. Case reports underscore the importance of considering contralateral embolic events in severe cases of iatrogenic ophthalmic artery occlusion after facial filler injection.
JOURNAL OF NEURO-OPHTHALMOLOGY
(2021)
Article
Pharmacology & Pharmacy
Min-Hwan Kim, Ju-Hwan Park, Duy-Thuc Nguyen, Sungyun Kim, Da In Jeong, Hyun-Jong Cho, Dae-Duk Kim
Summary: An HAase inhibitor-incorporated hyaluronic acid hydrogel was designed to reduce toxicity risk and slow biodegradation rate in subcutaneous tissue. The hydrogel, formulated with Quercetin as an HAase inhibitor and quetiapine as a model drug, exhibited sustained drug release and improved pharmacokinetic parameters in rats following subcutaneous injection. All results supported the designed hydrogel as a biocompatible formulation for sustained drug delivery.
Review
Surgery
Haodong Xiao, Wei Kou, Yuan Yang, Erkuan Dai, Xuerui Zhang, Yanjun Wen, Jie Peng, Ping Fei, Peiquan Zhao
Summary: This study reviewed cases of vision loss related to filler injections and discussed the potential efficacy of hyaluronidase treatment using different administration methods. The results showed that subcutaneous and intra-arterial administration of hyaluronidase helped with visual recovery to varying extents.
AESTHETIC PLASTIC SURGERY
(2022)
Article
Surgery
Congying Li, Wei Zhang
Summary: Hyaluronic acid filler injection is commonly used for facial shaping and filling. However, occasional incidents, such as alopecia at the injected site, have been reported. This case study reports the successful recovery of skin necrosis and alopecia in the left temple region through treatment with hyaluronidase and minoxidil.
JOURNAL OF CRANIOFACIAL SURGERY
(2023)
Article
Dermatology
Indu Ballani, Rashmi Sarkar
Summary: Hyaluronic acid injections can achieve facial tightening and slimming effects by targeting peripheral points on the face, but careful selection of the correct injection points is necessary.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Cedric Rouanet, Philippe Kestemont, Cecile Winter, Barbara Lerhe, Charles Savoldelli
Summary: In recent years, aesthetic medicine has made significant advancements, particularly in the field of facial rejuvenation with increasing use of hyaluronic acid injections. While considered low risk, these injections can rarely lead to vascular complications such as arterial embolization, with potential aesthetic and functional consequences. Early management is crucial for successful recovery, although diagnosis is often delayed. Various treatments have been suggested, with the use of hyaluronidase playing a decisive role.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Surgery
Shunichi Nomoto, Rei Ogawa
Summary: Facial injections with cosmetic fillers can cause local artery occlusion, leading to severe complications such as tissue necrosis. Timely diagnosis and treatment are crucial in preventing complications.
Article
Dermatology
Alexandra Bowles, Sabrina Ghalili, Oben B. Ojong, Gabriella F. Vasile, Yumeng M. Li, Shino Bay Aguilera
Summary: This study presents a case series of three patients who were successfully treated for granulomatous foreign body reaction (GFBR) caused by dermal filler. The treatment involved intralesional injection, oral medication, and laser therapy. The results showed significant improvement in both aesthetic and functional outcomes for the patients.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Ophthalmology
Shancheng Si, Wei Su, Lei Wang, Yicong Ji, Anming Chen, Yuntao Hu
Summary: This retrospective case-control study aimed to observe the long-term prognosis of anterior segment ischemia (ASI) following hyaluronic acid (HA) injection and propose a severity grading system for ASI and a predictive model for phthisis bulbi (PB) based on long-term secretion dysfunction of ciliary process. The study found that the severity of ASI could be divided into 4 grades based on the degrees of ciliary function damage. By assessing the ciliary function damage within 6 months, the occurrence and transformation of ASI following HA injection could be predicted.