microRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia

Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia

(2015) S. L. Maude et al.   BLOOD

JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo

(2014) P. Gallipoli et al.   BLOOD

Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells

(2014) Y. Ma et al.   EMBO JOURNAL

MiR-181 family: regulators of myeloid differentiation and acute myeloid leukemia as well as potential therapeutic targets

(2014) R Su et al.   ONCOGENE

Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia

(2013) A. Teramo et al.   BLOOD

GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation

(2013) Mikiko Suzuki et al.   GENES TO CELLS

Specificity and mechanism-of-action of the JAK2 tyrosine kinase inhibitors ruxolitinib and SAR302503 (TG101348)

(2013) T Zhou et al.   LEUKEMIA

JAK inhibitors suppress t(8;21) fusion protein-induced leukemia

(2013) M-C Lo et al.   LEUKEMIA

Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential

(2013) L M Neri et al.   LEUKEMIA

Acute erythroid leukemia (AEL) can be separated into distinct prognostic subsets based on cytogenetic and molecular genetic characteristics

(2013) V Grossmann et al.   LEUKEMIA

Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention

(2013) J A McCubrey et al.   LEUKEMIA

Mutations and prognosis in primary myelofibrosis

(2013) A M Vannucchi et al.   LEUKEMIA

A Feedback Loop Consisting of MicroRNA 23a/27a and the  -Like Globin Suppressors KLF3 and SP1 Regulates Globin Gene Expression

(2013) Y. Ma et al.   MOLECULAR AND CELLULAR BIOLOGY

A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis

(2013) Fang Wang et al.   NUCLEIC ACIDS RESEARCH

A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis

(2013) Yong Zhu et al.   NUCLEIC ACIDS RESEARCH

Block of red blood cell maturation in acute erythroid leukemia

(2012) S. Blum et al.   BLOOD

Blockade of miR-150 Maturation by MLL-Fusion/MYC/LIN-28 Is Required for MLL-Associated Leukemia

(2012) Xi Jiang et al.   CANCER CELL

Ruxolitinib: The First FDA Approved Therapy for the Treatment of Myelofibrosis

(2012) J. Mascarenhas et al.   CLINICAL CANCER RESEARCH

JAK/STAT signaling in hematological malignancies

(2012) W Vainchenker et al.   ONCOGENE

Spi-1, Fli-1 and Fli-3 (miR-17-92) Oncogenes Contribute to a Single Oncogenic Network Controlling Cell Proliferation in Friend Erythroleukemia

(2012) Samer Kayali et al.   PLoS One

FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors

(2011) Elena Mancini et al.   EMBO JOURNAL

The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells

(2011) K A Monaghan et al.   LEUKEMIA

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy

(2011) L S Steelman et al.   LEUKEMIA

Random small interfering RNA library screen identifies siRNAs that induce human erythroleukemia cell differentiation

(2011) Cuiqing Fan et al.   LEUKEMIA & LYMPHOMA

MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia

(2011) Xiao-ning Gao et al.   LEUKEMIA RESEARCH

HSP27 controls GATA-1 protein level during erythroid cell differentiation

(2010) A. de Thonel et al.   BLOOD

Acute Myeloid Leukemia and the Wnt Pathway

(2010) Connie J. Eaves et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acute erythroid leukemia: a reassessment using criteria refined in the 2008 WHO classification

(2009) R. P. Hasserjian et al.   BLOOD

Adult acute erythroleukemia: an analysis of 91 patients treated at a single institution

(2009) F P S Santos et al.   LEUKEMIA

Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation

(2009) S Hegde et al.   ONCOGENE

Direct Binding of pRb/E2F-2 to GATA-1 Regulates Maturation and Terminal Cell Division during Erythropoiesis

(2009) Zahra Kadri et al.   PLOS BIOLOGY

Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia

(2008) L S Steelman et al.   LEUKEMIA