Review
Oncology
Lana E. Kandalaft, Denarda Dangaj Laniti, George Coukos
Summary: This review proposes a classification system based on immunophenotypes to explain the failures of existing immunotherapies in high-grade serous ovarian cancers, and suggests that rational therapeutic approaches tailored to each immunophenotype might meet with improved success.
NATURE REVIEWS CANCER
(2022)
Article
Oncology
Li Zhao, Sara Corvigno, Shaolin Ma, Joseph Celestino, Nicole D. Fleming, Richard A. Hajek, Adrian Lankenau Ahumada, Nicholas B. Jennings, Erika J. Thompson, Hongli Tang, Shannon N. Westin, Amir A. Jazaeri, Jianhua Zhang, P. Andrew Futreal, Anil K. Sood, Sanghoon Lee
Summary: This study aimed to investigate if a simple blood sample can predict the response of ovarian cancer patients to treatment. The results showed that circulating extracellular vesicles isolated at diagnosis can distinguish between patients who will respond differently to the treatment, potentially serving as a novel predictive marker.
Review
Oncology
Camilla Nero, Giuseppe Vizzielli, Domenica Lorusso, Eleonora Cesari, Gennaro Daniele, Matteo Loverro, Giovanni Scambia, Claudio Sette
Summary: This review discusses the current status and unmet needs in managing HGSOC, as well as available treatment options and biomarkers for clinical decisions. It also introduces organoid technology as a promising strategy for studying cancer and developing personalized therapies, with a focus on Patient's Derived Organoids (PDOs) for drug sensitivity testing. Despite promising results, efficient generation and expansion of organoids are needed to enable drug screening within a clinically relevant timeframe. Organoid-based clinical trials should offer tailored approaches to ovarian cancer management, recognizing the limitations of a one-size-fits-all approach in therapeutic advancements.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Tova M. Bergsten, Sarah E. Levy, Katherine E. Zink, Hannah J. Lusk, Melissa R. Pergande, Stephanie M. Cologna, Joanna E. Burdette, Laura M. Sanchez
Summary: This study discovered that a secreted protein called SPARC, produced by tumorigenic fallopian tube epithelial cells, enhances the release of norepinephrine (NE) from the ovary, influencing the primary metastasis of high grade serous ovarian cancer (HGSOC).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Katelyn F. Handley, Travis T. Sims, Nicholas W. Bateman, Deanna Glassman, Katherine Foster, Sanghoon Lee, Jun Yao, Hui Yao, Bryan M. Fellman, Jinsong Liu, Zhen Lu, Kelly A. Conrads, Brian L. Hood, Waleed Barakat, Li Zhao, Jianhua Zhang, Shannon N. Westin, Joseph Celestino, Kelly M. Rangel, Sunil Badal, Igor Pereira, Prahlad T. Ram, George L. Maxwell, Livia S. Eberlin, P. Andrew Futreal, Robert C. Bast, Nicole D. Fleming, Thomas P. Conrads, Anil K. Sood
Summary: This study identified two novel, gross morphologic subtypes of HGSOC, each with unique clinical features and molecular signatures. These findings may have important implications for triaging patients to surgery or chemotherapy, evaluating outcomes, and developing tailored therapeutic strategies.
Article
Multidisciplinary Sciences
Aritro Nath, Patrick A. Cosgrove, Hoda Mirsafian, Elizabeth L. Christie, Lance Pflieger, Benjamin Copeland, Sumana Majumdar, Mihaela C. Cristea, Ernest S. Han, Stephen J. Lee, Edward W. Wang, Sian Fereday, Nadia Traficante, Ravi Salgia, Theresa Werner, Adam L. Cohen, Philip Moos, Jeffrey T. Chang, David D. L. Bowtell, Andrea H. Bild
Summary: The study reveals the core archetypes in progressive HGSOC and demonstrates consistent enrichment of subclones with the metabolism and proliferation archetype as resistance is acquired to multiple lines of therapy. The shifts in metabolism and proliferation are associated with treatment response and clonal heterogeneity in HGSOC.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Piera Tocci, Celia Roman, Rosanna Sestito, Valeriana Di Castro, Andrea Sacconi, Ivan Molineris, Francesca Paolini, Mariantonia Carosi, Giovanni Tonon, Giovanni Blandino, Anna Bagnato
Summary: PARP inhibitors have changed the treatment paradigm of HG-SOC, but their efficacy is limited in patients with high TP53 mutation rates. The overexpression of the ET-1/ET1R axis in HG-SOC is associated with poor prognosis and inhibits the DNA damage response induced by PARP inhibitors. The ET-1R antagonist macitentan, in combination with olaparib, shows promising results in suppressing metastatic progression in HG-SOC patient-derived xenografts.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Andreea Newtson, Henry Reyes, Eric J. Devor, Michael J. Goodheart, Jesus Gonzalez Bosquet
Summary: The study revealed a higher number of fusion transcripts in high grade serous ovarian cancer compared to normal fallopian tubes, with certain fusion transcripts significantly associated with overall survival. Validation was conducted using various analytical platforms and algorithms to identify fusion transcripts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Horacio Cardenas, Fang Fang, Guanglong Jiang, Susan M. Perkins, Chi Zhang, Robert E. Emerson, George Hutchins, Harold N. Keer, Yunlong Liu, Daniela Matei, Kenneth Nephew
Summary: This study investigated the impact of DNA methylation on the initiation and progression of high-grade serous ovarian cancer (HGSOC), as well as its association with platinum resistance. The findings suggest potential roles for hypomethylating agents in treating HGSOC, providing important insights into the epigenetic landscape of HGSOC tumorigenesis and potential therapeutic strategies.
Article
Oncology
Yacine Bareche, Sandra Pommey, Mayra Carneiro, Laurence Buisseret, Isabelle Cousineau, Pamela Thebault, Pavel Chrobak, Laudine Communal, David Allard, Simon C. Robson, Anne-Marie Mes-Masson, Diane Provencher, Rejean Lapointe, John Stagg
Summary: This study revealed the clinical, immunological, and subtype-specific impacts of eADO signaling in HGSC. It unveiled the chemoprotective effect of CD39 and supported the evaluation of eADO-targeting agents in patients with ovarian cancer. High levels of eADO gene signature were associated with worse prognosis, particularly in the immunoregulatory molecular subtype of HGSC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Obstetrics & Gynecology
Elizabeth Suh-Burgmann, Natasha Brasic, Priyanka Jha, Yun-Yi Hung, Ruth B. Goldstein
Summary: This study aimed to evaluate the ultrasound findings associated with clinically detected early-stage high-grade serous ovarian cancer. Early-stage high-grade serous cancers rarely presented as masses of <5 cm or masses without solid components other than septations.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Benjamin G. G. Bitler, Courtney A. A. Bailey, Tomomi M. M. Yamamoto, Alexandra McMellen, Hyunmin Kim, Zachary L. L. Watson
Summary: PARP inhibitors kill cancer cells by stalling DNA replication and preventing DNA repair. Resistance to PARP inhibitors is becoming a clinical problem in the treatment of high grade serous ovarian carcinoma (HGSOC). This study investigates the expression and activities of histone acetyltransferases (HATs) and epigenetic readers in PARP inhibitor-resistant HGSOC, and assesses the therapeutic potential of targeting H3K14ac or associated proteins.
MOLECULAR CARCINOGENESIS
(2023)
Article
Multidisciplinary Sciences
Olivia Graham, Jeimmy Rodriguez, Lillian van Biljon, Bisiayo Fashemi, Emily Graham, Katherine Fuh, Dlneo Khabele, Mary Mullen
Summary: Organoids are 3D tumor models grown from patient-derived ovarian tumor tissue, ascites, or pleural fluid, and they accurately mimic the clonal heterogeneity, tumor microenvironment, and cell-cell and cell-matrix interactions. This protocol provides a successful method to generate patient-derived ovarian cancer organoids with a high success rate, which can be utilized for long-term culture and passage for subsequent experiments.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Genetics & Heredity
Nikki L. Burdett, Madelynne O. Willis, Kathryn Alsop, Allison L. Hunt, Ahwan Pandey, Phineas T. Hamilton, Tamara Abulez, Xuan Liu, Therese Hoang, Stuart Craig, Sian Fereday, Joy Hendley, Dale W. Garsed, Katy Milne, Shreena Kalaria, Ashley Marshall, Brian L. Hood, Katlin N. Wilson, Kelly A. Conrads, Kathleen Pishas, Sumitra Ananda, Clare L. Scott, Yoland Antill, Orla McNally, Linda Mileshkin, Anne Hamilton, George Au-Yeung, Lisa Devereux, Heather Thorne, Andrea Bild, Nicholas W. Bateman, G. Larry Maxwell, Jeffrey T. Chang, Thomas P. P. Conrads, Brad H. Nelson, David D. L. Bowtell, Elizabeth L. L. Christie
Summary: A multiomics approach was used to study molecular diversity in end-stage HR-deficient HGSC, revealing polyclonal disease, resistance mechanisms such as reversion mutations and HR restoration, whole-genome duplication, and global changes in immune composition with evidence of immune escape.
Article
Oncology
Brooke E. Sanders, Tomomi M. Yamamoto, Alexandra McMellen, Elizabeth R. Woodruff, Amber Berning, Miriam D. Post, Benjamin G. Bitler
Summary: Identifying novel and durable treatments for HGSOC is crucial for extending patient survival. This study shows that the high expression of DUSP1 is associated with worse prognosis and therapy resistance in HGSOC.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Angela Russo, Austin A. Czarnecki, Matthew Dean, Dimple A. Modi, Daniel D. Lantvit, Laura Hardy, Seth Baligod, David A. Davis, Jian-Jun Wei, Joanna E. Burdette
Article
Oncology
Matthew Dean, Julia Austin, Ren Jinhong, Michael E. Johnson, Daniel D. Lantvit, Joanna E. Burdette
Article
Oncology
Matthew Dean, Vivian Jin, Angela Russo, Daniel D. Lantvit, Joanna E. Burdette
Article
Chemistry, Multidisciplinary
Katherine E. Zink, Matthew Dean, Joanna E. Burdette, Laura M. Sanchez
ACS CENTRAL SCIENCE
(2018)
Article
Multidisciplinary Sciences
Katherine E. Zink, Matthew Dean, Joanna E. Burdette, Laura M. Sanchez
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Review
Reproductive Biology
Matthew Dean
BIOLOGY OF REPRODUCTION
(2019)
Article
Oncology
Jose A. Colina, Peter Varughese, Subbulakshmi Karthikeyan, Amrita Salvi, Dimple A. Modi, Joanna E. Burdette
Article
Oncology
Matthew Dean, Vivian Jin, Tova M. Bergsten, Julia R. Austin, Daniel D. Lantvit, Angela Russo, Joanna E. Burdette
Review
Oncology
Tova M. Bergsten, Joanna E. Burdette, Matthew Dean
Article
Reproductive Biology
Ayelet Ziv-Gal, Malia D. Berg, Matthew Dean
Summary: This study investigated the effects of parabens on mouse oviductal secretory epithelial cells, revealing that parabens selectively reduce cell proliferation and colony numbers, disrupt cell cycle progression, and decrease levels of cell cycle regulators. Additionally, parabens selectively alter progesterone receptor levels.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Cell Biology
Angela Russo, Jose A. Colina, Junlone Moy, Seth Baligod, Austin A. Czarnecki, Peter Varughese, Daniel D. Lantvit, Matthew J. Dean, Joanna E. Burdette
Summary: Loss of PTEN in FTE leads to enrichment of cancer stem cell markers and altered cell function, while loss of PAX2 plays a crucial role in this process. Additionally, PTEN loss generates two distinct subpopulations of cells with different cancer stem-like cell marker expression and chemoresistance profiles.
CELL DEATH & DISEASE
(2021)
Article
Agriculture, Dairy & Animal Science
Kassandra Sandoval, Malia D. Berg, Anne R. Guadagnin, Felipe C. Cardoso, Matthew Dean
Summary: The study evaluated endometrial glycogen and associated enzymes in cattle on Days 1 and 11 of the estrous cycle. Results showed changes in glycogen content and enzyme distribution between the two days, indicating a cycle-dependent storage of glycogen in the uterus. Glucose released from endometrial glycogen stores may play a role in uterine metabolic processes.
ANIMAL REPRODUCTION SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ziting Chen, Kassandra Sandoval, Matthew Dean
Summary: Glycogen levels in the murine uterus undergo significant changes during early pregnancy, with a decrease before implantation and a dramatic increase after decidualization. This suggests that glycogen may play a role in supporting preimplantation embryos and that decidualization is involved in regulating glycogen levels.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2022)
Article
Developmental Biology
Alexis Gonzalez, Malia D. Berg, Bruce Southey, Matthew Dean
Summary: Glycogen storage in the uterine epithelium is regulated by IGF1, which is produced by uterine fibroblasts in response to E2. IGF1 increases glucose metabolism and glycogenesis in uterine epithelial cells, potentially providing glucose to the endometrium during estrus.
Review
Reproductive Biology
Ziting Chen, Matthew Dean
Summary: Research has found that glucose metabolism in the endometrium plays a crucial role in successful pregnancy. Glucose is essential for embryo development, uterine receptivity, and embryo attachment. Insufficient or excessive glucose intake can negatively affect these processes.
REPRODUCTION AND FERTILITY
(2023)