Article
Cell Biology
Angela Russo, Jose A. Colina, Junlone Moy, Seth Baligod, Austin A. Czarnecki, Peter Varughese, Daniel D. Lantvit, Matthew J. Dean, Joanna E. Burdette
Summary: Loss of PTEN in FTE leads to enrichment of cancer stem cell markers and altered cell function, while loss of PAX2 plays a crucial role in this process. Additionally, PTEN loss generates two distinct subpopulations of cells with different cancer stem-like cell marker expression and chemoresistance profiles.
CELL DEATH & DISEASE
(2021)
Article
Obstetrics & Gynecology
Jonathan S. Berek, Malte Renz, Sean Kehoe, Lalit Kumar, Michael Friedlander
Summary: In 2014, FIGO updated the staging of ovarian cancer to include ovarian, fallopian tube, and peritoneal cancer into the same system, and revised the categories of IC and IIIC.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Acoustics
Mai Le, Apurva Bonde, Bryan Foster
Summary: Isolated fallopian tube torsion (IFTT) is a rare subset of adnexal torsion that is challenging to diagnose preoperatively. This case series introduces the double ovary sign, a unique ultrasound observation that can help in the diagnosis of IFTT. Three cases in which IFTT was diagnosed preoperatively are presented.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Oncology
Anne Kathrin Hoehn, Sabine Klagges, Albrecht Glaeser, Sabine Taubenheim, Nadja Dornhoefer, Jens Einenkel, Grit Gesine Ruth Hiller, Christine E. Brambs, Lars-Christian Horn
Summary: For non-uterine pelvic cancers, there is an increase in tumors originating from the fallopian tubes and a decrease in tumors originating from the ovaries. This trend is likely due to the reclassification of tumors previously classified as ovarian and a greater emphasis on examining resection specimens of non-uterine pelvic cancers.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Pathology
Sonia Gatius, Xavier Matias Guiu, Ben Davidson
Summary: Gynecologic pathology has rapidly evolved from lacking molecular testing to becoming a routine diagnostic discipline with the relevance of molecular characterization to treatment choice. Molecular testing is expanding as a tool for diagnosing rare tumors and improving reproducible diagnoses and genetic disease consultation. Despite challenges in studying rare cancers, increased knowledge may lead to new therapeutic options for malignant rare cancers.
Review
Medicine, General & Internal
Dan L. Longo, Rachel C. Sisodia, Marcela G. del Carmen
Summary: Lesions of the ovary and fallopian tube can be acute or chronic, and it is important to distinguish between benign and malignant causes. Referral to a gynecologic oncologist is often necessary for diagnostic assessment.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemical Research Methods
Shuying Li, Hongbo Luo, Sitai Kou, Ian S. Hagemann, Quing Zhu
Summary: Due to the lack of reliable early-diagnostic tools, most ovarian cancers are diagnosed at late stages. Although optical coherence tomography (OCT) has shown promise for identifying diseased ovaries and fallopian tubes at an earlier stage, previous studies either did not provide quantitative scattering mapping or simply used Beer's law to fit the scattering coefficients of each A-line. In this paper, pixel-wise attenuation coefficients of ovaries and fallopian tubes in OCT images were calculated. Data from 73 freshly excised human ovaries and fallopian tubes from 36 patients have shown that statistical features are statistically different between cancerous ovaries, infundibula, and fimbriae and normal ones.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Surgery
Anthony I. Jang, Joshua D. Bernstock, David J. Segar, Marcello Distasio, Ursula Matulonis, Wenya Linda Bi
Summary: This case report presents a rare occurrence of fallopian tube cancer brain metastasis and reviews the literature on the subject. The patient underwent surgical resection of the brain lesions, which were confirmed to be of fallopian tube origin through immunohistochemical staining. The study highlights the need for further research on the treatment and management of brain metastasis from fallopian tube carcinoma.
FRONTIERS IN SURGERY
(2021)
Article
Urology & Nephrology
Bruce J. Trock, Yuezhou Jing, Brent Mabey, Zaina Sangale, Lauren Lenz, Nora Haney, Igor Vidal, Stephanie A. Glavaris, Gunes Guner, Onur Ertunc, Ibrahim Kulac, Javier A. Baena Del Valle, Tracy Jones, Misop Han, Alan W. Partin, Todd Cohen, Steven Stone, Angelo M. De Marzo
Summary: The study showed that cell-cycle progression was independently associated with metastasis-free survival in prostate cancer patients, particularly those receiving salvage radiotherapy, while phosphatase and tensin homolog had weaker correlation with metastasis after adjustment for post-surgical risk assessment.
JOURNAL OF UROLOGY
(2022)
Review
Obstetrics & Gynecology
Maria Lucia Moleiro, Alfredo Barroco Gouveia
Summary: This study reviewed the literature to understand the diagnostic challenges and prognostic features of ovarian and fallopian tube cancer presenting as extra-abdominal lymph nodes. The analysis of 65 English articles revealed that these cancers can spread through the lymphatic system or hematogenous spread, leading to distant disease without symptoms related to the primary cancer location. Histology and immunohistochemistry analysis, along with a high level of suspicion, are crucial for diagnosis in cases where extra-abdominal lymph nodes are the first manifested sign.
REPRODUCTIVE SCIENCES
(2023)
Article
Biology
Kai Doberstein, Rebecca Spivak, Hunter D. Reavis, Jagmohan Hooda, Yi Feng, Paul T. Kroeger, Sarah Stuckelberger, Gordon B. Mills, Kyle M. Devins, Lauren E. Schwartz, Marcin P. Iwanicki, Mina Fogel, Peter Altevogt, Ronny Drapkin
Summary: This research provides evidence that L1 cell adhesion molecule (L1CAM) plays a role in the dissemination of transformed fallopian tube secretory cells (FTSECs) to the ovary in the early stages of high-grade serous carcinoma (HGSC) development. L1CAM upregulates integrins and fibronectin in malignant cells and activates the AKT and ERK pathways, increasing cell survival under non-adherent conditions and facilitating ovarian colonization.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Angela Russo, Zizhao Yang, Georgette Moyle Heyrman, Brian P. Cain, Alfredo Lopez Carrero, Brett C. Isenberg, Matthew J. Dean, Jonathan Coppeta, Joanna E. Burdette
Summary: High grade serous ovarian cancers (HGSOC) mainly originate from the fallopian tube epithelium (FTE) and colonize the ovary before further metastasis. The ovary secretes specific factors during ovulation that attract tumor cells from the fallopian tube. A secreted protein of 50-100kDa in size was identified to enhance the migration of FTE cells through the Epidermal Growth Factor Receptor (EGFR). This protein, called Versican, was found to be correlated with ovulation and enhanced the adhesion and invasion of FTE cells to the ovary in an EGFR-dependent manner.
Article
Oncology
Jing Chen, Jingjing Sun, Qunfeng Wang, Yanze Du, Jie Cheng, Juan Yi, Bei Xie, Suya Jin, Gang Chen, Lina Wang, Xiaoyuan Wang, Hulai Wei
Summary: Functional loss or deletion of the tumor suppressor gene PTEN significantly enhances the proliferation, invasion, and metastasis of breast cancer cells. Inhibition of PTEN in the overall microenvironment also promotes the proliferation and metastasis of breast cancer cells. These findings suggest that PTEN mediates the proliferation, invasion, and metastasis of mouse breast cancer cells by regulating the PI3K-Akt signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Unnati Modi, Pooja Makwana, Rajesh Vasita
Summary: The review focuses on the role of molecular cross-talk between stromal cells and cancer cells in promoting metastasis through 3D cancer spheroid co-culture in vitro platform. This state-of-art approach highlights the potential for exploring effective treatments and personalized medicines to combat cancer metastasis and progression.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Medicine, General & Internal
Ling-Na Chen, Wen-Chao Sun, Mei Jin, Hao Chen, Hai-Ou Xu
Summary: Smart medical treatment offers a potential solution for the problems in the medical industry. This report discusses a rare case of pedicle torsion of mesosalpinx cyst in a female patient where surgical resection was the main treatment option.
ACTA MEDICA MEDITERRANEA
(2022)
Article
Oncology
Matthew Dean, Vivian Jin, Angela Russo, Daniel D. Lantvit, Joanna E. Burdette
Article
Multidisciplinary Sciences
Katherine E. Zink, Matthew Dean, Joanna E. Burdette, Laura M. Sanchez
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Oncology
Amrita Salvi, Chiraz Soumia M. Amrine, Julia R. Austin, KiAundra Kilpatrick, Angela Russo, Daniel Lantvit, Esther Calderon-Gierszal, Zachary Mattes, Cedric J. Pearce, Mark W. Grinstaff, Aaron H. Colby, Nicholas H. Oberlies, Joanna E. Burdette
MOLECULAR CANCER THERAPEUTICS
(2020)
Review
Oncology
Tova M. Bergsten, Joanna E. Burdette, Matthew Dean
Article
Oncology
Julia R. Austin, Brenna J. Kirkpatrick, Rocio Rivera Rodriguez, Michael E. Johnson, Daniel D. Lantvit, Joanna E. Burdette
Article
Reproductive Biology
Ayelet Ziv-Gal, Malia D. Berg, Matthew Dean
Summary: This study investigated the effects of parabens on mouse oviductal secretory epithelial cells, revealing that parabens selectively reduce cell proliferation and colony numbers, disrupt cell cycle progression, and decrease levels of cell cycle regulators. Additionally, parabens selectively alter progesterone receptor levels.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Cell Biology
Angela Russo, Jose A. Colina, Junlone Moy, Seth Baligod, Austin A. Czarnecki, Peter Varughese, Daniel D. Lantvit, Matthew J. Dean, Joanna E. Burdette
Summary: Loss of PTEN in FTE leads to enrichment of cancer stem cell markers and altered cell function, while loss of PAX2 plays a crucial role in this process. Additionally, PTEN loss generates two distinct subpopulations of cells with different cancer stem-like cell marker expression and chemoresistance profiles.
CELL DEATH & DISEASE
(2021)
Article
Plant Sciences
Jung-Ho Lee, Julia R. Austin, Joanna E. Burdette, Brian T. Murphy
Summary: The study found that a new secoiridoid, demethoxy-cornuside, along with other known secoiridoids isolated from the twigs of dogwood may potentiate progesterone signaling, affecting hormone-sensitive tissues.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Agriculture, Dairy & Animal Science
Kassandra Sandoval, Malia D. Berg, Anne R. Guadagnin, Felipe C. Cardoso, Matthew Dean
Summary: The study evaluated endometrial glycogen and associated enzymes in cattle on Days 1 and 11 of the estrous cycle. Results showed changes in glycogen content and enzyme distribution between the two days, indicating a cycle-dependent storage of glycogen in the uterus. Glucose released from endometrial glycogen stores may play a role in uterine metabolic processes.
ANIMAL REPRODUCTION SCIENCE
(2021)
Article
Plant Sciences
Julia R. Austin, Kailiang Li, Rocio Rivera Rodriguez, Daniel D. Lantvit, Brian T. Murphy, Joanna E. Burdette
Summary: The study found that irilone from red clover can increase progesterone receptor protein levels and exert its effects through an estrogen receptor-dependent pathway. Additionally, irilone interacts with the glucocorticoid receptor, enhancing progesterone signaling.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Plant Sciences
Kailiang Li, Djeneba Diakite, Julia Austin, Jung-Ho Lee, Daniel D. Lantvit, Brian T. Murphy, Joanna E. Burdette
Summary: Baicalein functions as a PR antagonist in vivo and attenuates the antiproliferative effect of P4 on luminal epithelium, while not changing levels of PR or GR RNA or protein in the uterus. RNA sequencing data suggest that transcripts significantly altered by baicalein are regulated in the opposite direction by P4, indicating potential opposing effects of baicalein and P4 in the uterus.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Ziting Chen, Kassandra Sandoval, Matthew Dean
Summary: Glycogen levels in the murine uterus undergo significant changes during early pregnancy, with a decrease before implantation and a dramatic increase after decidualization. This suggests that glycogen may play a role in supporting preimplantation embryos and that decidualization is involved in regulating glycogen levels.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2022)
Article
Developmental Biology
Alexis Gonzalez, Malia D. Berg, Bruce Southey, Matthew Dean
Summary: Glycogen storage in the uterine epithelium is regulated by IGF1, which is produced by uterine fibroblasts in response to E2. IGF1 increases glucose metabolism and glycogenesis in uterine epithelial cells, potentially providing glucose to the endometrium during estrus.
Review
Reproductive Biology
Ziting Chen, Matthew Dean
Summary: Research has found that glucose metabolism in the endometrium plays a crucial role in successful pregnancy. Glucose is essential for embryo development, uterine receptivity, and embryo attachment. Insufficient or excessive glucose intake can negatively affect these processes.
REPRODUCTION AND FERTILITY
(2023)