Article
Endocrinology & Metabolism
Paloma Elortegui Pascual, Maryann R. Rolands, Alison L. Eldridge, Amira Kassis, Fabio Mainardi, Kim-Anne Le, Leonidas G. Karagounis, Philipp Gut, Krista A. Varady
Summary: This meta-analysis compared the effectiveness of different intermittent fasting regimens with traditional caloric energy restriction for weight loss. The results showed that intermittent fasting was comparable to caloric energy restriction and is a promising alternative for weight loss. Among the three regimens examined, alternate day fasting showed the highest effectiveness, followed by caloric energy restriction and time-restricted eating. Further well-powered randomized controlled trials with longer durations are needed to draw solid conclusions.
Article
Nutrition & Dietetics
Saeedeh Hosseini Hooshiar, Akram Yazdani, Sadegh Jafarnejad
Summary: The present study aimed to evaluate the effect of Alternate-day Modified Fasting (ADMF) on sleep quality, body weight, and daytime sleepiness. The results showed that ADMF could be beneficial for controlling body weight and BMI, and significantly improve subjective sleep quality and daytime dysfunction.
FRONTIERS IN NUTRITION
(2023)
Article
Cell Biology
Mualla Ozcan, Zhen Guo, Carla Valenzuela Ripoll, Ahmed Diab, Antonino Picataggi, David Rawnsley, Aynaz Lotfinaghsh, Carmen Bergom, Jeff Szymanski, Daniel Hwang, Aarti Asnani, Mikhail Kosiborod, Jie Zheng, Robert J. Hayashi, Pamela K. Woodard, Attila Kovacs, Kenneth B. Margulies, Joel Schilling, Babak Razani, Abhinav Diwan, Ali Javaheri
Summary: Fasting strategies are being investigated in patients on chemotherapy. Alternate-day fasting was found to aggravate doxorubicin cardiotoxicity and increase mortality and impaired cardiac function in mice. The study also showed that TFEB and GDF15 pathways contribute to doxorubicin-induced heart failure.
Review
Dentistry, Oral Surgery & Medicine
Sameena Parveen
Summary: Scientific evidence suggests that calorie restriction and intermittent fasting are effective strategies for controlling inflammation and lifestyle-related diseases. Studies have shown that calorie restriction may reduce inflammation and tissue damage associated with periodontitis, but more research is needed in human subjects. Additionally, incorporating these dietary interventions into society remains challenging due to the prevalence of obesity.
PERIODONTOLOGY 2000
(2021)
Article
Cell Biology
David G. Le Couteur, Samantha M. Solon-Biet, Benjamin L. Parker, Tamara Pulpitel, Amanda E. Brandon, Nicholas J. Hunt, Jibran A. Wali, Rahul Gokarn, Alistair M. Senior, Gregory J. Cooney, David Raubenheimer, Victoria C. Cogger, David E. James, Stephen J. Simpson
Summary: Diet composition has a significant impact on the hepatic proteome, influencing not only metabolic pathways but also fundamental processes like mitochondrial function and RNA splicing.
Article
Cell Biology
Hassan Reda Hassan Elsayed, Mohammad El-Nablaway, Basma Adel Khattab, Rania N. Sherif, Wagdi Fawzy Elkashef, Asim Mohammed Abdalla, Eman Mohammad El Nashar, Mostafa Mohammed Abd-Elmonem, Randa El-Gamal
Summary: This study aimed to evaluate the therapeutic effect of alternate-day fasting (ADF) on non-alcoholic steatohepatitis (NASH), and found that ADF could improve HFF-induced NASH, reduce lipogenesis, apoptosis, and hepatic inflammation. The research also indicated that ADF could treat NASH by improving hepatic steatosis, inflammation, ballooning, and fibrosis.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Ana Teofilovic, Milos Vrataric, Natasa Velickovic, Danijela Vojnovic Milutinovic, Aleksandra Mladenovic, Milica Prvulovic, Ana Djordjevic
Summary: Late-onset calorie restriction has a positive impact on lipid metabolism but a negative impact on inflammation in the liver of old rats. It can restore age-related imbalance in lipid metabolism but does not improve expression of antioxidant enzymes and leads to progression of age-related inflammation in the liver.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Mary Priyanka Udumula, Harshit Singh, Faraz Rashid, Laila Poisson, Nivedita Tiwari, Irina Dimitrova, Miriana Hijaz, Radhika Gogoi, Margaret Swenor, Adnan Munkarah, Shailendra Giri, Ramandeep Rattan
Summary: In a study on mice with epithelial ovarian cancer (EOC), it was found that 16-hour intermittent fasting (IF) can inhibit tumor growth and enhance anti-tumor immune response. IF alters anti-cancer immunity by increasing CD4(+) and CD8(+) cells, Th1 and cytotoxic responses.
Editorial Material
Endocrinology & Metabolism
Huachun Pan, Shumin Yang, Wenke Cheng, Qiang Cai, Quazi T. H. Shubhra
Summary: Doxorubicin (Dox) is an effective chemotherapy drug, but its clinical use is limited due to cardiotoxicity and the risk of heart failure. Recent research by Ozcan et al. suggests that alternate-day fasting (ADF) can significantly worsen the cardiotoxicity of Dox.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Nutrition & Dietetics
Xiaoxiao Lin, Shuai Wang, Jinyu Huang
Summary: Alternate-day fasting (ADF) is a promising diet intervention for human health. A comprehensive bibliometric analysis was conducted to investigate publication trends and hotspots in the field of ADF. The study found that the main research hotspots are ADF for obesity and cardiometabolic risk, and ADF for different population groups including healthy adults and patients with diabetes, NAFLD, and cancer.
Article
Cell Biology
Mark Ezpeleta, Kelsey Gabel, Sofia Cienfuegos, Faiza Kalam, Shuhao Lin, Vasiliki Pavlou, Zhenyuan Song, Jacob M. Haus, Sean Koppe, Shaina J. Alexandria, Lisa Tussing-Humphreys, Krista A. Varady
Summary: This study compared the effects of alternate day fasting (ADF) combined with exercise to fasting alone, or exercise alone, on intrahepatic triglyceride (IHTG) content in patients with non-alcoholic fatty liver disease (NAFLD). The results showed that combining intermittent fasting with exercise is effective for reducing hepatic steatosis in patients with NAFLD but may offer no additional benefit versus fasting alone.
Review
Food Science & Technology
Lei Wang, Rong Wang, Xiaoyan Yu, Yuhuan Shi, Shengnan Li, Yongfang Yuan
Summary: This review summarizes the effects of energy restriction on macrophages in various diseases, offering valuable guidance for future research and insights into the clinical applications of calorie restriction and fasting.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Wentong Zhang, Jun Wang, Luanfeng Wang, Renjie Shi, Chuanqi Chu, Zhiling Shi, Pujie Liu, Yitong Li, Xuebo Liu, Zhigang Liu
Summary: Alternate-day fasting (ADF) regimen shows potential benefits in reducing obesity, improving non-alcoholic fatty liver disease (NAFLD), and alleviating cognitive decline. These effects may be mediated through the regulation of autophagy, energy metabolism, and inflammatory responses.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Alisa B. Beydogan, Zeynep M. Coskun Yazici, Sema Bolkent
Summary: The study aimed to investigate the effects of lipopolysaccharide (LPS) alone and in combination with calorie restriction (CR) on the pancreatic tissues in C57BL/6 mice modeled with pancreatic ductal adenocarcinoma (PDAC). The combination of low-dose LPS and 40% CR was found to be more effective in PDAC model mice.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Endocrinology & Metabolism
Bo Liu, Amy T. Hutchison, Campbell H. Thompson, Kylie Lange, Gary A. Wittert, Leonie K. Heilbronn
Summary: Intermittent fasting (IF) has different effects on lipid metabolism compared to caloric restriction (CR), leading to more weight and fat loss, but also reduced expression of antioxidant enzymes. However, fasting can cause insulin resistance and increased PLIN5 expression, possibly reflecting transient lipid storage.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)