Article
Cell Biology
Marta Perez-Frances, Maria Valentina Abate, Delphine Baronnier, Philipp E. Scherer, Yoshio Fujitani, Fabrizio Thorel, Pedro L. Herrera
Summary: This study investigates the developmental dynamics of pancreatic islet endocrine cell types using murine models. The researchers find that adult islet cells originate from embryonic hormone-expressing cells and there is no evidence of islet cell differentiation from precursor cells after birth. The study also reveals specific patterns of hormone gene activation and switching during islet morphogenesis.
Article
Biochemistry & Molecular Biology
Young-Gon Kim, Jisook Park, Eun Young Park, Sang-Mi Kim, Soo-Youn Lee
Summary: This study investigated the response of normal pancreatic islet cells to pancreatic cancer-derived exosomes in order to identify potential biomarkers for pancreatic cancer-induced diabetes mellitus (PC-DM) and pancreatic cancer itself. Changes in microRNA expression were evaluated, and 24 candidate miRNA markers were proposed. These markers showed relevance to diabetes mellitus and/or insulin resistance, suggesting a potential association with PC-DM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Ya-Qin Du, Xue-Ying Sha, Jie Cheng, Jin Wang, Jing-Yu Lin, Wen-Tao An, Wei Pan, Li-Jun Zhang, Xiao-Na Tao, Yun-Fei Xu, Ying-Li Jia, Zhao Yang, Peng Xiao, Ming Liu, Jin-Peng Sun, Xiao Yu
Summary: This study reveals the existence of endogenous LCFA-GPR120 circuits in pancreatic islets that modulate islet homeostasis. Oleic acid (OA) and linoleic acid (LA) were identified as GPR120 agonists within the islets, promoting insulin secretion by inhibiting somatostatin secretion. LA exerted higher potency compared to OA, depending on beta-arrestin2 function. Impaired GPR120 signaling in diabetic models could be improved by replenishing OA and LA, and LA administration improved glucose metabolism in db/db mice.
Article
Multidisciplinary Sciences
Hong Gao, Zhenlong Luo, Yudong Ji, Kechun Tang, Zhongmou Jin, Crystal Ly, Dorothy D. Sears, Sushil Mahata, Wei Ying
Summary: Obesity is associated with increased gut permeability, which leads to the leakage of microbial DNA into pancreatic beta-cells and promotes obesity-associated islet inflammation. Various microbial products leaked from the gut exacerbate tissue inflammation and metabolic disorders in obesity. Vsig4+ macrophages prevent the infiltration of bacteria and their products into host tissues, but their role in the communication between microbiota and beta cells in the pathogenesis of obesity-associated islet abnormalities is unclear.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Selina Wrublewsky, Thimoteus Speer, Lisa Nalbach, Anne S. Boewe, Mandy Pack, Dalia Alansary, Leticia P. Roma, Markus D. A. Hoffmann, Beate M. Schmitt, Andrea Weinzierl, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo
Summary: The inhibition of NLRP3 improves the survival and endocrine function of pancreatic islet grafts by enhancing revascularization and inducing insulin gene expression. This inhibition has significant therapeutic potential in pancreatic islet transplantation.
Article
Endocrinology & Metabolism
Neil Tanday, Aimee Coulter-Parkhill, R. Charlotte Moffett, Karthick Suruli, Vaibhav Dubey, Peter R. Flatt, Nigel Irwin
Summary: The study compares the metabolic and pancreatic islet adaptative responses between male and female mice after the administration of STZ and HC. The results show that both STZ and HC induce hyperglycemia and insulin resistance, but there are differences in pancreatic islet morphology and cell apoptosis between males and females.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Renata Spezani, Thatiany Souza Marinho, Luiz E. Macedo Cardoso, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Summary: Obesity and type 2 diabetes mellitus cause morphofunctional alterations in pancreatic islet alpha and beta cells. A new GLP-1/Glucagon receptor dual agonist cotadutide may benefit islet cell arrangement and function. The study found that cotadutide led to weight loss, reduced insulin resistance, and improved markers of transdifferentiation, proliferation, apoptosis, and ER stress in obese mice.
Article
Pharmacology & Pharmacy
Winifred P. S. Wong, Janice C. Wang, Matthew J. Schipma, Xiaomin Zhang, Joshua R. Edwards, Malek El Muayed
Summary: Cadmium exposure is associated with changes in gene expression and molecular regulatory networks in pancreatic islets, contributing to the development of Type II diabetes mellitus. Cadmium affects intracellular protein trafficking to the plasma membrane, impacting genes involved in glucose homeostasis.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Marine L. Croze, Marcus F. Flisher, Arthur Guillaume, Caroline Tremblay, Glyn M. Noguchi, Sabrina Granziera, Kevin Vivot, Vincent C. Castillo, Scott A. Campbell, Julien Ghislain, Mark O. Huising, Vincent Poitout
Summary: The study indicates that GPR120 in pancreatic islets plays a role in promoting insulin and glucagon secretion by reducing somatostatin release. Activation of GPR120 significantly improved glucose tolerance and increased levels of insulin and glucagon in experiments.
MOLECULAR METABOLISM
(2021)
Review
Pharmacology & Pharmacy
Oly Banerjee, Siddhartha Singh, Ishita Saha, Swagata Pal, Maitrayee Banerjee, Sudipta Kundu, Alak Kumar Syamal, Bithin Kumar Maji, Sandip Mukherjee
Summary: Bisphenol A (BPA) is an endocrine disrupting chemical that is widely present in industrial production and has potential harmful effects on human health. This review focuses on the different cellular and molecular pathways through which BPA affects pancreatic islets, considering both low and high dose effects. Understanding the mechanisms of BPA action on pancreatic islets provides meaningful insights into the risks associated with exposure to BPA at different doses.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Selina Wrublewsky, Julia Glas, Christopher Carlein, Lisa Nalbach, Markus Daniel Alexander Hoffmann, Mandy Pack, Eloisa Aparecida Vilas-Boas, Nathan Ribot, Reinhard Kappl, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo, Leticia Prates Roma
Summary: Islet transplantation is a promising treatment for type 1 diabetes mellitus. This study found that suppressing the activity of NADPH oxidase 2 (NOX2) in islets improves their engraftment and function, suggesting it as a potential therapeutic strategy.
Review
Multidisciplinary Sciences
Anneliese J. S. Flatt, Carla J. Greenbaum, James A. M. Shaw, Michael R. Rickels
Summary: Type 1 diabetes is characterized by loss and dysfunction of pancreatic islet beta cells, leading to insulin deficiency and hyperglycemia. Assessment of beta cell secretory capacity can detect the loss of beta cells during a presymptomatic phase of autoimmune attack. Islet transplantation can restore physiologic reserve capacity for insulin secretion.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Multidisciplinary Sciences
Mahboba Jabary, Atsuto Onoda, Yuma Kitase, Kazuto Ueda, Haruka Mimatsu, Shoji Go, Ryosuke Miura, Masahiro Tsuji, Yoshiyuki Takahashi, Masahiro Hayakawa, Yoshiaki Sato
Summary: This study aimed to investigate the effects of fetal growth restriction (FGR) and early catch-up growth on the pathogenesis of type 2 diabetes, specifically focusing on glucose tolerance, pancreatic islet morphology, and fibrosis, and using proteomics analysis to elucidate the underlying mechanism. The results showed that FGR and early catch-up growth caused pancreatic islet morphological abnormalities and fibrosis, resulting in glucose intolerance and dyslipidemia in male rats.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Fangfang Zhang, Yue Yang, Xi Chen, Yue Liu, Qianxing Hu, Bin Huang, Yuhong Liu, Yi Pan, Yanfeng Zhang, Dechen Liu, Rui Liang, Guoqing Li, Qiong Wei, Ling Li, Liang Jin
Summary: Obesity-induced reduction of the long noncoding RNA beta Faar in mouse islets impairs beta-cell function via miR-138-5p and survival via TRAF3 Interacting Protein 2, indicating a crucial role of beta Faar in obesity-induced beta-cell injury and apoptosis.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jerad Dumolt, Theresa L. Powell, Thomas Jansson, Fredrick J. Rosario
Summary: Infants born to obese mothers have a higher risk of childhood obesity and insulin resistance. Lower levels of maternal adiponectin, a hormone associated with placental nutrient transport and fetal overgrowth, contribute to these risks. Previous research showed that supplementing adiponectin in obese mice during pregnancy prevented obesity and metabolic dysfunction in their offspring. This study further demonstrates the importance of maternal adiponectin levels in the development of metabolic diseases in offspring and suggests that improving these levels could prevent long-term metabolic dysfunction in children of obese mothers.
Review
Biochemistry & Molecular Biology
Fabiane Ferreira Martins, Vanessa Souza-Mello, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Summary: Brown adipose tissue (BAT) plays a role in thermogenesis and has the potential to be targeted for the treatment of obesity and its comorbidities. Brown adipokines (batokines) have effects on multiple organs and may be effective targets for treating obesity. This review discusses the importance of six emerging batokines and their interactions with other organs, focusing on their physiological significance and changes induced by diet.
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Fabiane Ferreira Martins, Thiago Santos-Reis, Thatiany Souza Marinho, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Summary: The aim of this study was to examine the effects of semaglutide on neuropeptide signaling in the hypothalamic energy metabolism of diet-induced obese mice. The results showed that semaglutide improved leptin sensitivity and anorexigenic signaling, while decreasing orexigenic signaling. Furthermore, semaglutide also affected biometric data and hypothalamic gene expressions. Therefore, semaglutide can activate anorexigenic signaling by restoring leptin, amylin, and POMC pathways in diet-induced obese mice.
Article
Medicine, Research & Experimental
Matheus Ajackson, Brenda A. Nagagata, Ilitch A. Marcondes-de-Castro, Carlos A. Mandarim-de-Lacerda, Marcia Barbosa Aguila
Summary: The aim of this study was to investigate the effects of melatonin supplementation in the liver of adult offspring from obese mothers during pregnancy and lactation. The results showed that supplementation of melatonin reduced body weight and liver lipid levels in offspring from high-fat diet-fed mothers. Additionally, melatonin supplementation improved lipid metabolism, inflammation, oxidative stress, and endoplasmic reticulum stress in the offspring's liver.
Article
Endocrinology & Metabolism
Ilitch Aquino Marcondes-de-Castro, Thamiris Ferreira Oliveira, Renata Spezani, Thatiany Souza Marinho, Luiz Eduardo Macedo Cardoso, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Summary: Cotadutide has anti-obesity effects and can improve glucose intolerance and insulin resistance. It also shows beneficial effects on liver lipid metabolism and mitigates steatosis, inflammation, and ER stress. Therefore, Cotadutide could be a potential treatment for type 2 diabetes and associated obesity.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Luiz E. M. Cardoso, Thatiany Souza Marinho, Fabiane Ferreira Martins, Marcia Barbosa Aguila, Carlos A. Mandarim-de-Lacerda
Summary: In this study, the effects of a glucagon-like peptide type 1 receptor agonist, semaglutide, on the turnover of islet extracellular matrix (ECM) components in an obese mouse model were investigated. The results showed that semaglutide improved the turnover of ECM components and reduced the formation of amyloid deposits.
Article
Endocrinology & Metabolism
Daiana Araujo Santana-Oliveira, Henrique Souza-Tavares, Aline Fernandes-da-Silva, Flavia Maria Silva-Veiga, Gustavo Casimiro-Lopes, Patricia Cristina Lisboa, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello
Summary: This study shows that high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) can prevent obesity by modulating gut microbiota and inflammatory signals. These exercise modalities restore body weight, improve glucose tolerance, and reduce insulin levels in high-fat-fed mice. Furthermore, they prevent gut dysbiosis and maintain the integrity of the gut barrier, leading to decreased inflammatory signals to brown adipose tissue. These findings are important for understanding the impact of exercise on obesity and metabolic health.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Renata Spezani, Thatiany Souza Marinho, Luiz E. Macedo Cardoso, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Summary: Obesity and type 2 diabetes mellitus cause morphofunctional alterations in pancreatic islet alpha and beta cells. A new GLP-1/Glucagon receptor dual agonist cotadutide may benefit islet cell arrangement and function. The study found that cotadutide led to weight loss, reduced insulin resistance, and improved markers of transdifferentiation, proliferation, apoptosis, and ER stress in obese mice.
Article
Public, Environmental & Occupational Health
Brenda A. Nagagata, Matheus Ajackson, Fernanda Ornellas, Carlos A. Mandarim-de-Lacerda, Marcia Barbosa Aguila
Summary: Supplementing obese mothers with melatonin during gestation and lactation has benefits for the pancreatic islet cellular composition and beta-cell function in adult male offspring. The study found that melatonin supplementation improved glucose metabolism and weight loss in both mothers and offspring, while reducing pro-inflammatory markers and endoplasmic reticulum stress. Additionally, antioxidant enzymes were improved, beta-cell mass and hyperinsulinemia were reduced, and beta-cell maturity and identity gene expressions were enhanced in the offspring. Overall, melatonin supplementation in obese mothers helps preserve pancreatic islets and functioning beta cells in their offspring.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Anatomy & Morphology
Patricia de Castro De Paiva, Thatiany Souza Marinho, Carlos Alberto Mandarim-De-Lacerda, Marcia Barbosa Aguila
Summary: High-Intensity Interval training (HIIT) has positive effects on myokines and endoplasmic reticulum (ER) stress in obese mice, reducing weight gain and improving muscle function. The study suggests that HIIT can prevent chronic inflammation and muscle dysfunction associated with obesity.
INTERNATIONAL JOURNAL OF MORPHOLOGY
(2023)
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.