Post-ExSELEX stabilization of an unnatural-base DNA aptamer targeting VEGF165toward pharmaceutical applications

Post-SELEX optimization of aptamers

(2016) Shunxiang Gao et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Enhancing aptamer function and stability via in vitro selection using modified nucleic acids

(2016) Kirsten N. Meek et al.   METHODS

Fit for the Eye: Aptamers in Ocular Disorders

(2016) Daniel W. Drolet et al.   Nucleic Acid Therapeutics

High Fidelity, Efficiency and Functionalization of Ds–Px Unnatural Base Pairs in PCR Amplification for a Genetic Alphabet Expansion System

(2016) Itaru Okamoto et al.   ACS Synthetic Biology

Aptamer Nanomedicine for Cancer Therapeutics: Barriers and Potential for Translation

(2015) Yeh-Hsing Lao et al.   ACS Nano

The Expanded Genetic Alphabet

(2015) Denis A. Malyshev et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aptamers as a replacement for antibodies in enzyme-linked immunosorbent assay

(2015) Saw Yi Toh et al.   BIOSENSORS & BIOELECTRONICS

Replacing antibodies with aptamers in lateral flow immunoassay

(2015) Ailiang Chen et al.   BIOSENSORS & BIOELECTRONICS

Nucleic acid aptamers in cancer research, diagnosis and therapy

(2015) Haitao Ma et al.   CHEMICAL SOCIETY REVIEWS

Evolution of Functional Six-Nucleotide DNA

(2015) Liqin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics

(2015) John Bruno   MOLECULES

Transcription yield of fully 2′-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants

(2015) Adam J. Meyer et al.   NUCLEIC ACIDS RESEARCH

Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer

(2015) Laure Yatime et al.   Nature Communications

Architecture of high-affinity unnatural-base DNA aptamers toward pharmaceutical applications

(2015) Ken-ichiro Matsunaga et al.   Scientific Reports

Aptamers: Active Targeting Ligands for Cancer Diagnosis and Therapy

(2015) Xu Wu et al.   Theranostics

High-affinity RNA Aptamers Against the HIV-1 Protease Inhibit Both In Vitro Protease Activity and Late Events of Viral Replication

(2015) Sonald Duclair et al.   Molecular Therapy-Nucleic Acids

Towards applications of synthetic genetic polymers in diagnosis and therapy

(2014) Alexander I Taylor et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Identification of a T7 RNA polymerase variant that permits the enzymatic synthesis of fully 2′-O-methyl-modified RNA

(2013) Jenny Ibach et al.   JOURNAL OF BIOTECHNOLOGY

Aptamer BAX 499 mediates inhibition of tissue factor pathway inhibitor via interaction with multiple domains of the protein

(2013) E. K. Waters et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Generation of high-affinity DNA aptamers using an expanded genetic alphabet

(2013) Michiko Kimoto et al.   NATURE BIOTECHNOLOGY

In vitro selection with artificial expanded genetic information systems

(2013) K. Sefah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-Aptamers: A Bead-Based Selection Method for Random Incorporation of Druglike Moieties onto Next-Generation Aptamers for Enhanced Binding

(2012) Weiguo He et al.   BIOCHEMISTRY

Unnatural base pair systems toward the expansion of the genetic alphabet in the central dogma

(2012) Ichiro HIRAO et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor

(2011) E. K. Waters et al.   BLOOD

Aptamers: Selection, Modification and Application to Nervous System Diseases

(2011) Y. Yang et al.   CURRENT MEDICINAL CHEMISTRY

Improving the Stability of Aptamers by Chemical Modification

(2011) R. E. Wang et al.   CURRENT MEDICINAL CHEMISTRY

Highly specific unnatural base pair systems as a third base pair for PCR amplification

(2011) Rie Yamashige et al.   NUCLEIC ACIDS RESEARCH

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

The Therapeutic Potential of Cell-Internalizing Aptamers

(2009) Jiehua Zhou et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779

(2009) J. L. DIENER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

SELEX with modified nucleotides

(2008) Anthony D Keefe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

An unnatural base pair system for efficient PCR amplification and functionalization of DNA molecules

(2008) Michiko Kimoto et al.   NUCLEIC ACIDS RESEARCH