Overhang polarity of chromosomal double-strand breaks impacts kinetics and fidelity of yeast non-homologous end joining

TDP1 promotes assembly of non-homologous end joining protein complexes on DNA

(2015) Jinho Heo et al.   DNA REPAIR

Requirement of POL3 and POL4 on non-homologous and microhomology-mediated end joining in rad50/xrs2 mutants of Saccharomyces cerevisiae

(2015) A. Galli et al.   MUTAGENESIS

DNA polymerases δ and λ cooperate in repairing double-strand breaks by microhomology-mediated end-joining inSaccharomyces cerevisiae

(2015) Damon Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential role for polymerase specialization in cellular nonhomologous end joining

(2015) John M. Pryor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sae2 promotes DNA damage resistance by removing the Mre11–Rad50–Xrs2 complex from DNA and attenuating Rad53 signaling

(2015) Huan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic Subunit

(2015) Derek S. Woods et al.   PLoS One

Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining

(2014) Hind Ghezraoui et al.   MOLECULAR CELL

Requirements for 5′dRP/AP lyase activity in Ku

(2014) Natasha T. Strande et al.   NUCLEIC ACIDS RESEARCH

Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates

(2014) H. Ghodke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin

(2014) M. K. Ayrapetov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

End Resection at Double-Strand Breaks: Mechanism and Regulation

(2014) L. S. Symington   Cold Spring Harbor Perspectives in Biology

The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining

(2014) Crystal A. Waters et al.   Nature Communications

Cancer translocations in human cells induced by zinc finger and TALE nucleases

(2013) M. Piganeau et al.   GENOME RESEARCH

Processing of DNA Double-stranded Breaks and Intermediates of Recombination and Repair bySaccharomyces cerevisiaeMre11 and Its Stimulation by Rad50, Xrs2, and Sae2 Proteins

(2013) Indrajeet Ghodke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RPA Coordinates DNA End Resection and Prevents Formation of DNA Hairpins

(2013) Huan Chen et al.   MOLECULAR CELL

Quantitation of DNA double-strand break resection intermediates in human cells

(2013) Yi Zhou et al.   NUCLEIC ACIDS RESEARCH

Nonhomologous End Joining-Mediated Gene Replacement in Plant Cells

(2013) D. M. Weinthal et al.   PLANT PHYSIOLOGY

Relationship of DNA degradation by Saccharomyces cerevisiae Exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection

(2013) E. Cannavo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

Repair of Double-Strand Breaks by End Joining

(2013) K. K. Chiruvella et al.   Cold Spring Harbor Perspectives in Biology

Saccharomyces cerevisiae DNA Ligase IV Supports Imprecise End Joining Independently of Its Catalytic Activity

(2013) Kishore K. Chiruvella et al.   PLoS Genetics

Ligand-switchable Substrates for a Ubiquitin-Proteasome System

(2011) Emily L. Egeler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

(2011) Xuefeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A novel zinc-finger nuclease platform with a sequence-specific cleavage module

(2011) Benno Schierling et al.   NUCLEIC ACIDS RESEARCH

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

(2011) Tomas Cermak et al.   NUCLEIC ACIDS RESEARCH

Cell Cycle-Dependent Induction of Homologous Recombination by a Tightly Regulated I-SceI Fusion Protein

(2011) Andrea Hartlerode et al.   PLoS One

Blunt-ended DNA double-strand breaks induced by endonucleases PvuII and EcoRV are poor substrates for repair in Saccharomyces cerevisiae

(2010) James W. Westmoreland et al.   DNA REPAIR

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

(2010) Eun Yong Shim et al.   EMBO JOURNAL

Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

(2010) M. Christian et al.   GENETICS

Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends

(2010) Steven A. Roberts et al.   NATURE

Mre11–Rad50–Xrs2 and Sae2 promote 5′ strand resection of DNA double-strand breaks

(2010) Matthew L Nicolette et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Loop 1 modulates the fidelity of DNA polymerase  

(2010) K. Bebenek et al.   NUCLEIC ACIDS RESEARCH

End-processing during non-homologous end-joining: a role for exonuclease 1

(2010) K. Bahmed et al.   NUCLEIC ACIDS RESEARCH

Yeast Tdp1 regulates the fidelity of nonhomologous end joining

(2010) K. Bahmed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tyrosyl-DNA phosphodiesterase and the repair of 3′-phosphoglycolate-terminated DNA double-strand breaks

(2009) Tong Zhou et al.   DNA REPAIR

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL

Break dosage, cell cycle stage and DNA replication influence DNA double strand break response

(2008) Christian Zierhut et al.   EMBO JOURNAL

The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends

(2008) J. Aniukwu et al.   GENES & DEVELOPMENT

Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 Complex to a Double-Strand Break Requires Interactions With Yku80 and the Xrs2 FHA Domain

(2008) P. L. Palmbos et al.   GENETICS

Recruitment and Dissociation of Nonhomologous End Joining Proteins at a DNA Double-Strand Break in Saccharomyces cerevisiae

(2008) D. Wu et al.   GENETICS

A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining

(2008) Katherine S. Pawelczak et al.   NUCLEIC ACIDS RESEARCH

Evidence that base stacking potential in annealed 3′ overhangs determines polymerase utilization in yeast nonhomologous end joining

(2007) James M. Daley et al.   DNA REPAIR