A novel zinc-finger nuclease platform with a sequence-specific cleavage module

The reaction mechanism of FokI excludes the possibility of targeting zinc finger nucleases to unique DNA sites

(2011) Stephen E. Halford et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Photocaged Variants of the MunI and PvuII Restriction Enzymes

(2011) Arunas Silanskas et al.   BIOCHEMISTRY

Generation of Novel Nucleases with Extended Specificity by Rational and Combinatorial Strategies

(2011) Alfred Pingoud et al.   CHEMBIOCHEM

Zinc-Finger Nucleases: A Panoramic View

(2011) Dana Carroll   CURRENT GENE THERAPY

Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy

(2011) George Silva et al.   CURRENT GENE THERAPY

Zinc-Finger Nuclease Based Genome Surgery: Its All About Specificity

(2011) Eva-Maria Handel et al.   CURRENT GENE THERAPY

Genome Engineering With Zinc-Finger Nucleases

(2011) Dana Carroll   GENETICS

Zinc-Finger Nucleases for Somatic Gene Therapy: The Next Frontier

(2011) Shamim H. Rahman et al.   HUMAN GENE THERAPY

Gene Editing of Human Embryonic Stem Cells via an Engineered Baculoviral Vector Carrying Zinc-finger Nucleases

(2011) Yuning Lei et al.   MOLECULAR THERAPY

An unbiased genome-wide analysis of zinc-finger nuclease specificity

(2011) Richard Gabriel et al.   NATURE BIOTECHNOLOGY

On target? Tracing zinc-finger-nuclease specificity

(2011) Claudio Mussolino et al.   NATURE METHODS

Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection

(2011) Vikram Pattanayak et al.   NATURE METHODS

Creating highly specific nucleases by fusion of active restriction endonucleases and catalytically inactive homing endonucleases

(2011) Ines Fonfara et al.   NUCLEIC ACIDS RESEARCH

Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes

(2011) Ting Li et al.   NUCLEIC ACIDS RESEARCH

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity

(2011) Claudio Mussolino et al.   NUCLEIC ACIDS RESEARCH

Zinc Finger Recombinases with Adaptable DNA Sequence Specificity

(2011) Chris Proudfoot et al.   PLoS One

p53 Gene Repair with Zinc Finger Nucleases Optimised by Yeast 1-Hybrid and Validated by Solexa Sequencing

(2011) Frank Herrmann et al.   PLoS One

Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases

(2011) J. J. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tapping natural reservoirs of homing endonucleases for targeted gene modification

(2011) Ryo Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concise Review: Putting a Finger on Stem Cell Biology: Zinc Finger Nuclease-Driven Targeted Genetic Editing in Human Pluripotent Stem Cells

(2011) Joseph Collin et al.   STEM CELLS

The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation

(2010) Aaron Klug   Annual Review of Biochemistry

The down regulation of target genes by photo activated DNA nanoscissors

(2010) Tsung-Lin Tsai et al.   BIOMATERIALS

Gene therapy, gene targeting and induced pluripotent stem cells: Applications in monogenic disease treatment

(2010) Gabriel Kun Yung Wong et al.   BIOTECHNOLOGY ADVANCES

Zinc Finger Nucleases as tools to understand and treat human diseases

(2010) David Davis et al.   BMC Medicine

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

(2010) R. C. DeKelver et al.   GENOME RESEARCH

Directed Evolution of an Enhanced and Highly Efficient FokI Cleavage Domain for Zinc Finger Nucleases

(2010) Jing Guo et al.   JOURNAL OF MOLECULAR BIOLOGY

Creating Designed Zinc-Finger Nucleases with Minimal Cytotoxicity

(2010) Sivaprakash Ramalingam et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeted integration in rat and mouse embryos with zinc-finger nucleases

(2010) Xiaoxia Cui et al.   NATURE BIOTECHNOLOGY

A TALE nuclease architecture for efficient genome editing

(2010) Jeffrey C Miller et al.   NATURE BIOTECHNOLOGY

Transient cold shock enhances zinc-finger nuclease–mediated gene disruption

(2010) Yannick Doyon et al.   NATURE METHODS

Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)

(2010) Jeffry D Sander et al.   NATURE METHODS

Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

(2010) Yannick Doyon et al.   NATURE METHODS

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion

(2010) Cem Şöllü et al.   NUCLEIC ACIDS RESEARCH

Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases

(2010) Ankit Gupta et al.   NUCLEIC ACIDS RESEARCH

Directed evolution of recombinase specificity by split gene reassembly

(2010) Charles A. Gersbach et al.   NUCLEIC ACIDS RESEARCH

Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template

(2010) Michael J. Metzger et al.   NUCLEIC ACIDS RESEARCH

Structure-guided reprogramming of serine recombinase DNA sequence specificity

(2010) T. Gaj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome editing in plant cells by zinc finger nucleases

(2010) Dan Weinthal et al.   TRENDS IN PLANT SCIENCE

Gene Targeting of a Disease-Related Gene in Human Induced Pluripotent Stem and Embryonic Stem Cells

(2009) Jizhong Zou et al.   Cell Stem Cell

Genetic Analysis of Zinc-Finger Nuclease-Induced Gene Targeting in Drosophila

(2009) A. Bozas et al.   GENETICS

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

(2009) Vipula K. Shukla et al.   NATURE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

(2009) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY

Targeting individual subunits of the FokI restriction endonuclease to specific DNA strands

(2009) K. L. Sanders et al.   NUCLEIC ACIDS RESEARCH

Precise targeted integration by a chimaeric transposase zinc-finger fusion protein

(2009) Xiaofeng Feng et al.   NUCLEIC ACIDS RESEARCH

Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells

(2009) Glenna E. Meister et al.   NUCLEIC ACIDS RESEARCH

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

(2009) Sylvestre Grizot et al.   NUCLEIC ACIDS RESEARCH

Controlling the enzymatic activity of a restriction enzyme by light

(2009) B. Schierling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of Zinc Finger Nuclease Toxicity by Small-Molecule Regulation of Protein Levels

(2009) Shondra M. Pruett-Miller et al.   PLoS Genetics

Enhanced Cleavage of Double-Stranded DNA by Artificial Zinc-Finger Nuclease Sandwiched between Two Zinc-Finger Proteins

(2008) Yusuke Mineta et al.   BIOCHEMISTRY

One- and Two-Metal Ion Catalysis: Global Single-Turnover Kinetic Analysis of the PvuII Endonuclease Mechanism†

(2008) Fuqian Xie et al.   BIOCHEMISTRY

Rapid “Open-Source” Engineering of Customized Zinc-Finger Nucleases for Highly Efficient Gene Modification

(2008) Morgan L. Maeder et al.   MOLECULAR CELL

Comparison of Zinc Finger Nucleases for Use in Gene Targeting in Mammalian Cells

(2008) Shondra M Pruett-Miller et al.   MOLECULAR THERAPY

Expanding or Restricting the Target Site Repertoire of Zinc-finger Nucleases: The Inter-domain Linker as a Major Determinant of Target Site Selectivity

(2008) Eva-Maria Händel et al.   MOLECULAR THERAPY

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

(2008) Elena E Perez et al.   NATURE BIOTECHNOLOGY

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

(2008) Yannick Doyon et al.   NATURE BIOTECHNOLOGY

DNA-binding Specificity Is a Major Determinant of the Activity and Toxicity of Zinc-finger Nucleases

(2007) Tatjana I Cornu et al.   MOLECULAR THERAPY