The Construction of 3-Methyl-4-arylpiperidinesviaatrans- Perhydroindolic Acid-Catalyzed Asymmetric Aza-Diels-Alder Reaction

Asymmetric tandem reactions of N-sulfonylimines and α,β-unsaturated aldehydes: an alternative reaction pathway to that of using saturated aldehydes

(2015) Qianjin An et al.   CHEMICAL COMMUNICATIONS

Bifunctional Amino Sulfonohydrazide Catalyzed Direct Asymmetric Mannich Reaction of Cyclic Ketimines with Ketones: Highly Diastereo- and Enantioselective Construction of Quaternary Carbon Stereocenters

(2015) Sheng Zhang et al.   ORGANIC LETTERS

Characterization of BU09059: A Novel Potent Selective κ-Receptor Antagonist

(2014) Joseph J. Casal-Dominguez et al.   ACS Chemical Neuroscience

Optimized Protein Kinase Cθ (PKCθ) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis

(2014) Dawn M. George et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of (3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) Analogues: In Vitro Pharmacology and ADME Profile

(2014) Chad M. Kormos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

β,γ-Regioselective Inverse-Electron-Demand Aza-Diels–Alder Reactions with α,β-Unsaturated Aldehydes via Dienamine Catalysis

(2014) Jing Gu et al.   ORGANIC LETTERS

Asymmetric Domino Reaction of Cyclic N-Sulfonylimines and Simple Aldehydes with trans-Perhydroindolic Acid as an Organocatalyst

(2014) Qianjin An et al.   ORGANIC LETTERS

Highly Enantioselective Aza-Diels-Alder Reaction of 1-Azadienes with Enecarbamates Catalyzed by Chiral Phosphoric Acids

(2013) Long He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trienamines Derived from Interrupted Cyclic 2,5-Dienones: Remote δ,ε-CC Bond Activation for Asymmetric Inverse-Electron-Demand Aza-Diels-Alder Reaction

(2013) Xin Feng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amygdala Deep Brain Stimulation Is Superior to Paroxetine Treatment in a Rat Model of Posttraumatic Stress Disorder

(2013) David A. Stidd et al.   Brain Stimulation

A highly efficient access to enantiopure tetrahydropyridines: dual-organocatalyst-promoted asymmetric cascade reaction

(2013) Hua Lin et al.   CHEMICAL COMMUNICATIONS

Recent Developments in Catalytic Asymmetric Inverse-Electron-Demand Diels–Alder Reaction

(2013) Xianxing Jiang et al.   CHEMICAL REVIEWS

Synthesis of (2S,3aR,7aS)-Benzyl Octahydro-1H-indole-2-carboxylate

(2013) Tao Shi et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Aminocatalytic Asymmetric Diels–Alder Reactions via HOMO Activation

(2012) Jun-Long Li et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Synthesis oftrans-Perhydroindolic Acids and their Application in Asymmetric Domino Reactions of Aldehyde Esters with β,γ-Unsaturated α-Keto Esters

(2012) Jiefeng Shen et al.   ADVANCED SYNTHESIS & CATALYSIS

Bifunctional Organocatalytic Strategy for Inverse-Electron-Demand Diels-Alder Reactions: Highly Efficient In Situ Substrate Generation and Activation to Construct Azaspirocyclic Skeletons

(2012) Xianxing Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dihydropyridones: Catalytic Asymmetric Synthesis, N- to C-Sulfonyl Transfer, and Derivatizations

(2012) Carmen Simal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic-Carbene-Catalyzed Asymmetric Oxidative Hetero-Diels-Alder Reactions with Simple Aliphatic Aldehydes

(2012) Xiaodan Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric aza-Diels-Alder and Cation-olefin Cyclization Sequence: a Concise Way to Fused Chiral Cyclopenta[b]piperidines

(2012) Qing-Zhu Li et al.   ChemCatChem

Evaluation and Comparison of a 3,5-Dimethylphenyl Isocyanate Teicoplanin with Phenyl Isocyanate Teicoplanin Chiral Stationary Phase Using RP-HPLC

(2012) Baochun Shen et al.   CHINESE JOURNAL OF CHEMISTRY

The studies on chemoenzymatic synthesis of Femoxetine

(2012) Anna Brodzka et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Highly efficient asymmetric Michael addition of aldehyde to nitroolefin using perhydroindolic acid as a chiral organocatalyst

(2012) Lina Zhao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalytic Sequential Hetero-Diels–Alder and Friedel–Crafts Reaction: Constructions of Fused Heterocycles with Scaffold Diversity

(2011) Si-Li Zhou et al.   ORGANIC LETTERS

Aminocatalytic asymmetric inverse-electron-demand aza-Diels–Alder reaction of N-Ts-1-aza-1,3-butadienes based on coumarin cores

(2010) Jun-Long Li et al.   CHEMICAL COMMUNICATIONS

Enantioselective [4+2] cycloaddition of ketenes and 1-azadienes catalyzed by N-heterocyclic carbenes

(2010) Teng-Yue Jian et al.   CHEMICAL COMMUNICATIONS

Ytterbium Triflate Catalyzed Synthesis of Alkoxy-Substituted Donor−Acceptor Cyclobutanes and Their Formal [4 + 2] Cycloaddition with Imines: Stereoselective Synthesis of Piperidines

(2010) Mahmoud M. Abd Rabo Moustafa et al.   ORGANIC LETTERS

Enantio- and Diastereoselective Synthesis of Piperidines by Coupling of Four Components in a “One-Pot” Sequence Involving Diphenylprolinol Silyl Ether Mediated Michael Reaction

(2010) Tatsuya Urushima et al.   ORGANIC LETTERS

Organocatalytic Regio- and Stereoselective Inverse-Electron-Demand Aza-Diels-Alder Reaction of α,β-Unsaturated Aldehydes andN-Tosyl-1-aza-1,3-butadienes

(2009) Bo Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and In Vitro Opioid Receptor Functional Antagonism of Methyl-Substituted Analogues of (3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic)†

(2009) Juan Pablo Cueva et al.   JOURNAL OF MEDICINAL CHEMISTRY

One-Pot Asymmetric Synthesis of Substituted Piperidines by Exocyclic Chirality Induction

(2009) Yunfeng Chen et al.   ORGANIC LETTERS

Zn(II)-Catalyzed Synthesis of Piperidines from Propargyl Amines and Cyclopropanes

(2009) Terry P. Lebold et al.   ORGANIC LETTERS

Hydroalkylation leading to heterocyclic compounds (Part 2): practical synthesis of polysubstituted 1,2,3,4-tetrahydropyridines through multicomponent reactions (MCRs)

(2009) Wei-Bing Liu et al.   TETRAHEDRON

Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (−)-Paroxetine

(2009) Guillem Valero et al.   TETRAHEDRON LETTERS

Organocatalytic Asymmetric Inverse-Electron-Demand Aza-Diels-Alder Reaction ofN-Sulfonyl-1-aza-1,3-butadienes and Aldehydes

(2008) Bo Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effects of Substituents in the β-Position of 1,3-Dicarbonyl Compounds in Bromodimethylsulfonium Bromide-Catalyzed Multicomponent Reactions: A Facile Access to Functionalized Piperidines

(2008) Abu T. Khan et al.   JOURNAL OF ORGANIC CHEMISTRY

Gallium iodide/iodine as a versatile reagent for the aza-Prins cyclization: an expeditious synthesis of 4-iodopiperidines

(2008) J.S. Yadav et al.   TETRAHEDRON LETTERS

A novel three-component reaction of anilines, formaldehyde and dimedone: simple synthesis of spirosubstituted piperidines

(2008) Nikolas G. Kozlov et al.   TETRAHEDRON LETTERS

Enantioselective Aza-Diels−Alder Reaction of Aldimines with “Danishefsky-Type Diene” Catalyzed by Chiral Scandium(III)-N,N‘-Dioxide Complexes

(2007) Deju Shang et al.   JOURNAL OF ORGANIC CHEMISTRY

BiCl3 promoted aza-Prins type cyclization: a rapid and efficient synthesis of 2,4-disubstituted piperidines

(2007) M.S.R. Murty et al.   TETRAHEDRON LETTERS