The Nitro to Carbonyl Conversion (Nef Reaction): New Perspectives for a Classical Transformation

Zinc-Catalyzed Direct Cyanation of Indoles and Pyrroles: Nitromethane as a Source of a Cyano Group

(2014) Yuta Nagase et al.   ADVANCED SYNTHESIS & CATALYSIS

Remarkable Enhancement of Enantioselectivity in the Asymmetric Conjugate Addition of Dimethylzinc to (Z)-Nitroalkenes with a Catalytic [(MeCN)4Cu]PF6-Hoveyda Ligand Complex

(2014) Xingzhong Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of 2,4,5-trisubstituted oxazoles through tin(iv) chloride-mediated reaction of trans-2-aryl-3-nitro-cyclopropane-1,1-dicarboxylates with nitriles

(2014) Thangavel Selvi et al.   CHEMICAL COMMUNICATIONS

Highly enantioselective aza-Henry reaction with isatin N-Boc ketimines

(2014) Melireth Holmquist et al.   CHEMICAL COMMUNICATIONS

Diphenylprolinol Silyl Ether Catalyzed Asymmetric Michael Reaction of Nitroalkanes and β,β-Disubstituted α,β-Unsaturated Aldehydes for the Construction of All-Carbon Quaternary Stereogenic Centers

(2014) Yujiro Hayashi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Nef Reaction with Molecular Oxygen in the Absence of Metal Additives, and Mechanistic Insights

(2014) Shigenobu Umemiya et al.   CHEMISTRY-A EUROPEAN JOURNAL

Higher Efficiently Conversion of Heterocyclic Aryl Nitroalkenes to Ketones

(2014) Dushu Huang et al.   CURRENT ORGANIC SYNTHESIS

Synthesis of 24 Bacteriochlorin Isotopologues, Each Containing a Symmetrical Pair of 13C or 15N Atoms in the Inner Core of the Macrocycle

(2014) Chih-Yuan Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Boron Trifluoride Mediated Ring-Opening Reactions of trans-2-Aryl-3-nitro-cyclopropane-1,1-dicarboxylates. Synthesis of Aroylmethylidene Malonates as Potential Building Blocks for Heterocycles

(2014) Thangavel Selvi et al.   JOURNAL OF ORGANIC CHEMISTRY

Umpolung Amide Synthesis Using Substoichiometric N-Iodosuccinimide (NIS) and Oxygen as a Terminal Oxidant

(2014) Kenneth E. Schwieter et al.   ORGANIC LETTERS

Domino Asymmetric Conjugate Addition–Conjugate Addition

(2014) Nicolas Germain et al.   ORGANIC LETTERS

Synthesis of Naturally Occurring Pyranonaphthoquinones: (±) 9-Demethoxyeleutherin, (±) 9-Demethoxyisoeleutherin, and Pentalongin via Nef Reaction

(2014) Rohan A. Limaye et al.   SYNTHETIC COMMUNICATIONS

Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities

(2014) Fatima El Bahhaj et al.   TETRAHEDRON

Base-promoted diastereoselective addition of nitromethane and nitroethane to N-tert-butylsulfinyl imines: synthesis of N-protected α-amino acids and amino ketones

(2014) M. Jesús García-Muñoz et al.   TETRAHEDRON-ASYMMETRY

N-Hydroxymethyl derivatives of α-amino aldehydes used for the stereoselective syntheses of β-amino-α-hydroxy acids

(2014) Youngran Seo et al.   TETRAHEDRON-ASYMMETRY

Cooperative Bimetallic Asymmetric Catalysis: Comparison of a Planar Chiral Ruthenocene Bis-Palladacycle to the Corresponding Ferrocene

(2014) Tina Hellmuth et al.   ACS Catalysis

The Baylis–Hillman acetates in organic synthesis: Unprecedented sodium nitrite induced intramolecular Friedel–Crafts cyclization of secondary nitro compounds

(2014) Deevi Basavaiah et al.   RSC Advances

Cascade reactions initiated by radical addition of tetrahydrofuran to β-bromonitrostyrenes

(2014) Xin Ge et al.   RSC Advances

Enantioselective Organocatalytic Addition of Nitroalkanes to Oxindolylideneindolenines for the Construction of Chiral 3,3-Disubstituted Oxindoles

(2013) Jian-Zhou Huang et al.   ADVANCED SYNTHESIS & CATALYSIS

Pot Economy in the Synthesis of Prostaglandin A1and E1Methyl Esters

(2013) Yujiro Hayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Palladium(II)-Catalyzed Cascade Reaction Giving Quaternary Amino Succinimides by 1,4-Addition and a Nef-Type Reaction

(2013) Manuel Weber et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

(2013) Christopher K. Prier et al.   CHEMICAL REVIEWS

Flow chemistry syntheses of natural products

(2013) Julio C. Pastre et al.   CHEMICAL SOCIETY REVIEWS

1,3-Dinitro Alkanes: An Emerging Class of Bidentate Compounds

(2013) Roberto Ballini et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Unusual reactions mediated by FMN-dependent ene- and nitro-reductases

(2013) Katharina Durchschein et al.   GREEN CHEMISTRY

Bifunctional Iminophosphorane Organocatalysts for Enantioselective Synthesis: Application to the Ketimine Nitro-Mannich Reaction

(2013) Marta G. Núñez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nitration of Silyl Allenes To Form Functionalized Nitroalkenes

(2013) Venkata R. Sabbasani et al.   ORGANIC LETTERS

New Approach to Oximes through Reduction of Nitro Compounds Enabled by Visible Light Photoredox Catalysis

(2013) Shunyou Cai et al.   ORGANIC LETTERS

A Mild Multistep Conversion of N-Protected α-Amino Acids into N-Protected β3-Amino Acids Utilizing the Nef Reaction

(2013) Andrew Hughes et al.   SYNLETT

Henry–Nef reaction: a practical and versatile chiral pool route to 2-substituted pyrrolidine and piperidine alkaloids

(2013) Chinmay Bhat et al.   TETRAHEDRON

Enantioselective Grignard addition to nitroolefin

(2013) Prashanth Reddy et al.   TETRAHEDRON LETTERS

A Concise Stereocontrolled Total Synthesis of (±)-Stemoamide

(2013) Zhengnian Li et al.   Asian Journal of Organic Chemistry

Divergent Process for C10, C11and C12ω-Amino Acid and α,ω-Dicarboxylic Acid Monomers of Polyamides from Castor Oil as a Renewable Resource

(2012) Moo-Hyun Koh et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Reaction of nitroalkanes with polyfluoroaromatic compounds

(2012) R. Vaidyanathaswamy et al.   JOURNAL OF FLUORINE CHEMISTRY

Nitroalkenes as Carbonyl Surrogates in Arylmethyl-homoallylic Alcohol Forming One-Pot Allylation Reactions in Water

(2012) Mei-Huey Lin et al.   JOURNAL OF ORGANIC CHEMISTRY

2-Aryl-2-nitroacetates as Central Precursors to Aryl Nitromethanes, α-Ketoesters, and α-Amino Acids

(2012) Alison E. Metz et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of Manzamine A and Related Alkaloids

(2012) Pavol Jakubec et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of α-Oxy Amides via Umpolung Amide Synthesis

(2012) Matthew W. Leighty et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones

(2012) Eleonora D. Ilieva et al.   MOLECULES

A one-pot sequence for the efficient synthesis of highly functionalized macrocarbocycles or bridged 2,8-dioxabicyclo[3.2.1]octanes from 1-nitrobicyclic compounds

(2012) Giorgio Giorgi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Palladium-Catalyzed Nitromethylation of Aryl Halides: An Orthogonal Formylation Equivalent

(2012) Ryan R. Walvoord et al.   ORGANIC LETTERS

Highly Enantioselective Nitro-Mannich Reaction Catalyzed by Cinchona Alkaloids and N-Benzotriazole Derived Ammonium Salts

(2012) Yu Wei et al.   ORGANIC LETTERS

Diverse alkaloid-like structures from a common building block

(2012) Dane A. Goff   TETRAHEDRON

CuCN catalyzed one pot synthesis of γ-keto diesters: domino double Michael addition followed by Nef reaction

(2012) Saleem Farooq et al.   TETRAHEDRON LETTERS

Novel condensations of nitroacetic esters with aromatic aldehydes leading to 5-hydroxy-1,2-oxazin-6-ones

(2012) Mikhail S. Baranov et al.   TETRAHEDRON LETTERS

A Site-Saturated Mutagenesis Study of Pentaerythritol Tetranitrate Reductase Reveals that Residues 181 and 184 Influence Ligand Binding, Stereochemistry and Reactivity

(2011) Helen S. Toogood et al.   CHEMBIOCHEM

Sequential Continuous Flow Processes for the Oxidation of Amines and Azides by using HOF⋅MeCN

(2011) Christopher B. McPake et al.   ChemSusChem

Highly Enantioselective Synthesis of Orthogonally Protected (2S)-2,3-Diaminopropanoates through Catalytic Phase-Transfer Aza-Henry Reaction

(2011) Gullapalli Kumaraswamy et al.   HELVETICA CHIMICA ACTA

Reductive biotransformation of nitroalkenes via nitroso-intermediates to oxazetes catalyzed by xenobiotic reductase A (XenA)

(2011) Katharina Durchschein et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Total Synthesis of Echinopines A and B: Exploiting a Bioinspired Late-Stage Intramolecular Cyclopropanation

(2011) Philippe A. Peixoto et al.   ORGANIC LETTERS

Enantioselective Palladium-Catalyzed [3 + 2] Cycloadditions of Trimethylenemethane with Nitroalkenes

(2011) Barry M. Trost et al.   ORGANIC LETTERS

Highly Enantioselective One-Pot Synthesis of Spirocyclopentaneoxindoles Containing the Oxime Group by Organocatalyzed Michael Addition/ISOC/Fragmentation Sequence

(2011) Xiang Li et al.   ORGANIC LETTERS

Multijet Oscillating Disc Millireactor: A Novel Approach for Continuous Flow Organic Synthesis

(2011) Lucia Liguori et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Ring Opening Reactions of 3-Phosphonocoumarin Under Michael Reaction Conditions

(2011) Eleonora D. Ilieva et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Discovery of competing anaerobic and aerobic pathways in umpolung amide synthesis allows for site-selective amide 18O-labeling

(2011) J. P. Shackleford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stereoselective Synthesis and Characterization of (Z)-(−)-4-(1′-Alkoxyl-1′-alkyloxycarbonyl-methylidene)-5(R)-[(1R)-menthyloxy]-γ-butyrolactones

(2011) Zhiqiang Feng et al.   SYNTHETIC COMMUNICATIONS

Synthesis of (−)-hygrine, (−)-norhygrine, (−)-pseudohygroline and (−)-hygroline via Nef reaction

(2011) Chinmay Bhat et al.   TETRAHEDRON LETTERS

Synthesis of β-Trifluoromethylated Δ1-Pyrrolines

(2010) Olivier Marrec et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of Poly-Substituted Phenolds from Baylis-Hillman Adducts and 1,3-Dinitroalkanes

(2010)   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

One-pot asymmetric cyclocarbohydroxylation sequence for the enantioselective synthesis of functionalised cyclopentanes

(2010) Wilfried Raimondi et al.   CHEMICAL COMMUNICATIONS

Chemistry around imidazopyrazine and ibuprofen: Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors

(2010) Frédéric De Wael et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure–activity relationship study

(2010) Bang-Le Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The flavoprotein-catalyzed reduction of aliphatic nitro-compounds represents a biocatalytic equivalent to the Nef-reaction

(2010) Katharina Durchschein et al.   GREEN CHEMISTRY

Formation of γ-Oxoacids and 1H-Pyrrol-2(5H)-ones from α,β-Unsaturated Ketones and Ethyl Nitroacetate

(2010) Maialen Aginagalde et al.   JOURNAL OF ORGANIC CHEMISTRY

Umpolung reactivity in amide and peptide synthesis

(2010) Bo Shen et al.   NATURE

Organosilicon-mediated total synthesis of the triquinane sesquiterpenes (±)-β-isocomene and (±)-isocomene

(2010) Arndt W. Schmidt et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rauhut–Currier type homo- and heterocouplings involving nitroalkenes and nitrodienes

(2010) Pramod Shanbhag et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

KMnO4-Mediated Oxidation as a Continuous Flow Process

(2010) Jörg Sedelmeier et al.   ORGANIC LETTERS

Mild Oxidative Conversion of Nitroalkanes into Carbonyl Compounds in Ionic Liquids

(2010) Olga Bortolini et al.   SYNTHETIC COMMUNICATIONS

Total Synthesis of (±)-Armepavines and (±)-Nuciferines From (2-Nitroethenyl)benzene Derivatives

(2010) Chia-Fu Chang et al.   SYNTHETIC COMMUNICATIONS

Esterase-mediated synthesis of optically active GABA analogues containing a stereogenic all-carbon quaternary carbon atom

(2010) Fulvia Felluga et al.   TETRAHEDRON-ASYMMETRY

Nitrolaldol reaction of (R)-2,3-cyclohexylideneglyceraldehyde: a simple and stereoselective synthesis of the cytotoxic Pachastrissamine (Jaspine B)

(2010) Prasad Vichare et al.   TETRAHEDRON-ASYMMETRY

Michael Addition Initiated Carbocyclization Sequences with Nitroolefins for the Stereoselective Synthesis of Functionalized Heterocyclic and Carbocyclic Systems

(2009) Estelle Dumez et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of 15-Cyano-12-oxopentadecano-15-lactone and 15-Cyano- 12-oxopentadecano-15-lactam

(2009) Peng Wu et al.   HELVETICA CHIMICA ACTA

Diastereoselective Synthesis of 2,3,6-Trisubstituted Piperidines

(2009) John M. Humphrey et al.   JOURNAL OF ORGANIC CHEMISTRY

AuBr3-Catalyzed Thiooxime-to-Carbonyl Conversion: From Chiral Aliphatic Nitro Compounds to Ketones without Racemization

(2009) Jordi Burés et al.   ORGANIC LETTERS

An Efficient Synthesis of β,γ -Disubstituted α -Diethoxyphosphoryl-γ -lactones: A Convenient Approach to α -Methylene-γ -lactones

(2009) Henryk Krawczyk et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

One step from nitro to oxime: a convenient preparation of unsaturated oximes by the reduction of the corresponding vinylnitro compounds

(2009) Kewei Wang et al.   TETRAHEDRON

A formal synthesis to (+)-nephrosteranic acid from chiral nitroalkyl derivatives

(2009) Cleber B. Barreto et al.   TETRAHEDRON LETTERS

A modular and organocatalytic approach to γ-butyrolactone autoregulators from Streptomycetes

(2008) Petteri Elsner et al.   CHEMICAL COMMUNICATIONS

A diastereo- and enantioselective synthesis of α-substituted anti-α,β-diaminophosphonic acid derivatives

(2008) Jeremy C. Wilt et al.   CHEMICAL COMMUNICATIONS

Stereoselective and Efficient Total Synthesis of Optically Active Tetrodotoxin fromd-Glucose

(2008) Ken-ichi Sato et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoselective Alkylations of Chiral Nitro Imine and Nitro Hydrazone Dianions. Synthesis of Enantiomerically Enriched 3-Substituted 1-Nitrocyclohexenes†

(2008) Scott E. Denmark* et al.   JOURNAL OF ORGANIC CHEMISTRY

A General One-Step Synthesis of β-Nitronitriles

(2008) James C. Anderson et al.   ORGANIC LETTERS

Development of a Practical Route for the Manufacture ofN-[5-(3-Imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]acetamide

(2008) Hans Hirt et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Reação entre fenilnitrometanos e enoato derivado do D-manitol na presença de TBAF ou DBU: adição conjugada sin-seletiva e reação de NEF consecutiva

(2008) Ayres G. Dias et al.   QUIMICA NOVA

A total synthesis of (±)-frondosins A and B

(2008) Goverdhan Mehta et al.   TETRAHEDRON LETTERS

Direct conversion of 1-deoxy-1-nitroalditols to methyl glycofuranosides

(2008) M. Vojtech et al.   TETRAHEDRON LETTERS

Mn(III)-based radical addition reactions of 2-nitroindole with activated CH compounds

(2008) Dmitry A. Androsov et al.   TETRAHEDRON LETTERS

A facile chemoenzymatic approach to chiral non-racemic β-alkyl-γ-amino acids and 2-alkylsuccinic acids. A concise synthesis of (S)-(+)-Pregabalin

(2008) Fulvia Felluga et al.   TETRAHEDRON-ASYMMETRY

Catalytic, PMe3-mediated conversion of secondary nitroalkanes to ketones: a very mild Nef-type process

(2007) Jordi Burés et al.   TETRAHEDRON LETTERS