Urothelial ATP signaling: what is its role in bladder sensation?

Receptors, channels and signalling in the urothelial sensory system in the bladder

(2016) Liana Merrill et al.   Nature Reviews Urology

Detrusor underactivity and the underactive bladder: Symptoms, function, cause-what do we mean? ICI-RS think tank 2014

(2016) Phillip P. Smith et al.   NEUROUROLOGY AND URODYNAMICS

Authentic role of ATP signaling in micturition reflex

(2016) Kentaro Takezawa et al.   Scientific Reports

Pannexin 1 channels mediate the release of ATP into the lumen of the rat urinary bladder

(2015) Jonathan M. Beckel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male rats

(2014) Liana Merrill et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Functional Role for Piezo1 in Stretch-evoked Ca2+Influx and ATP Release in Urothelial Cell Cultures

(2014) Tatsuya Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Role of CXCR2 and TRPV1 in functional, inflammatory and behavioural changes in the rat model of cyclophosphamide-induced haemorrhagic cystitis

(2013) Fabiana N Dornelles et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRP channels in lower urinary tract dysfunction

(2013) J Franken et al.   BRITISH JOURNAL OF PHARMACOLOGY

An Updated Systematic Review and Statistical Comparison of Standardised Mean Outcomes for the Use of Botulinum Toxin in the Management of Lower Urinary Tract Disorders

(2013) Altaf Mangera et al.   EUROPEAN UROLOGY

Urothelial Signaling

(2013) Lori Birder et al.   PHYSIOLOGICAL REVIEWS

Alteration in TRPV1 and Muscarinic (M3) receptor expression and function in idiopathic overactive bladder urothelial cells

(2012) L. A. Birder et al.   Acta Physiologica

Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers

(2012) Bérengère Fromy et al.   NATURE MEDICINE

Intravesical treatments of bladder pain syndrome/interstitial cystitis

(2012) Jochen Neuhaus et al.   Nature Reviews Urology

Anticholinergic Therapy vs. OnabotulinumtoxinA for Urgency Urinary Incontinence

(2012) Anthony G. Visco et al.   NEW ENGLAND JOURNAL OF MEDICINE

Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm

(2012) Hiromitsu Negoro et al.   Nature Communications

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

(2010) W. Everaerts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Release of Adenosine Triphosphate from the Urothelium of Human Bladders with Detrusor Overactivity, Both Neurogenic and Idiopathic

(2009) Vivek Kumar et al.   EUROPEAN UROLOGY

The TRPV4 Cation Channel Mediates Stretch-evoked Ca2+Influx and ATP Release in Primary Urothelial Cell Cultures

(2009) Tsutomu Mochizuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronic acid ameliorates bladder hyperactivity via the inhibition of H2O2-enhanced purinergic and muscarinic signaling in the rat

(2009) Chung-Hsin Yeh et al.   NEUROUROLOGY AND URODYNAMICS

Persistence of antimuscarinic drug use

(2008) Søren Brostrøm et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Activation of Muscarinic Receptors in Rat Bladder Sensory Pathways Alters Reflex Bladder Activity

(2008) F. A. Kullmann et al.   JOURNAL OF NEUROSCIENCE

GRC-6211, a New Oral Specific TRPV1 Antagonist, Decreases Bladder Overactivity and Noxious Bladder Input in Cystitis Animal Models

(2008) Ana Charrua et al.   JOURNAL OF UROLOGY

The neural control of micturition

(2008) Clare J. Fowler et al.   NATURE REVIEWS NEUROSCIENCE

Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice

(2008) Zun-Yi Wang et al.   PAIN