Article
Neurosciences
Rui Zhang, Timothy D. Bryson, Garrett M. Fogo, Jinhui Liao, Sarita Raghunayakula, Jennifer Mathieu, Joseph M. Wider, Xiaodan Ren, Kathleen J. Maheras, Katlynn J. Emaus, Erin Gruley, Yuguo Chen, Robert W. Neumar, Thomas H. Sanderson
Summary: Intramuscular delivery of MgSO4 during CPR rapidly increases serum magnesium concentrations, but has no significant effect on survival or neurologic outcomes.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Shoaib, Rishabh C. Choudhary, Rupesh K. Chillale, Nancy Kim, Santiago J. Miyara, Shabirul Haque, Tai Yin, Maya Frankfurt, Ernesto P. Molmenti, Stavros Zanos, Junhwan Kim, Lance B. Becker
Summary: Cardiac arrest causes severe multiorgan damage, especially brain injury, and metformin may serve as an effective intervention to improve survival, protect mitochondrial function, and mitigate brain damage.
Review
Multidisciplinary Sciences
Alyson Katz, Shari B. Brosnahan, John Papadopoulos, Sam Parnia, Jason Q. Lam
Summary: Cardiac arrest leads to an imbalance between oxygen supply and demand, resulting in various post-arrest events such as excitotoxicity, mitochondrial dysfunction, oxidative stress, and inflammation. Understanding the complex pathophysiology underlying global brain hypoxic ischemia is crucial in developing neuroprotective strategies to reduce secondary neuronal injury and improve outcomes. Pharmacologic agents like memantine, perampanel, and others may have a potential role in mitigating these injurious pathways post-cardiac arrest.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Plant Sciences
Yan Mi, Kun Jiao, Ji-kai Xu, Kun Wei, Jing-yu Liu, Qing-qi Meng, Ting-ting Guo, Xue-ni Zhang, Di Zhou, De-gang Qing, Yu Sun, Ning Li, Yue Hou
Summary: The study explored the effect of kellerin on cerebral ischemia and its possible mechanisms using MCAO model and LPS-activated microglia model. Kellerin improved neurological outcome, reduced brain infarct size, and alleviated neuron damage by inhibiting microglial activation under pathologic conditions of focal cerebral ischemia. In in vitro studies, kellerin protected neuronal cells from damage by suppressing pro-inflammatory cytokines, NF-kappa B signaling pathway, ROS generation, and NADPH oxidase activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Critical Care Medicine
Claudio Sandroni, Tobias Cronberg, Mypinder Sekhon
Summary: PCABI is caused by initial ischaemia and subsequent reperfusion of the brain following resuscitation, leading to coma and being the main cause of mortality and long-term disability in patients admitted to intensive care unit after cardiac arrest.
INTENSIVE CARE MEDICINE
(2021)
Review
Medicine, General & Internal
Rishabh C. Choudhary, Muhammad Shoaib, Samantha Sohnen, Daniel M. Rolston, Daniel Jafari, Santiago J. Miyara, Kei Hayashida, Ernesto P. Molmenti, Junhwan Kim, Lance B. Becker
Summary: Cardiac arrest causes global ischemia-reperfusion injury, leading to tissue damage throughout the body. While current non-pharmacologic therapies like therapeutic hypothermia and extracorporeal cardiopulmonary resuscitation have shown benefits in protecting against brain injury post-CA, their universal implementation is challenging. Preclinical pharmacotherapy for CA has primarily targeted singular pathways and combination therapies have yielded mixed results. Future interventions for CA should aim to target multiple pathways simultaneously to alleviate the various processes involved in brain injury.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Suchan Liao, Ying Luo, Titikorn Chunchai, Kodchanan Singhanat, Busarin Arunsak, Juthipong Benjanuwattra, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: This study reveals that cardiac dysfunction, brain apoptosis, brain inflammation, microglial hyperactivation, and reactive astrogliosis occur following myocardial infarction and ischemia-reperfusion injury. Pretreatment with Z-VAD can attenuate brain apoptosis, reduce brain inflammation, suppress microglial and astrocytic hyperactivation and proliferation, and improve cardiac function, suggesting its neuroprotective effects against cardiac I/R injury.
INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Hoai T. Ton, Katherine Raffensperger, Michael Shoykhet
Summary: The study established a rat model of prolonged pediatric asphyxial cardiac arrest to investigate microglial activation and neuronal degeneration in the thalamus after resuscitation. Results showed that injury severity increased with longer arrest durations, with prominent effects observed in the thalamic Reticular Nucleus (nRT). Hypothermia did not prevent nRT injury, revealing selective vulnerability of certain GABA-ergic neurons to hypoxic-ischemic injury.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Jing Wu, Zhen Fan, Yuxing Zhao, Qiunan Chen, Qian Xiao
Summary: Research has shown that under diabetic conditions, hippocampal injury and cognitive decline are often accompanied by upregulation of sEH. Using an sEH inhibitor can prevent cognitive dysfunction and restore synaptic plasticity in the hippocampus.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Anesthesiology
Tison Schoenthal, Ryan Hoiland, Donald E. Griesdale, Mypinder S. Sekhon
Summary: Hypoxic ischemic brain injury (HIBI) following cardiac arrest is the primary determinant of adverse outcomes. The pathophysiology of HIBI can be divided into primary and secondary injury, with a focus on optimizing cerebral oxygen delivery to prevent further damage. Current studies on manipulating arterial carbon dioxide tension and mean arterial pressure augmentation have shown no improvement in clinical outcomes. Patient-specific phenotypes may play a role in personalizing care for HIBI patients.
MINERVA ANESTESIOLOGICA
(2023)
Article
Critical Care Medicine
Ran Li, Yuntian Shen, Xuan Li, Liping Lu, Zhuoran Wang, Huaxin Sheng, Ulrike Hoffmann, Wei Yang
Summary: The study demonstrates that activation of the XBP1 UPR branch in the post-cardiac arrest brain has neuroprotective effects, indicating a promising target for cardiac arrest therapy.
Article
Critical Care Medicine
Filippo Annoni, Fuhong Su, Lorenzo Peluso, Ilaria Lisi, Enrico Caruso, Francesca Pischiutta, Elisa Gouvea Bogossian, Bruno Garcia, Hassane Njimi, Jean-Louis Vincent, Nicolas Gaspard, Lorenzo Ferlini, Jacques Creteur, Elisa R. R. Zanier, Fabio Silvio Taccone
Summary: Prognosis after resuscitation from cardiac arrest (CA) is poor, but hypertonic sodium lactate (HSL) infusion may have beneficial effects on brain and cardiac injury. This study aimed to test the effects of HSL infusion in an experimental model of CA.
Review
Pharmacology & Pharmacy
Jose Martinez-Orgado, Maria Villa, Aaron del Pozo
Summary: CBD shows neuroprotective effects in newborn pigs and rodents with HIBI, modulating the major components of HIBI pathophysiology. It has the potential to be an effective treatment for neonatal HIBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Ana M. Najar, Marina Romero-Bernal, Carmen del Rio, Joan Montaner
Summary: There is a growing interest in consuming halophytes as a healthy food. Salicornia ramosissima is a Mediterranean halophyte with a rich profile of bioactive compounds, including over 60 identified polyphenols with various biological activities. These polyphenols have shown potential protective effects against brain ischemia, mainly through reducing oxidative stress and inflammation, inhibiting cell death pathways, and preserving vascular function. Although most of these compounds have been found to be neuroprotective, human studies on their effects are still limited. Considering the safe profile of polyphenols in S. ramosissima, this halophyte could be a valuable source of bioactive compounds for the nutraceutical industry.
Review
Pharmacology & Pharmacy
Lalita Subedi, Bhakta Prasad Gaire
Summary: The search for novel therapeutic agents for cerebral ischemia/stroke has led to a focus on neuroprotective phytochemicals with anti-inflammatory properties as potential drug candidates. Studies have shown that these compounds reduce brain inflammation by decreasing proinflammatory microglia and macrophages while promoting anti-inflammatory responses, leading to improved outcomes in animal stroke models.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Critical Care Medicine
Shin Nakayama, Elton Migliati, Mahmood Amiry-Moghaddam, Ole P. Ottersen, Anish Bhardwaj
CRITICAL CARE MEDICINE
(2016)
Article
Critical Care Medicine
Shin Nakayama, Mahmood Amiry-Moghaddam, Ole Petter Ottersen, Anish Bhardwaj
NEUROCRITICAL CARE
(2016)
Article
Critical Care Medicine
Shin Nakayama, Noriko Taguchi, Yumi Isaka, Takako Nakamura, Makoto Tanaka
NEUROCRITICAL CARE
(2018)
Article
Critical Care Medicine
Shin Nakayama, Noriko Taguchi, Makoto Tanaka
THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT
(2018)
Article
Endocrinology & Metabolism
Jia Jia, Saurabh Verma, Shin Nakayama, Nidia Quillinan, Marjorie R. Grafe, Patricia D. Hurn, Paco S. Herson
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2011)
Article
Biochemistry & Molecular Biology
S. Nakayama, R. Vest, R. J. Traystman, P. S. Herson
JOURNAL OF MOLECULAR NEUROSCIENCE
(2013)
Article
Critical Care Medicine
Xiaoqin Liu, Shin Nakayama, Mahmood Amiry-Moghaddam, Ole Petter Ottersen, Anish Bhardwaj
NEUROCRITICAL CARE
(2010)
Article
Critical Care Medicine
Noriko Taguchi, Shin Nakayama, Makoto Tanaka
Article
Critical Care Medicine
Shin Nakayama, Noriko Taguchi, Yumi Isaka, Takako Nakamura, Makoto Tanaka
NEUROCRITICAL CARE
(2020)