Article
Neurosciences
Carol A. Gianessi, Stephanie M. Groman, Jane R. Taylor
Summary: Emerging data suggest that endocannabinoid signaling is crucial for habitual behavior formation, and inhibiting FAAH and MAGL disrupts habit formation while AM251 exposure affects response rates. Further studies are needed to clarify the role of CB1R signaling in habitual responding and the potential clinical utility of augmenting endocannabinoids.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Stewart Ramsay, Nick J. Spencer, Vladimir Zagorodnyuk
Summary: The aim of this study is to determine the role of endocannabinoids, anandamide (AEA) and 2-arachidonolylglycerol (2-AG), in regulating mechanosensitivity of probable nociceptive neurons innervating the bladder - capsaicin-sensitive mucosal afferents. The results showed that AEA potentiated the mechanical response of mucosal afferents, while 2-AG inhibited their response. These findings have important implications for understanding the role of endocannabinoids in regulating bladder sensation and function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Alex Straiker, Michaela Dvorakova, Taryn Bosquez-Berger, Jaroslav Blahos, Ken Mackie
Summary: Autaptic hippocampal neurons are a simple model for studying neurotransmission and cannabinoid signaling. Through our research, we have discovered interesting negative findings in these neurons, which we hope will benefit other laboratories and lead to discussions on their relevance and significance.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Mohammad Bashashati, Emma Leishman, Heather Bradshaw, Solmaz Sigaroodi, Eric Tatro, Tamis Bright, Richard McCallum, Irene Sarosiek
Summary: The study revealed that endocannabinoids and cannabimimetic fatty acid derivatives are reduced in female patients with diabetic gastroparesis, potentially contributing to symptom development in these subjects. No similar changes were observed in male patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Psychiatry
S. Alisha Epps
Summary: Depression and epilepsy show bidirectional comorbidity, and exploring the endocannabinoid system may lead to more effective treatments for both conditions.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Bashir Bietar, Sophie Tanner, Christian Lehmann
Summary: The endocannabinoid system offers a promising avenue for therapeutic interventions, but the presence of cannabinoid receptors in various organs and tissues can complicate targeted treatments. Injuries to the central nervous system can induce neuroinflammation and potentially affect the immune system. Exploring immunomodulatory therapies provides a hopeful alternative in the face of challenges in traditional preventive treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Hailey Cuddihey, Wallace K. MacNaughton, Keith A. Sharkey
Summary: This review illustrates the role of the endocannabinoid system in regulating intestinal homeostasis, including the regulation of intestinal permeability, fluid secretion, and immune regulation. It also emphasizes the reciprocal regulation between the endocannabinoid system and the gut microbiome.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Neurosciences
Christopher Martinez-Aguirre, Resat Cinar, Luisa Rocha
Summary: Epilepsy is a common neurological disorder worldwide. Recent studies have shown that the use of cannabinoids and activation of the endocannabinoid system (ECS) can be a therapeutic strategy for controlling epilepsy. However, there are controversial findings regarding the effects of ECS activation.
Article
Cell Biology
Anne-Sophie Archambault, Francesco Tinto, Elizabeth Dumais, Volatiana Rakotoarivelo, Magdalena Kostrzewa, Pier-Luc Plante, Cyril Martin, Melissa Simard, Cristoforo Silvestri, Roxane Pouliot, Michel Laviolette, Louis-Philippe Boulet, Rosa Maria Vitale, Alessia Ligresti, Vincenzo Di Marzo, Nicolas Flamand
Summary: Endocannabinoids 2-arachidonoyl-glycerol and N-arachidonoyl-ethanolamine are lipids that regulate various physiological processes, including inflammation, and are being studied as potential anti-inflammatory agents. Human eosinophils and neutrophils have been found to metabolize 1-linoleoyl-glycerol (1-LG) and N-linoleoyl-ethanolamine (LEA) into novel endogenous 15-lipoxygenase metabolites 13-HODE-G and 13-HODE-EA, although the biological significance of these metabolites is not yet fully understood.
Article
Neurosciences
Alba Huerga-Gomez, Tania Aguado, Anibal Sanchez-de la Torre, Ana Bernal-Chico, Carlos Matute, Susana Mato, Manuel Guzman, Ismael Galve-Roperh, Javier Palazuelos
Summary: This study demonstrates that acute THC administration in early postnatal mice enhances OL development and CNS myelination by promoting oligodendrocyte precursor cell cycle exit and differentiation, which is mediated by CB1 and CB2 cannabinoid receptors and relies on the activation of the mTORC1 signaling pathway.
Review
Biology
Giulia Abate, Daniela Uberti, Simone Tambaro
Summary: This paper summarizes the potential and limitations of cannabinoids as therapeutics for AD, focusing on recent pre-clinical and clinical evidence. AD is a detrimental brain disorder characterized by cognitive decline and neuronal deterioration, with current treatments effective only in the early stages. Emerging research shows promising effects of cannabinoids in reducing amyloid plaque deposition and stimulating hippocampal neurogenesis in AD rodent models.
Article
Neurosciences
Philippe De Deurwaerdere, Maurizio Casarrubea, Daniel Cassar, Manuela Radic, Emilie Puginier, Abdeslam Chagraoui, Giuseppe Crescimanno, Vincenzo Crunelli, Giuseppe Di Giovanni
Summary: Childhood absence epilepsy is often accompanied by neuropsychological comorbidities such as anxiety. This study found that the synthetic cannabinoid receptor agonist WIN 55,212-2 had strain-dependent effects on anxiety-like and motor behavior in rats with absence epilepsy. The study also revealed alterations in cerebral monoaminergic levels in these rats, suggesting a role of endocannabinoids and monoamines in the comorbidities.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Almudena Robledo-Menendez, Maria Vella, Pedro Grandes, Edgar Soria-Gomez
Summary: Hippocampal circuits play a crucial role in cognitive performance and are deeply affected in pathological conditions. Cannabinoid receptors regulate different cell types within hippocampal circuitries. Understanding the precise mechanisms triggered by cannabinoid receptor activation at a cellular and subcellular level helps in grasping hippocampal pathophysiological states.
Review
Pharmacology & Pharmacy
Kenneth B. Walsh, Amanda E. McKinney, Andrea E. Holmes
Summary: The medicinal use of cannabis has a long history, with recent breakthroughs in understanding the pharmacology of minor cannabinoids showing potential therapeutic benefits in the treatment of various conditions. Although studies demonstrate their agonist and antagonist activities at multiple targets, further research is needed to fully understand their pharmacological mechanisms.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dor Danan, Doron Todder, Joseph Zohar, Hagit Cohen
Summary: Endocannabinoids play a crucial role in response to stress and regulating the release of glucocorticoids, potentially contributing to the development of post-traumatic-stress-disorder (PTSD). Research shows elevated levels of 2-AG in the CSF of PTSD-phenotype rats, inversely correlated with corticosterone levels, and reduced levels of endocannabinoids in the hippocampus and hypothalamus in the PTSD-phenotype group, indicating a potential mechanism for PTSD symptomology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Chong Qiao, Kewu Bai, Meng Xu, Songyou Wang, Cai-Zhuang Wang, Kai-Ming Ho, Xiangshui Miao, Ming Xu
Summary: The study investigates the pressure-driven rapid crystallization behavior of amorphous Ge15Sb85 (a-GS), revealing the fluctuations and competitions between short-range order (SRO) and medium-range order (MRO) in a-GS under different pressures, and discloses the rapid phase transition mechanism under pressure.
Article
Physics, Atomic, Molecular & Chemical
Yu Ji, Shao-yun Wang, Chao-hui Tong
Summary: The study highlights the importance of charge fraction of grafted star chains and salt concentration in competitive adsorption of charged monomers and trivalent salt coions on the electrode. At high charge fraction, charged monomers dominate the adsorption, while at low charge fraction, trivalent salt coions have stronger affinity for the electrode.
CHINESE JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Chemistry, Physical
Xudan Zhu, Junbo He, Rongjun Zhang, Chunxiao Cong, Yuxiang Zheng, Hao Zhang, Songyou Wang, Haibin Zhao, Meiping Zhu, Shanwen Zhang, Shaojuan Li, Liangyao Chen
Summary: The research demonstrates that inserting 1L-hBN can slightly block the interlayer electron transfer from the WS2 layer to the MoS2 layer, while weakening the interlayer coupling effect by releasing quantum confinement and reducing efficient dielectric screening. This results in a blueshift of exciton binding energies in WS2/hBN/MoS2 heterostructures, while the quasi-particle bandgap remains unchanged.
Article
Chemistry, Physical
Jinjin Wang, Hong Shen, Riyi Yang, Kun Xie, Chao Zhang, Liangyao Chen, Kai-Ming Ho, Cai-Zhuang Wang, Songyou Wang
Summary: Interatomic potentials based on neural-network machine learning method have been widely studied for their ability to balance accuracy and efficiency. A neural-network potential for carbon was developed in this study, which accurately predicts various properties of carbon structures and offers a promising tool for fast and cost-effective atomistic simulations.
Article
Physics, Condensed Matter
Kun Xie, Chong Qiao, Hong Shen, Riyi Yang, Ming Xu, Chao Zhang, Yuxiang Zheng, Rongjun Zhang, Liangyao Chen, Kai-Ming Ho, Cai-Zhuang Wang, Songyou Wang
Summary: A deep neural network potential of Zr-Rh system is developed using machine learning, which improves the accuracy and efficiency of molecular dynamics simulations and lays a foundation for exploring the complex structures in amorphous Zr77Rh23.
JOURNAL OF PHYSICS-CONDENSED MATTER
(2022)
Article
Physics, Multidisciplinary
Riyi Yang, Yu-Yo Chen, Yanrong Guo, Hong Shen, Songyou Wang, Yu Jia, Wan-Sheng Su
Summary: This study investigates the effect of uniaxial strain on the electronic properties of alpha-Te nanotubes (NTs) using first-principles calculations. The results show that the atomic structure of alpha-Te NTs remains stable under +/- 10% strain, demonstrating good flexibility. Increasing strain leads to a decrease in the band gap, with armchair (5, 5) alpha-Te NTs experiencing a semiconductor-metal transition. The valence band maximum and conduction band minimum charge density affect the type of band gap in the NTs, and strain can significantly modulate the optical properties. Understanding the electronic and optical properties of alpha-Te NTs under strain modulation is important for future optoelectronic applications.
NEW JOURNAL OF PHYSICS
(2022)
Article
Materials Science, Multidisciplinary
Zhi-Yuan Yu, Yu-Chen Zhang, Shuai Li, Xi-Yuan Dai, Xia-Yan Xue, Hong Shen, Song -You Wang, Ming Lu
Summary: A synergistic approach of interface engineering is reported to efficiently improve the performance of silicon nanocrystal light-emitting diode (Si-NC LED). This method can significantly increase the brightness of the LED by improving charge injection and transport, and controlling the radiative recombination of the injected charges.
Article
Materials Science, Multidisciplinary
Zhi-Yu Yu, Zhi-He Guo, Yu-Chen Zhang, Xun Zhang, Yan Wang, Feng-Yang Ma, Yu Liu, Xia-Yan Xue, Qing-Yuan Jin, Jing Li, Jian Sun, Song-You Wang, Dong-Chen Wang, Ming Lu
Summary: A luminescent Si nanocrystal thin film with high photoluminescence quantum yield was successfully fabricated, achieving a net optical gain structure and threshold behavior under optical pumping. Various laser characteristics were observed, such as spectral narrowing, polarization, and small emission angles.
RESULTS IN PHYSICS
(2022)
Article
Nanoscience & Nanotechnology
Rongchuan Gu, Meng Xu, Chong Qiao, Cai-Zhuang Wang, Kai-Ming Ho, Songyou Wang, Ming Xu, Xiangshui Miao
Summary: Arsenic doping affects the structure and dynamic properties of a-GeAsSe, resulting in higher stability and more disordered configuration. These research findings provide insights for the design and application of OTS materials.
SCRIPTA MATERIALIA
(2022)
Article
Physics, Applied
Junbo He, Cheng Chen, Weiming Liu, Xudan Zhu, Yuxiang Zheng, Songyou Wang, Liangyao Chen, Rongjun Zhang
Summary: In this study, we enhanced the light absorption of layered PtSe2 by engineering the optical impedance and the attenuation of the PtSe2-based metal-insulator-metal absorber. For a monolayer PtSe2-based absorber, near-perfect absorption (99.95%) was achieved by compensating the impedance mismatch with a top patterned metal array, leading to 8.6 times enhancement of absorption in the visible spectra. Few-layer PtSe2-based absorbers showed broadband absorption, insensitive to incident angle and polarization, due to the modulation of the self-impedance of the PtSe2 layer. These findings improve the feasibility of PtSe2-based optoelectronic and photonic devices and provide insights for absorber design with hybrid 2D materials.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Meng Xu, Qundao Xu, Rongchuan Gu, Songyou Wang, Cai-Zhuang Wang, Kai-Ming Ho, Zhongrui Wang, Ming Xu, Xiangshui Miao
Summary: It is discovered that a large fraction of over-coordinated clusters fails to generate mid-gap states, which are probably caused by hypervalent bonding, a multi-centered covalent bond participated by delocalized lone-pair electrons. In practical applications, compatible dopants can be used to change the number of hypervalent bonds, thus controlling the number of mid-gap states and consequently the performance of PCM and OTS materials. These results reveal the origin of mid-gap states in chalcogenide glasses, enabling extensive control in the development of pioneering electrical switching materials.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Physics, Applied
Chong Qiao, Shengzhao Wang, Lanli Chen, Bin Liu, Shouyan Bai, Rongchuan Gu, Songyou Wang, Cai-Zhuang Wang, Kai-Ming Ho, Xiangshui Miao, Ming Xu
Summary: This study investigates the structure and electronic characteristics of amorphous GeS using ab initio molecular dynamics simulations. The results reveal that amorphous GeS is mainly composed of Ge-S bonds, with Ge- and S-centered clusters predominantly in the form of octahedral structures in liquid GeS. During the amorphization process, most Ge-centered clusters become highly coordinated octahedrons or tetrahedrons, while S-centered clusters gradually deviate from the octahedral structure. These structural features result in a high switching voltage in amorphous GeS.
APPLIED PHYSICS LETTERS
(2023)
Article
Nanoscience & Nanotechnology
Li Wu, Liang Yu, Xiyuan Dai, Fengyang Ma, Songyou Wang, Ming Lu, Jian Sun
Summary: A bulk defect-mediated absorption sub-bandgap all-Si photodetector with low dark current and high detectivity was developed. The introduction of passivating and blocking layers significantly reduced the dark current while achieving high specific detectivity. The optimized device demonstrated promising applications in low-light-level, NIR detection and imaging.
Article
Chemistry, Physical
Hong Shen, Riyi Yang, Jian Zhou, Zhiyuan Yu, Ming Lu, Yuxiang Zheng, Rongjun Zhang, Liangyao Chen, Wan-Sheng Su, Songyou Wang
Summary: This study utilizes the particle swarm optimization algorithm to design direct-band Si-Ge alloys, and through calculations and simulations, it is found that these structures are stable in terms of dynamics, thermodynamics, and mechanics. They exhibit semiconductor behavior and show variations in carrier transportation and scattering processes. Three direct-band materials are identified, which have the potential to be used in high-efficiency emitters or solar cells.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Optics
Sun Xiao-Jie, Gao Meng-Yu, Zheng Yu-Xiang, Zhang Rong-Jun, Wang Song-You, Li Jing, Chen Liang-Yao
Summary: The paper reviews the history, principles, structures and materials of radiative cooling, introduces the design, preparation and characterization methods, as well as application fields, and proposes the future of radiative cooling materials and technology.
JOURNAL OF INFRARED AND MILLIMETER WAVES
(2022)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
