Repeated Social Defeat, Neuroinflammation and Behavior: Monocytes Carry the Signal

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

(2016) Masaaki Iwata et al.   BIOLOGICAL PSYCHIATRY

Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat

(2016) Daniel B. McKim et al.   BIOLOGICAL PSYCHIATRY

GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations

(2016) Karol Ramirez et al.   BRAIN BEHAVIOR AND IMMUNITY

The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome

(2016) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat

(2016) Daniel B. McKim et al.   JOURNAL OF NEUROSCIENCE

Molecular mechanisms of repeated social defeat-induced glucocorticoid resistance: Role of microRNA

(2015) Seung Ho Jung et al.   BRAIN BEHAVIOR AND IMMUNITY

Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance

(2015) Karol Ramirez et al.   BRAIN BEHAVIOR AND IMMUNITY

Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming

(2015) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells

(2015) Simon J. O’Carroll et al.   Journal of Neuroinflammation

Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome

(2015) M. D. Weber et al.   JOURNAL OF NEUROSCIENCE

DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury

(2015) A. Liesz et al.   JOURNAL OF NEUROSCIENCE

Resolving the neural circuits of anxiety

(2015) Gwendolyn G Calhoon et al.   NATURE NEUROSCIENCE

Neuroimmune mechanisms of depression

(2015) Georgia E Hodes et al.   NATURE NEUROSCIENCE

Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain

(2015) C.M. Sawicki et al.   NEUROSCIENCE

Peripheral and central effects of repeated social defeat stress: Monocyte trafficking, microglial activation, and anxiety

(2015) B.F. Reader et al.   NEUROSCIENCE

Prior chronic stress induces persistent polyI:C-induced allodynia and depressive-like behavior in rats: Possible involvement of glucocorticoids and microglia

(2015) Takeharu Chijiwa et al.   PHYSIOLOGY & BEHAVIOR

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

An Efficient Chronic Unpredictable Stress Protocol to Induce Stress-Related Responses in C57BL/6 Mice

(2015) Susana Monteiro et al.   Frontiers in Psychiatry

Inflammatory dysregulation of blood monocytes in Parkinson’s disease patients

(2014) Veselin Grozdanov et al.   ACTA NEUROPATHOLOGICA

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers

(2014) Gregory E. Miller et al.   BRAIN BEHAVIOR AND IMMUNITY

Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides

(2014) Susana G. Torres-Platas et al.   BRAIN BEHAVIOR AND IMMUNITY

Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease

(2014) Diego Gómez-Nicola et al.   GLIA

Knockdown of Interleukin-1 Receptor Type-1 on Endothelial Cells Attenuated Stress-Induced Neuroinflammation and Prevented Anxiety-Like Behavior

(2014) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

CCR2+Ly6Chi Inflammatory Monocyte Recruitment Exacerbates Acute Disability Following Intracerebral Hemorrhage

(2014) M. D. Hammond et al.   JOURNAL OF NEUROSCIENCE

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

Chronic variable stress activates hematopoietic stem cells

(2014) Timo Heidt et al.   NATURE MEDICINE

Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress

(2014) Georgia E. Hodes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Re-establishment of Anxiety in Stress-Sensitized Mice Is Caused by Monocyte Trafficking from the Spleen to the Brain

(2013) Eric S. Wohleb et al.   BIOLOGICAL PSYCHIATRY

Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge

(2013) Michael D. Weber et al.   BRAIN BEHAVIOR AND IMMUNITY

CYTOKINE TARGETS IN THE BRAIN: IMPACT ON NEUROTRANSMITTERS AND NEUROCIRCUITS

(2013) Andrew H. Miller et al.   DEPRESSION AND ANXIETY

Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behavior

(2013) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

(2013) T Kreisel et al.   MOLECULAR PSYCHIATRY

Differential effects of homotypic vs. heterotypic chronic stress regimens on microglial activation in the prefrontal cortex

(2013) Brittany L. Kopp et al.   PHYSIOLOGY & BEHAVIOR

Bone Marrow Cell Recruitment to the Brain in the Absence of Irradiation or Parabiosis Bias

(2013) Katrin Kierdorf et al.   PLoS One

Association Studies of MMP-9 in Parkinson’s Disease and Amyotrophic Lateral Sclerosis

(2013) Xianghua He et al.   PLoS One

Chronic Psychological Stress Induces the Accumulation of Myeloid-Derived Suppressor Cells in Mice

(2013) Jianfeng Jin et al.   PLoS One

Bone Marrow-Derived Microglia Infiltrate into the Paraventricular Nucleus of Chronic Psychological Stress-Loaded Mice

(2013) Koji Ataka et al.   PLoS One

Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via  -adrenergic induction of myelopoiesis

(2013) N. D. Powell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clustering of Depression and Inflammation in Adolescents Previously Exposed to Childhood Adversity

(2012) Gregory E. Miller et al.   BIOLOGICAL PSYCHIATRY

Beta adrenergic blockade decreases the immunomodulatory effects of social disruption stress

(2012) M.L. Hanke et al.   BRAIN BEHAVIOR AND IMMUNITY

Learning, memory, and glial cell changes following recovery from chronic unpredictable stress

(2012) Yanqing Bian et al.   BRAIN RESEARCH BULLETIN

Chronic Stress Induced Remodeling of the Prefrontal Cortex: Structural Re-Organization of Microglia and the Inhibitory Effect of Minocycline

(2012) M. Hinwood et al.   CEREBRAL CORTEX

Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51

(2012) Natalia M. Galigniana et al.   JOURNAL OF NEUROCHEMISTRY

Beta-adrenergic receptor activation primes microglia cytokine production

(2012) John D. Johnson et al.   JOURNAL OF NEUROIMMUNOLOGY

Psychosocial stressors and the prognosis of major depression: a test of Axis IV

(2012) S. E. Gilman et al.   PSYCHOLOGICAL MEDICINE

Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice

(2012) Eric S. Wohleb et al.   PSYCHONEUROENDOCRINOLOGY

Stress-induced redistribution of immune cells—From barracks to boulevards to battlefields: A tale of three hormones – Curt Richter Award Winner

(2012) Firdaus S. Dhabhar et al.   PSYCHONEUROENDOCRINOLOGY

Toll-like receptor (TLR) and inflammasome actions in the central nervous system

(2012) Richa Hanamsagar et al.   TRENDS IN IMMUNOLOGY

Colony stimulating factors and myeloid cell biology in health and disease

(2012) John A. Hamilton et al.   TRENDS IN IMMUNOLOGY

The danger theory: 20 years later

(2012) Thomas Pradeu et al.   Frontiers in Immunology

Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses

(2011) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex

(2011) M. Hinwood et al.   CEREBRAL CORTEX

A novel Ly6C/Ly6G-based strategy to analyze the mouse splenic myeloid compartment

(2011) Shawn Rose et al.   CYTOMETRY PART A

Sensing damage by the NLRP3 inflammasome

(2011) Jaklien C. Leemans et al.   IMMUNOLOGICAL REVIEWS

Hemorrhagic Shock Activation of NLRP3 Inflammasome in Lung Endothelial Cells

(2011) M. Xiang et al.   JOURNAL OF IMMUNOLOGY

Deficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages

(2011) D. J. Donnelly et al.   JOURNAL OF NEUROSCIENCE

 -Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

(2011) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

(2011) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions

(2010) Ross J. Tynan et al.   BRAIN BEHAVIOR AND IMMUNITY

Endothelial IL-1R1 is a critical mediator of EAE pathogenesis

(2010) Qiming Li et al.   BRAIN BEHAVIOR AND IMMUNITY

The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights

(2010) Agnes E. Coutinho et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The myeloid cells of the central nervous system parenchyma

(2010) Richard M. Ransohoff et al.   NATURE

Review: Leucocyte-endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to the brain

(2010) J. Greenwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Targeting HMGB1 in inflammation

(2009) Huan Yang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions

(2009) Kyle J. Eash et al.   BLOOD

Role of Endothelial TLR4 for Neutrophil Recruitment into Central Nervous System Microvessels in Systemic Inflammation

(2009) H. Zhou et al.   JOURNAL OF IMMUNOLOGY

Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factor  Signaling during Peripheral Organ Inflammation

(2009) C. D'Mello et al.   JOURNAL OF NEUROSCIENCE

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Neural regulation of endocrine and autonomic stress responses

(2009) Yvonne M. Ulrich-Lai et al.   NATURE REVIEWS NEUROSCIENCE

Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling

(2009) G. E. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monocyte-Mediated Defense Against Microbial Pathogens

(2008) Natalya V. Serbina et al.   Annual Review of Immunology

A Functional Genomic Fingerprint of Chronic Stress in Humans: Blunted Glucocorticoid and Increased NF-κB Signaling

(2008) Gregory E. Miller et al.   BIOLOGICAL PSYCHIATRY

Repeated social defeat activates dendritic cells and enhances Toll-like receptor dependent cytokine secretion

(2008) Nicole D. Powell et al.   BRAIN BEHAVIOR AND IMMUNITY

Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier

(2008) Svetlana Stamatovic et al.   Current Neuropharmacology

CXCR4 is required for the quiescence of primitive hematopoietic cells

(2008) Yuchun Nie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rod-Shaped Monocytes Patrol the Brain Vasculature and Give Rise to Perivascular Macrophages under the Influence of Proinflammatory Cytokines and Angiopoietin-2

(2008) J. Audoy-Remus et al.   JOURNAL OF NEUROSCIENCE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE