Article
Biochemistry & Molecular Biology
Yijie Wang, Xiong Liu, Min Liu, Yu Wang, Shuo Wang, Lai Jin, Min Liu, Jun Zhou, Yan Chen
Summary: It has been found that UBE3B acts as an E3 ligase for HIF-2 alpha, promoting its polyubiquitination and inhibiting its degradation, which plays a crucial role in breast cancer growth and metastasis.
Article
Biochemistry & Molecular Biology
Yijie Wang, Xiong Liu, Min Wang, Yu Wang, Shuo Wang, Lai Jin, Min Liu, Jun Zhou, Yan Chen
Summary: This study reveals that UBE3B is an E3 ligase for HIF-2 & alpha; and its depletion inhibits breast cancer progression. UBE3B physically interacts with HIF-2 & alpha; and promotes its polyubiquitination, thereby inhibiting its degradation. UBE3B depletion also inhibits breast cancer cell proliferation, migration, and invasion, and suppresses tumor growth and metastasis.
Article
Cell Biology
Hui Yang, Yue-Hang Geng, Peng Wang, Hong-Quan Zhang, Wei-Gang Fang, Xin-Xia Tian
Summary: We found that extracellular ATP stimulates HIF-1α signaling and enhances chemoresistance in breast cancer cells. We demonstrated that STAT3-ALDOA mediates ATP-HIF-1α signaling, and PI3K/AKT acts upstream of HIF-1α, contributing to chemoresistance. Inhibition of HIF-1α or combined treatment with HIF inhibitors and ATP hydrolase apyrase increased drug sensitivity in breast cancer cells. Our findings highlight the importance of ATP-HIF-1α signaling in chemoresistance and suggest it as a potential target for breast cancer therapies.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Ping Liu, Huiqiong Huang, Xiaorong Qi, Ce Bian, Meng Cheng, Lili Liu, Luqi Xue, Xia Zhao, Tao Yi, Yi Quan
Summary: The lncRNA-MIR210HG is induced by hypoxia in ovarian cancer, mainly located in the cytosol, and promotes cancer progression by inhibiting HIF-1 alpha degradation. Its upregulation is associated with tumor progression and poor prognosis in ovarian cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Corry D. Bondi, Brittney M. Rush, Hannah L. Hartman, Jiaxuan Wang, Mohammad M. Al-Bataineh, Rebecca P. Hughey, Roderick J. Tan
Summary: Acute kidney injury (AKI) is a rapid decline in renal function that can occur after ischemia/reperfusion injury (IRI). Severe IRI reduces NRF2 activity, while mild IRI increases NRF2 activity and aids in renal recovery. We found that hypoxia-inducible factor-1 alpha (HIF-1 alpha) mediates NRF2 activity, and severe ischemic AKI suppresses NRF2 through HIF-1 alpha, leading to disease progression.
Article
Biochemistry & Molecular Biology
Zhu Zeng, Yong Zhao, QingYong Chen, Shuai Zhu, Yi Niu, Zeng Ye, Ping Hu, Ding Chen, Peng Xu, Jinghuang Chen, Chaojie Hu, Yuhang Hu, Fengyu Xu, Jiang Tang, Fan Wang, Shengbo Han, Mengqi Huang, Chunyou Wang, Gang Zhao
Summary: Research shows that hypoxic exosomal circZNF91 can enhance chemoresistance in pancreatic cancer cells through the miR-23b-3p/SIRT1/HIF-1α pathway. Clinical data also indicates that upregulated circZNF91 is associated with overexpression of glycolytic enzymes and shorter overall survival time in PC patients.
Article
Medicine, Research & Experimental
Qiancheng He, Qiongyu Hao, Yanyuan Wu, Jaydutt V. Vadgama, Yiyan Jiang
Summary: The long-term prognosis for breast cancer patients with metastasis is very poor, and genetic alterations in tumor cells lead to cellular heterogeneity, promoting cancer cell invasion and colonization. CircRNAs play an important role in identifying disease mechanisms and developing effective treatments. However, the role of aberrant circRNA expression in breast cancer progression is still largely unknown.
Article
Cell Biology
Shaojun Wu, Ying Zhang, Shilong You, Saien Lu, Naijin Zhang, Yingxian Sun
Summary: Septin4 interacts with HIF-1α at the GTPase domain, enhances its binding with VHL to down-regulate HIF-1α levels, exacerbating cardiomyocyte apoptosis induced by hypoxia.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Ioanna Maria Gkotinakou, Christina Befani, Martina Samiotaki, George Panayotou, Panagiotis Liakos
Summary: Hypoxia-inducible factor 2 (HIF-2) plays a crucial role in cellular response to low oxygen levels and interacts with Reptin52 to affect cellular functions, primarily in the cytoplasm. This interaction can modulate HIF-2 transcriptional activity, leading to changes in EPO secretion and impacting physiological activities in the body.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Giusi La Camera, Luca Gelsomino, Rocco Malivindi, Ines Barone, Salvatore Panza, Daniela De Rose, Francesca Giordano, Vittoria D'Esposito, Pietro Formisano, Daniela Bonofiglio, Sebastiano Ando, Cinzia Giordano, Stefania Catalano
Summary: The study demonstrates that adipocyte-derived EVs can enhance breast cancer cell malignancy through the induction of HIF-1 alpha activity, with EV release in obese settings playing a potentially key role in breast cancer progression.
Article
Oncology
Gang Wen, Naixing Xin
Summary: The study showed that Dexmetomidine promotes the activity of breast cancer cells by inhibiting miR-199a and enhancing its downregulation, thus promoting the progression of breast cancer through the miR-199a/HIF-1 alpha axis.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Li You, Yi Dou, Yu Zhang, Hongwei Xiao, Hong Lv, Gong-Hong Wei, Dazhi Xu
Summary: Gastric cancer is a common malignancy that ranks fourth in cancer-related deaths worldwide. The role of SDC2 in gastric cancer and its underlying molecular mechanisms remain unknown. This study found that SDC2 is highly expressed in gastric cancer and its upregulation is associated with poor prognosis. Depletion of SDC2 inhibits the growth and invasiveness of gastric cancer cells, while overexpression of SDC2 has the opposite effect. Bioinformatics and experimental analyses revealed that overexpression of SDC2 activates the AKT signaling pathway in gastric cancer by interacting with PDK1-PH domain, thereby promoting AKT activation. SDC2 also acts as a co-receptor for FGF2 and is involved in the FGF2-AKT signaling axis in gastric cancer. Furthermore, USP14-mediated stabilization of SDC2 contributes to its upregulation in gastric cancer tissues, and IU1, a USP14 inhibitor, reduces the abundance of SDC2 in gastric cancer cells. This study suggests that SDC2 functions as a novel oncogene in gastric cancer and has potential as a diagnostic marker and therapeutic target.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Monica Vara-Perez, Matteo Rossi, Chris van den Haute, Hannelore Maes, Maria Livia Sassano, Vivek Venkataramani, Bernhard Michalke, Erminia Romano, Kristine Rillaerts, Abhishek D. Garg, Corentin Schepkens, Francesca M. Bosisio, Jasper Wouters, Ana Isabel Oliveira, Peter Vangheluwe, Wim Annaert, Johannes Swinnen, Jean Marie Colet, Joost J. van den Oord, Sarah-Maria Fendt, Massimiliano Mazzone, Patrizia Agostinis
Summary: The study revealed that elevated BNIP3 levels correlated with poorer melanoma patient survival, and depletion of BNIP3 compromised tumor growth. Moreover, BNIP3-deprived melanoma cells displayed increased intracellular iron levels, affecting HIF-1 alpha stabilization.
Article
Chemistry, Multidisciplinary
Bin Zhang, Zhi-yi Liu, Rui Wu, Cheng-ming Zhang, Kuan Cao, Wen-gang Shan, Zhen Liu, Ming Ji, Zi-lu Tian, Gautam Sethi, Heng-liang Shi, Ren-hao Wang
Summary: CTR9, a scaffold protein of the PAF1 complex, plays essential roles in hepatocellular carcinoma by promoting cell proliferation, invasion, and migration. CTR9 also promotes HCC development by enhancing the transcription of the oncogene PEG10. Targeting CTR9 may provide a novel therapeutic strategy for HCC.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Jiawei Cao, Du Wu, Guang Wu, Yaqi Wang, Tianhao Ren, Yang Wang, Yingshuai Lv, Wei Sun, Jieyi Wang, Changrui Qian, Licai He, Kaiyan Yang, Hongzhi Li, Haihua Gu
Summary: The study reveals that the deubiquitinase USP35 located in 11q14.1 is associated with ER+ breast cancer and poor survival, promoting cancer growth by enhancing ER alpha stability and transcriptional activity. USP35 and ER alpha form a positive feedback loop in promoting ER+ breast cancer growth, making USP35 a potential therapeutic target for endocrine resistance or PIK3CA mutations.
CELL DEATH & DISEASE
(2021)
