Article
Biochemistry & Molecular Biology
Eman K. Aldous, Salman M. Toor, Aijaz Parray, Yasser Al-Sarraj, Ilhame Diboun, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Naveed Akhtar, Sajitha Pananchikkal, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: This study conducted comprehensive circulating miRNA profiling in patients with ischemic stroke and identified a panel of miRNAs with potential diagnostic and prognostic significance. A multivariate classifier based on this miRNA panel showed high sensitivity and specificity in differentiating between stroke patients and healthy controls, and it outperformed other available biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Salman M. Toor, Eman K. Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Sajitha V. Pananchikkal, Ghulam Jeelani Pir, Raheem Ayadathil, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: Transient ischemic attack (TIA) is a temporary neurologic deficit caused by ischemic insult to the brain, spinal cord, or retina. TIA is associated with a high risk of impending acute ischemic stroke (AIS), a condition characterized by focal infarction in the brain, spinal cord, or retina. This study investigated the differences in circulating microRNA profiles between AIS and TIA patients and identified a panel of differentially regulated microRNAs. Furthermore, a multivariate classifier was developed that could potentially be used as a biomarker to distinguish AIS and TIA patients. Understanding the molecular pathways in AIS compared to TIA may have important implications for therapeutic targeting in clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Salman M. Toor, Eman K. Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Sajitha V. Pananchikkal, Ghulam Jeelani Pir, Raheem Ayadathil Thazhhe Kuni, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: This study conducted comprehensive circulating miRNA profiling in ischemic stroke patients with and without type 2 diabetes mellitus, identifying 5 differentially regulated miRNAs between the two groups. The findings offer insights into potential pathways associated with stroke and diabetes comorbidity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
T. Marc Eastin, Justin A. Dye, Promod Pillai, Miguel A. Lopez-Gonzalez, Lei Huang, John H. Zhang, Warren W. Boling
Summary: Stroke is a significant cause of death and disability worldwide, with post-stroke cognitive impairment causing a decline in the quality of life. Currently, only pharmacological and mechanical thrombolysis interventions are advised for revascularization. However, these treatments are limited to the acute phase of stroke. Advances in neuroimaging and interventional devices have expanded the potential revascularization window, with delayed revascularization showing positive outcomes beyond the recommended therapeutic window. This review discusses the understanding of ischemic stroke, the latest revascularization doctrine, and evidence from clinical studies on effective delayed revascularization.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Guangwen Li, Xiaoqing Ma, Haiping Zhao, Junfen Fan, Tianwei Liu, Yumin Luo, Yunliang Guo
Summary: This study reveals that long non-coding RNA H19 regulates the expression of C1QTNF6 in leukocytes by sponging miR-29b, leading to leukocyte inflammation during acute ischemic stroke. This finding provides new insights into the inflammatory mechanism of stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Qin Xu, Lele Hu, Lu Chen, Hao Li, Xue Tian, Yingting Zuo, Yijun Zhang, Xiaoli Zhang, Ping Sun, Yongjun Wang, Xia Meng, Anxin Wang
Summary: The aim of this study was to investigate the association between serum magnesium and all-cause mortality and poor functional outcome after stroke. The study found that low serum magnesium levels were associated with an increased risk of poor functional outcome in patients with acute ischemic stroke or transient ischemic attack.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Anna K. Bonkhoff, Markus D. Schirmer, Martin Bretzner, Mark Etherton, Kathleen Donahue, Carissa Tuozzo, Marco Nardin, Anne-Katrin Giese, Ona Wu, Vince D. Calhoun, Christian Grefkes, Natalia S. Rost
Summary: This study aimed to explore the whole-brain dynamic functional connectivity patterns in acute ischemic stroke (AIS) patients and their relation to stroke severity. The research identified differences in dynamic connectivity configurations between patients with different levels of stroke severity and highlighted the importance of dynamic connectivity involving default mode network components for recovery in the first 3 months poststroke.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Christian Heitkamp, Laurens Winkelmeier, Jeremy J. J. Heit, Gregory W. W. Albers, Maarten G. G. Lansberg, Max Wintermark, Gabriel Broocks, Noel van Horn, Helge C. C. Kniep, Peter B. B. Sporns, Kamil Zelenak, Jens Fiehler, Tobias D. D. Faizy
Summary: This study aimed to investigate imaging biomarkers associated with unfavorable functional outcomes despite successful recanalization in AIS-LVO patients. The results showed that unfavorable venous outflow (Vo) on admission is a strong predictor of unfavorable functional outcomes in AIS-LVO patients, even with successful recanalization.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lingling Jiang, Weiqi Chen, Jinyi Ye, Yilong Wang
Summary: Ischemic stroke is a life-threatening disease that causes disability and death globally. Currently, there are no effective treatments available in clinical practice, but exosome-based therapy has shown potential. Exosomes play a positive role in neurorestoration through the delivery of microRNA cargo, providing a viable treatment strategy for ischemic stroke patients.
Letter
Clinical Neurology
Marina Buciuc, Gian Marco Conte, Eugene L. Scharf
Summary: Additional digital content is available in the text.
Article
Neurosciences
Donghua Mi, Zixiao Li, Hongqiu Gu, Yingyu Jiang, Xingquan Zhao, Yilong Wang, Yongjun Wang
Summary: This study aimed to examine the association between stress-induced hyperglycemia and the occurrence of in-hospital death in patients with diabetes and acute ischemic stroke. The results showed that hyperglycemia in stroke patients with diabetes mellitus is associated with a higher risk of in-hospital death.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Geriatrics & Gerontology
Joao Pinho, Charlotte Kueppers, Omid Nikoubashman, Martin Wiesmann, Joerg B. Schulz, Arno Reich, Cornelius J. Werner
Summary: Frailty is an independent predictor of outcomes in AIS patients undergoing EST, with patients at high frailty risk more likely to have unfavorable results at 3 months.
Article
Oncology
Anxin Wang, Kehua Quan, Xue Tian, Yingting Zuo, Xia Meng, Pan Chen, Hao Li, Yongjun Wang
Summary: The study revealed that different leukocyte subtypes were associated with adverse clinical outcomes in patients with acute ischemic cerebrovascular events. Higher counts of neutrophils and monocytes were linked to increased risks, while higher counts of lymphocytes and eosinophils were associated with reduced risks. Basophil counts did not seem to correlate with adverse outcomes. Additionally, the percentages of leukocyte subtypes also showed significant associations with adverse clinical outcomes.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Barend W. Florijn, Roel Bijkerk, Nyika D. Kruyt, Anton Jan van Zonneveld, Marieke J. H. Wermer
Summary: This review highlights the importance of sex differences in stroke mechanisms, explores the role of sex-specific microRNAs in ischemic stroke, and their potential clinical applications in diagnosis, prognosis, and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yoonkyung Chang, Chi Kyung Kim, Min-Kyung Kim, Woo-Keun Seo, Kyungmi Oh
Summary: Insulin resistance is associated with poor prognosis in non-diabetic stroke patients, indicating the importance of treating insulin resistance in acute ischemic stroke patients with normal blood glucose levels.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Kaylynn Purdy, Rebecca Long, Glen Jickling
Summary: This article reports a case of COVID-19 infection-induced vertebral artery dissection and lateral medullary stroke, highlighting the potential role of infection in contributing to certain cases of CeAD. COVID-19 infection can cause endothelial dysfunction and inflammatory response, leading to vascular damage.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Meeting Abstract
Clinical Neurology
Paulina Carmona-Mora, Bodie Knepp, Glen Jickling, Xinhua Zhan, Marisa Hakoupian, Heather Hull, Noor Alomar, Hajar Amini, Frank R. Sharp, Boryana Stamova, Bradley Ander
Editorial Material
Clinical Neurology
Sarina R. Falcione, Glen C. Jickling
Article
Clinical Neurology
Laura Ibanez, Laura Heitsch, Caty Carrera, Fabiana H. G. Farias, Jorge L. Del Aguila, Rajat Dhar, John Budde, Kristy Bergmann, Joseph Bradley, Oscar Harari, Chia Ling Phuah, Robin Lemmens, Alessandro A. Viana Oliveira Souza, Francisco Moniche, Antonio Cabezas-Juan, Juan Francisco Arenillas, Jerzy Krupinksi, Natalia Cullell, Nuria Torres-Aguila, Elena Muino, Jara Carcel-Marquez, Joan Marti-Fabregas, Raquel Delgado-Mederos, Rebeca Marin-Bueno, Alejandro Hornick, Cristofol Vives-Bauza, Rosa Diaz Navarro, Silvia Tur, Carmen Jimenez, Victor Obach, Tomas Segura, Gemma Serrano-Heras, Jong Won Chung, Jaume Roquer, Carol Soriano-Tarraga, Eva Giralt-Steinhauer, Marina Mola-Caminal, Joanna Pera, Katarzyna Lapicka-Bodzioch, Justyna Derbisz, Antoni Davalos, Elena Lopez-Cancio, Lucia Munoz, Turgut Tatlisumak, Carlos Molina, Marc Ribo, Alejandro Bustamante, Tomas Sobrino, Jose Castillo-Sanchez, Francisco Campos, Emilio Rodriguez-Castro, Susana Arias-Rivas, Manuel Rodriguez-Yanez, Christina Herbosa, Andria L. Ford, Alonso Gutierrez-Romero, Rodrigo Uribe-Pacheco, Antonio Arauz, Iscia Lopes-Cendes, Theodore Lowenkopf, Miguel A. Barboza, Hajar Amini, Boryana Stamova, Bradley P. Ander, Frank R. Sharp, Gyeong Moon Kim, Oh Young Bang, Jordi Jimenez-Conde, Agnieszka Slowik, Daniel Stribian, Ellen A. Tsai, Linda C. Burkly, Joan Montaner, Israel Fernandez-Cadenas, Jin Moo Lee, Carlos Cruchaga
Summary: This study aimed to determine the genetic architecture of early neurological instability after stroke. It identified eight significant loci that are associated with neurological instability, suggesting that excitotoxicity may contribute to this instability.
Article
Clinical Neurology
Ali Z. Nomani, Jeremy L. Rempel, Khurshid A. Khan, Ashfaq Shuaib, Glen C. Jickling
Summary: This study evaluated the variable rate of infarct progression in acute ischemic stroke using different thresholds. It found that a substantial proportion of patients were excluded when assessed by various time or core constraints. However, the hypoperfusion index (HI) showed comprehensive evaluation of the fast and slow rate of infarct progression and provided indications for reperfusion and clinical outcomes assessment.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Review
Clinical Neurology
Anas Alrohimi, Glen Jickling, Brian Buck, Ken S. Butcher
Summary: Patients with atrial fibrillation and ischemic stroke are at high risk for stroke recurrence. Early anticoagulation may reduce the risk of recurrent events but is usually avoided due to the risk of hemorrhagic transformation. Direct oral anticoagulants have demonstrated lower risk of intracranial hemorrhage compared to older anticoagulants. However, the optimal timing of DOAC initiation after AF-related ischemic stroke is still unclear.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Immunology
Hajar Amini, Bodie Knepp, Fernando Rodriguez, Glen C. Jickling, Heather Hull, Paulina Carmona-Mora, Cheryl Bushnell, Bradley P. Ander, Frank R. Sharp, Boryana Stamova
Summary: This study identified early immune gene responses in peripheral blood associated with 90-day ischemic stroke (IS) outcomes. Whole-transcriptome analyses revealed genes and networks associated with poor and good 90-day outcomes. The study suggests that the immune response after stroke may impact functional outcomes and some early post-stroke gene expression markers could be used for predicting outcomes and improving outcomes.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Raluca Todoran, Sarina R. Falcione, Michael Clarke, Twinkle Joy, Roobina Boghozian, Glen C. Jickling
Summary: microRNA (miRNA) regulates gene expression and has the potential to be used as a treatment for ischemic stroke. This review focuses on the role of miRNA in reducing thrombosis, blood brain barrier disruption, hemorrhagic transformation, inflammation, and angiogenesis. Although no miRNA has been approved for human use yet, clinical trials have shown promising results in treating conditions such as hepatitis C. The benefits, barriers, and future directions of using miRNA as a treatment for ischemic stroke are also discussed.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Paulina Carmona-Mora, Bodie Knepp, Glen C. Jickling, Xinhua Zhan, Marisa Hakoupian, Heather Hull, Noor Alomar, Hajar Amini, Frank R. Sharp, Boryana Stamova, Bradley P. Ander
Summary: After ischemic stroke, peripheral leukocytes infiltrate the damaged region and modulate the response to injury. Peripheral blood cells display distinctive gene expression signatures post-stroke, reflecting changes in immune responses to stroke. Analyzing the temporal dynamics of gene expression after stroke can improve our understanding of immune and clotting responses at the molecular and cellular level, and may assist with time-targeted, cell-specific therapy.
Article
Clinical Neurology
Anas Alrohimi, David Z. Rose, W. Scott Burgin, Swetha Renati, Nicholas Corbin Hilker, Wei Deng, Guilherme H. Oliveira, Theresa M. Beckie, Arthur J. Labovitz, Michael G. Fradley, Nhi Tran, Laura C. Gioia, Mahesh Kate, Kelvin Ng, Dar Dowlatshahi, Thalia S. Field, Shelagh B. Coutts, Muzzafar Siddiqui, Michael D. Hill, Jodi Miller, Glen Jickling, Ashfaq Shuaib, Brian Buck, Mike Sharma, Ken S. Butcher
Summary: This study aimed to assess the risk of hemorrhagic transformation (HT) in acute ischemic stroke (AIS) associated with the initiation of direct oral anticoagulant (DOAC). The results showed that initiating DOAC within 48 hours post-stroke was not associated with an increased risk of HT, and no patients developed symptomatic HT. However, early DOAC use was not significant in reducing the risk of recurrent ischemic events.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Editorial Material
Clinical Neurology
Roobina Boghozian, Sarina Falcione, Glen C. Jickling
Meeting Abstract
Endocrinology & Metabolism
B. Knepp, M. Durocher, A. Yee, G. Jickling, H. Hull, N. Alomar, K. Ng, X. Zhan, P. Carmona-Mora, H. Amini, M. Hakoupian, B. Ander, F. Sharp, B. Stamova
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Meeting Abstract
Endocrinology & Metabolism
M. Hakoupian, E. Ferino, H. Amini, B. Stamova, H. Hull, P. Carmona-Mora, B. Ander, B. Knepp, N. Alomar, G. Jickling, F. Sharp, X. Zhan
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Meeting Abstract
Endocrinology & Metabolism
P. Carmona-Mora, B. Knepp, G. Jickling, X. Zhan, M. Hakoupian, H. Hull, N. Alomar, H. Amini, F. Sharp, B. Stamova, B. Ander
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Letter
Medicine, General & Internal
Joseph Kamtchum-Tatuene, Glen C. Jickling