Sex-Specific MicroRNAs in Neurovascular Units in Ischemic Stroke

Pericytes regulate vascular immune homeostasis in the CNS

(2021) Orsolya Török et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estradiol-driven metabolism in transwomen associates with reduced circulating extracellular vesicle microRNA-224/452

(2021) Barend W Florijn et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

miR-652 protects rats from cerebral ischemia/reperfusion oxidative stress injury by directly targeting NOX2

(2020) Mei-Ling Zuo et al.   BIOMEDICINE & PHARMACOTHERAPY

Endothelium-Targeted Deletion of microRNA-15a/16-1 Promotes Poststroke Angiogenesis and Improves Long-Term Neurological Recovery

(2020) Ping Sun et al.   CIRCULATION RESEARCH

Sex differences in acute ischemic stroke patients: clinical presentation, causes and outcomes

(2020) Friedrich Medlin et al.   EUROPEAN JOURNAL OF NEUROLOGY

Changes in Whole-Blood microRNA Profiles during the Onset and Treatment Process of Cerebral Infarction: A Human Study

(2020) Arata Abe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CDKN1B Mediates Apoptosis of Neuronal Cells and Inflammation Induced by Oxyhemoglobin via miR-502-5p After Subarachnoid Hemorrhage

(2020) Dong Chen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Estradiol-dependent axogenesis and Ngn3 expression are determined by XY sex chromosome complement in hypothalamic neurons

(2020) Carla Daniela Cisternas et al.   Scientific Reports

Cell-specific metabolomic responses to injury: novel insights into blood-brain barrier modulation

(2020) Sheng-Fu Huang et al.   Scientific Reports

Implication of MicroRNA503 in Brain Endothelial Cell Function and Ischemic Stroke

(2020) Huiting Zhang et al.   Translational Stroke Research

miR-18b attenuates cerebral ischemia/reperfusion injury through regulation of ANXA3 and PI3K/Akt signaling pathway

(2020) Xiao-li Min et al.   BRAIN RESEARCH BULLETIN

miR-188-5p inhibits apoptosis of neuronal cells during oxygen-glucose deprivation (OGD)-induced stroke by suppressing PTEN

(2020) Lijing Li et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Neuronal regulation of the blood–brain barrier and neurovascular coupling

(2020) Luke Kaplan et al.   NATURE REVIEWS NEUROSCIENCE

MicroRNA-532-5p protects against atherosclerosis through inhibiting vascular smooth muscle cell proliferation and migration

(2020) Huijuan Sun et al.   Cardiovascular Diagnosis and Therapy

Sex differences in intracranial and extracranial atherosclerosis in patients with acute ischemic stroke

(2020) S Voigt et al.   International Journal of Stroke

miR-98-5p Protects Against Cerebral ischemia/reperfusion Injury Through Anti-apoptosis and Anti-oxidative stress in Mice

(2020) Shan Yu et al.   JOURNAL OF BIOCHEMISTRY

Neuron-Derived Estrogen Is Critical for Astrocyte Activation and Neuroprotection of the Ischemic Brain

(2020) Yujiao Lu et al.   JOURNAL OF NEUROSCIENCE

Sex differences in the association between major risk factors and the risk of stroke in the UK Biobank cohort study

(2020) Sanne A.E. Peters et al.   NEUROLOGY

MicroRNA‑503‑5p improves carotid artery stenosis by inhibiting the proliferation of vascular smooth muscle cells

(2020) Zhiyuan Yan et al.   Experimental and Therapeutic Medicine

Sex-specific microRNAs in women with diabetes and left ventricular diastolic dysfunction or HFpEF associate with microvascular injury

(2020) Barend W. Florijn et al.   Scientific Reports

Measurement of the Estradiol Concentration in Cerebrospinal Fluid from Infants and Its Correlation with Serum Estradiol and Exosomal MicroRNA-126-5p

(2020) Masahiro Ishii et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Circulating angiopoietin-2 and angiogenic microRNAs associate with cerebral small vessel disease and cognitive decline in older patients reaching end stage renal disease

(2020) Roel Bijkerk et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

miR-221 Exerts Neuroprotective Effects in Ischemic Stroke by Inhibiting the Proinflammatory Response

(2020) Yuan Shan et al.   Journal of Stroke & Cerebrovascular Diseases

Stroke and the neurovascular unit: glial cells, sex differences and hypertension

(2019) Helena W Morrison et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Relationship Between Endothelial Function and the Eliciting Shear Stress Stimulus in Women: Changes Across the Lifespan Differ to Men

(2019) Sophie M. Holder et al.   Journal of the American Heart Association

Persistent metabolic youth in the aging female brain

(2019) Manu S. Goyal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can MiR-503 be used as a marker in diabetic patients with ischemic stroke?

(2019) Saba Sheikhbahaei et al.   BMC Endocrine Disorders

Sex Differences in Presentation and Outcome After an Acute Transient or Minor Neurologic Event

(2019) Amy Y. X. Yu et al.   JAMA Neurology

miR-424–5p maybe regulate blood-brain barrier permeability in a model in vitro with Abeta incubated endothelial cells

(2019) Meiqing Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MiR‐424 prevents astrogliosis after cerebral ischemia/reperfusion in elderly mice by enhancing repressive H3K27me3 via NFIA/DNMT1 signaling

(2019) Haiping Zhao et al.   FEBS Journal

Does the Association of Diabetes With Stroke Risk Differ by Age, Race, and Sex? Results From the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study

(2019) Gargya Malla et al.   DIABETES CARE

Involvement of Epigenetic Mechanisms and Non-coding RNAs in Blood-Brain Barrier and Neurovascular Unit Injury and Recovery After Stroke

(2019) Svetlana M. Stamatovic et al.   Frontiers in Neuroscience

miR-98 reduces endothelial dysfunction by protecting blood–brain barrier (BBB) and improves neurological outcomes in mouse ischemia/reperfusion stroke model

(2019) David L Bernstein et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sex differences in treatment and outcome after stroke

(2019) Cheryl Carcel et al.   NEUROLOGY

ΜicroRNA‑221 participates in cerebral ischemic stroke by modulating endothelial cell function by regulating the PTEN/PI3K/AKT pathway

(2019) Han Peng et al.   Experimental and Therapeutic Medicine

Anti-miR-223-5p Ameliorates Ischemic Damage and Improves Neurological Function by Preventing NCKX2 Downregulation after Ischemia in Rats

(2019) Ornella Cuomo et al.   Molecular Therapy-Nucleic Acids

Blood-Brain Barrier Dysfunction in Ischemic Stroke: Targeting Tight Junctions and Transporters for Vascular Protection

(2018) Wazir Abdullahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

MicroRNA-Mediated Therapy Modulating Blood–Brain Barrier Disruption Improves Vascular Cognitive ImpairmentHighlights

(2018) Kensuke Toyama et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of PTEN protects PC12 cells against oxygen-glucose deprivation induced cell death through mitoprotection

(2018) Fereshteh Farajdokht et al.   BRAIN RESEARCH

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

(2018) Rikesh M. Rajani et al.   Science Translational Medicine

Preeclampsia

(2018) Mollie McDermott et al.   STROKE

Diagnostic and Immunosuppressive Potential of Elevated Mir-424 Levels in Circulating Immune Cells of Ischemic Stroke Patients

(2018) Guangwen Li et al.   Aging and Disease

Identification and Analysis of Human Sex-biased MicroRNAs

(2018) Chunmei Cui et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

The inverted pattern of circulating miR-221-3p and miR-222-3p associated with isolated low HDL-C phenotype

(2018) Yuntao Zhou et al.   Lipids in Health and Disease

Contributions of the glycocalyx, endothelium, and extravascular compartment to the blood–brain barrier

(2018) Nikolay Kutuzov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting ninjurin 2 by miR-764 regulates hydrogen peroxide (H2O2)-induced neuronal cell death

(2018) Ding Jing et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diversity and Specificity of Astrocyte–neuron Communication

(2018) Caitlin A. Durkee et al.   NEUROSCIENCE

Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke

(2018) Changjun Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Impact of 17beta-estradiol and progesterone on inflammatory and apoptotic microRNA expression after ischemia in a rat model

(2017) Rebecca Herzog et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Micro-RNAs in ALS muscle: Differences in gender, age at onset and disease duration

(2017) Valentina Pegoraro et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Inhibition of miR-181a protects female mice from transient focal cerebral ischemia by targeting astrocyte estrogen receptor-α

(2017) Creed M. Stary et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mir363-3p improves ischemic stroke outcomes in female but not male rats

(2017) Amutha Selvamani et al.   NEUROCHEMISTRY INTERNATIONAL

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

The Transcription Factor IRF6 Co-Represses PPARγ-Mediated Cytoprotection in Ischemic Cerebrovascular Endothelial Cells

(2017) Rongzhong Huang et al.   Scientific Reports

The Role of Astrocytes in Neuroprotection after Brain Stroke: Potential in Cell Therapy

(2017) Andrea Becerra-Calixto et al.   Frontiers in Molecular Neuroscience

17β-estradiol enhances vascular endothelial Ets-1/miR-126-3p expression: the possible mechanism for attenuation of atherosclerosis

(2016) Ping Li et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Astrocytic response to cerebral ischemia is influenced by sex differences and impaired by aging

(2016) Nioka C. Chisholm et al.   NEUROBIOLOGY OF DISEASE

Sex differences in astrocyte and microglia responses immediately following middle cerebral artery occlusion in adult mice

(2016) Helena W. Morrison et al.   NEUROSCIENCE

An integrative transcriptomics approach identifies miR-503 as a candidate master regulator of the estrogen response in MCF-7 breast cancer cells

(2016) Jeanette Baran-Gale et al.   RNA

Replenishment of microRNA-188-5p restores the synaptic and cognitive deficits in 5XFAD Mouse Model of Alzheimer’s Disease

(2016) Kihwan Lee et al.   Scientific Reports

Association of MicroRNAs and YRNAs With Platelet FunctionNovelty and Significance

(2015) Dorothee Kaudewitz et al.   CIRCULATION RESEARCH

Estrogen action: Receptors, transcripts, cell signaling, and non-coding RNAs in normal physiology and disease

(2015) Carolyn M. Klinge   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems

(2015) Ari Waisman et al.   TRENDS IN IMMUNOLOGY

Ischemic brain extract increases SDF-1 expression in astrocytes through the CXCR2/miR-223/miR-27b pathway

(2014) Jin Hee Shin et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Increase of circulating miR-223 and insulin-like growth factor-1 is associated with the pathogenesis of acute ischemic stroke in patients

(2014) Yang Wang et al.   BMC Neurology

Identification of Circulating MicroRNAs as Potential Biomarkers for Detecting Acute Ischemic Stroke

(2014) Pengfei Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Gender differences and woman-specific trends in acute stroke: Results from a hospital-based registry (1986–2009)

(2014) Adrià Arboix et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Widespread context dependency of microRNA-mediated regulation

(2014) F. Erhard et al.   GENOME RESEARCH

Detection of platelet microRNA expression in patients with diabetes mellitus with or without ischemic stroke

(2014) Xiaomei Duan et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Diabetes as a risk factor for stroke in women compared with men: a systematic review and meta-analysis of 64 cohorts, including 775 385 individuals and 12 539 strokes

(2014) Sanne A E Peters et al.   LANCET

Risk of a Thrombotic Event after the 6-Week Postpartum Period

(2014) Hooman Kamel et al.   NEW ENGLAND JOURNAL OF MEDICINE

C-Reactive Protein as a Prognostic Marker After Lacunar Stroke

(2014) Mitchell S.V. Elkind et al.   STROKE

Cognitive profile in patients with a first-ever lacunar infarct with and without silent lacunes: a comparative study

(2013) Lorena Blanco-Rojas et al.   BMC Neurology

X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease

(2013) Jeannie T. Lee et al.   CELL

Circulating MicroRNAs as Novel Biomarkers for Platelet Activation

(2013) Peter Willeit et al.   CIRCULATION RESEARCH

X and Y Chromosome Complement Influence Adiposity and Metabolism in Mice

(2013) Xuqi Chen et al.   ENDOCRINOLOGY

Aspirin treatment hampers the use of plasma microRNA-126 as a biomarker for the progression of vascular disease

(2013) Hetty C. de Boer et al.   EUROPEAN HEART JOURNAL

Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression

(2013) G. Giordano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overexpression of X-Linked genes in T cells from women with lupus

(2013) Anura Hewagama et al.   JOURNAL OF AUTOIMMUNITY

Serum microRNA-21 and microRNA-221 as Potential Biomarkers for Cerebrovascular Disease

(2013) Pei-Chien Tsai et al.   JOURNAL OF VASCULAR RESEARCH

Mechanisms of vascular calcification in CKD—evidence for premature ageing?

(2013) Catherine M. Shanahan   Nature Reviews Nephrology

Male-Female Differences in Upregulation of Vasoconstrictor Responses in Human Cerebral Arteries

(2013) Hilda Ahnstedt et al.   PLoS One

MiRNA-424 Protects Against Permanent Focal Cerebral Ischemia Injury in Mice Involving Suppressing Microglia Activation

(2013) Haiping Zhao et al.   STROKE

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

Soluble Epoxide Hydrolase

(2012) Nandita C. Gupta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Association of the miR-146a , miR-149 , miR-196a2 , and miR-499 Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk

(2012) Young Joo Jeon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

Mechanism of the sex difference in neuronal ischemic cell death

(2012) S.L. Fairbanks et al.   NEUROSCIENCE

MicroRNA-223 is neuroprotective by targeting glutamate receptors

(2012) M. M. Harraz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of X-chromosome inactivation by the X-inactivation centre

(2011) Sandrine Augui et al.   NATURE REVIEWS GENETICS

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Estrogen Receptor α Controls a Gene Network in Luminal-Like Breast Cancer Cells Comprising Multiple Transcription Factors and MicroRNAs

(2010) Luigi Cicatiello et al.   AMERICAN JOURNAL OF PATHOLOGY

Sex Chromosome Effects Unmasked in Angiotensin II–Induced Hypertension

(2010) Hong Ji et al.   HYPERTENSION

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

(2010) C. C. Alano et al.   JOURNAL OF NEUROSCIENCE

Gender-Specific Reduction of Estrogen-Sensitive Small RNA, miR-30b, in Subjects With Schizophrenia

(2010) Nikolaos Mellios et al.   SCHIZOPHRENIA BULLETIN

Rapid evolution of mammalian X-linked testis microRNAs

(2009) Xuejiang Guo et al.   BMC GENOMICS

Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization

(2009) Xin Ye et al.   CELL

Many X-linked microRNAs escape meiotic sex chromosome inactivation

(2009) Rui Song et al.   NATURE GENETICS

Estradiol-regulated microRNAs control estradiol response in breast cancer cells

(2009) Poornima Bhat-Nakshatri et al.   NUCLEIC ACIDS RESEARCH

The estrogen receptor- -induced microRNA signature regulates itself and its transcriptional response

(2009) L. Castellano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Do Presenting Symptoms Explain Sex Differences in Emergency Department Delays Among Patients With Acute Stroke?

(2009) Julia Warner Gargano et al.   STROKE

Gender Differences in Acute Ischemic Stroke

(2009) Alex Förster et al.   STROKE

Sex Differences in Caspase Activation After Stroke

(2009) Fudong Liu et al.   STROKE

Argonaute-2 Expression Is Regulated by Epidermal Growth Factor Receptor and Mitogen-Activated Protein Kinase Signaling and Correlates with a Transformed Phenotype in Breast Cancer Cells

(2008) Brian D. Adams et al.   ENDOCRINOLOGY

Inflammation and Hemostasis Biomarkers for Predicting Stroke in Postmenopausal Women: The Women's Health Initiative Observational Study

(2008) Robert C. Kaplan et al.   Journal of Stroke & Cerebrovascular Diseases

Pathways to ischemic neuronal cell death: are sex differences relevant?

(2008) Jesse T Lang et al.   Journal of Translational Medicine

Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons

(2008) S. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysfunctional Cell-Cell Signaling in the Neurovascular Unit as a Paradigm for Central Nervous System Disease

(2008) S. Guo et al.   STROKE