Mithramycin A Alleviates Cognitive Deficits and Reduces Neuropathology in a Transgenic Mouse Model of Alzheimer’s Disease

Co-localization and Distribution of Cerebral APP and SP1 and its Relationship to Amyloidogenesis

(2017) Brian Brock et al.   JOURNAL OF ALZHEIMERS DISEASE

Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease

(2015) Kaj Blennow et al.   Alzheimers & Dementia

Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice

(2015) Qiong Zhou et al.   ANNALS OF NEUROLOGY

Advances in Alzheimer’s Disease Drug Development

(2015) Michael S Rafii et al.   BMC Medicine

Deficits in hippocampal-dependent transfer generalization learning accompany synaptic dysfunction in a mouse model of amyloidosis

(2015) Karienn S. Montgomery et al.   HIPPOCAMPUS

Tolfenamic acid reduces tau and CDK5 levels: implications for dementia and tauopathies

(2014) Lina Adwan et al.   JOURNAL OF NEUROCHEMISTRY

Tolfenamic acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer's disease related biomarkers

(2014) Lina Adwan et al.   NEUROPHARMACOLOGY

The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons

(2014) K. Zavala et al.   NEUROSCIENCE LETTERS

Physiological and pathological phosphorylation of tau by Cdk5

(2014) Taeko Kimura et al.   Frontiers in Molecular Neuroscience

The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease

(2013) Johanna L. Crimins et al.   AGEING RESEARCH REVIEWS

Mithramycin, an Agent for Developing New Therapeutic Drugs for Neurodegenerative Diseases

(2013) Nobuhiro Osada et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Further insights into Alzheimer disease pathogenesis

(2013) Michael W. Weiner   Nature Reviews Neurology

Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer's disease mice

(2013) Gehad M. Subaiea et al.   NEUROBIOLOGY OF AGING

Biomarkers in Amyloid-β Immunotherapy Trials in Alzheimer’s Disease

(2013) Kaj Blennow et al.   NEUROPSYCHOPHARMACOLOGY

RETRACTED: Multiple inflammatory pathways are involved in the development and progression of cognitive deficits in APPswe/PS1dE9 mice

(2012) Wei Zhang et al.   NEUROBIOLOGY OF AGING

Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease

(2011) Wei Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Tolfenamic Acid Interrupts the De Novo Synthesis of the β-Amyloid Precursor Protein and Lowers Amyloid Beta Via a Transcriptional Pathway

(2011) L. I. Adwan et al.   Current Alzheimer Research

Mithramycin Is a Gene-Selective Sp1 Inhibitor That Identifies a Biological Intersection between Cancer and Neurodegeneration

(2011) S. F. Sleiman et al.   JOURNAL OF NEUROSCIENCE

Protective action of mithramycin against neurodegeneration and impairment of synaptic plasticity in the hippocampal CA1 area after transient global ischemia

(2011) Nobuhiro Osada et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective effect of mithramycin against endoplasmic reticulum stress-induced neurotoxicity in organotypic hippocampal slice cultures

(2011) Yasuhiro Kosuge et al.   NEUROPHARMACOLOGY

Combined Treatment of Pancreatic Cancer with Mithramycin A and Tolfenamic Acid Promotes Sp1 Degradation and Synergistic Antitumor Activity

(2010) Z. Jia et al.   CANCER RESEARCH

Towards Disease-Modifying Treatment of Alzheimers Disease: Drugs Targeting β -Amyloid

(2010) V. Frisardi et al.   Current Alzheimer Research

Targeting Tau Protein in Alzheimerʼs Disease

(2010) Cheng-Xin Gong et al.   DRUGS & AGING

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells

(2009) Alvaro Valin et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mithramycin protects against dopaminergic neurotoxicity in the mouse brain after administration of methamphetamine

(2009) Hiroko Hagiwara et al.   BRAIN RESEARCH

Amyloid Deposition and Inflammation in APPswe/PS1dE9 Mouse Model of Alzheimers Disease

(2009) Lingfei Ruan et al.   Current Alzheimer Research

Transcription factor Sp1 dysregulation in Alzheimer's disease

(2008) Bruce A. Citron et al.   JOURNAL OF NEUROSCIENCE RESEARCH