Role of Corticotropin-releasing Factor in Gastrointestinal Permeability

Small intestinal permeability is increased in diarrhoea predominant IBS, while alterations in gastroduodenal permeability in all IBS subtypes are largely attributable to confounders

(2014) Z. Mujagic et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Mucosal Barrier, Bacteria and Inflammatory Bowel Disease: Possibilities for Therapy

(2014) Yvette Merga et al.   DIGESTIVE DISEASES

The role of the adaptive immune system in regulation of gut microbiota

(2014) Lucia M. Kato et al.   IMMUNOLOGICAL REVIEWS

Tight junctions and IBS - the link between epithelial permeability, low-grade inflammation, and symptom generation?

(2014) T. Piche   NEUROGASTROENTEROLOGY AND MOTILITY

The Intestinal Mucus Layer is a Critical Component of the Gut Barrier that is Damaged During Acute Pancreatitis

(2014) Jordan E. Fishman et al.   SHOCK

Regional Differences in Chronic Stress-induced Alterations in Mast Cell and Protease-activated Receptor-2-positive Cell Numbers in the Colon of Ws/Ws Rats

(2014) Yong Sung Kim et al.   Journal of Neurogastroenterology and Motility

Corticotropin releasing hormone activates CD14+cells to induce endothelial barrier dysfunction

(2013) Jiang-Ping Song et al.   CELL BIOLOGY INTERNATIONAL

Eosinophil recruitment to nasal nerves after allergen challenge in allergic rhinitis

(2013) Margaret A. Thornton et al.   CLINICAL IMMUNOLOGY

Sealing the Broken Barrier in IBD: Intestinal Permeability, Epithelial Cells and Junctions

(2013) Walter Fries et al.   CURRENT DRUG TARGETS

The intricate association between gut microbiota and development of Type 1, Type 2 and Type 3 diabetes

(2013) Pjotr Bekkering et al.   Expert Review of Clinical Immunology

Impaired Emotional Learning and Involvement of the Corticotropin-Releasing Factor Signaling System in Patients With Irritable Bowel Syndrome

(2013) Jennifer S. Labus et al.   GASTROENTEROLOGY

Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia

(2013) Hanne Vanheel et al.   GUT

Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

(2013) Tim Vanuytsel et al.   GUT

Limited Fluid Resuscitation Attenuates Lung and Intestine Injury Caused by Hemorrhagic Shock in Rats

(2013) Yousheng Li et al.   JOURNAL OF INVESTIGATIVE SURGERY

Reduced E-cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS

(2013) E. Wilcz-Villega et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Corticotropin-releasing factor is present in intestinal tissue of patients with gastrointestinal dysfunction following shock and abdominal surgery

(2013) Lauren T. Hill et al.   NUTRITION

Intestinal permeability in children with food allergy on specific elimination diets

(2013) Kirsi M. Järvinen et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation

(2013) Keith C. Summa et al.   PLoS One

Broad MICA/B Expression in the Small Bowel Mucosa: A Link between Cellular Stress and Celiac Disease

(2013) Yessica L. Allegretti et al.   PLoS One

Gastrointestinal involvement in patients affected with 22q11.2 deletion syndrome

(2013) Giuliana Giardino et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Effects of rhein on intestinal epithelial tight junction in IgA nephropathy

(2013) Sheng-Nan Peng   WORLD JOURNAL OF GASTROENTEROLOGY

Corticotropin-releasing factor receptor subtype 2 in human colonic mucosa: Down-regulation in ulcerative colitis

(2013) Ekaterini Chatzaki   WORLD JOURNAL OF GASTROENTEROLOGY

Life Events and the Onset of Celiac Disease from a Patient’s Perspective

(2013) Carolina Ciacci et al.   Nutrients

Mucosal Mast Cell Count Is Associated With Intestinal Permeability in Patients With Diarrhea Predominant Irritable Bowel Syndrome

(2013) Hyuk Lee et al.   Journal of Neurogastroenterology and Motility

Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned from Animal Models and Human Genetics

(2013) Luca Pastorelli et al.   Frontiers in Immunology

The Jejunum of Diarrhea-Predominant Irritable Bowel Syndrome Shows Molecular Alterations in the Tight Junction Signaling Pathway That Are Associated With Mucosal Pathobiology and Clinical Manifestations

(2012) Cristina Martínez et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Role of Urea in Intestinal Barrier Dysfunction and Disruption of Epithelial Tight Junction in Chronic Kidney Disease

(2012) Nosratola D. Vaziri et al.   AMERICAN JOURNAL OF NEPHROLOGY

Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier

(2012) Cristina Martínez et al.   GUT

IL-1β and TSH disturb thyroid epithelium integrity in autoimmune thyroid diseases

(2012) Sandra A. Rebuffat et al.   IMMUNOBIOLOGY

Urocortin increased LPS-induced endothelial permeability by regulating the cadherin-catenin complex via corticotrophin-releasing hormone receptor 2

(2012) Rong Wan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypothesis for a systems connectivity model of autism spectrum disorder pathogenesis: Links to gut bacteria, oxidative stress, and intestinal permeability

(2012) Colin A. Heberling et al.   MEDICAL HYPOTHESES

Acute experimental stress evokes a differential gender-determined increase in human intestinal macromolecular permeability

(2012) C. Alonso et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Expression of corticotropin releasing factor receptor type 1 (CRF1) in the human gastrointestinal tract and upregulation in the colonic mucosa in patients with ulcerative colitis

(2012) Pu-Qing Yuan et al.   PEPTIDES

CRF Induces Intestinal Epithelial Barrier Injury via the Release of Mast Cell Proteases and TNF-α

(2012) Elizabeth L. Overman et al.   PLoS One

Gliadin Peptides Induce Tissue Transglutaminase Activation and ER-Stress through Ca2+ Mobilization in Caco-2 Cells

(2012) Ivana Caputo et al.   PLoS One

Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats

(2012) Afifa Ait-Belgnaoui et al.   PSYCHONEUROENDOCRINOLOGY

Gastroesophageal Reflux Symptoms and Comorbid Asthma and Posttraumatic Stress Disorder Following the 9/11 Terrorist Attacks on World Trade Center in New York City

(2011) Jiehui Li et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Expression and the Cellular Distribution of the Tight Junction Proteins Are Altered in Irritable Bowel Syndrome Patients With Differences According to the Disease Subtype

(2011) Nathalie Bertiaux-Vandaële et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Mast cell–nerve axis with a focus on the human gut

(2011) Sabine Buhner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity

(2011) Anna Sapone et al.   BMC Medicine

Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?

(2011) Dervla O’Malley et al.   BRAIN BEHAVIOR AND IMMUNITY

The new link between gut–brain axis and neuropsychiatric disorders

(2011) Sergueï O. Fetissov et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Eosinophils Express Muscarinic Receptors and Corticotropin-Releasing Factor to Disrupt the Mucosal Barrier in Ulcerative Colitis

(2011) Conny Wallon et al.   GASTROENTEROLOGY

Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique

(2011) R. Farre et al.   GUT

Substance P (SP) Induces Expression of Functional Corticotropin-Releasing Hormone Receptor-1 (CRHR-1) in Human Mast Cells

(2011) Shahrzad Asadi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Short-term and medium-term health effects of 9/11

(2011) Sharon E Perlman et al.   LANCET

Chronic psychosocial stress induces reversible mitochondrial damage and corticotropin-releasing factor receptor type-1 upregulation in the rat intestine and IBS-like gut dysfunction

(2011) María Vicario et al.   PSYCHONEUROENDOCRINOLOGY

Corticotropin-releasing factor secretion from dendritic cells stimulated by commensal bacteria

(2011) Mariko Hojo   WORLD JOURNAL OF GASTROENTEROLOGY

Lactobacillus plantarum ameliorates colonic epithelial barrier dysfunction by modulating the apical junctional complex and PepT1 in IL-10 knockout mice

(2010) Hong-Qi Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Corticotropin-releasing hormone-receptor 2 is required for acute stress-induced bladder vascular permeability and release of vascular endothelial growth factor

(2010) William Boucher et al.   BJU INTERNATIONAL

Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress

(2010) María Vicario et al.   BRAIN BEHAVIOR AND IMMUNITY

The active Zot domain (aa 288–293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation

(2010) Simeon E. Goldblum et al.   FASEB JOURNAL

Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity

(2010) Christopher R. Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple facets of intestinal permeability and epithelial handling of dietary antigens

(2010) S Ménard et al.   Mucosal Immunology

Stress-induced barrier disruption of rat follicle-associated epithelium involves corticotropin-releasing hormone, acetylcholine, substance P, and mast cells

(2010) å. v. Keita et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Epithelial crosstalk at the microbiota-mucosal interface

(2010) J. M. Wells et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Do NSAIDs, Antibiotics, Infections, or Stress Trigger Flares in IBD?

(2009) Sunny Singh et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Cortagine, a CRF1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathways

(2009) Muriel Larauche et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Early weaning stress impairs development of mucosal barrier function in the porcine intestine

(2009) Feli Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Stress-related modulation of inflammation in experimental models of bowel disease and post-infectious irritable bowel syndrome: Role of corticotropin-releasing factor receptors

(2009) Cornelia Kiank et al.   BRAIN BEHAVIOR AND IMMUNITY

Differential actions of urocortins on neurons of the myenteric division of the enteric nervous system in guinea pig distal colon

(2009) S Liu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Local Secretion of Urocortin 1 Promotes Microvascular Permeability during Lipopolysaccharide-Induced Inflammation

(2009) Elizabeth L. Cureton et al.   ENDOCRINOLOGY

Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestine

(2009) P-Y Zheng et al.   GUT

Metabotyping of Biofluids Reveals Stress-Based Differences in Gut Permeability in Healthy Individuals

(2009) Serge Rezzi et al.   JOURNAL OF PROTEOME RESEARCH

Role of p38 MAPK in Burn-Induced Intestinal Barrier Breakdown

(2009) Todd W. Costantini et al.   JOURNAL OF SURGICAL RESEARCH

Chronic peripheral administration of corticotropin-releasing factor causes colonic barrier dysfunction similar to psychological stress

(2008) Aaron A. Teitelbaum et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pathophysiological Mechanisms of Stress-Induced Intestina Damage

(2008) Melanie Gareau et al.   CURRENT MOLECULAR MEDICINE

Maladaptive Intestinal Epithelial Responses to Life Stress May Predispose Healthy Women to Gut Mucosal Inflammation

(2008) Carmen Alonso et al.   GASTROENTEROLOGY

Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3

(2008) Karen M. Lammers et al.   GASTROENTEROLOGY

Targeted Epithelial Tight Junction Dysfunction Causes Immune Activation and Contributes to Development of Experimental Colitis

(2008) Liping Su et al.   GASTROENTEROLOGY

Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

(2008) T Piche et al.   GUT

Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects1

(2008) G. P. Lambert   JOURNAL OF ANIMAL SCIENCE

Eosinophil–nerve interactions and neuronal plasticity in rat gut associated lymphoid tissue (GALT) in response to enteric parasitism

(2008) L.M. O'Brien et al.   JOURNAL OF NEUROIMMUNOLOGY

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Effects of serotonin 5-HT3receptor antagonists on stress-induced colonic hyperalgesia and diarrhoea in rats: a comparative study with opioid receptor agonists, a muscarinic receptor antagonist and a synthetic polymer

(2008) t. hirata et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Stress neuropeptides evoke epithelial responses via mast cell activation in the rat colon

(2008) Javier Santos et al.   PSYCHONEUROENDOCRINOLOGY