Inhibition of Large Neutral Amino Acid Transporters Suppresses Kynurenic Acid Production Via Inhibition of Kynurenine Uptake in Rodent Brain

Is the interaction between fatty acids and tryptophan responsible for the efficacy of a ketogenic diet in epilepsy? The new hypothesis of action

(2016) P. Maciejak et al.   NEUROSCIENCE

Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro

(2015) Airi Sekine et al.   SpringerPlus

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

(2014) Leandro Z. Agudelo et al.   CELL

Reduction of Brain Kynurenic Acid Improves Cognitive Function

(2014) R. Kozak et al.   JOURNAL OF NEUROSCIENCE

JPH203, an L-Type Amino Acid Transporter 1–Selective Compound, Induces Apoptosis of YD-38 Human Oral Cancer Cells

(2014) Dae-Woong Yun et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer

(2013) Kyoichi Kaira et al.   BMC CANCER

The Niacin Required for Optimum Growth Can Be Synthesized from L-Tryptophan in Growing Mice Lacking Tryptophan-2,3-Dioxygenase

(2013) Miki Terakata et al.   JOURNAL OF NUTRITION

The SLC3 and SLC7 families of amino acid transporters

(2013) Dimitrios Fotiadis et al.   MOLECULAR ASPECTS OF MEDICINE

Large neutral amino acids: dietary effects on brain neurochemistry and function

(2012) John D. Fernstrom   AMINO ACIDS

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia

(2012) Amy B. Dounay et al.   ACS Medicinal Chemistry Letters

Metabolism and Pharmacokinetic Studies of JPH203, an L-Amino Acid Transporter 1 (LAT1) Selective Compound

(2011) Michael F. Wempe et al.   Drug Metabolism and Pharmacokinetics

Ketogenic diet increases concentrations of kynurenic acid in discrete brain structures of young and adult rats

(2011) Tomasz Żarnowski et al.   JOURNAL OF NEURAL TRANSMISSION

High tryptophan diet reduces extracellular dopamine release via kynurenic acid production in rat striatum

(2011) Alato Okuno et al.   JOURNAL OF NEUROCHEMISTRY

Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory

(2011) Ana Pocivavsek et al.   NEUROPSYCHOPHARMACOLOGY

The kynurenine pathway in major depression: Haplotype analysis of three related functional candidate genes

(2011) Stephan Claes et al.   PSYCHIATRY RESEARCH

Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry

(2010) Å. Konradsson-Geuken et al.   NEUROSCIENCE

Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia

(2010) K. R. Linderholm et al.   SCHIZOPHRENIA BULLETIN

L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning

(2009) Amy C. Chess et al.   BEHAVIOURAL BRAIN RESEARCH

l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth

(2009) Koji Oda et al.   CANCER SCIENCE

Pharmacological Manipulation of Kynurenic Acid

(2009) Sophie Erhardt et al.   CNS DRUGS

Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release

(2009) A. Zmarowski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

On the relationship between the two branches of the kynurenine pathway in the rat brainin vivo

(2009) Laura Amori et al.   JOURNAL OF NEUROCHEMISTRY

Meal ingestion, amino acids and brain neurotransmitters: Effects of dietary protein source on serotonin and catecholamine synthesis rates

(2009) SuJean Choi et al.   PHYSIOLOGY & BEHAVIOR

Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice

(2009) Masaaki Kanai et al.   Molecular Brain

BCH, an Inhibitor of System L Amino Acid Transporters, Induces Apoptosis in Cancer Cells

(2008) Chun Sung Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum

(2008) L. Amori et al.   NEUROSCIENCE