Article
Geriatrics & Gerontology
Aladdin H. Shadyab, Linda K. McEvoy, Steve Horvath, Eric A. Whitsel, Stephen R. Rapp, Mark A. Espeland, Susan M. Resnick, JoAnn E. Manson, Jiu-Chiuan Chen, Brian H. Chen, Wenjun Li, Kathleen M. Hayden, Wei Bao, Cynthia D. J. Kusters, Andrea Z. LaCroix
Summary: The study examined the association between epigenetic age acceleration and cognitive impairment, finding that intrinsic AgeAccel was not significantly associated with cognitive impairment overall, but was associated with impairment among women who developed coronary heart disease.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Aron S. Buchman, Ana W. Capuano, Veronique VanderHorst, Robert S. Wilson, Shahram Oveisgharan, Julie A. Schneider, David A. Bennett
Summary: This study examined the relationship between changes in body mass index (BMI) and cognitive decline in older adults. The results showed that BMI changes were associated with cognitive decline, and this association was mediated by certain brain pathologies, such as beta-amyloid accumulation. Understanding the molecular mechanisms underlying these associations may lead to the development of interventions for maintaining brain health and metabolic homeostasis in old age.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Marta Sochocka, Julia Karska, Magdalena Pszczolowska, Michal Ochnik, Michal Fulek, Katarzyna Fulek, Donata Kurpas, Justyna Chojdak-Lukasiewicz, Anna Rosner-Tenerowicz, Jerzy Leszek
Summary: Early and premature menopause, known as premature ovarian insufficiency (POI), affects 1% of women under 40. This review explores the impact of early and premature menopause on cognitive decline. Cognitive complaints are more common during menopause due to decreased hormone levels, particularly estrogen. Premature reduction in estrogen increases the risk of cardiovascular disease, depression, osteoporosis, and cognitive disorders. Hormone therapy during menopause may reduce the risk of mild cognitive impairment (MCI) and Alzheimer's disease (AD) later in life. Multidisciplinary care is necessary to maintain mental health in women with earlier menopause.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Janusz Wieslaw Blaszczyk
Summary: According to Alzheimer's Disease International, there are 55 million people worldwide living with dementia, which is a set of symptoms resulting from brain damage. The symptoms involve progressive impairments in memory, thinking, and behavior, often accompanied by emotional problems, language difficulties, and decreased motivation. Although attempts to treat dementia by addressing symptoms have failed, this narrative review aims to explain the etiology of dementia and Alzheimer's disease through the perspective of energy and cognitive metabolism dysfunction in an aging brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Bogdan Stefanowski, Marek Kucharski, Anna Szeliga, Milena Snopek, Anna Kostrzak, Roman Smolarczyk, Marzena Maciejewska-Jeske, Anna Duszewska, Olga Niwczyk, Slawomir Drozd, Monika Englert-Golon, Katarzyna Smolarczyk, Blazej Meczekalski
Summary: Globally, cognitive decline and dementia pose a major challenge to public health. The causes of these conditions can be genetic or triggered by various factors. The association between estrogen decline after menopause and cognitive decline/dementia remains inconclusive. This article explores the prevention of cognitive decline and dementia in postmenopausal women, focusing on pharmacological intervention for primary prevention and diet/weight reduction for secondary prevention. Further research is needed to determine the role of menopausal hormone therapy (MHT) in dementia.
Article
Cell Biology
Hemant Srivastava, Alexander Tate Lasher, Akash Nagarajan, Liou Y. Sun
Summary: Alzheimer's disease (AD) is a prevalent form of dementia that is characterized by cognitive decline with age. Treatment options for AD are limited, making it a significant public health concern. Recent research has shown that metabolic dysfunction and insulin therapy may play a role in the development of AD. In this study, the TgF344-AD rat model was used to examine the relationship between body composition, insulin sensitivity, glucose tolerance, and behavioral assessments of learning, memory, and anxiety. The results showed that female TgF344-AD rats exhibited impaired glucose clearance and reduced insulin sensitivity, while male rats showed no differences or improved glucose clearance. Male rats also displayed impairments in learning and memory, while female rats showed impairments only at a later age. Additionally, female rats displayed increased anxiety at a younger age, but no differences were detected in males. These findings suggest that metabolic impairments occur before or simultaneously with cognitive decline and anxiety, in a sexually dimorphic manner, in the TgF344-AD rat model.
Review
Geriatrics & Gerontology
Steven Jett, Eva Schelbaum, Grace Jang, Camila Boneu Yepez, Jonathan P. Dyke, Silky Pahlajani, Roberta Diaz Brinton, Lisa Mosconi
Summary: Ovarian hormones play a crucial role in women's cognition, and the decline of 17 beta-estradiol during menopause is associated with cognitive aging and Alzheimer's disease risk.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Food Science & Technology
Alba Tor-Roca, Alex Sanchez-Pla, Aniko Korosi, Merce Pallas, Paul J. Lucassen, Pol Castellano-Escuder, Ludwig Aigner, Raul Gonzalez-Dominguez, Claudine Manach, Francisco Carmona, Esteban Vegas, Catherine Helmer, Catherine Feart, Sophie Lefevre-Arbogast, Jeanne Neuffer, Hyunah Lee, Sandrine Thuret, Cristina Andres-Lacueva, Cecilia Samieri, Mireia Urpi-Sarda
Summary: This study found that greater adherence to the Mediterranean diet is associated with lower odds of cognitive decline in older adults.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Endocrinology & Metabolism
Chrisandra L. Shufelt, JoAnn E. Manson
Summary: Menopausal hormone therapy has varying effects on cardiometabolic markers and cardiovascular disease risk depending on formulation, dose, and route of delivery. Oral estrogens without progestogens have positive effects on lipoprotein levels, glycemia, insulin, and CVD risk, while adding progestogens blunts the lipid-related effects. Transdermal estrogens have less impact on coagulation, inflammation, and lipids compared to oral estrogens, potentially posing a lower risk of venous thromboembolism and stroke.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Petra Stute, Johanna Wienges, Anne-Sophie Koller, Christina Giese, Wiebke Wesemueller, Heidrun Janka, Sabrina Baumgartner
Summary: Dementia, predominantly Alzheimer's disease, affects 10 out of 100 women above age 65. Menopausal Hormone Therapy (MHT) is not recommended for prevention. Studies show that MHT may reduce dementia risk by 11-33%, but results vary depending on factors like MHT type and age at initiation.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Immunology
Brandilyn A. Peters, David B. Hanna, Anjali Sharma, Kathryn Anastos, Donald R. Hoover, Qiuhu Shi, Caitlin A. Moran, Elizabeth A. Jackson, Maria L. Alcaide, Igho Ofotokun, Adaora A. Adimora, Sabina A. Haberlen, Mardge Cohen, Phyllis C. Tien, Katherine G. Michel, Steven R. Levine, Howard N. Hodis, Robert C. Kaplan, Michael T. Yin
Summary: In this cohort study, ever use of estrogen-based hormone therapy was associated with less progression of subclinical atherosclerosis over time in women with and without HIV. This suggests that hormone therapy may confer a similar cardiovascular benefit for both groups.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Geriatrics & Gerontology
Jorge J. Llibre-Guerra, Yan Li, Isabel Elaine Allen, Juan C. Llibre-Guerra, Ana M. Rodriguez Salgado, Ana Ibis Penalver, Arianna Almirall Sanchez, Jennifer S. Yokoyama, Lea Grinberg, Victor Valcour, Bruce L. Miller, Juan J. Llibre-Rodriguez
Summary: This study examines the effects of self-identified race and genetic admixture on dementia prevalence and cognitive performance. The results show no independent association between self-identified race and African ancestry proportion with dementia prevalence and cognitive performance. This suggests that observed differences in dementia prevalence among diverse populations may be primarily influenced by social determinants of health.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
David Vogrinc, Milica Gregoric Kramberger, Andreja Emersic, Sasa Cucnik, Katja Goricar, Vita Dolzan
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease with a complex genetic background. Genome-wide association studies (GWAS) have identified numerous AD risk loci. This study aims to assess the associations between SNPs in well-established GWAS AD risk loci and CSF biomarker levels or cognitive test results in Slovenian patients with cognitive decline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Cynthia A. Stuenkel
Summary: VMS in older women may persist into advanced age and increase cardiovascular disease risks. Nonhormonal treatment options are available for those who elect not to use, or are advised not to use, menopausal hormone therapies.
Article
Agriculture, Multidisciplinary
Zhuoyan Fan, Haichao Wen, Xiaoxu Zhang, Jingming Li, Jiachen Zang
Summary: Metabolic disorder is an important sign of aging, and early dietary intervention can be effective in preventing or delaying brain aging. This study found that cyanidin 3-O-beta-galactoside from black chokeberry has positive effects on energy metabolism and cognitive function in aging mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Editorial Material
Neurosciences
Allyson C. Rosen, Jalayne J. Arias, J. Wesson Ashford, Deborah Blacker, Jasmeer P. Chhatwal, Nathan A. Chin, Lindsay Clark, Sharon S. Denny, Jill S. Goldman, Carey E. Gleason, Joshua D. Grill, Judith L. Heidebrink, Victor W. Henderson, James A. Lavacot, Jennifer H. Lingler, Malavika Menon, Rachel L. Nosheny, Fabricio F. Oliveira, Monica W. Parker, Annalise Rahman-Filipiak, Anwita Revoori, Malia C. Rumbaugh, Danurys L. Sanchez, Suzanne E. Schindler, Christopher G. Schwarz, Leslie Toy, Jamie Tyrone, Sarah Walter, Li-San Wang, Ellen M. Wijsman, Doris T. Zallen, Neelum T. Aggarwala
Summary: The public is increasingly recognizing the value of accessing dementia risk evidence (DRE) as it can guide diagnosis and clinical management, while researchers are considering how to share and use this evidence.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Qian Xiao, Aladdin H. Shadyab, Stephen R. Rapp, Katie L. Stone, Kristin Yaffe, Joshua N. Sampson, Jiu-Chiuan Chen, Kathleen M. Hayden, Victor W. Henderson, Andrea Z. LaCroix
Summary: This study found a predictive association between weakened rest-activity rhythms and cognitive decline, mild cognitive impairment, and dementia among older women.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Clinical Neurology
Sigrun Alba Johannesdottir Schmidt, Katalin Veres, Henrik Toft Sorensen, Niels Obel, Victor W. Henderson
Summary: Based on nationwide Danish registries, this study investigated the association between herpes zoster and dementia. The results showed that there is no increased risk of dementia associated with herpes zoster, and there may even be a small decrease in risk.
Article
Public, Environmental & Occupational Health
Blean Girma, Dora Kormendine Farkas, Kristina Laugesen, Nils Skajaa, Victor W. Henderson, Paolo Boffetta, Henrik Toft Sorensen
Summary: GBS patients have a three-fold increased risk of cancer diagnosis in the first year of follow-up. The absolute cancer risk was almost 3.0%. A GBS diagnosis was an adverse prognostic marker for survival following cancer diagnosis.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Clinical Neurology
Marian Shahid, Ashley Rawls, Veronica Ramirez, Sephira Ryman, Veronica E. Santini, Laurice Yang, Sharon J. Sha, Jacob N. Hall, Thomas J. Montine, Amy Lin, Lu Tian, Victor W. Henderson, Brenna Cholerton, Maya Yutsis, Kathleen L. Poston
Summary: This study aimed to investigate pareidolias in patients across the Lewy body disease spectrum. Illusory responses were studied in 300 participants, and it was found that cognitively impaired LB patients were more likely to endorse illusory responses compared to other groups. The Noise Pareidolia Task can be used to screen for unobtrusive pareidolias in LB patients before the onset of hallucinations and delusions.
ANNALS OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Natalie Piehl, Lynn van Olst, Abhirami Ramakrishnan, Victoria Teregulova, Brooke Simonton, Ziyang Zhang, Emma Tapp, Divya Channappa, Hamilton Oh, Patricia M. Losada, Jarod Rutledge, Alexandra N. Trelle, Elizabeth C. Mormino, Fanny Elahi, Douglas R. Galasko, Victor W. Henderson, Anthony D. Wagner, Tony Wyss-Coray, David Gate
Summary: This study revealed dysregulation of cerebrospinal fluid immune system during healthy brain aging and cognitive impairment. Age-related upregulation of lipid transport genes in monocytes and altered cytokine signaling to CD8 T cells were observed in cognitively normal subjects. In cognitively impaired subjects, downregulation of lipid transport genes in monocytes occurred alongside the upregulation of CXCR6 in CD8 T cells and elevated expression of CXCL16 in the CSF, indicating a potential mechanism for antigen-specific T cell entry into the brain.
Article
Clinical Neurology
Edward N. Wilson, Christina B. Young, Javier Ramos Benitez, Michelle S. Swarovski, Igor Feinstein, Manu Vandijck, Yann Le Guen, Nandita M. Kasireddy, Marian Shahid, Nicole K. Corso, Qian Wang, Gabriel Kennedy, Alexandra N. Trelle, Betty Lind, Divya Channappa, Malia Belnap, Veronica Ramirez, Irina Skylar-Scott, Kyan Younes, Maya V. Yutsis, Nathalie Le Bastard, Joseph F. Quinn, Christopher H. van Dyck, Angus Nairn, Carolyn A. Fredericks, Lu Tian, Geoffrey A. Kerchner, Thomas J. Montine, Sharon J. Sha, Guido Davidzon, Victor W. Henderson, Frank M. Longo, Michael D. Greicius, Anthony D. Wagner, Tony Wyss-Coray, Kathleen L. Poston, Elizabeth C. Mormino, Katrin I. Andreasson
Summary: This study evaluated the diagnostic and prognostic performance of a fully automated Lumipulse plasma p-tau181 assay for detecting Alzheimer's disease. The results showed that the assay had high accuracy in diagnosing AD and was strongly associated with CSF biomarkers and amyloid PET. Additionally, baseline plasma p-tau181 could predict long-term cognitive and functional changes.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Nils Skajaa, Kasper Adelborg, Erzsebet Horvath-Puho, Kenneth J. Rothman, Victor W. Henderson, Lau Caspar Thygesen, Henrik Toft Sorensen
Summary: This study examined labor market participation and retirement among stroke patients and the general population, focusing on different subtypes of stroke. The results showed that most patients took sick leave within three weeks of diagnosis and were less likely to return to the labor market, especially those with intracerebral hemorrhage. The main reasons for non-participation in the labor market were sick leave and receipt of a disability pension.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Behavioral Sciences
Nils Skajaa, Emil Bjerregaard Riahi, Szimonetta Komjathine Szepligeti, Erzsebet Horvath-Puho, Trine Toft Sorensen, Victor W. Henderson, Henrik Toft Sorensen
Summary: Using Danish nationwide registries, this study found that patients with type 2 diabetes and obesity had a reduced risk of ALS compared to the general population, especially among men and those aged 60 or above.
BRAIN AND BEHAVIOR
(2023)
Article
Public, Environmental & Occupational Health
Soren Hauge Okholm, David Nagy, Dora Koermendine Farkas, Cecilia Hvitfeldt Fuglsang, Frederikke Schonfeldt Troelsen, Victor Henderson, Henrik Toft Sorensen
Summary: This cohort study examined the association between non-traumatic subdural hematoma and cancer risk. The results showed that the risk of a new cancer diagnosis was clearly increased in patients with non-traumatic subdural hematoma during the first year of follow-up. However, the absolute risk was low, thus limiting the clinical relevance of early cancer detection in these patients.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Yashi Mi, Guoyuan Qi, Francesca Vitali, Yuan Shang, Adam C. Raikes, Tian Wang, Yan Jin, Roberta D. Brinton, Haiwei Gu, Fei Yin
Summary: Mi, Qi et al. have identified a mechanism in which defective oxidative phosphorylation in astrocytes disrupts astroglial lipid homeostasis, leading to neuronal damage and microglial reactivity. This mechanism involves the accumulation of lipid droplets in astrocytes, which triggers neurodegeneration resembling Alzheimer's disease. The study reveals the importance of astrocytic oxidative phosphorylation in fatty acid degradation and lipid homeostasis maintenance, and highlights the role of astrocyte dysfunction in neuroinflammation and neurodegeneration.
Article
Pharmacology & Pharmacy
Ha M. Dang, Mark D. Krailo, Todd A. Alonzo, Wendy J. Mack, John A. Kairalla
Summary: The choice of methods to estimate information fraction for futility monitoring in a non-inferiority trial was debated. The Total Control Only (TCO) method was identified as the only method that provides unbiased estimates of information fraction regardless of hypothesis assumptions and exhibits good power and comparable type I error rate.
PHARMACEUTICAL STATISTICS
(2023)
Article
Clinical Neurology
Holly Elser, Erzsebet Horvath-Puho, Jaimie L. Gradus, Meghan L. Smith, Timothy L. Lash, M. Maria Glymour, Henrik Toft Sorensen, Victor W. Henderson
Summary: This study found that early-, middle-, and late-life depression is associated with an increased risk of dementia. Depression may be an early symptom or response to preclinical disease. The risk of dementia was more than doubled for both men and women with diagnosed depression. The persistent association between dementia and depression diagnosed in early and middle life suggests that depression may increase dementia risk.
Article
Clinical Neurology
Holly Elser, Erzsebet Horvath-Puho, Jaimie L. Gradus, Meghan L. Smith, Timothy L. Lash, M. Maria Glymour, Henrik Toft Sorensen, Victor W. Henderson
Summary: Late-life depressive symptoms are associated with subsequent dementia diagnosis and may be an early symptom or response to preclinical disease. Evaluating associations with early- and middle-life depression will help clarify whether depression influences dementia risk.
Meeting Abstract
Clinical Neurology
Holly Elser, Erzsebet Horvath-Puho, Jaimie Gradus, Meghan Smith, Timothy Lash, Maria Glymour, Henrik Sorensen, Victor Henderson
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
